EE03929B1 - Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid - Google Patents

Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid

Info

Publication number: EE03929B1
Authority: EE; Estonia
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; synthetic polysaccharides; polysaccharides
Prior art date: 1996-07-19

Application number

EEP199900015A

Other languages

English (en)

Estonian (et)

Other versions

EE9900015A (et

Inventor

Alexandre Driguez Pierre

Duchaussoy Philippe

Herbert Jean-Marc

Petitou Maurice

Adriaan Anton Van Boeckel Constant

Grootenhuis Peter

Egbertus Maria Basten Johannes

Maria Dreef-Tromp Corn�lia

Original Assignee

Sanofi

Akzo Nobel N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-19

Filing date

1997-07-18

Publication date

2002-12-16

1997-07-18 Application filed by Sanofi, Akzo Nobel N.V. filed Critical Sanofi

1999-08-16 Publication of EE9900015A publication Critical patent/EE9900015A/xx

2002-12-16 Publication of EE03929B1 publication Critical patent/EE03929B1/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Diabetes (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EEP199900015A 1996-07-19 1997-07-18 Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid EE03929B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9609116A FR2751334B1 (fr)	1996-07-19	1996-07-19	Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1997/001344 WO1998003554A1 (fr)	1996-07-19	1997-07-18	Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number	Publication Date
EE9900015A EE9900015A (et)	1999-08-16
EE03929B1 true EE03929B1 (et)	2002-12-16

Family

ID=9494266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900015A EE03929B1 (et)	1996-07-19	1997-07-18	Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid

Country Status (36)

