ECSP15008695A - Combinaciones farmacéuticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa - Google Patents

Combinaciones farmacéuticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa

Info

Publication number
ECSP15008695A
ECSP15008695A ECIEPI20158695A ECPI201508695A ECSP15008695A EC SP15008695 A ECSP15008695 A EC SP15008695A EC IEPI20158695 A ECIEPI20158695 A EC IEPI20158695A EC PI201508695 A ECPI201508695 A EC PI201508695A EC SP15008695 A ECSP15008695 A EC SP15008695A
Authority
EC
Ecuador
Prior art keywords
inhibitor
optionally
pi3k
egfr
raf
Prior art date
Application number
ECIEPI20158695A
Other languages
English (en)
Inventor
Darrin Stuart
Giordano Caponigro
Parseval Laure Moutouh-De
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48980368&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP15008695(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP15008695A publication Critical patent/ECSP15008695A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a una combinación terapéutica, la cual comprende: (a) un inhibidor de B-Raf, (b) un inhibidor del receptor del factor de crecimiento epidérmico (EGFR) y, opcionalmente, (c) un inhibidor de PI3K, útil para su 5 administración separada, simultánea o en secuencia en un sujeto que lo necesite, para el tratamiento o la prevención de una enfermedad proliferativa. La presente invención se refiere en especial a una combinación terapéutica, la cual comprende: (a) un inhibidor de B-Raf de la fórmula: 10 o una sal farmacéuticamente aceptable del mismo (posteriormente referido en la presente como el Compuesto A), (b) un inhibidor del receptor del factor de crecimiento epidérmico (EGFR) y, opcionalmente, 15 (c) un inhibidor de PI3K.
ECIEPI20158695A 2012-08-07 2015-03-06 Combinaciones farmacéuticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa ECSP15008695A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261680473P 2012-08-07 2012-08-07

Publications (1)

Publication Number Publication Date
ECSP15008695A true ECSP15008695A (es) 2019-03-29

Family

ID=48980368

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI20158695A ECSP15008695A (es) 2012-08-07 2015-03-06 Combinaciones farmacéuticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa

Country Status (39)

Country Link
US (1) US9474754B2 (es)
EP (2) EP2882440B1 (es)
JP (3) JP6342396B2 (es)
KR (1) KR102112885B1 (es)
CN (1) CN104519887B (es)
AR (1) AR092045A1 (es)
AU (1) AU2013299841B8 (es)
CA (1) CA2879548C (es)
CL (1) CL2015000294A1 (es)
CO (1) CO7200273A2 (es)
CY (1) CY1122143T1 (es)
DK (1) DK2882440T3 (es)
EA (1) EA028420B1 (es)
EC (1) ECSP15008695A (es)
ES (1) ES2717911T3 (es)
GT (1) GT201500025A (es)
HK (2) HK1204976A1 (es)
HR (1) HRP20190537T1 (es)
HU (1) HUE042877T2 (es)
IL (1) IL236934B (es)
IN (1) IN2015DN00450A (es)
JO (1) JOP20130236B1 (es)
LT (1) LT2882440T (es)
MA (1) MA37829A1 (es)
MX (1) MX359403B (es)
MY (1) MY176031A (es)
NZ (1) NZ703940A (es)
PE (2) PE20150673A1 (es)
PH (1) PH12015500246A1 (es)
PL (1) PL2882440T3 (es)
PT (1) PT2882440T (es)
RS (1) RS58734B1 (es)
SG (1) SG11201500321YA (es)
SI (1) SI2882440T1 (es)
TN (1) TN2015000027A1 (es)
TR (1) TR201904980T4 (es)
TW (1) TWI607754B (es)
UA (1) UA115786C2 (es)
WO (1) WO2014025688A1 (es)

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KR102112885B1 (ko) * 2012-08-07 2020-05-19 노파르티스 아게 B-raf 억제제, egfr 억제제 및 임의로 pi3k-알파 억제제를 포함하는 제약 조합물
NZ712184A (en) 2013-03-21 2020-01-31 Array Biopharma Inc Combination therapy comprising a b-raf inhibitor and a second inhibitor
WO2015145388A2 (en) * 2014-03-27 2015-10-01 Novartis Ag Methods of treating colorectal cancers harboring upstream wnt pathway mutations
PL3155126T3 (pl) * 2014-06-16 2019-01-31 Worldwide Innovative Network Sposób wybierania spersonalizowanej terapii potrójnej do leczenia nowotworu
WO2016193955A1 (en) * 2015-06-04 2016-12-08 Giorgio Stassi Combinations of kinase inhibitors for treating colorectal cancer
JP2018526375A (ja) * 2015-08-28 2018-09-13 ノバルティス アーゲー 組み合わせ療法
WO2017037573A1 (en) * 2015-08-28 2017-03-09 Novartis Ag Pharmaceutical combination comprising the pi3k inhibitor alpelisib and the b-raf inhibitor dabrafenib; the use of such combination in the treatment or prevention of cancer
WO2017066664A1 (en) * 2015-10-16 2017-04-20 Millennium Pharmaceuticals, Inc. Combination therapy including a raf inhibitor for the treatment of colorectal cancer
UA125436C2 (uk) * 2016-06-03 2022-03-09 Еррей Біофарма, Інк. Фармацевтичні комбінації
CN109715163B (zh) * 2016-09-19 2022-11-22 诺华股份有限公司 包含raf抑制剂和erk抑制剂的治疗组合
CA3069564A1 (en) * 2017-08-03 2019-02-07 Novartis Ag Therapeutic combination of a third-generation egfr tyrosine kinase inhibitor and a raf inhibitor
EP4364798A2 (en) 2018-10-05 2024-05-08 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity
TW202043225A (zh) * 2019-01-25 2020-12-01 英屬開曼群島商百濟神州有限公司 B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途
WO2020164997A1 (en) * 2019-02-12 2020-08-20 Bayer Aktiengesellschaft Combination of pi3k-inhibitors
WO2023145530A1 (ja) * 2022-01-27 2023-08-03 国立大学法人東北大学 癌治療剤
WO2023230554A1 (en) 2022-05-25 2023-11-30 Pfizer Inc. Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer
WO2024073364A1 (en) * 2022-09-26 2024-04-04 Beigene, Ltd. Combinations of a b-raf inhibitor, and an anti-egfr antibody for the treatment of cancer

