CO7200273A2 - Combinaciones farmaceúticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa - Google Patents

Combinaciones farmaceúticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa

Info

Publication number
CO7200273A2
CO7200273A2 CO15024921A CO15024921A CO7200273A2 CO 7200273 A2 CO7200273 A2 CO 7200273A2 CO 15024921 A CO15024921 A CO 15024921A CO 15024921 A CO15024921 A CO 15024921A CO 7200273 A2 CO7200273 A2 CO 7200273A2
Authority
CO
Colombia
Prior art keywords
inhibitor
optionally
pi3k
egfr
raf
Prior art date
Application number
CO15024921A
Other languages
English (en)
Inventor
Giordano Caponigro
Darrin Stuart
Parseval Laure Moutouh-De
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48980368&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7200273(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO7200273A2 publication Critical patent/CO7200273A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Una combinación farmacéutica, la cual comprende: (a) un inhibidor de B-Raf, (b) un inhibidor del receptor del factor de crecimiento epidérmico (EGFR) y, opcionalmente, (c) un inhibidor de PI3K; los usos de dicha combinación en el tratamiento de enfermedades proliferativas; y los métodos para el tratamiento de un sujeto que padezca de una enfermedad proliferativa, los cuales comprenden administrar una cantidad terapéuticamente efectiva de dicha combinación.
CO15024921A 2012-08-07 2015-02-06 Combinaciones farmaceúticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa CO7200273A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261680473P 2012-08-07 2012-08-07

Publications (1)

Publication Number Publication Date
CO7200273A2 true CO7200273A2 (es) 2015-02-27

Family

ID=48980368

Family Applications (1)

Application Number Title Priority Date Filing Date
CO15024921A CO7200273A2 (es) 2012-08-07 2015-02-06 Combinaciones farmaceúticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa

Country Status (39)

Country Link
US (1) US9474754B2 (es)
EP (2) EP2882440B1 (es)
JP (3) JP6342396B2 (es)
KR (1) KR102112885B1 (es)
CN (1) CN104519887B (es)
AR (1) AR092045A1 (es)
AU (1) AU2013299841B8 (es)
CA (1) CA2879548C (es)
CL (1) CL2015000294A1 (es)
CO (1) CO7200273A2 (es)
CY (1) CY1122143T1 (es)
DK (1) DK2882440T3 (es)
EA (1) EA028420B1 (es)
EC (1) ECSP15008695A (es)
ES (1) ES2717911T3 (es)
GT (1) GT201500025A (es)
HK (2) HK1204976A1 (es)
HR (1) HRP20190537T1 (es)
HU (1) HUE042877T2 (es)
IL (1) IL236934B (es)
IN (1) IN2015DN00450A (es)
JO (1) JOP20130236B1 (es)
LT (1) LT2882440T (es)
MA (1) MA37829A1 (es)
MX (1) MX359403B (es)
MY (1) MY176031A (es)
NZ (1) NZ703940A (es)
PE (2) PE20191655A1 (es)
PH (1) PH12015500246A1 (es)
PL (1) PL2882440T3 (es)
PT (1) PT2882440T (es)
RS (1) RS58734B1 (es)
SG (1) SG11201500321YA (es)
SI (1) SI2882440T1 (es)
TN (1) TN2015000027A1 (es)
TR (1) TR201904980T4 (es)
TW (1) TWI607754B (es)
UA (1) UA115786C2 (es)
WO (1) WO2014025688A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE042877T2 (hu) * 2012-08-07 2019-07-29 Novartis Ag Gyógyászati kombinációk egy B-Raf inhibitor, egy EGFR inhibitor és adott esetben egy PI13K-alfa inhibitor tartalommal
SI2976106T1 (sl) 2013-03-21 2021-08-31 Array Biopharma Inc. Kombinacijska terapija, ki vsebuje zaviralec B-Raf in drugi zaviralec
WO2015145388A2 (en) * 2014-03-27 2015-10-01 Novartis Ag Methods of treating colorectal cancers harboring upstream wnt pathway mutations
EP3392348A3 (en) * 2014-06-16 2018-11-21 Worldwide Innovative Network Method for selecting personalized tri-therapy for cancer treatment
WO2016193955A1 (en) * 2015-06-04 2016-12-08 Giorgio Stassi Combinations of kinase inhibitors for treating colorectal cancer
JP2018526375A (ja) * 2015-08-28 2018-09-13 ノバルティス アーゲー 組み合わせ療法
JP2018525402A (ja) * 2015-08-28 2018-09-06 ノバルティス アーゲー Ｐｉ３ｋ阻害剤のアルペリシブおよびｂ−ｒａｆ阻害剤のダブラフェニブを含む組合せ医薬、がんの治療または予防におけるそのような組合せの使用
WO2017066664A1 (en) * 2015-10-16 2017-04-20 Millennium Pharmaceuticals, Inc. Combination therapy including a raf inhibitor for the treatment of colorectal cancer
WO2017210538A1 (en) 2016-06-03 2017-12-07 Giordano Caponigro Pharmaceutical combinations
MX2019003095A (es) * 2016-09-19 2019-07-04 Novartis Ag Combinaciones terapeuticas que comprenden un inhibidor de raf y un inhibidor de erk.
WO2019026007A1 (en) * 2017-08-03 2019-02-07 Novartis Ag THERAPEUTIC ASSOCIATION OF THIRD GENERATION TYFRSINE KINASE INHIBITOR AND RAF INHIBITOR
EA202190952A1 (ru) 2018-10-05 2021-12-22 Аннапурна Байо, Инк. Соединения и композиции для лечения патологических состояний, связанных с активностью рецептора apj
TW202043225A (zh) * 2019-01-25 2020-12-01 英屬開曼群島商百濟神州有限公司 B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途
WO2020164997A1 (en) * 2019-02-12 2020-08-20 Bayer Aktiengesellschaft Combination of pi3k-inhibitors
WO2023145530A1 (ja) * 2022-01-27 2023-08-03 国立大学法人東北大学 癌治療剤
WO2023230554A1 (en) 2022-05-25 2023-11-30 Pfizer Inc. Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer

