DOP2019000021A - Derivado de triazolopirazinona útil como un inhibidor de pde1 humana - Google Patents

Derivado de triazolopirazinona útil como un inhibidor de pde1 humana

Info

Publication number
DOP2019000021A
DOP2019000021A DO2019000021A DO2019000021A DOP2019000021A DO P2019000021 A DOP2019000021 A DO P2019000021A DO 2019000021 A DO2019000021 A DO 2019000021A DO 2019000021 A DO2019000021 A DO 2019000021A DO P2019000021 A DOP2019000021 A DO P2019000021A
Authority
DO
Dominican Republic
Prior art keywords
triazolopirazinone
derived
useful
pde1 inhibitor
human pde1
Prior art date
Application number
DO2019000021A
Other languages
English (en)
Inventor
David Rekhter Mark
Shi Qing
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DOP2019000021A publication Critical patent/DOP2019000021A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Abstract

La presente invención se refiere a un compuesto de Fórmula I: o una sal del mismo farmacéuticamente aceptable, para uso como un inhibidor de PDE1 humana.
DO2019000021A 2016-08-25 2019-01-30 Derivado de triazolopirazinona útil como un inhibidor de pde1 humana DOP2019000021A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662379372P 2016-08-25 2016-08-25

Publications (1)

Publication Number Publication Date
DOP2019000021A true DOP2019000021A (es) 2019-02-28

Family

ID=59762063

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2019000021A DOP2019000021A (es) 2016-08-25 2019-01-30 Derivado de triazolopirazinona útil como un inhibidor de pde1 humana

Country Status (37)

Country Link
US (1) US10138244B2 (es)
EP (1) EP3504208B1 (es)
JP (1) JP6633246B2 (es)
KR (1) KR20190028544A (es)
CN (1) CN109641902B (es)
AR (1) AR109328A1 (es)
AU (1) AU2017317111A1 (es)
BR (1) BR112019000988A2 (es)
CA (1) CA3034828A1 (es)
CL (1) CL2019000487A1 (es)
CO (1) CO2019001644A2 (es)
CR (1) CR20190078A (es)
CY (1) CY1123406T1 (es)
DK (1) DK3504208T3 (es)
DO (1) DOP2019000021A (es)
EA (1) EA201990313A1 (es)
EC (1) ECSP19013196A (es)
ES (1) ES2800433T3 (es)
HR (1) HRP20201187T1 (es)
HU (1) HUE050419T2 (es)
JO (1) JOP20170164A1 (es)
LT (1) LT3504208T (es)
MA (1) MA46039B1 (es)
MD (1) MD3504208T2 (es)
ME (1) ME03791B (es)
MX (1) MX2019002065A (es)
PE (1) PE20190452A1 (es)
PH (1) PH12019500370A1 (es)
PL (1) PL3504208T3 (es)
PT (1) PT3504208T (es)
RS (1) RS60442B1 (es)
SG (1) SG11201901311WA (es)
SI (1) SI3504208T1 (es)
SV (1) SV2019005838A (es)
TN (1) TN2019000038A1 (es)
TW (1) TWI651323B (es)
WO (1) WO2018039051A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR112457A1 (es) * 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
AR112346A1 (es) 2017-08-10 2019-10-16 Lilly Co Eli Derivados de [1,2,4]triazolo
US11453673B2 (en) 2018-02-06 2022-09-27 Eli Lilly And Company Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
ES2536906T3 (es) * 2006-12-13 2015-05-29 Aska Pharmaceutical Co., Ltd. Derivado de quinoxalina
WO2008103357A1 (en) 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
AU2011299936A1 (en) 2010-09-07 2013-03-28 Astellas Pharma Inc. Quinoxaline compound
EP2861603B1 (en) 2012-06-18 2018-12-19 Dart NeuroScience (Cayman) Ltd 6-Benzyl-6H-pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5-one and 6-benzyl-[1,2,4]triazolo[1,5-c]pteridin-5(6H)-one derivatives as PDE1 inhibitors for treating e.g. neurological disorders
WO2016022825A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
US20160083400A1 (en) * 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
TW201629064A (zh) * 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之***並吡酮
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑

