FR2949114B1 - OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE - Google Patents

OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Info

Publication number
FR2949114B1
FR2949114B1 FR0903968A FR0903968A FR2949114B1 FR 2949114 B1 FR2949114 B1 FR 2949114B1 FR 0903968 A FR0903968 A FR 0903968A FR 0903968 A FR0903968 A FR 0903968A FR 2949114 B1 FR2949114 B1 FR 2949114B1
Authority
FR
France
Prior art keywords
octasaccharides
acylated
preparation
therapeutic application
fgf receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0903968A
Other languages
English (en)
Other versions
FR2949114A1 (fr
Inventor
Pierre Alexandre Driguez
Philippe Duchaussoy
Pierre Fons
Corentin Herbert
Gilbert Lassalle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42035764&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2949114(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0903968A priority Critical patent/FR2949114B1/fr
Priority to SG10201404221RA priority patent/SG10201404221RA/en
Priority to JP2012524265A priority patent/JP5671536B2/ja
Priority to AU2010283614A priority patent/AU2010283614B2/en
Priority to SG2012010203A priority patent/SG178405A1/en
Priority to EP10761049A priority patent/EP2464667A2/fr
Priority to NZ598174A priority patent/NZ598174A/en
Priority to KR1020127006510A priority patent/KR101718567B1/ko
Priority to MX2012001947A priority patent/MX2012001947A/es
Priority to PCT/FR2010/051703 priority patent/WO2011018588A2/fr
Priority to BR112012007883A priority patent/BR112012007883A2/pt
Priority to PE2012000205A priority patent/PE20120915A1/es
Priority to CA2771056A priority patent/CA2771056C/fr
Priority to EA201270277A priority patent/EA020485B1/ru
Priority to CN201080046585.0A priority patent/CN102574931B/zh
Priority to ARP100102985A priority patent/AR078094A1/es
Priority to TW099127180A priority patent/TWI572615B/zh
Priority to UY0001032843A priority patent/UY32843A/es
Publication of FR2949114A1 publication Critical patent/FR2949114A1/fr
Application granted granted Critical
Publication of FR2949114B1 publication Critical patent/FR2949114B1/fr
Priority to TNP2012000052A priority patent/TN2012000052A1/fr
Priority to DO2012000037A priority patent/DOP2012000037A/es
Priority to US13/369,675 priority patent/US9012413B2/en
Priority to IL218068A priority patent/IL218068A/en
Priority to CO12024409A priority patent/CO6612193A2/es
Priority to ECSP12011671 priority patent/ECSP12011671A/es
Priority to NI201200026A priority patent/NI201200026A/es
Priority to ZA2012/01028A priority patent/ZA201201028B/en
Priority to CL2012000393A priority patent/CL2012000393A1/es
Priority to MA34673A priority patent/MA33573B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
FR0903968A 2009-08-14 2009-08-14 OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE Expired - Fee Related FR2949114B1 (fr)

Priority Applications (28)

