CO2017004784A2 - Isómeros de ácido-1-[(3-cloro-2-fluoro-fenil)metil]-4-[[3-fluoro-6-[(5-metil-1h-pirazol-3-il)amino]-2-piridil]metil]-2-metil-piperidin-4-carboxílico como inhibidores de la cinasa aurora a - Google Patents

Isómeros de ácido-1-[(3-cloro-2-fluoro-fenil)metil]-4-[[3-fluoro-6-[(5-metil-1h-pirazol-3-il)amino]-2-piridil]metil]-2-metil-piperidin-4-carboxílico como inhibidores de la cinasa aurora a

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Publication number
CO2017004784A2
CO2017004784A2 CONC2017/0004784A CO2017004784A CO2017004784A2 CO 2017004784 A2 CO2017004784 A2 CO 2017004784A2 CO 2017004784 A CO2017004784 A CO 2017004784A CO 2017004784 A2 CO2017004784 A2 CO 2017004784A2
Authority
CO
Colombia
Prior art keywords
methyl
fluoro
acid
pyrazol
piperidine
Prior art date
Application number
CONC2017/0004784A
Other languages
English (en)
Inventor
James Robert Henry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO2017004784A2 publication Critical patent/CO2017004784A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un compuesto de aminopiridina, o una sal del mismo farmacéuticamente aceptable, que inhibe a Aurora A y, por lo tanto puede ser útil en el tratamiento de cáncer.
CONC2017/0004784A 2014-11-14 2017-05-12 Isómeros de ácido-1-[(3-cloro-2-fluoro-fenil)metil]-4-[[3-fluoro-6-[(5-metil-1h-pirazol-3-il)amino]-2-piridil]metil]-2-metil-piperidin-4-carboxílico como inhibidores de la cinasa aurora a CO2017004784A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462079742P 2014-11-14 2014-11-14
PCT/US2015/059390 WO2016077161A1 (en) 2014-11-14 2015-11-06 Aurora a kinase inhibitor

Publications (1)

Publication Number Publication Date
CO2017004784A2 true CO2017004784A2 (es) 2017-08-31

Family

ID=54697647

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0004784A CO2017004784A2 (es) 2014-11-14 2017-05-12 Isómeros de ácido-1-[(3-cloro-2-fluoro-fenil)metil]-4-[[3-fluoro-6-[(5-metil-1h-pirazol-3-il)amino]-2-piridil]metil]-2-metil-piperidin-4-carboxílico como inhibidores de la cinasa aurora a

Country Status (41)

Country Link
US (2) US9637474B2 (es)
EP (2) EP3473619B8 (es)
JP (1) JP6159029B2 (es)
KR (1) KR101930182B1 (es)
CN (1) CN107108567B (es)
AR (1) AR102463A1 (es)
AU (1) AU2015347043B2 (es)
BR (1) BR112017007239B1 (es)
CA (1) CA2963473C (es)
CL (1) CL2017001209A1 (es)
CO (1) CO2017004784A2 (es)
CR (1) CR20170158A (es)
CY (2) CY1121334T1 (es)
DK (2) DK3473619T3 (es)
DO (1) DOP2017000111A (es)
EA (1) EA032102B1 (es)
EC (1) ECSP17029203A (es)
ES (2) ES2826448T3 (es)
HR (2) HRP20190324T1 (es)
HU (2) HUE051530T2 (es)
IL (1) IL251406B (es)
JO (1) JO3488B1 (es)
LT (2) LT3473619T (es)
ME (1) ME03325B (es)
MX (1) MX2017006275A (es)
MY (1) MY188313A (es)
NZ (1) NZ730771A (es)
PE (1) PE20170898A1 (es)
PH (1) PH12017500881B1 (es)
PL (1) PL3218366T3 (es)
PT (2) PT3473619T (es)
RS (2) RS58347B1 (es)
SG (1) SG11201703394RA (es)
SI (2) SI3218366T1 (es)
SV (1) SV2017005418A (es)
TN (1) TN2017000116A1 (es)
TR (1) TR201902686T4 (es)
TW (1) TWI693218B (es)
UA (1) UA117983C2 (es)
WO (1) WO2016077161A1 (es)
ZA (1) ZA201702199B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019230679A1 (ja) * 2018-05-29 2019-12-05 大鵬薬品工業株式会社 抗腫瘍剤及び腫瘍治療方法
JP2022508183A (ja) * 2018-11-30 2022-01-19 イーライ リリー アンド カンパニー 神経芽細胞腫の治療における使用のためのオーロラａキナーゼ阻害剤
CN112239465A (zh) * 2019-07-16 2021-01-19 微境生物医药科技(上海)有限公司 极光激酶抑制剂及其用途
CN112898292A (zh) * 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型极光激酶抑制剂及其用途
TWI785474B (zh) * 2020-01-22 2022-12-01 大陸商北京加科思新藥研發有限公司 用作選擇性Aurora A抑制劑的新型雜環化合物
CN117177971A (zh) 2021-05-24 2023-12-05 江苏恒瑞医药股份有限公司 含氮杂环类化合物、其制备方法及其在医药上的应用
CN117836285A (zh) * 2021-07-28 2024-04-05 北京加科思新药研发有限公司 Aurora a选择性抑制剂的多晶型及其用途
WO2023196887A1 (en) 2022-04-08 2023-10-12 Eli Lilly And Company Method of treatment including kras g12c inhibitors and aurora a inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006008874A1 (ja) * 2004-05-21 2008-05-01 萬有製薬株式会社 アミノチアゾ−ル骨格を有するＣｄｋ４、６選択的阻害剤
NZ554441A (en) * 2004-10-29 2009-07-31 Banyu Pharma Co Ltd Novel aminopyridine derivatives having aurora A selective inhibitory action
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
EP2254888B1 (en) * 2008-02-22 2014-12-24 Msd K.K. Novel aminopyridine derivatives having aurora a selective inhibitory action
WO2010111056A1 (en) * 2009-03-24 2010-09-30 Banyu Pharmaceutical Co., Ltd. Novel aminopyridine derivatives having aurora a selective inhibitory action
TWI485146B (zh) * 2012-02-29 2015-05-21 Taiho Pharmaceutical Co Ltd Novel piperidine compounds or salts thereof

