ECSP19030134A - Compuesto de piridina - Google Patents

Compuesto de piridina

Info

Publication number
ECSP19030134A
ECSP19030134A ECSENADI201930134A ECDI201930134A ECSP19030134A EC SP19030134 A ECSP19030134 A EC SP19030134A EC SENADI201930134 A ECSENADI201930134 A EC SENADI201930134A EC DI201930134 A ECDI201930134 A EC DI201930134A EC SP19030134 A ECSP19030134 A EC SP19030134A
Authority
EC
Ecuador
Prior art keywords
pyridine compound
pharmaceutically acceptable
acceptable salt
compound
formula
Prior art date
Application number
ECSENADI201930134A
Other languages
English (en)
Inventor
Yasuyuki Kaneta
Yoshihiro Shibata
Hiroaki Inagaki
Hidenori Namiki
Kiyoshi Nakayama
Hideaki Kageji
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of ECSP19030134A publication Critical patent/ECSP19030134A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención tiene relación con un compuesto que tiene acción inhibidora de quinasa RET o una sal farmacéuticamente aceptable del mismo, útil en el tratamiento de enfermedades como cáncer. En particular un compuesto representado por la siguiente fórmula general (I) como se define en este documento: [Fórmula I] (ver figura) o una sal farmacéuticamente aceptable del mismo.
ECSENADI201930134A 2016-09-29 2019-04-29 Compuesto de piridina ECSP19030134A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016191725A JP2018052878A (ja) 2016-09-29 2016-09-29 ピリジン化合物
PCT/GB2017/052913 WO2018060714A1 (en) 2016-09-29 2017-09-28 Pyridine compound

Publications (1)

Publication Number Publication Date
ECSP19030134A true ECSP19030134A (es) 2019-08-30

Family

ID=60020249

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201930134A ECSP19030134A (es) 2016-09-29 2019-04-29 Compuesto de piridina

Country Status (32)

Country Link
US (2) US10851092B2 (es)
EP (2) EP3519398B1 (es)
JP (2) JP2018052878A (es)
KR (1) KR102520543B1 (es)
CN (2) CN113788824A (es)
AU (2) AU2017335242C1 (es)
BR (1) BR112019006047A2 (es)
CA (1) CA3035860A1 (es)
CL (1) CL2019000844A1 (es)
CO (1) CO2019004034A2 (es)
CY (1) CY1123988T1 (es)
DK (1) DK3519398T3 (es)
EA (1) EA037103B1 (es)
EC (1) ECSP19030134A (es)
ES (1) ES2868748T3 (es)
HR (1) HRP20210447T1 (es)
HU (1) HUE054824T2 (es)
IL (1) IL265630B (es)
LT (1) LT3519398T (es)
MA (2) MA54910A (es)
MD (1) MD3519398T2 (es)
MX (1) MX2019003747A (es)
PE (1) PE20190805A1 (es)
PH (1) PH12019500480A1 (es)
PL (1) PL3519398T3 (es)
PT (1) PT3519398T (es)
RS (1) RS61640B1 (es)
SG (1) SG11201901937WA (es)
SI (1) SI3519398T1 (es)
UA (1) UA123964C2 (es)
WO (1) WO2018060714A1 (es)
ZA (1) ZA201902232B (es)

Families Citing this family (15)

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NZ742351A (en) 2015-11-02 2023-03-31 Blueprint Medicines Corp Inhibitors of ret
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物
TW201932464A (zh) 2018-01-18 2019-08-16 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CA3096043A1 (en) 2018-04-03 2019-10-10 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
MX2022005991A (es) * 2019-11-18 2022-06-17 Chugai Pharmaceutical Co Ltd Farmaco combinado.
CN113121524B (zh) 2019-12-31 2023-04-25 南京创济生物医药有限公司 杂环亚砜亚胺化合物及其中间体、制备方法和应用
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2021164741A1 (zh) * 2020-02-20 2021-08-26 南京明德新药研发有限公司 苯基双酰胺类化合物
JP7461605B2 (ja) 2020-02-20 2024-04-04 広州白雲山医薬集団股▲フン▼有限公司白雲山制薬総廠 キノリン系化合物
WO2022238706A1 (en) 2021-05-14 2022-11-17 Bp Asset Viii, Inc. Ret inhibitor for the treatment of ret altered medullary thyroid cancer or ret altered non-small cell lung cancer
US20230233691A1 (en) 2021-10-22 2023-07-27 University Of Houston System Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues
CN115090331B (zh) * 2022-07-21 2023-05-16 扬州大学 超分子手性催化剂、其制备方法及其催化d-a反应的应用

Family Cites Families (24)

