EA201890522A1 - Способ получения противогрибковых соединений - Google Patents

Способ получения противогрибковых соединений

Info

Publication number
EA201890522A1
EA201890522A1 EA201890522A EA201890522A EA201890522A1 EA 201890522 A1 EA201890522 A1 EA 201890522A1 EA 201890522 A EA201890522 A EA 201890522A EA 201890522 A EA201890522 A EA 201890522A EA 201890522 A1 EA201890522 A1 EA 201890522A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fiber connections
obtaining anti
present
obtaining
connections
Prior art date
Application number
EA201890522A
Other languages
English (en)
Other versions
EA038214B1 (ru
Inventor
Дэвид Дэйл Вирт
Кристофер М. Йейтс
Уиллиам Дж. Хекстра
Мартин Ф. Биндль
Эдуард Хартманн
Original Assignee
Майковиа Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Майковиа Фармасьютикалс, Инк. filed Critical Майковиа Фармасьютикалс, Инк.
Publication of EA201890522A1 publication Critical patent/EA201890522A1/ru
Publication of EA038214B1 publication Critical patent/EA038214B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • B01J31/0244—Nitrogen containing compounds with nitrogen contained as ring member in aromatic compounds or moieties, e.g. pyridine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
    • B01J2231/341—1,2-additions, e.g. aldol or Knoevenagel condensations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Настоящее изобретение относится к способу получения соединения формулы 5 или 5* или их смеси, которое полезно в качестве противогрибкового средства. В частности, настоящее изобретение обеспечивает новую методику получения соединения 7, 7*и 11, 11* и их замещенных производных.
EA201890522A 2015-09-18 2016-09-16 Способ получения противогрибковых соединений EA038214B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562220384P 2015-09-18 2015-09-18
US201662275504P 2016-01-06 2016-01-06
PCT/US2016/052128 WO2017049080A1 (en) 2015-09-18 2016-09-16 Antifungal compound process

Publications (2)

Publication Number Publication Date
EA201890522A1 true EA201890522A1 (ru) 2018-08-31
EA038214B1 EA038214B1 (ru) 2021-07-23

Family

ID=58289604

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201890522A EA038214B1 (ru) 2015-09-18 2016-09-16 Способ получения противогрибковых соединений
EA201890752A EA036098B1 (ru) 2015-09-18 2016-09-16 Способ получения противогрибковых соединений
EA201890751A EA037521B1 (ru) 2015-09-18 2016-09-16 Противогрибковые соединения и способы их получения

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA201890752A EA036098B1 (ru) 2015-09-18 2016-09-16 Способ получения противогрибковых соединений
EA201890751A EA037521B1 (ru) 2015-09-18 2016-09-16 Противогрибковые соединения и способы их получения

Country Status (17)

