DK75291A - Hidtil ukendte 4-substituerede anthracyclinoner og anthracyclinglycosider samt fremgangsmaade til fremstilling deraf - Google Patents

Hidtil ukendte 4-substituerede anthracyclinoner og anthracyclinglycosider samt fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK75291A
DK75291A DK075291A DK75291A DK75291A DK 75291 A DK75291 A DK 75291A DK 075291 A DK075291 A DK 075291A DK 75291 A DK75291 A DK 75291A DK 75291 A DK75291 A DK 75291A
Authority
DK
Denmark
Prior art keywords
group
substituted
anthracycling
lycosides
procedures
Prior art date
Application number
DK075291A
Other languages
English (en)
Other versions
DK75291D0 (da
DK168597B1 (da
Inventor
Walter Cabri
Silvia De Bernardinis
Franco Francalanci
Sergio Penco
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK75291D0 publication Critical patent/DK75291D0/da
Publication of DK75291A publication Critical patent/DK75291A/da
Application granted granted Critical
Publication of DK168597B1 publication Critical patent/DK168597B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK075291A 1988-10-25 1991-04-24 4-substituerede demethoxy-daunomydinoner og anthracyclinglycosider deraf samt fremgangsmåde til fremstilling af glycosiderne DK168597B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8824947 1988-10-25
GB888824947A GB8824947D0 (en) 1988-10-25 1988-10-25 New 4-substituted anthracyclinones & process for preparing them
PCT/EP1989/001266 WO1990004601A1 (en) 1988-10-25 1989-10-24 New 4-substituted anthracyclinones and anthracycline glycosides and the process for preparing them
EP8901266 1989-10-24

Publications (3)

Publication Number Publication Date
DK75291D0 DK75291D0 (da) 1991-04-24
DK75291A true DK75291A (da) 1991-06-20
DK168597B1 DK168597B1 (da) 1994-05-02

Family

ID=10645743

Family Applications (1)

Application Number Title Priority Date Filing Date
DK075291A DK168597B1 (da) 1988-10-25 1991-04-24 4-substituerede demethoxy-daunomydinoner og anthracyclinglycosider deraf samt fremgangsmåde til fremstilling af glycosiderne

Country Status (18)

Country Link
US (1) US5587495A (da)
EP (1) EP0366973B1 (da)
JP (1) JPH04501414A (da)
KR (1) KR900701812A (da)
AT (1) ATE99318T1 (da)
AU (1) AU624444B2 (da)
DE (1) DE68911855T2 (da)
DK (1) DK168597B1 (da)
ES (1) ES2061871T3 (da)
FI (1) FI93364C (da)
GB (1) GB8824947D0 (da)
HU (1) HU207733B (da)
IE (1) IE64161B1 (da)
IL (1) IL92052A (da)
NZ (1) NZ231052A (da)
PT (1) PT92080B (da)
WO (1) WO1990004601A1 (da)
ZA (1) ZA898052B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
CN100379749C (zh) * 2003-05-21 2008-04-09 獀洛克斯股份有限公司 4-r-取代的4-去甲氧基柔红霉素的制备方法
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4116981A (en) * 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
AU567978B2 (en) * 1983-10-19 1987-12-10 Anti-Cancer Council Of Victoria Carminomycinone precursors and analogues and derivatives thereof.
EP0159357B1 (en) * 1983-10-19 1992-09-09 The University Of Melbourne Carminomycinone precursors and analogues and derivatives thereof

Also Published As

Publication number Publication date
PT92080A (pt) 1990-04-30
HU896397D0 (en) 1991-07-29
IE64161B1 (en) 1995-07-12
IL92052A (en) 1994-06-24
EP0366973A1 (en) 1990-05-09
KR900701812A (ko) 1990-12-04
FI93364B (fi) 1994-12-15
AU624444B2 (en) 1992-06-11
HU207733B (en) 1993-05-28
EP0366973B1 (en) 1993-12-29
NZ231052A (en) 1991-04-26
IE893407L (en) 1990-04-25
FI93364C (fi) 1995-03-27
ZA898052B (en) 1990-08-29
WO1990004601A1 (en) 1990-05-03
PT92080B (pt) 1995-06-30
GB8824947D0 (en) 1988-11-30
US5587495A (en) 1996-12-24
ATE99318T1 (de) 1994-01-15
JPH04501414A (ja) 1992-03-12
FI911952A0 (fi) 1991-04-22
AU4496289A (en) 1990-05-14
DE68911855T2 (de) 1994-04-21
DK75291D0 (da) 1991-04-24
IL92052A0 (en) 1990-07-12
HUT57228A (en) 1991-11-28
DE68911855D1 (de) 1994-02-10
DK168597B1 (da) 1994-05-02
ES2061871T3 (es) 1994-12-16

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed