EE9500064A - Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid - Google Patents

Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid

Info

Publication number
EE9500064A
EE9500064A EE9500064A EE9500064A EE9500064A EE 9500064 A EE9500064 A EE 9500064A EE 9500064 A EE9500064 A EE 9500064A EE 9500064 A EE9500064 A EE 9500064A EE 9500064 A EE9500064 A EE 9500064A
Authority
EE
Estonia
Prior art keywords
imidazoles
substituted
preparation
methods
pharmaceutical compositions
Prior art date
Application number
EE9500064A
Other languages
English (en)
Inventor
Geerts Jean-Pierre
Motte Genevi�ve
Differding Edmond
Henichart Jean-Pierre
Original Assignee
Ucb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb filed Critical Ucb
Publication of EE9500064A publication Critical patent/EE9500064A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
EE9500064A 1994-12-14 1995-12-12 Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid EE9500064A (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
EE9500064A true EE9500064A (et) 1996-06-17

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9500064A EE9500064A (et) 1994-12-14 1995-12-12 Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid

Country Status (26)

Country Link
US (1) US5658938A (et)
EP (1) EP0717037A1 (et)
JP (1) JPH08208622A (et)
KR (1) KR960022474A (et)
CN (1) CN1054376C (et)
AR (1) AR002257A1 (et)
AU (1) AU693614B2 (et)
BG (1) BG63043B1 (et)
BR (1) BR9505815A (et)
CA (1) CA2165133A1 (et)
CZ (1) CZ327195A3 (et)
EE (1) EE9500064A (et)
FI (1) FI955927A (et)
GB (1) GB9425211D0 (et)
HU (1) HUT73980A (et)
IL (1) IL116325A (et)
IS (1) IS4311A (et)
MX (1) MX9505063A (et)
NO (1) NO305316B1 (et)
NZ (1) NZ280646A (et)
PL (1) PL311736A1 (et)
RO (1) RO113346B1 (et)
RU (1) RU2156239C2 (et)
SK (1) SK155095A3 (et)
TW (1) TW303362B (et)
ZA (1) ZA9510554B (et)

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GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
ZA981080B (en) * 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
NZ522274A (en) 2000-05-08 2004-11-26 Orion Corp New polycyclic indanylimidazoles with alpha2 adrenergic activity
TW200930291A (en) * 2002-04-29 2009-07-16 Bayer Cropscience Ag Pesticidal heterocycles
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
JP2009524618A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置における２−イミダゾールの使用
EP2076496B1 (en) * 2006-10-19 2010-03-31 F. Hoffmann-Roche AG Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
AU2007312390B2 (en) * 2006-10-19 2013-03-28 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
ATE533755T1 (de) * 2006-11-02 2011-12-15 Hoffmann La Roche Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren
WO2008058867A2 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
ATE509628T1 (de) * 2006-12-13 2011-06-15 Hoffmann La Roche Neue 2-imidazole als liganden für trace amine associated receptors (taar)
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
EP2114906B1 (en) 2007-02-02 2014-08-06 F. Hoffmann-La Roche AG 2-aminooxazolines as taar1 ligands for cns disorders
RU2009134059A (ru) * 2007-02-13 2011-03-20 Шеринг Корпорейшн (US) Функционально селективные агонисты альфа2с адренорецептора
CN101657429A (zh) * 2007-02-13 2010-02-24 先灵公司 功能选择性α2C肾上腺素能受体激动剂
JP2010518161A (ja) * 2007-02-13 2010-05-27 シェーリング コーポレイション 機能選択性α２Ｃアドレナリン受容体アゴニストとしてのクロマン誘導体および類似体
CA2676944C (en) * 2007-02-15 2016-01-19 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
MX2009013742A (es) 2007-07-02 2010-01-26 Hoffmann La Roche 2-imidazolinas.
EP2173719A1 (en) * 2007-07-03 2010-04-14 F. Hoffmann-Roche AG 4-imidazolines and their use as antidepressants
AU2008281918A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
CA2695071A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of cns disorders
EP2185502A1 (en) * 2007-08-03 2010-05-19 F. Hoffmann-Roche AG Pyridinecarboxamide and benzamide derivatives as taar1 ligands
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
WO2009105504A2 (en) 2008-02-21 2009-08-27 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
CN102083805A (zh) * 2008-07-24 2011-06-01 弗·哈夫曼-拉罗切有限公司 4,5-二氢-唑-2-基衍生物
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
EP2323734A1 (en) * 2008-08-04 2011-05-25 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
EP2356106A1 (en) 2008-10-07 2011-08-17 Schering Corporation Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
ES2554843T3 (es) 2012-01-12 2015-12-23 F. Hoffmann-La Roche Ag Derivados heterocíclicos como receptores asociados de trazas de amina (TAARs)
JP2015531782A (ja) 2012-09-14 2015-11-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ うつ病、糖尿病及びパーキンソン病のような幾つかの障害の処置において使用するためのｔａａｒ調節薬としてのピラゾールカルボキサミド誘導体
JP6027244B2 (ja) 2012-09-17 2016-11-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ トリアゾールカルボキサミド誘導体
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
MX2016016488A (es) 2014-08-27 2017-03-30 Hoffmann La Roche Derivados de azetidina sustituidos como ligandos de receptores asociados a aminas en trazas (taar).
CA2953040A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
EP3560911B1 (en) * 2016-03-17 2021-05-05 FMC Corporation Process for converting s-enantiomer to its racemic form
EP3757102A1 (en) 2016-03-17 2020-12-30 F. Hoffmann-La Roche AG 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6048972A (ja) * 1983-08-25 1985-03-16 Dai Ichi Seiyaku Co Ltd テトラヒドロナフタレン誘導体
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5151526A (en) * 1990-10-11 1992-09-29 The United States Of America As Represented By The Secretary Of The Army 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic
JPH04210680A (ja) * 1990-12-01 1992-07-31 Nissan Chem Ind Ltd イミダゾール誘導体および植物生長調節剤
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles

Also Published As

Publication number Publication date
BG100208A (bg) 1996-07-31
NO955034L (no) 1996-06-17
FI955927A (fi) 1996-06-15
TW303362B (et) 1997-04-21
GB9425211D0 (en) 1995-02-15
IL116325A (en) 1999-10-28
JPH08208622A (ja) 1996-08-13
SK155095A3 (en) 1997-02-05
CN1054376C (zh) 2000-07-12
PL311736A1 (en) 1996-06-24
AR002257A1 (es) 1998-03-11
NO955034D0 (no) 1995-12-12
IL116325A0 (en) 1996-03-31
HUT73980A (en) 1996-10-28
BR9505815A (pt) 1998-01-06
KR960022474A (ko) 1996-07-18
ZA9510554B (en) 1996-06-13
CA2165133A1 (en) 1996-06-15
NO305316B1 (no) 1999-05-10
CN1133837A (zh) 1996-10-23
BG63043B1 (bg) 2001-02-28
IS4311A (is) 1996-06-15
RU2156239C2 (ru) 2000-09-20
AU4036895A (en) 1996-06-20
RO113346B1 (ro) 1998-06-30
NZ280646A (en) 1996-08-27
EP0717037A1 (fr) 1996-06-19
FI955927A0 (fi) 1995-12-11
US5658938A (en) 1997-08-19
AU693614B2 (en) 1998-07-02
MX9505063A (es) 1997-01-31
HU9503549D0 (en) 1996-02-28
CZ327195A3 (en) 1996-07-17

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