EA201890278A1 - Антитела к pd-l1 - Google Patents
Антитела к pd-l1Info
- Publication number
- EA201890278A1 EA201890278A1 EA201890278A EA201890278A EA201890278A1 EA 201890278 A1 EA201890278 A1 EA 201890278A1 EA 201890278 A EA201890278 A EA 201890278A EA 201890278 A EA201890278 A EA 201890278A EA 201890278 A1 EA201890278 A1 EA 201890278A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- monotherapy
- chemotherapy
- ligand
- bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к антителам, которые связывают лиганд 1 белка запрограммированной гибели клеток человека (PD-L1) и могут быть пригодны для лечения солидных и гематологических опухолей как в качестве монотерапии, так и в комбинации с химиотерапией и другими терапевтическими средствами.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562209056P | 2015-08-24 | 2015-08-24 | |
PCT/US2016/047528 WO2017034916A1 (en) | 2015-08-24 | 2016-08-18 | Pd-l1 ("programmed death-ligand 1") antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201890278A1 true EA201890278A1 (ru) | 2018-07-31 |
Family
ID=56801855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201890278A EA201890278A1 (ru) | 2015-08-24 | 2016-08-18 | Антитела к pd-l1 |
Country Status (25)
Country | Link |
---|---|
US (2) | US10214586B2 (ru) |
EP (1) | EP3341020B1 (ru) |
JP (1) | JP6518005B2 (ru) |
KR (1) | KR20180030899A (ru) |
CN (1) | CN107921131A (ru) |
AR (1) | AR105654A1 (ru) |
AU (1) | AU2016313404B2 (ru) |
BR (1) | BR112018001506A2 (ru) |
CA (1) | CA2994425C (ru) |
CL (1) | CL2018000454A1 (ru) |
CO (1) | CO2018002009A2 (ru) |
CR (1) | CR20180048A (ru) |
DO (1) | DOP2018000045A (ru) |
EA (1) | EA201890278A1 (ru) |
EC (1) | ECSP18013690A (ru) |
ES (1) | ES2777603T3 (ru) |
HK (1) | HK1249023A1 (ru) |
IL (1) | IL256922A (ru) |
MX (1) | MX2018002170A (ru) |
PE (1) | PE20180604A1 (ru) |
PH (1) | PH12018500394A1 (ru) |
SV (1) | SV2018005640A (ru) |
TN (1) | TN2018000044A1 (ru) |
TW (1) | TW201718650A (ru) |
WO (1) | WO2017034916A1 (ru) |
Families Citing this family (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140031250A1 (en) | 2010-10-07 | 2014-01-30 | David Tsai Ting | Biomarkers of Cancer |
WO2015048312A1 (en) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
RU2718914C2 (ru) | 2014-09-13 | 2020-04-15 | Новартис Аг | Сочетанные способы лечения с использованием ингибиторов alk |
CR20170143A (es) | 2014-10-14 | 2017-06-19 | Dana Farber Cancer Inst Inc | Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas |
SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
JP2018531278A (ja) * | 2015-11-24 | 2018-10-25 | イーライ リリー アンド カンパニー | 癌のための併用療法 |
CN113773387B (zh) | 2016-06-13 | 2024-06-21 | 天境生物科技(上海)有限公司 | Pd-l1抗体及其用途 |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
EP3471754A1 (en) | 2016-06-20 | 2019-04-24 | Kymab Limited | Anti-pd-l1 antibodies |
BR112019002529A2 (pt) | 2016-08-09 | 2019-05-28 | Kymab Ltd | anticorpo isolado, composição, método para modular o equilíbrio de células t, método para tratar uma doença ou afecção tratável com terapia, método para tratar câncer, combinação de anticorpo igg1, anticorpo anti-icos, mamífero não humano transgênico, e método para produzir um anticorpo |
JP7258747B2 (ja) | 2016-10-28 | 2023-04-17 | ブリストル-マイヤーズ スクイブ カンパニー | 抗pd-1抗体を用いた尿路上皮癌の処置方法 |