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TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
JP2009528335A (ja) 2006-03-02 2009-08-06 アストラゼネカ アクチボラグ キナゾリン誘導体
EP1994024A2 (en) 2006-03-02 2008-11-26 AstraZeneca AB Quinoline derivatives
WO2007113565A1 (en) 2006-04-06 2007-10-11 Astrazeneca Ab Naphthyridine derivatives as anti-cancer agents
WO2007113548A1 (en) 2006-04-06 2007-10-11 Astrazeneca Ab Naphthyridine derivatives
FR2933700B1 (fr) 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
AU2010218748B2 (en) * 2009-02-27 2015-03-26 Teijin Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
JP2013502429A (ja) 2009-08-19 2013-01-24 アムビト ビオスシエンセス コルポラチオン ビアリール化合物及びその使用方法
NZ598588A (en) 2009-08-25 2014-05-30 Abraxis Bioscience Llc Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
EP2560652A4 (en) 2010-04-23 2013-08-14 Kineta Inc ANTIVIRAL CONNECTIONS
US9073895B2 (en) 2010-12-16 2015-07-07 Boehringer Ingelheim International Gmbh Biarylamide inhibitors of leukotriene production
AU2013289938A1 (en) 2012-07-13 2015-01-29 Indiana University Research & Technology Corporation Compounds for treatment of spinal muscular atrophy
BR112015023618A2 (pt) 2013-03-15 2017-07-18 Glaxosmithkline Ip Dev Ltd derivados de piridina como inibidores de quinase reorganizada durante a transfecção (ret)
WO2015031613A1 (en) * 2013-08-30 2015-03-05 Ambit Biosciences Corporation Biaryl acetamide compounds and methods of use thereof
GB201321146D0 (en) 2013-11-29 2014-01-15 Cancer Rec Tech Ltd Quinazoline compounds
JPWO2015163435A1 (ja) * 2014-04-24 2017-04-20 田辺三菱製薬株式会社 新規２−アミノ−ピリジン及び２−アミノ−ピリミジン誘導体及びその医薬用途
CA2960730A1 (en) * 2014-09-10 2016-03-17 Glaxosmithkline Intellectual Property Development Limited Novel compounds as rearranged during transfection (ret) inhibitors
RS58813B1 (sr) * 2014-09-10 2019-07-31 Glaxosmithkline Ip Dev Ltd Piridonski derivati korišćeni kao inhibitori kinaze reorganizovane tokom transfekcije (ret)
EP3206689B1 (en) 2014-10-14 2021-12-08 La Jolla Institute of Allergy & Immunology Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
CN104844589B (zh) 2014-12-26 2018-04-20 中国科学院合肥物质科学研究院 一种pi3k激酶抑制剂
US10202365B2 (en) * 2015-02-06 2019-02-12 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
EA035049B1 (ru) 2015-07-16 2020-04-22 Аррэй Байофарма Инк. СОЕДИНЕНИЯ ЗАМЕЩЕННОГО ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物

Also Published As

Publication number Publication date
HRP20210447T1 (hr) 2021-07-23
HUE054824T2 (hu) 2021-10-28
AU2017335242A1 (en) 2019-05-02
ES2868748T3 (es) 2021-10-21
SG11201901937WA (en) 2019-04-29
ZA201902232B (en) 2022-12-21
CL2019000844A1 (es) 2019-06-07
RS61640B1 (sr) 2021-04-29
PE20190805A1 (es) 2019-06-10
KR20190086442A (ko) 2019-07-22
JP7098609B2 (ja) 2022-07-11
DK3519398T3 (da) 2021-03-29
WO2018060714A1 (en) 2018-04-05
MA54910A (fr) 2022-04-13
EA201990833A1 (ru) 2019-10-31
BR112019006047A2 (pt) 2019-06-25
CN110036007B (zh) 2021-10-15
LT3519398T (lt) 2021-05-10
SI3519398T1 (sl) 2021-07-30
MD3519398T2 (ro) 2021-05-31
AU2021261899A1 (en) 2021-12-02
PT3519398T (pt) 2021-03-24
MX2019003747A (es) 2019-09-19
AU2017335242B2 (en) 2021-08-19
EP3519398B1 (en) 2021-02-24
JP2019534871A (ja) 2019-12-05
EP3519398A1 (en) 2019-08-07
US10851092B2 (en) 2020-12-01
CA3035860A1 (en) 2018-04-05
JP2018052878A (ja) 2018-04-05
AU2017335242C1 (en) 2021-12-09
CN113788824A (zh) 2021-12-14
IL265630B (en) 2021-10-31
MA46337B1 (fr) 2021-04-30
IL265630A (en) 2019-05-30
CY1123988T1 (el) 2022-05-27
PL3519398T3 (pl) 2021-06-28
UA123964C2 (uk) 2021-06-30
CO2019004034A2 (es) 2019-07-10
KR102520543B1 (ko) 2023-04-10
EP3828178A1 (en) 2021-06-02
MA46337A (fr) 2019-08-07
CN110036007A (zh) 2019-07-19
PH12019500480A1 (en) 2019-08-05
US20210163464A1 (en) 2021-06-03
US20200039974A1 (en) 2020-02-06
EA037103B1 (ru) 2021-02-05

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