Country Link
US (4) US10513505B2 (ru)
EP (3) EP3349753A4 (ru)
JP (4) JP6887993B2 (ru)
KR (3) KR20180053393A (ru)
CN (3) CN108289457B (ru)
AU (3) AU2016324148B2 (ru)
BR (2) BR112018005198A2 (ru)
CA (3) CA2998808A1 (ru)
EA (3) EA038214B1 (ru)
ES (2) ES2858314T3 (ru)
HK (4) HK1263287A1 (ru)
HU (1) HUE053638T2 (ru)
MX (3) MX2018003280A (ru)
PL (1) PL3349586T3 (ru)
TW (3) TWI730986B (ru)
WO (3) WO2017049096A1 (ru)
ZA (1) ZA201801404B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015143142A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
WO2015143162A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
HUE052446T2 (hu) 2014-03-19 2021-04-28 Mycovia Pharmaceuticals Inc Eljárás gombaellenes vegyület elõállítása céljából
CA2942979A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
WO2015143192A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EA201691648A1 (ru) 2014-03-19 2017-01-30 Ваймет Фармасьютикалс, Инк. Способ получения противогрибковых соединений
JP6887993B2 (ja) 2015-09-18 2021-06-16 エヌキューピー １５９８，リミテッド 抗真菌化合物調製方法
CN109666019B (zh) * 2017-10-14 2021-04-06 朱允涛 一种氘代的氮唑醇类化合物及其制备方法和用途
WO2019092086A1 (en) 2017-11-13 2019-05-16 Bayer Aktiengesellschaft Tetrazolylpropyl derivatives and their use as fungicides
WO2021188404A1 (en) * 2020-03-19 2021-09-23 Assia Chemical Industries Ltd Solid state forms of oteseconazole and process for preparation thereof
CN117915913A (zh) * 2021-07-22 2024-04-19 迈科维亚医药公司 包含奥特康唑的组合物
CN114573557B (zh) * 2022-03-28 2024-03-08 浙江天宇药业股份有限公司 一种奥特康唑的制备方法
CN114573503B (zh) * 2022-03-28 2024-04-09 浙江天宇药业股份有限公司 一种制备奥特康唑中间体的方法
WO2024067784A1 (zh) * 2022-09-30 2024-04-04 上海济煜医药科技有限公司 双环类化合物的无定形、结晶固体及其制备方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854015B2 (de) 1978-12-14 1980-10-09 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur Herstellung von !H-TetrazoI-1-essigsauren und bestimmter Ester derselben
DE3262386D1 (en) 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
CS228931B2 (cs) 1981-06-06 1984-05-14 Pfizer Způsob výroby 2-(2,4-difluorfenyl)-l,3-bis(lH-l,2,4-triazol-l-yl)propan- -2-oiu
GB8304282D0 (en) 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
ATE107176T1 (de) 1989-12-04 1994-07-15 Searle & Co System zur transdermalen albuterol applikation.
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
WO1993011938A1 (en) 1991-12-18 1993-06-24 Minnesota Mining And Manufacturing Company Multilayered barrier structures
EP0553769B1 (de) 1992-01-29 1996-01-03 FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG Ballspielschläger, insbesondere Tennisschläger
JP2000344744A (ja) 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
CN1565118A (zh) * 2001-10-08 2005-01-12 皇家飞利浦电子股份有限公司 用于运动估计的装置和方法
JP2004359646A (ja) 2003-06-09 2004-12-24 Ss Pharmaceut Co Ltd 抗真菌活性を有する新規アゾール誘導体
US7241800B2 (en) * 2004-03-17 2007-07-10 Mai De Ltd. Anhydrous amorphous form of fluvastatin sodium
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
KR100889937B1 (ko) 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
UA108596C2 (xx) * 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
KR101109215B1 (ko) 2009-06-17 2012-01-30 보령제약 주식회사 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법
JP2012530111A (ja) 2009-06-18 2012-11-29 ビーエーエスエフ ソシエタス・ヨーロピア ５−硫黄置換基を有する抗菌類性１，２，４−トリアゾリル誘導体
DK2563771T3 (en) 2010-04-24 2016-02-29 Viamet Pharmaceuticals Inc Metalloenzyminhibitorforbindelser
CN103764646A (zh) 2011-06-19 2014-04-30 威尔金制药有限公司 金属酶抑制剂化合物
EA025406B1 (ru) * 2011-06-19 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
IN2014DN00286A (ru) 2011-06-23 2015-06-05 Viamet Pharmaceuticals Inc
TW201329025A (zh) 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
EA025437B1 (ru) * 2011-12-11 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
AU2013209516A1 (en) 2012-01-20 2014-08-28 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
BR112014017799A8 (pt) 2012-01-20 2017-07-11 Viamet Pharmaceuticals Inc Compostos inibidores de metaloenzima
CN110354132A (zh) * 2012-06-04 2019-10-22 药品循环有限责任公司 布鲁顿酪氨酸激酶抑制剂的晶形
EP2894981B1 (en) 2012-09-12 2019-12-04 Dow AgroSciences LLC Metalloenzyme inhibitor compounds
JP2016508487A (ja) 2013-01-28 2016-03-22 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害剤化合物
US9598340B2 (en) 2013-04-05 2017-03-21 The Regents Of The University Of California Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds
JP6387401B2 (ja) 2013-05-28 2018-09-05 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 殺真菌組成物
AU2014278172B2 (en) 2013-06-12 2018-08-09 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP2017512777A (ja) 2014-03-19 2017-05-25 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
WO2015143192A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
EA201691648A1 (ru) 2014-03-19 2017-01-30 Ваймет Фармасьютикалс, Инк. Способ получения противогрибковых соединений
WO2015143142A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942979A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
HUE052446T2 (hu) * 2014-03-19 2021-04-28 Mycovia Pharmaceuticals Inc Eljárás gombaellenes vegyület elõállítása céljából
WO2015143162A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EA037556B1 (ru) * 2015-03-19 2021-04-14 Майковиа Фармасьютикалс, Инк. Полиморфные формы противогрибковых соединений и способы их получения
LT3297998T (lt) 2015-05-18 2020-06-10 Viamet Pharmaceuticals (NC), Inc. Priešgrybeliniai junginiai
JP6887993B2 (ja) 2015-09-18 2021-06-16 エヌキューピー １５９８，リミテッド 抗真菌化合物調製方法
US10513506B2 (en) 2015-11-17 2019-12-24 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl and processes of preparation
CA3005862A1 (en) 2015-11-17 2017-05-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
US20180354928A1 (en) 2015-11-17 2018-12-13 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
CA3005744A1 (en) 2015-11-17 2017-05-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-oxoethyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
JP6803923B2 (ja) 2015-12-30 2020-12-23 エヌキューピー １５９８，リミテッド 金属酵素阻害化合物