PE20191131A1 (es) | 2016-11-03 | 2019-09-02 | Bristol Myers Squibb Co | Anticuerpos anti antigeno 4 del linfocito t citotoxico (ctla-4) activables y sus usos |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
WO2018089688A1 (en) | 2016-11-09 | 2018-05-17 | Jinjun Shi | Restoration of tumor suppression using mrna-based delivery system |
BR112019011025A2 (pt) | 2016-12-03 | 2019-10-08 | Juno Therapeutics Inc | métodos para modulação de células t car |
US11512134B2 (en) | 2017-08-01 | 2022-11-29 | Eli Lilly And Company | Anti-CD137 antibodies |
TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
US20210101980A1 (en) | 2017-03-31 | 2021-04-08 | Bristol-Myers Squibb Company | Methods of treating tumor |
US11571459B2 (en) | 2017-04-03 | 2023-02-07 | Oncxerna Therapeutics, Inc. | Methods for treating cancer using PS-targeting antibodies with immuno-oncology agents |
TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
JOP20190222A1 (ar) | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
AU2018277824A1 (en) | 2017-05-30 | 2019-10-17 | Bristol-Myers Squibb Company | Treatment of LAG-3 positive tumors |
US11723975B2 (en) | 2017-05-30 | 2023-08-15 | Bristol-Myers Squibb Company | Compositions comprising an anti-LAG-3 antibody or an anti-LAG-3 antibody and an anti-PD-1 or anti-PD-L1 antibody |
EP3630842A2 (en) | 2017-05-30 | 2020-04-08 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
EP3630840A1 (en) | 2017-06-01 | 2020-04-08 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-pd-1 antibody |
JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗pdl1抗体、およびその使用方法 |
AU2018279105A1 (en) * | 2017-06-07 | 2019-12-19 | Silverback Therapeutics, Inc. | Antibody conjugates of immune-modulatory compounds and uses thereof |
GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
AR112603A1 (es) | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
AU2018301681B2 (en) | 2017-07-14 | 2022-07-14 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
WO2019075097A1 (en) | 2017-10-11 | 2019-04-18 | Board Of Regents, The University Of Texas System | PD-L1 HUMAN ANTIBODIES AND METHODS OF USE |
WO2019075468A1 (en) | 2017-10-15 | 2019-04-18 | Bristol-Myers Squibb Company | TUMOR TREATMENT METHODS |
CA3078517A1 (en) | 2017-10-18 | 2019-04-25 | Alpine Immune Sciences, Inc. | Variant icos ligand immunomodulatory proteins and related compositions and methods |
WO2019090330A1 (en) | 2017-11-06 | 2019-05-09 | Bristol-Myers Squibb Company | Methods of treating a tumor |
EP3728316A1 (en) * | 2017-12-19 | 2020-10-28 | F-Star Beta Limited | Fc binding fragments comprising a pd-l1 antigen-binding site |
GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
US11629189B2 (en) | 2017-12-19 | 2023-04-18 | Kymab Limited | Bispecific antibody for ICOS and PD-L1 |
CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
WO2019143607A1 (en) | 2018-01-16 | 2019-07-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
AU2019210332A1 (en) | 2018-01-22 | 2020-09-10 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
CN111629731A (zh) | 2018-01-22 | 2020-09-04 | 百时美施贵宝公司 | 治疗癌症的组合物和方法 |
WO2019157087A1 (en) | 2018-02-06 | 2019-08-15 | The General Hospital Corporation | Repeat rna as biomarkers of tumor immune response |
TWI702954B (zh) | 2018-03-01 | 2020-09-01 | 美商美國禮來大藥廠 | Cd73抑制劑 |
AU2019239620A1 (en) | 2018-03-23 | 2020-09-10 | Board Of Regents, The University Of Texas System | Human PD-L2 antibodies and methods of use therefor |