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Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
PL2139484T3 (pl) 2007-04-10 2013-12-31 Exelixis Inc Sposoby leczenia raka z zastosowaniem pirydopirymidynonów jako inhibitorów PI3K alfa
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
KR20120050493A (ko) * 2009-08-24 2012-05-18 제넨테크, 인크. Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정
JO3002B1 (ar) * 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
JP2013507442A (ja) * 2009-10-12 2013-03-04 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 組合せ
US20120045433A1 (en) 2010-08-17 2012-02-23 Kapil Dhingra Combination therapy
CA2815492C (en) * 2010-11-08 2019-04-09 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
AU2012335665A1 (en) 2011-11-10 2014-07-03 Memorial Sloan-Kettering Cancer Center Treatment of ovarian cancer with 2-amino-4H-naphtho[1,2-B]pyran-3-carbonitriles
JP6150813B2 (ja) * 2011-11-11 2017-06-21 ノバルティス アーゲー 増殖性疾患の治療方法
HUE042877T2 (hu) * 2012-08-07 2019-07-29 Novartis Ag Gyógyászati kombinációk egy B-Raf inhibitor, egy EGFR inhibitor és adott esetben egy PI13K-alfa inhibitor tartalommal

Also Published As

Publication number Publication date
UA115786C2 (uk) 2017-12-26
DK2882440T3 (da) 2019-05-06
JP2015524472A (ja) 2015-08-24
KR102112885B1 (ko) 2020-05-19
JOP20130236B1 (ar) 2021-08-17
JP6342396B2 (ja) 2018-06-13
HUE042877T2 (hu) 2019-07-29
ES2717911T3 (es) 2019-06-26
PE20191655A1 (es) 2019-11-07
JP2018109022A (ja) 2018-07-12
TWI607754B (zh) 2017-12-11
US20150265616A1 (en) 2015-09-24
BR112015002384A2 (pt) 2017-07-04
PH12015500246B1 (en) 2015-03-30
KR20150040905A (ko) 2015-04-15
BR112015002384A8 (pt) 2019-07-30
TN2015000027A1 (en) 2016-06-29
CN104519887A (zh) 2015-04-15
MX2015001732A (es) 2015-06-03
HK1204976A1 (en) 2015-12-11
MY176031A (en) 2020-07-22
JP6595024B2 (ja) 2019-10-23
CL2015000294A1 (es) 2015-05-08
TW201410247A (zh) 2014-03-16
PT2882440T (pt) 2019-04-23
EP2882440A1 (en) 2015-06-17
JP2020019780A (ja) 2020-02-06
JP6974669B2 (ja) 2021-12-01
PH12015500246A1 (en) 2015-03-30
CA2879548C (en) 2020-07-21
NZ703940A (en) 2018-04-27
IL236934B (en) 2018-11-29
HRP20190537T1 (hr) 2019-06-28
AU2013299841B2 (en) 2016-11-24
EA028420B1 (ru) 2017-11-30
AU2013299841A1 (en) 2015-02-12
HK1211831A1 (en) 2016-06-03
CY1122143T1 (el) 2020-11-25
GT201500025A (es) 2017-09-28
ECSP15008695A (es) 2019-03-29
SG11201500321YA (en) 2015-04-29
EP2882440B1 (en) 2019-02-27
RS58734B1 (sr) 2019-06-28
AU2013299841A8 (en) 2017-01-05
CA2879548A1 (en) 2014-02-13
EP3574904A1 (en) 2019-12-04
TR201904980T4 (tr) 2019-05-21
AU2013299841B8 (en) 2017-01-05
IN2015DN00450A (es) 2015-06-26
MX359403B (es) 2018-09-26
MA37829A1 (fr) 2017-01-31
AR092045A1 (es) 2015-03-18
CN104519887B (zh) 2017-06-27
SI2882440T1 (sl) 2019-05-31
PE20150673A1 (es) 2015-05-20
LT2882440T (lt) 2019-04-25
PL2882440T3 (pl) 2019-07-31
US9474754B2 (en) 2016-10-25
EA201590332A1 (ru) 2015-06-30
WO2014025688A1 (en) 2014-02-13

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