Also Published As

Publication number Publication date
CR20170158A (es) 2017-06-21
JO3488B1 (ar) 2020-07-05
US9637474B2 (en) 2017-05-02
HRP20190324T1 (hr) 2019-04-19
BR112017007239A2 (pt) 2017-12-19
ECSP17029203A (es) 2018-01-31
EP3473619A1 (en) 2019-04-24
DK3473619T3 (da) 2020-09-21
US20170119751A1 (en) 2017-05-04
JP6159029B2 (ja) 2017-07-05
ES2716732T3 (es) 2019-06-14
SI3473619T1 (sl) 2020-10-30
HUE051530T2 (hu) 2021-03-01
WO2016077161A1 (en) 2016-05-19
BR112017007239B1 (pt) 2023-01-31
SI3218366T1 (sl) 2019-02-28
HUE043759T2 (hu) 2019-09-30
EP3218366A1 (en) 2017-09-20
AU2015347043B2 (en) 2018-03-22
KR101930182B1 (ko) 2018-12-17
JP2016539942A (ja) 2016-12-22
MY188313A (en) 2021-11-27
TWI693218B (zh) 2020-05-11
RS60999B1 (sr) 2020-11-30
PT3218366T (pt) 2019-04-01
IL251406A0 (en) 2017-05-29
LT3473619T (lt) 2020-11-10
CY1121334T1 (el) 2020-05-29
EA032102B1 (ru) 2019-04-30
US20160137628A1 (en) 2016-05-19
CL2017001209A1 (es) 2018-01-12
ES2826448T3 (es) 2021-05-18
TW201629038A (zh) 2016-08-16
CA2963473A1 (en) 2016-05-19
AR102463A1 (es) 2017-03-01
PH12017500881A1 (en) 2017-11-06
ZA201702199B (en) 2018-12-19
AU2015347043A1 (en) 2017-05-04
CY1123592T1 (el) 2022-03-24
SG11201703394RA (en) 2017-05-30
HRP20201681T1 (hr) 2020-12-25
IL251406B (en) 2019-08-29
TR201902686T4 (tr) 2019-03-21
NZ730771A (en) 2018-07-27
EP3473619B8 (en) 2020-11-04
CA2963473C (en) 2018-12-18
PL3218366T3 (pl) 2019-06-28
PE20170898A1 (es) 2017-07-12
SV2017005418A (es) 2018-10-09
UA117983C2 (uk) 2018-10-25
CN107108567A (zh) 2017-08-29
KR20170066623A (ko) 2017-06-14
PH12017500881B1 (en) 2017-11-06
DOP2017000111A (es) 2017-06-15
PT3473619T (pt) 2020-11-11
MX2017006275A (es) 2017-08-14
CN107108567B (zh) 2020-01-10
EP3473619B1 (en) 2020-09-09
US10010540B2 (en) 2018-07-03
DK3218366T3 (en) 2019-04-01
EA201790838A1 (ru) 2017-12-29
RS58347B1 (sr) 2019-03-29
EP3218366B1 (en) 2019-01-09
LT3218366T (lt) 2019-04-10
TN2017000116A1 (en) 2018-07-04
ME03325B (me) 2019-10-20

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