JP7351845B2 (ja) | 2018-03-23 | 2023-09-27 | ブリストル-マイヤーズ スクイブ カンパニー | Micaおよび/またはmicbに対する抗体ならびにそれらの使用 |
EA202092265A1 (ru) | 2018-03-23 | 2020-12-24 | Эли Лилли Энд Компани | Антитела против cd137 для комбинации с антителами против pd-l1 |
TW202003569A (zh) | 2018-03-30 | 2020-01-16 | 荷蘭商美勒斯公司 | 多價抗體 |
KR20200139724A (ko) | 2018-03-30 | 2020-12-14 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
WO2019195452A1 (en) | 2018-04-04 | 2019-10-10 | Bristol-Myers Squibb Company | Anti-cd27 antibodies and uses thereof |
JP7351850B2 (ja) | 2018-04-25 | 2023-09-27 | イネイト・テューマー・イミュニティ・インコーポレイテッド | Nlrp3修飾因子 |
MX2020012782A (es) * | 2018-05-28 | 2021-04-28 | ORION Biotechnology Switzerland Sarl | Inhibidor de ccr5 para el uso en el tratamiento de cancer. |
WO2019227490A1 (en) * | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
CN117442717A (zh) | 2018-06-01 | 2024-01-26 | 大有华夏生物医药集团有限公司 | 治疗疾病或病况的组合物及其用途 |
JP2019208422A (ja) * | 2018-06-04 | 2019-12-12 | コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー | ヒアルロニダーゼを含む新規な組換えエキソソーム及びその用途 |
CN112041348B (zh) | 2018-07-25 | 2023-09-22 | 天境生物科技(上海)有限公司 | 抗cd73抗pd-l1双特异性抗体 |
TWI728400B (zh) | 2018-07-26 | 2021-05-21 | 美商美國禮來大藥廠 | Cd226促效劑抗體 |
CN112739371A (zh) | 2018-07-26 | 2021-04-30 | 百时美施贵宝公司 | 用于治疗癌症的lag-3组合疗法 |
EP3837015B1 (en) | 2018-08-16 | 2024-02-14 | Innate Tumor Immunity, Inc. | Imidazo[4,5-c]quinoline derived nlrp3-modulators |
KR20210046023A (ko) | 2018-08-16 | 2021-04-27 | 인네이트 튜머 이뮤니티, 인코포레이티드 | 이미다조[4,5-c]퀴놀린 유래 NLRP3-조정제 |
SG11202101486RA (en) | 2018-08-16 | 2021-03-30 | Innate Tumor Immunity Inc | Substitued 4-amino-1h-imidazo[4,5-c]quinoline compounds and improved methods for their preparation |
US20210395392A1 (en) | 2018-10-09 | 2021-12-23 | Bristol-Myers Squibb Company | Anti-mertk antibodies for treating cancer |
US20210338813A1 (en) | 2018-10-19 | 2021-11-04 | Bristol-Myers Squibb Company | Combination Therapy for Melanoma |
KR20210081384A (ko) | 2018-10-23 | 2021-07-01 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
WO2020102375A1 (en) | 2018-11-14 | 2020-05-22 | Regeneron Pharmaceuticals, Inc. | Intralesional administration of pd-1 inhibitors for treating skin cancer |
BR112021009111A2 (pt) | 2018-11-16 | 2021-08-24 | Bristol-Myers Squibb Company | Anticorpos anti-nkg2a e usos dos mesmos |
WO2020117849A1 (en) | 2018-12-04 | 2020-06-11 | Bristol-Myers Squibb Company | Methods of analysis using in-sample calibration curve by multiple isotopologue reaction monitoring |
TW202039534A (zh) | 2018-12-14 | 2020-11-01 | 美商美國禮來大藥廠 | KRAS變體mRNA分子 |
KR20210102327A (ko) | 2019-01-11 | 2021-08-19 | 일라이 릴리 앤드 캄파니 | 암 치료를 위한 tim-3 항체 및 다른 체크포인트 억제제와의 조합 |
KR20210114983A (ko) | 2019-01-14 | 2021-09-24 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Nlrp3 조정제 |
CN113301963A (zh) | 2019-01-14 | 2021-08-24 | 先天肿瘤免疫公司 | 用于治疗癌症的作为nlrp3调节剂的取代的喹唑啉类 |
ES2930151T3 (es) | 2019-01-14 | 2022-12-07 | Innate Tumor Immunity Inc | Moduladores heterocíclicos de NLRP3, para su uso en el tratamiento del cáncer |
EP3911641A1 (en) | 2019-01-14 | 2021-11-24 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
WO2020176699A1 (en) | 2019-02-28 | 2020-09-03 | Regeneron Pharmaceuticals, Inc. | Administration of pd-1 inhibitors for treating skin cancer |
KR20210136071A (ko) | 2019-03-06 | 2021-11-16 | 리제너론 파아마슈티컬스, 인크. | 암을 치료하는데 있어서 증진된 효능을 위한 il-4/il-13 경로 억제제 |