Application Number Priority Date Filing Date Title
FR0903968A FR2949114B1 (fr) 2009-08-14 2009-08-14 OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
CN201080046585.0A CN102574931B (zh) 2009-08-14 2010-08-12 激活fgf受体的n-酰基八糖、其制备方法、及其用途
BR112012007883A BR112012007883A2 (pt) 2009-08-14 2010-08-12 octa-sacarídeos n-acilas ativadores dos receptores dos fgfs, o respectivo preparo e a respectiva aplicação em terapêutica
AU2010283614A AU2010283614B2 (en) 2009-08-14 2010-08-12 FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof
SG2012010203A SG178405A1 (en) 2009-08-14 2010-08-12 Fgf receptor-activating n-acyl octasaccharides, preparation thereof, and therapeutic use thereof
EP10761049A EP2464667A2 (fr) 2009-08-14 2010-08-12 OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
NZ598174A NZ598174A (en) 2009-08-14 2010-08-12 Fgf receptor-activating n-acyl octasaccharides, preparation thereof, and therapeutic use thereof
KR1020127006510A KR101718567B1 (ko) 2009-08-14 2010-08-12 Ｆｇｆ 수용체-활성화 ｎ-아실 옥타사카라이드, 그의 제조법, 및 그의 치료 용도
MX2012001947A MX2012001947A (es) 2009-08-14 2010-08-12 Octasacaridos n-acilos activadores de los receptores de fgf, su preparacion y su uso en terapeutica.
PCT/FR2010/051703 WO2011018588A2 (fr) 2009-08-14 2010-08-12 OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
JP2012524265A JP5671536B2 (ja) 2009-08-14 2010-08-12 Ｆｇｆ受容体活性化ｎ−アシル８糖類、これの調製、およびこれの治療的使用
PE2012000205A PE20120915A1 (es) 2009-08-14 2010-08-12 Octasacaridos n-acilos activadores de los receptores de los fgf y su preparacion
CA2771056A CA2771056C (fr) 2009-08-14 2010-08-12 Octasaccharides n-acyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
EA201270277A EA020485B1 (ru) 2009-08-14 2010-08-12 N-ацилированные октасахариды, активирующие рецепторы fgf, их получение и применение в терапии
SG10201404221RA SG10201404221RA (en) 2009-08-14 2010-08-12 Fgf receptor-activating n-acyl octasaccharides, preparation thereof, and therapeutic use thereof
ARP100102985A AR078094A1 (es) 2009-08-14 2010-08-13 Octasacaridos n-acilos activadores de los receptores de los fgf, su preparacion y su aplicacion en terapeutica
UY0001032843A UY32843A (es) 2009-08-14 2010-08-13 Octasacáridos n-acilos activadores de los receptores de los fgf, su preparación y su aplicación en terapéutica
TW099127180A TWI572615B (zh) 2009-08-14 2010-08-13 作為ｆｇｆ受體活化劑之ｎ－醯基八糖，其製備及其治療用途
TNP2012000052A TN2012000052A1 (fr) 2009-08-14 2012-02-03 OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
DO2012000037A DOP2012000037A (es) 2009-08-14 2012-02-08 Octasacáridos n-acilos activadores de los receptores de los fgf, su preparación y su aplicación en terapéutica.
US13/369,675 US9012413B2 (en) 2009-08-14 2012-02-09 FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof
IL218068A IL218068A (en) 2009-08-14 2012-02-12 N-noble-octasaccharides that effect the fgf receptor, their preparation and medical use
ZA2012/01028A ZA201201028B (en) 2009-08-14 2012-02-13 Fgf receptor-activating n-acyl octasaccharides,preparation thereof,and therapeutic use thereof
CO12024409A CO6612193A2 (es) 2009-08-14 2012-02-13 Octasacàridos n-acilos activadores de los receptores de los fgf su preparación y su aplicación en terapéutica
NI201200026A NI201200026A (es) 2009-08-14 2012-02-13 Octasacáridos n-acilos activadores de los receptores de los fgf, su preparación y su aplicación en terapéutica.
ECSP12011671 ECSP12011671A (es) 2009-08-14 2012-02-13 Octasacáridos n-acilos activadores de los receptores de los fgf, su preparación y su aplicación en terapéutica
CL2012000393A CL2012000393A1 (es) 2009-08-14 2012-02-14 Compuestos octasacaridos n-acilados; composicion farmaceutica; intermediarios; utiles en el tratamiento de enfermedades tales como isquemia, angina de pecho, aterosclerosis, entre otras.
MA34673A MA33573B1 (fr) 2009-08-14 2012-03-08 Octasaccharides n-acyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903968A FR2949114B1 (fr) 2009-08-14 2009-08-14 OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
FR2949114A1 FR2949114A1 (fr) 2011-02-18
FR2949114B1 true FR2949114B1 (fr) 2011-08-26

Family

ID=42035764

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0903968A Expired - Fee Related FR2949114B1 (fr) 2009-08-14 2009-08-14 OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Country Status (27)