Also Published As

Publication number Publication date
MX2018003284A (es) 2018-08-23
US20190194160A1 (en) 2019-06-27
ES2821021T3 (es) 2021-04-23
US10464921B2 (en) 2019-11-05
JP6887993B2 (ja) 2021-06-16
EP3349587A4 (en) 2019-04-24
ES2858314T3 (es) 2021-09-30
JP2018532719A (ja) 2018-11-08
TWI766842B (zh) 2022-06-11
BR112018005194B1 (pt) 2022-11-08
PL3349586T3 (pl) 2021-05-31
US10513505B2 (en) 2019-12-24
EP3349587A1 (en) 2018-07-25
AU2016323767A1 (en) 2018-03-15
EP3349586B1 (en) 2020-12-02
ZA201801404B (en) 2018-12-19
TW201718497A (zh) 2017-06-01
US20180265492A1 (en) 2018-09-20
TWI730986B (zh) 2021-06-21
EA201890752A1 (ru) 2018-08-31
US10836740B2 (en) 2020-11-17
EP3349587B1 (en) 2020-07-22
EA201890751A1 (ru) 2018-08-31
EA037521B1 (ru) 2021-04-07
TW201718541A (zh) 2017-06-01
KR20180100297A (ko) 2018-09-10
HK1258863A1 (zh) 2019-11-22
CN108289457A (zh) 2018-07-17
US10308632B2 (en) 2019-06-04
MX2018003357A (es) 2018-08-16
HUE053638T2 (hu) 2021-07-28
TW201718540A (zh) 2017-06-01
AU2016324148A1 (en) 2018-03-15
WO2017049196A1 (en) 2017-03-23
JP2018529687A (ja) 2018-10-11
JP6847458B2 (ja) 2021-03-24
KR20180052755A (ko) 2018-05-18
CA2998805C (en) 2023-09-26
CN108348511A (zh) 2018-07-31
US20200024252A1 (en) 2020-01-23
US20180258068A1 (en) 2018-09-13
BR112018005194A2 (pt) 2018-10-09
CA2998807A1 (en) 2017-03-23
EP3349586A1 (en) 2018-07-25
CA2998808A1 (en) 2017-03-23
EP3349753A4 (en) 2019-01-23
CN108289457B (zh) 2021-08-06
AU2016323782B2 (en) 2020-11-26
MX2018003280A (es) 2018-08-16
HK1263287A1 (zh) 2020-03-20
EP3349753A1 (en) 2018-07-25
WO2017049096A1 (en) 2017-03-23
BR112018005198A2 (pt) 2018-10-09
KR20180053393A (ko) 2018-05-21
EA036098B1 (ru) 2020-09-28
EA038214B1 (ru) 2021-07-23
AU2016324148B2 (en) 2020-10-29
AU2016323782A1 (en) 2018-03-22
WO2017049080A1 (en) 2017-03-23
TWI723047B (zh) 2021-04-01
CA2998805A1 (en) 2017-03-23
CN108347949B (zh) 2021-08-13
HK1257225A1 (zh) 2019-10-18
EP3349586A4 (en) 2019-04-17
HK1258862A1 (zh) 2019-11-22
CN108347949A (zh) 2018-07-31
JP2021121606A (ja) 2021-08-26
JP2018527367A (ja) 2018-09-20
AU2016323767B2 (en) 2020-10-15

Similar Documents

Publication Publication Date Title
EA201890752A1 (ru) Способ получения противогрибковых соединений
EA201892147A1 (ru) Бициклические соединения
EA201792535A1 (ru) Гетероциклические амиды в качестве ингибиторов киназ
EA201691648A1 (ru) Способ получения противогрибковых соединений
EA201691649A1 (ru) Способ получения противогрибковых соединений
EA201890373A1 (ru) Пиридиновые соединения, пригодные для борьбы с фитопатогенными грибами
EA201692193A1 (ru) Способы получения ингибитора jak1 и его новых форм
EA201792067A1 (ru) Противогрибковые соединения и способы получения
EA201890899A1 (ru) Модуляторы фарнезоидного x-рецептора
EA201691272A1 (ru) Тетрагидропиридопиразины в качестве модуляторов gpr6
EA201591889A1 (ru) 6-(5-гидрокси-1h-пиразол-1-ил)никотинамидные ингибиторы phd
EA201692526A1 (ru) Замещенные [1,2,4]триазольные соединения
EA201692525A1 (ru) Замещенные соединения [1,2,4]триазола и имидазола в качестве фунгицидов
EA201790983A1 (ru) Синтез копанлисиба и его дигидрохлорида
PH12019501362A1 (en) Polymorphs
EA201891770A1 (ru) Малеатная соль агониста tlr7, ее кристаллические формы c, d и e, способы получения и применение малеатной соли и кристаллических форм
EA201992421A1 (ru) Способ получения озанимода
EA201891379A1 (ru) Ингибиторы тирозинкиназы брутона и способы их применения
EA201790982A1 (ru) Синтез копанлисиба и его дигидрохлорида
EA201892515A1 (ru) Стероидные 6,7-бета-эпоксиды в качестве интермедиатов
MX2019013979A (es) Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.
EA201692289A1 (ru) Замещенные [1,2,4]триазольные и имидазольные соединения в качестве фунгицидов
EA201690523A1 (ru) Триазолопиридины, композиции и способы их применения
MX2018007219A (es) Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol.
WO2017064627A3 (en) Process for preparation of eribulin and intermediates thereof