WO2020198672A1 (en) | 2019-03-28 | 2020-10-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2020198676A1 (en) | 2019-03-28 | 2020-10-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
KR20220016157A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 세포 국재화 시그너쳐 및 조합 요법 |
KR20220016155A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법 |
JP2022534967A (ja) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | 多腫瘍遺伝子シグネチャーおよびその使用 |
KR20220007118A (ko) * | 2019-06-10 | 2022-01-18 | 샨동 보안 바이오테크놀로지 컴퍼니, 리미티드 | PDL1 및 TGFβ에 대한 2기능성 융합 단백질 및 이의 용도 |
WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
WO2021041319A1 (en) | 2019-08-29 | 2021-03-04 | Eli Lilly And Company | Crystalline forms of a cd73 inhibitor |
EP4031873A1 (en) | 2019-09-22 | 2022-07-27 | Bristol-Myers Squibb Company | Quantitative spatial profiling for lag-3 antagonist therapy |
AU2020353079A1 (en) | 2019-09-25 | 2022-04-14 | Bristol-Myers Squibb Company | Composite biomarker for cancer therapy |
WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
AU2020378280A1 (en) | 2019-11-07 | 2022-04-07 | Oncxerna Therapeutics, Inc. | Classification of tumor microenvironments |
KR20220093349A (ko) | 2019-11-08 | 2022-07-05 | 브리스톨-마이어스 스큅 컴퍼니 | 흑색종에 대한 lag-3 길항제 요법 |
US20220396619A1 (en) | 2019-11-12 | 2022-12-15 | Eli Lilly And Company | Cd200 receptor antagonist binding molecules |
WO2021097256A1 (en) | 2019-11-14 | 2021-05-20 | Cohbar, Inc. | Cxcr4 antagonist peptides |
US20230089255A1 (en) | 2019-12-19 | 2023-03-23 | Bristol-Myers Squibb Company | Combinations of dgk inhibitors and checkpoint antagonists |
IL294608A (en) | 2020-01-10 | 2022-09-01 | Brigham & Womens Hospital Inc | Methods and compositions for administering immunotherapy agents across the blood-brain barrier for the treatment of brain cancer |
US20230348458A1 (en) | 2020-01-10 | 2023-11-02 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
JP7480307B2 (ja) | 2020-01-29 | 2024-05-09 | メルス ナムローゼ フェンノートシャップ | 免疫細胞関与効果を調節するための手段および方法 |
CN115397859A (zh) | 2020-01-30 | 2022-11-25 | Ona疗法有限公司 | 治疗癌症和癌症转移的联合疗法 |
EP4100426A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Il-10 and uses thereof |
CN116568341A (zh) | 2020-02-28 | 2023-08-08 | 百时美施贵宝公司 | 基于纤连蛋白的放射性标记的支架和抗体及其治疗诊断用途 |
IL295979A (en) | 2020-03-06 | 2022-10-01 | Ona Therapeutics S L | Anti-cd36 antibodies and their use for cancer treatment |
AU2021230575A1 (en) | 2020-03-06 | 2022-10-20 | Celgene Quanticel Research, Inc. | Combination of an LSD-1 inhibitor and nivolumab for use in treating SCLC or sqNSCLC |
KR20220157446A (ko) | 2020-03-23 | 2022-11-29 | 브리스톨-마이어스 스큅 컴퍼니 | 암을 치료하기 위한 항-ccr8 항체 |
JP7240512B2 (ja) | 2020-05-26 | 2023-03-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Pd-1阻害剤を投与することにより子宮頸がんを処置する方法 |
MX2023000197A (es) | 2020-07-07 | 2023-02-22 | BioNTech SE | Arn terapeutico para el cancer positivo para vph. |
IL300328A (en) | 2020-08-26 | 2023-04-01 | Regeneron Pharma | Methods for treating cancer by administering a PD-1 inhibitor |
US20230265188A1 (en) | 2020-08-28 | 2023-08-24 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hepatocellular carcinoma |
AU2021334361A1 (en) | 2020-08-31 | 2023-05-11 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
IL300975A (en) | 2020-09-03 | 2023-04-01 | Regeneron Pharma | Methods for treating cancer pain by administering a PD-1 inhibitor |