Country Link
US (1) US9012413B2 (fr)
EP (1) EP2464667A2 (fr)
JP (1) JP5671536B2 (fr)
KR (1) KR101718567B1 (fr)
CN (1) CN102574931B (fr)
AR (1) AR078094A1 (fr)
AU (1) AU2010283614B2 (fr)
BR (1) BR112012007883A2 (fr)
CA (1) CA2771056C (fr)
CL (1) CL2012000393A1 (fr)
CO (1) CO6612193A2 (fr)
DO (1) DOP2012000037A (fr)
EA (1) EA020485B1 (fr)
EC (1) ECSP12011671A (fr)
FR (1) FR2949114B1 (fr)
IL (1) IL218068A (fr)
MA (1) MA33573B1 (fr)
MX (1) MX2012001947A (fr)
NI (1) NI201200026A (fr)
NZ (1) NZ598174A (fr)
PE (1) PE20120915A1 (fr)
SG (2) SG178405A1 (fr)
TN (1) TN2012000052A1 (fr)
TW (1) TWI572615B (fr)
UY (1) UY32843A (fr)
WO (1) WO2011018588A2 (fr)
ZA (1) ZA201201028B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) * 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2970969B1 (fr) * 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
WO2012121617A1 (fr) * 2011-03-10 2012-09-13 Industrial Research Limited Composés oligosaccharidiques
CN104370980B (zh) * 2014-10-17 2017-12-01 九芝堂股份有限公司 一种抑制内源性因子x酶活性的寡糖类化合物及其药物组合物

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EP0300099A1 (fr) * 1987-07-20 1989-01-25 Akzo N.V. Pentasaccharides
EP0333243A3 (fr) * 1988-03-10 1989-09-27 Akzo N.V. Antigène K5 sulfaté et ses fragments
AU1902592A (en) * 1991-04-17 1992-11-17 Glycomed Incorporated Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr) 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ES2147216T3 (es) 1993-09-01 2000-09-01 Akzo Nobel Nv Bisconjugados que comprenden dos sacaridos y un grupo de union.
FR2749849B1 (fr) * 1996-06-14 1998-09-04 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773804B1 (fr) 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
US6617316B1 (en) 1999-10-22 2003-09-09 Aventis Pharma Oligosaccharides, their preparation and pharmaceutical compositions containing them
FR2800074B1 (fr) * 1999-10-22 2001-12-21 Aventis Pharma Sa Nouveaux oligosaccharides, leur preparation et les compositions pharmaceutiques les contenant
US7582737B2 (en) 2004-07-20 2009-09-01 Academia Sinica Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharides
FR2873377B1 (fr) 2004-07-23 2006-10-13 Sanofi Synthelabo Derives d'azasucre, inhibiteurs d'heparanases, leur procede de preparation, les compositions en contenant et leur utilisation
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FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
ECSP12011671A (es) 2012-03-30
DOP2012000037A (es) 2012-04-15
EA201270277A1 (ru) 2012-09-28
AR078094A1 (es) 2011-10-12
AU2010283614B2 (en) 2016-03-31
CN102574931B (zh) 2014-07-02
US9012413B2 (en) 2015-04-21
KR20120106716A (ko) 2012-09-26
EA020485B1 (ru) 2014-11-28
CN102574931A (zh) 2012-07-11
JP2013501839A (ja) 2013-01-17
KR101718567B1 (ko) 2017-03-21
CL2012000393A1 (es) 2012-09-07
WO2011018588A3 (fr) 2011-07-07
UY32843A (es) 2011-03-31
MX2012001947A (es) 2012-09-12
BR112012007883A2 (pt) 2016-03-15
AU2010283614A1 (en) 2012-03-08
US20120214754A1 (en) 2012-08-23
CA2771056C (fr) 2017-11-14
NI201200026A (es) 2012-05-24
SG178405A1 (en) 2012-03-29
JP5671536B2 (ja) 2015-02-18
TW201109020A (en) 2011-03-16
IL218068A0 (en) 2012-04-30
ZA201201028B (en) 2013-07-31
CO6612193A2 (es) 2013-02-01
EP2464667A2 (fr) 2012-06-20
PE20120915A1 (es) 2012-08-17
TWI572615B (zh) 2017-03-01
TN2012000052A1 (fr) 2013-09-19
NZ598174A (en) 2014-01-31
IL218068A (en) 2015-07-30
MA33573B1 (fr) 2012-09-01
WO2011018588A2 (fr) 2011-02-17
CA2771056A1 (fr) 2011-02-17
FR2949114A1 (fr) 2011-02-18
SG10201404221RA (en) 2014-09-26

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