Country	Link
US (1)	US6534481B1 (ar)
EP (1)	EP0912613B1 (ar)
JP (1)	JP3345020B2 (ar)
KR (1)	KR100311857B1 (ar)
CN (1)	CN1200003C (ar)
AR (1)	AR008068A1 (ar)
AT (1)	ATE224917T1 (ar)
AU (1)	AU726679B2 (ar)
BR (1)	BR9710739B1 (ar)
CA (1)	CA2261597C (ar)
CZ (1)	CZ301009B6 (ar)
DE (1)	DE69715866T2 (ar)
DK (1)	DK0912613T3 (ar)
EE (1)	EE03929B1 (ar)
ES (1)	ES2184123T3 (ar)
FR (1)	FR2751334B1 (ar)
HK (1)	HK1019757A1 (ar)
HU (1)	HU223691B1 (ar)
ID (1)	ID20604A (ar)
IL (2)	IL128018A0 (ar)
IS (1)	IS1968B (ar)
MY (1)	MY124548A (ar)
NO (1)	NO319682B1 (ar)
NZ (1)	NZ333721A (ar)
PL (1)	PL190397B1 (ar)
PT (1)	PT912613E (ar)
RU (1)	RU2167163C2 (ar)
SA (1)	SA99200037B1 (ar)
SI (1)	SI0912613T1 (ar)
SK (1)	SK284881B6 (ar)
TR (1)	TR199900114T2 (ar)
TW (1)	TW520376B (ar)
UA (1)	UA61921C2 (ar)
WO (1)	WO1998003554A1 (ar)
YU (1)	YU49247B (ar)
ZA (1)	ZA976340B (ar)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2773801B1 (fr)	1998-01-19	2000-05-12	Sanofi Sa	Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2814463B1 (fr) *	2000-09-22	2002-11-15	Sanofi Synthelabo	Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
US7138531B2 (en) *	2001-10-15	2006-11-21	Kemin Pharma B.V.B.A.	Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity
EP1574516A1 (en) *	2004-03-05	2005-09-14	Sanofi-Aventis	Antithrombotic compound
US7563780B1 (en) *	2004-06-18	2009-07-21	Advanced Cardiovascular Systems, Inc.	Heparin prodrugs and drug delivery stents formed therefrom
FR2874924B1 (fr)	2004-09-09	2006-12-01	Sanofi Aventis Sa	Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) *	2004-12-23	2013-08-01	Merck Sharp & Dohme	包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) *	2005-02-01	2012-11-11	Msd Oss Bv	Conjugates of a polypeptide and an oligosaccharide
IL181431A0 (en) *	2007-02-19	2007-07-04	Micha Shemer	Fruit juice and puree with a lowered amount of available sugars
KR101646960B1 (ko)	2007-10-16	2016-08-09	프로젠 피지500 시리즈 피티와이 리미티드	신규한 황산화된 올리고사카라이드 유도체
KR101529061B1 (ko)	2008-05-30	2015-06-16	모멘타 파머슈티컬스 인코포레이티드	당류 구조물, 그리고 이러한 구조물의 제조 및 사용 방법
FR2935386B1 (fr) *	2008-08-26	2010-09-10	Sanofi Aventis	Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
US8288515B2 (en)	2009-07-31	2012-10-16	Reliable Biopharmaceutical Corporation	Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949115B1 (fr)	2009-08-14	2012-11-02	Sanofi Aventis	OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr)	2009-08-14	2011-08-26	Sanofi Aventis	OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en)	2009-10-30	2013-04-16	Reliable Biopharmaceutical Corporation	Efficient and scalable process for the manufacture of Fondaparinux sodium
KR101682466B1 (ko) *	2010-02-01	2016-12-05	롯데정밀화학 주식회사	아세틸화 셀룰로오스 에테르 및 이를 포함하는 물품
EP2614089A1 (fr)	2010-09-10	2013-07-17	Sanofi-Aventis	Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2970969B1 (fr)	2011-01-27	2013-10-18	Sanofi Aventis	Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
CN109134555B (zh) *	2017-06-15	2021-09-28	南京正大天晴制药有限公司	抗凝血的五糖类化合物及其制备方法和医药用途
CN109134554B (zh) *	2017-06-15	2021-09-28	南京正大天晴制药有限公司	抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) *	2017-06-15	2021-09-28	南京正大天晴制药有限公司	抗凝血的五糖类化合物及其制备方法和医药用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4801583A (en)	1982-01-15	1989-01-31	Choay S.A.	Oligosaccharides and their biological applications
EP0300099A1 (en)	1987-07-20	1989-01-25	Akzo N.V.	New pentasaccharides
US5382570A (en)	1990-04-23	1995-01-17	Akzo, N.V.	Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en)	1990-04-23	1995-01-03	Akzo N.V.	Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
IL102758A (en)	1991-08-23	1997-03-18	Akzo Nv	Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr)	1993-04-22	1995-07-21	Sanofi Elf	3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ES2147216T3 (es)	1993-09-01	2000-09-01	Akzo Nobel Nv	Bisconjugados que comprenden dos sacaridos y un grupo de union.
FR2749849B1 (fr) *	1996-06-14	1998-09-04	Sanofi Sa	Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