JP2023544410A (ja) | 2020-10-05 | 2023-10-23 | ブリストル-マイヤーズ スクイブ カンパニー | タンパク質を濃縮するための方法 |
WO2022076596A1 (en) | 2020-10-06 | 2022-04-14 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
WO2022087402A1 (en) | 2020-10-23 | 2022-04-28 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for lung cancer |
CA3196535A1 (en) | 2020-10-28 | 2022-05-05 | Alfredo C. Castro | Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine |
WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性rna |
WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
US20220233693A1 (en) | 2020-12-28 | 2022-07-28 | Bristol-Myers Squibb Company | Antibody Compositions and Methods of Use Thereof |
CA3196999A1 (en) | 2020-12-28 | 2022-07-07 | Masano HUANG | Methods of treating tumors |
WO2022204672A1 (en) | 2021-03-23 | 2022-09-29 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer in immunosuppressed or immunocompromised patients by administering a pd-1 inhibitor |
CA3213049A1 (en) | 2021-03-25 | 2022-09-29 | Laura E. BENJAMIN | Targeted therapies in cancer |
TW202304506A (zh) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | 涉及抗claudin 18.2抗體的組合治療以治療癌症 |
AU2022246593A1 (en) | 2021-03-29 | 2023-10-12 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
WO2022243378A1 (en) | 2021-05-18 | 2022-11-24 | Kymab Limited | Uses of anti-icos antibodies |
GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
EP4370552A1 (en) | 2021-07-13 | 2024-05-22 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
AU2022314735A1 (en) | 2021-07-19 | 2024-02-22 | Regeneron Pharmaceuticals, Inc. | Combination of checkpoint inhibitors and an oncolytic virus for treating cancer |
CA3226281A1 (en) | 2021-07-30 | 2023-02-02 | ONA Therapeutics S.L. | Anti-cd36 antibodies and their use to treat cancer |
WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
CA3224890A1 (en) | 2021-10-29 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
WO2023147371A1 (en) | 2022-01-26 | 2023-08-03 | Bristol-Myers Squibb Company | Combination therapy for hepatocellular carcinoma |
WO2023159102A1 (en) | 2022-02-17 | 2023-08-24 | Regeneron Pharmaceuticals, Inc. | Combinations of checkpoint inhibitors and oncolytic virus for treating cancer |
WO2023164638A1 (en) | 2022-02-25 | 2023-08-31 | Bristol-Myers Squibb Company | Combination therapy for colorectal carcinoma |
WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
WO2023170606A1 (en) | 2022-03-08 | 2023-09-14 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
WO2023178329A1 (en) | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
WO2023196987A1 (en) | 2022-04-07 | 2023-10-12 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2023196964A1 (en) | 2022-04-08 | 2023-10-12 | Bristol-Myers Squibb Company | Machine learning identification, classification, and quantification of tertiary lymphoid structures |
WO2023222854A1 (en) | 2022-05-18 | 2023-11-23 | Kymab Limited | Uses of anti-icos antibodies |
WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2024023740A1 (en) | 2022-07-27 | 2024-02-01 | Astrazeneca Ab | Combinations of recombinant virus expressing interleukin-12 with pd-1/pd-l1 inhibitors |
WO2024054992A1 (en) | 2022-09-09 | 2024-03-14 | Bristol-Myers Squibb Company | Methods of separating chelator |
WO2024069009A1 (en) | 2022-09-30 | 2024-04-04 | Alentis Therapeutics Ag | Treatment of drug-resistant hepatocellular carcinoma |