Also Published As

Publication number Publication date
TWI651323B (zh) 2019-02-21
SI3504208T1 (sl) 2020-08-31
WO2018039051A1 (en) 2018-03-01
CN109641902A (zh) 2019-04-16
KR20190028544A (ko) 2019-03-18
CL2019000487A1 (es) 2019-07-12
CR20190078A (es) 2019-04-05
HRP20201187T1 (hr) 2020-11-13
EP3504208B1 (en) 2020-06-10
PH12019500370A1 (en) 2019-10-21
CO2019001644A2 (es) 2019-05-21
JP2019526567A (ja) 2019-09-19
HUE050419T2 (hu) 2020-12-28
US10138244B2 (en) 2018-11-27
MD3504208T2 (ro) 2020-08-31
TW201819379A (zh) 2018-06-01
DK3504208T3 (da) 2020-07-27
SV2019005838A (es) 2019-04-04
AR109328A1 (es) 2018-11-21
TN2019000038A1 (en) 2020-07-15
ES2800433T3 (es) 2020-12-30
PE20190452A1 (es) 2019-03-29
MA46039B1 (fr) 2020-09-30
US20180057494A1 (en) 2018-03-01
JP6633246B2 (ja) 2020-01-22
MX2019002065A (es) 2019-06-03
SG11201901311WA (en) 2019-03-28
LT3504208T (lt) 2020-08-10
CY1123406T1 (el) 2021-12-31
PL3504208T3 (pl) 2020-11-16
CN109641902B (zh) 2021-06-08
RS60442B1 (sr) 2020-07-31
ME03791B (me) 2021-04-20
CA3034828A1 (en) 2018-03-01
JOP20170164A1 (ar) 2019-01-30
EA201990313A1 (ru) 2019-07-31
BR112019000988A2 (pt) 2019-05-14
PT3504208T (pt) 2020-08-31
EP3504208A1 (en) 2019-07-03
ECSP19013196A (es) 2019-03-29
AU2017317111A1 (en) 2019-01-31

Similar Documents

Publication Publication Date Title
PH12018500041A1 (en) Substituted aza compoounds as irak-4 inhibitors
DOP2016000085A (es) Amino-heteroaril-benzamidas como inhibidores de cinasa
CL2017001050A1 (es) Nuevos compuestos de metil-quinolina útiles para inhibir la sintasa-1 de prostaglandina microsomal e2
EA201692219A1 (ru) Способы получения противовирусных соединений
EA201692203A1 (ru) Соединения, ингибирующие tank-связывающую киназу
CR20150418A (es) Compuestos de tetrahidropirrolotiazina
BR112016023558A2 (pt) compostos úteis como imunomoduladores
ECSP17054980A (es) Inhibidores selectivos de bace1
UY35683A (es) Polimorfo de inhibidores de tirosina quinasa de bazo (syk)
EA201590224A1 (ru) Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы
EA201790395A1 (ru) Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
EA201692526A1 (ru) Замещенные [1,2,4]триазольные соединения
BR112016029333A2 (pt) síntese de compostos de carbamoilpiridona policíclico
EA201591634A1 (ru) Дигидропиридопиримидиновые соединения
EA201792021A1 (ru) Ингибитор jak
SV2017005381A (es) Compuestos de imidazopiridazina
EA201500931A1 (ru) Производные пиридин-4-ила
EA201790982A1 (ru) Синтез копанлисиба и его дигидрохлорида
AR095097A1 (es) Compuestos de fenoxietoxi
AR105821A1 (es) COMPUESTOS ÚTILES PARA INHIBIR ROR-g-T
EA201790687A1 (ru) Хинолинкарбоксамиды для применения в лечении множественной миеломы
DOP2019000021A (es) Derivado de triazolopirazinona útil como un inhibidor de pde1 humana
EA201791645A1 (ru) Новые соли и полиморфы scy-078
EA201600002A1 (ru) Производные пролекарства замещенных триазолопиридинов
CY1119540T1 (el) Υποκατασταθεντα απο γλυκοπυρανοσυλιο παραγωγα ινδολο-ουριας και η χρηση τους ως αναστολεις sglt