1996
- 1996-07-19 FR FR9609116A patent/FR2751334B1/fr not_active Expired - Lifetime
1997
- 1997-07-08 US US09/230,139 patent/US6534481B1/en not_active Expired - Lifetime
- 1997-07-17 ZA ZA976340A patent/ZA976340B/xx unknown
- 1997-07-17 AR ARP970103200A patent/AR008068A1/es unknown
- 1997-07-18 NZ NZ333721A patent/NZ333721A/xx not_active IP Right Cessation
- 1997-07-18 DK DK97934596T patent/DK0912613T3/da active
- 1997-07-18 ES ES97934596T patent/ES2184123T3/es not_active Expired - Lifetime
- 1997-07-18 AT AT97934596T patent/ATE224917T1/de active
- 1997-07-18 UA UA99020967A patent/UA61921C2/uk unknown
- 1997-07-18 HU HU9902287A patent/HU223691B1/hu active IP Right Grant
- 1997-07-18 CA CA002261597A patent/CA2261597C/fr not_active Expired - Lifetime
- 1997-07-18 CN CNB971976171A patent/CN1200003C/zh not_active Expired - Lifetime
- 1997-07-18 EE EEP199900015A patent/EE03929B1/xx unknown
- 1997-07-18 BR BRPI9710739-5A patent/BR9710739B1/pt not_active IP Right Cessation
- 1997-07-18 AU AU37747/97A patent/AU726679B2/en not_active Expired
- 1997-07-18 JP JP50665198A patent/JP3345020B2/ja not_active Expired - Lifetime
- 1997-07-18 SI SI9730424T patent/SI0912613T1/xx unknown
- 1997-07-18 PL PL97331259A patent/PL190397B1/pl unknown
- 1997-07-18 RU RU99103646/04A patent/RU2167163C2/ru active
- 1997-07-18 DE DE69715866T patent/DE69715866T2/de not_active Expired - Lifetime
- 1997-07-18 YU YU1999A patent/YU49247B/sh unknown
- 1997-07-18 SK SK53-99A patent/SK284881B6/sk not_active IP Right Cessation
- 1997-07-18 CZ CZ0016099A patent/CZ301009B6/cs not_active IP Right Cessation
- 1997-07-18 WO PCT/FR1997/001344 patent/WO1998003554A1/fr active IP Right Grant
- 1997-07-18 IL IL12801897A patent/IL128018A0/xx active IP Right Grant
- 1997-07-18 PT PT97934596T patent/PT912613E/pt unknown
- 1997-07-18 EP EP97934596A patent/EP0912613B1/fr not_active Expired - Lifetime
- 1997-07-18 MY MYPI97003269A patent/MY124548A/en unknown
- 1997-07-18 TR TR1999/00114T patent/TR199900114T2/xx unknown
- 1997-07-21 ID IDP972525A patent/ID20604A/id unknown
- 1997-08-20 TW TW086111937A patent/TW520376B/zh not_active IP Right Cessation
1999
- 1999-01-12 IL IL128018A patent/IL128018A/en not_active IP Right Cessation
- 1999-01-18 NO NO19990215A patent/NO319682B1/no not_active IP Right Cessation
- 1999-01-18 IS IS4945A patent/IS1968B/is unknown
- 1999-01-18 KR KR1019997000366A patent/KR100311857B1/ko not_active IP Right Cessation
- 1999-04-25 SA SA99200037A patent/SA99200037B1/ar unknown
- 1999-11-01 HK HK99104901A patent/HK1019757A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1200003C (zh)	2005-05-04
TR199900114T2 (xx)	1999-03-22
FR2751334A1 (fr)	1998-01-23
HUP9902287A1 (hu)	1999-10-28
HK1019757A1 (en)	2000-02-25
HU223691B1 (hu)	2004-12-28
DE69715866D1 (de)	2002-10-31
EE9900015A (et)	1999-08-16
IS4945A (is)	1999-01-18
KR100311857B1 (ko)	2001-11-14
BR9710739B1 (pt)	2008-11-18
EP0912613B1 (fr)	2002-09-25
CA2261597A1 (fr)	1998-01-29
SA99200037B1 (ar)	2006-08-23
CA2261597C (fr)	2004-12-14
AU726679B2 (en)	2000-11-16
RU2167163C2 (ru)	2001-05-20
DK0912613T3 (da)	2003-01-27
PL190397B1 (pl)	2005-12-30
AR008068A1 (es)	1999-12-09
MY124548A (en)	2006-06-30
YU49247B (sh)	2004-12-31
IL128018A0 (en)	1999-11-30
UA61921C2 (uk)	2003-12-15
ZA976340B (en)	1999-01-22
NO990215D0 (no)	1999-01-18
NO319682B1 (no)	2005-09-05
FR2751334B1 (fr)	1998-10-16
YU1999A (sh)	2000-03-21
KR20000067909A (ko)	2000-11-25
WO1998003554A1 (fr)	1998-01-29
IS1968B (is)	2004-12-15
NZ333721A (en)	2000-08-25
PT912613E (pt)	2003-01-31
ATE224917T1 (de)	2002-10-15
SK284881B6 (sk)	2006-02-02
JP3345020B2 (ja)	2002-11-18
EP0912613A1 (fr)	1999-05-06
DE69715866T2 (de)	2003-05-28
IL128018A (en)	2007-10-31
PL331259A1 (en)	1999-07-05
JP2000500807A (ja)	2000-01-25
CN1228785A (zh)	1999-09-15
BR9710739A (pt)	1999-08-17
SI0912613T1 (en)	2003-04-30
ID20604A (id)	1999-01-21
CZ16099A3 (cs)	1999-06-16
AU3774797A (en)	1998-02-10
US6534481B1 (en)	2003-03-18
SK5399A3 (en)	2000-05-16
TW520376B (en)	2003-02-11
CZ301009B6 (cs)	2009-10-14
NO990215L (no)	1999-03-18
ES2184123T3 (es)	2003-04-01
HUP9902287A3 (en)	2001-09-28