WO2024115725A1 (en) | 2022-12-01 | 2024-06-06 | BioNTech SE | Multispecific antibody against cd40 and cd137 in combination therapy with anti-pd1 ab and chemotherapy |
WO2024126457A1 (en) | 2022-12-14 | 2024-06-20 | Astellas Pharma Europe Bv | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60033293D1 (de) | 1999-08-23 | 2007-03-22 | Dana Farber Cancer Inst Inc | Neue b7-4 moleküle und deren verwendungen |
AU784634B2 (en) | 1999-11-30 | 2006-05-18 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
WO2002086083A2 (en) | 2001-04-20 | 2002-10-31 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
DE60128914T2 (de) * | 2001-10-05 | 2008-05-08 | Affimed Therapeutics Ag | Antikörper menschlichen Ursprungs zur Hemmung der Thrombozytenaggregation |
JP4488740B2 (ja) | 2001-11-13 | 2010-06-23 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | 免疫細胞活性化を調節する作用剤およびその使用方法 |
EP1469851B1 (en) * | 2002-01-23 | 2006-10-11 | Eli Lilly And Company | Melanocortin receptor agonists |
ES2654064T3 (es) | 2002-07-03 | 2024-03-13 | Ono Pharmaceutical Co | Composiciones inmunopotenciadoras que comprenden anticuerpos anti-PD-L1 |
HUE039237T2 (hu) | 2004-10-06 | 2018-12-28 | Mayo Found Medical Education & Res | B7-H1 és PD-1 vesesejt karcinoma kezelésében |
KR101888321B1 (ko) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
PL2170959T3 (pl) * | 2007-06-18 | 2014-03-31 | Merck Sharp & Dohme | Przeciwciała przeciwko ludzkiemu receptorowi programowanej śmierci PD-1 |
CA2735006A1 (en) | 2008-08-25 | 2010-03-11 | Amplimmune, Inc. | Pd-1 antagonists and methods of use thereof |
WO2010036959A2 (en) | 2008-09-26 | 2010-04-01 | Dana-Farber Cancer Institute | Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor |
KR101050829B1 (ko) | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 항암제 |
KR20210060670A (ko) | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도 |
WO2011066389A1 (en) | 2009-11-24 | 2011-06-03 | Medimmmune, Limited | Targeted binding agents against b7-h1 |
WO2012145493A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
CA2856895C (en) | 2011-11-28 | 2021-10-26 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
KR20200079568A (ko) | 2012-05-31 | 2020-07-03 | 제넨테크, 인크. | Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법 |
AU2013267161A1 (en) * | 2012-05-31 | 2014-11-20 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
EP2890715B1 (en) | 2012-08-03 | 2020-12-16 | Dana-Farber Cancer Institute, Inc. | Single agent anti-pd-l1 and pd-l2 dual binding antibodies and methods of use |
CN107892719B (zh) | 2012-10-04 | 2022-01-14 | 达纳-法伯癌症研究所公司 | 人单克隆抗-pd-l1抗体和使用方法 |
AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
MX2017000419A (es) | 2014-07-11 | 2017-08-16 | Genentech Inc | Anticuerpos anti-pd-l1 y sus usos de diagnóstico. |
CN110023338A (zh) * | 2016-12-08 | 2019-07-16 | 伊莱利利公司 | 用于与抗pd-l1抗体组合的抗tim-3抗体 |
-
2016
- 2016-08-09 AR ARP160102439A patent/AR105654A1/es unknown
- 2016-08-10 TW TW105125503A patent/TW201718650A/zh unknown
- 2016-08-18 TN TNP/2018/000044A patent/TN2018000044A1/en unknown
- 2016-08-18 JP JP2018509789A patent/JP6518005B2/ja not_active Expired - Fee Related
- 2016-08-18 EP EP16757470.6A patent/EP3341020B1/en active Active
- 2016-08-18 MX MX2018002170A patent/MX2018002170A/es unknown
