EA202090547A3 - Макроциклические деаза-оксипурины для лечения вирусных инфекций - Google Patents

Макроциклические деаза-оксипурины для лечения вирусных инфекций

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Publication number
EA202090547A3
EA202090547A3 EA202090547A EA202090547A EA202090547A3 EA 202090547 A3 EA202090547 A3 EA 202090547A3 EA 202090547 A EA202090547 A EA 202090547A EA 202090547 A EA202090547 A EA 202090547A EA 202090547 A3 EA202090547 A3 EA 202090547A3
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EA
Eurasian Patent Office
Prior art keywords
dease
macrocyclic
treatment
viral infections
oxipurins
Prior art date
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EA202090547A
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English (en)
Other versions
EA202090547A2 (ru
Inventor
Жан-Франсуа Бонфанти
Жером Мишель Клод Фортэн
Филипп Мюллер
Фредерик Марк Морис Дубле
Пьер Жан-Мари Бернар Рабуассон
Эрик Пьер Александр Арну
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
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Application filed by Янссен Сайенсиз Айрлэнд Юси filed Critical Янссен Сайенсиз Айрлэнд Юси
Publication of EA202090547A2 publication Critical patent/EA202090547A2/ru
Publication of EA202090547A3 publication Critical patent/EA202090547A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к производным макроциклических деаза-оксипуринов, способам их получения, фармацевтическим композициям и их применению при лечении вирусных инфекций.
EA202090547A 2013-03-29 2014-03-28 Макроциклические деаза-оксипурины для лечения вирусных инфекций EA202090547A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13161865 2013-03-29

Publications (2)

Publication Number Publication Date
EA202090547A2 EA202090547A2 (ru) 2020-09-30
EA202090547A3 true EA202090547A3 (ru) 2020-12-30

Family

ID=48040051

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202090547A EA202090547A3 (ru) 2013-03-29 2014-03-28 Макроциклические деаза-оксипурины для лечения вирусных инфекций
EA201591887A EA035110B1 (ru) 2013-03-29 2014-03-28 Макроциклические деаза-оксипурины в качестве модуляторов tlr7

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201591887A EA035110B1 (ru) 2013-03-29 2014-03-28 Макроциклические деаза-оксипурины в качестве модуляторов tlr7

Country Status (22)

Country Link
US (3) US10266543B2 (ru)
EP (1) EP2978429B1 (ru)
JP (2) JP6336036B2 (ru)
KR (1) KR102280554B1 (ru)
CN (2) CN110590809B (ru)
AU (1) AU2014242954B2 (ru)
BR (1) BR112015024411B1 (ru)
CA (1) CA2902837C (ru)
CL (1) CL2015002891A1 (ru)
DK (1) DK2978429T3 (ru)
EA (2) EA202090547A3 (ru)
ES (1) ES2625456T3 (ru)
HR (1) HRP20170654T1 (ru)
HU (1) HUE031908T2 (ru)
IL (1) IL240765A0 (ru)
MX (1) MX366481B (ru)
PH (1) PH12015502261B1 (ru)
PL (1) PL2978429T3 (ru)
PT (1) PT2978429T (ru)
SG (1) SG11201508078XA (ru)
UA (1) UA115588C2 (ru)
WO (1) WO2014154859A1 (ru)

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