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2004-08-16	GB1A	Change in the ownership or in the address of the owner
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231

Publication	Publication Date	Title
EE03929B1 (et)	2002-12-16	Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE9500064A (et)	1996-06-17	Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
EE200000168A (et)	2001-04-16	Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE04498B1 (et)	2005-06-15	Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon
EE200000791A (et)	2002-02-15	Uudsed atsüülpseudopeptiidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
FI963566A0 (fi)	1996-09-10	Uusia piperatsiinijohdoksia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä koostumuksia
EE9700333A (et)	1998-06-15	Substitueeritud 4-fenüülaminotiasoolid, nende valmistamise meetod ja neid sisaldavad farmakoloogilised kompositsioonid
EE9700323A (et)	1998-06-15	Taksoidid, meetod nende valmistamiseks ja neid sisaldavad farmatseutilised kompositsioonid
HUP9700358A3 (en)	1999-08-30	New oxazolidinon derivatives, process for their preparation and pharmaceutical compositions containing them
EE9800028A (et)	1998-08-17	Iprotroopiumsoolad, neid sisaldavad ravimkompositsioonid ja nende kasutamine
FI973279A (fi)	1997-08-08	Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset koostumukset
EE9800426A (et)	1999-06-15	Asendatud 2,4-tiasolidiindiooni derivaadid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
EE03825B1 (et)	2002-08-15	2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE200000429A1 (et)	2003-06-16	Sünteetilised polüsahhariidid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
FI950625A (fi)	1995-08-15	Polysubstituoituja 3-asyyliamino-5-fenyyli-1,4-bentsodiatsepiini-2-onijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
EE9800264A (et)	1999-02-15	Taksoidid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
FI960316A0 (fi)	1996-01-23	Oksatiolaanit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
HU9700955D0 (en)	1997-07-28	Substituted 2-naphtoylguanidine derivatives, their production, their use and pharmaceutical compositions containing them
EE03996B1 (et)	2003-04-15	Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
FI956278A0 (fi)	1995-12-27	Substituoituja 4-fenyylitiatsolijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
HU9700954D0 (en)	1997-07-28	Substituted 1-naphtoylguanidine derivatives, their production, their use and pharmaceutical compositions containing them
FI972129A0 (fi)	1997-05-19	6-metoksi-1H-bentsotriatsoli-5-karboksamidijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä lääkekoostumuksia
HUP9902041A3 (en)	2000-07-28	New quuinoxalindione derivatives, their preparation and pharmaceutical compositions containing them
FI953360A (fi)	1996-01-09	Substituoituja 1-(7-kloorikinol-4-yyli)pyratsoli-3-karboksiamidi-H-oksidijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE03179B1 (et)	1999-04-15	Asendatud 2-propanooli derivaadid, neid sisaldavad farmatseutilised segud ja nende valmistamise protsessid