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US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
DK2139484T3 (da) 2007-04-10 2013-10-21 Exelixis Inc Fremgangsmåder til behandling af cancer ved brug af pyridopyrimidinon-inhibitorer af PI3K-alfa
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
SG10201402917XA (en) * 2009-08-24 2014-08-28 Genentech Inc Determining sensitivity of cells to b-raf inhibitor treatment by detecting kras mutation and rtk expression levels
AR077975A1 (es) * 2009-08-28 2011-10-05 Irm Llc Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
BR112012008519A2 (pt) * 2009-10-12 2016-04-05 Glaxosmithkline Llc combinação
US20120045433A1 (en) 2010-08-17 2012-02-23 Kapil Dhingra Combination therapy
JP2013542228A (ja) * 2010-11-08 2013-11-21 ノバルティス アーゲー Ｅｇｆｒ依存性疾患またはｅｇｆｒファミリーメンバーを標的とする薬剤に対して獲得耐性を有する疾患の治療における２−カルボキサミドシクロアミノウレア誘導体の使用
CN104185631A (zh) 2011-11-10 2014-12-03 纪念斯隆-凯特琳癌症中心 用2-氨基-4H-萘并[1,2-b]吡喃-3-甲腈治疗卵巢癌
CN103917236A (zh) * 2011-11-11 2014-07-09 诺华股份有限公司 治疗增生性疾病的方法
KR102112885B1 (ko) * 2012-08-07 2020-05-19 노파르티스 아게 B-raf 억제제, egfr 억제제 및 임의로 pi3k-알파 억제제를 포함하는 제약 조합물

Also Published As

Publication number Publication date
PT2882440T (pt) 2019-04-23
AR092045A1 (es) 2015-03-18
SG11201500321YA (en) 2015-04-29
EA028420B1 (ru) 2017-11-30
JP6974669B2 (ja) 2021-12-01
MA37829A1 (fr) 2017-01-31
ES2717911T3 (es) 2019-06-26
TWI607754B (zh) 2017-12-11
MX359403B (es) 2018-09-26
PE20150673A1 (es) 2015-05-20
KR20150040905A (ko) 2015-04-15
MY176031A (en) 2020-07-22
CL2015000294A1 (es) 2015-05-08
AU2013299841B8 (en) 2017-01-05
US9474754B2 (en) 2016-10-25
EP2882440A1 (en) 2015-06-17
JOP20130236B1 (ar) 2021-08-17
PH12015500246B1 (en) 2015-03-30
MX2015001732A (es) 2015-06-03
JP2018109022A (ja) 2018-07-12
UA115786C2 (uk) 2017-12-26
US20150265616A1 (en) 2015-09-24
AU2013299841A1 (en) 2015-02-12
CY1122143T1 (el) 2020-11-25
DK2882440T3 (da) 2019-05-06
AU2013299841B2 (en) 2016-11-24
RS58734B1 (sr) 2019-06-28
EP2882440B1 (en) 2019-02-27
BR112015002384A8 (pt) 2019-07-30
CA2879548A1 (en) 2014-02-13
JP2020019780A (ja) 2020-02-06
JP2015524472A (ja) 2015-08-24
HRP20190537T1 (hr) 2019-06-28
GT201500025A (es) 2017-09-28
JP6595024B2 (ja) 2019-10-23
KR102112885B1 (ko) 2020-05-19
HUE042877T2 (hu) 2019-07-29
TW201410247A (zh) 2014-03-16
SI2882440T1 (sl) 2019-05-31
EP3574904A1 (en) 2019-12-04
CO7200273A2 (es) 2015-02-27
NZ703940A (en) 2018-04-27
HK1211831A1 (en) 2016-06-03
TR201904980T4 (tr) 2019-05-21
CN104519887A (zh) 2015-04-15
BR112015002384A2 (pt) 2017-07-04
AU2013299841A8 (en) 2017-01-05
PL2882440T3 (pl) 2019-07-31
CA2879548C (en) 2020-07-21
WO2014025688A1 (en) 2014-02-13
LT2882440T (lt) 2019-04-25
PH12015500246A1 (en) 2015-03-30
PE20191655A1 (es) 2019-11-07
IN2015DN00450A (es) 2015-06-26
EA201590332A1 (ru) 2015-06-30
TN2015000027A1 (en) 2016-06-29
CN104519887B (zh) 2017-06-27
JP6342396B2 (ja) 2018-06-13
IL236934B (en) 2018-11-29
HK1204976A1 (en) 2015-12-11

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