- 2016-08-18 BR BR112018001506A patent/BR112018001506A2/pt not_active Application Discontinuation
- 2016-08-18 CR CR20180048A patent/CR20180048A/es unknown
- 2016-08-18 CA CA2994425A patent/CA2994425C/en not_active Expired - Fee Related
- 2016-08-18 ES ES16757470T patent/ES2777603T3/es active Active
- 2016-08-18 CN CN201680048919.5A patent/CN107921131A/zh active Pending
- 2016-08-18 EA EA201890278A patent/EA201890278A1/ru unknown
- 2016-08-18 PE PE2018000240A patent/PE20180604A1/es unknown
- 2016-08-18 AU AU2016313404A patent/AU2016313404B2/en not_active Expired - Fee Related
- 2016-08-18 US US15/239,959 patent/US10214586B2/en not_active Expired - Fee Related
- 2016-08-18 KR KR1020187005071A patent/KR20180030899A/ko not_active Application Discontinuation
- 2016-08-18 WO PCT/US2016/047528 patent/WO2017034916A1/en active Application Filing
-
2018
- 2018-01-15 IL IL256922A patent/IL256922A/en unknown
- 2018-02-12 DO DO2018000045A patent/DOP2018000045A/es unknown
- 2018-02-20 CL CL2018000454A patent/CL2018000454A1/es unknown
- 2018-02-22 EC ECIEPI201813690A patent/ECSP18013690A/es unknown
- 2018-02-22 PH PH12018500394A patent/PH12018500394A1/en unknown
- 2018-02-23 SV SV2018005640A patent/SV2018005640A/es unknown
- 2018-02-23 CO CONC2018/0002009A patent/CO2018002009A2/es unknown
- 2018-07-05 HK HK18108695.1A patent/HK1249023A1/zh unknown
-
2019
- 2019-01-25 US US16/258,192 patent/US20190144544A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PE20180604A1 (es) | 2018-04-09 |
IL256922A (en) | 2018-03-29 |
CR20180048A (es) | 2018-03-20 |
US10214586B2 (en) | 2019-02-26 |
BR112018001506A2 (pt) | 2018-09-18 |
CL2018000454A1 (es) | 2018-08-03 |
MX2018002170A (es) | 2018-04-24 |
KR20180030899A (ko) | 2018-03-26 |
TW201718650A (zh) | 2017-06-01 |
AU2016313404A1 (en) | 2018-02-08 |
CN107921131A (zh) | 2018-04-17 |
DOP2018000045A (es) | 2018-03-30 |
ES2777603T3 (es) | 2020-08-05 |
HK1249023A1 (zh) | 2018-10-26 |
SV2018005640A (es) | 2018-07-23 |
PH12018500394A1 (en) | 2018-08-29 |
US20190144544A1 (en) | 2019-05-16 |
JP6518005B2 (ja) | 2019-05-22 |
EP3341020B1 (en) | 2020-02-26 |
CO2018002009A2 (es) | 2018-05-10 |
AR105654A1 (es) | 2017-10-25 |
JP2018531219A (ja) | 2018-10-25 |
TN2018000044A1 (en) | 2019-07-08 |
CA2994425C (en) | 2020-04-28 |
WO2017034916A1 (en) | 2017-03-02 |
ECSP18013690A (es) | 2018-04-30 |
US20170058033A1 (en) | 2017-03-02 |
CA2994425A1 (en) | 2017-03-02 |
EP3341020A1 (en) | 2018-07-04 |
AU2016313404B2 (en) | 2019-04-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201890278A1 (ru) | Антитела к pd-l1 | |
EA201890285A1 (ru) | Антитела против pd-1, активируемые антитела против pd-1 и способы их применения | |
PH12018500233A1 (en) | Single domain antibody programmed death-ligand (pd-l1) and derived protein thereof | |
MY199019A (en) | Pd-1 antibodies | |
PH12018500664A1 (en) | Anti-lag3 antibodies and uses thereof | |
EA201992757A1 (ru) | Биспецифические антитела-ингибиторы контрольной точки | |
EA201791393A3 (ru) | Антитела к erbb3 и их применение | |
MY195110A (en) | Antibodies to PD-1 and uses Thereof | |
EA201991156A1 (ru) | АНТИТЕЛА К Tim-3 ДЛЯ КОМБИНАЦИИ С АНТИТЕЛАМИ К PD-1 | |
BR112018002824A2 (pt) | anticorpo, polinucleotídeo, vetor, célula, métodos para expressar o anticorpo, para tratar uma condição associada com pd-1 e para tratar uma condição em um sujeito, kit, composição farmacêutica e uso do anticorpo | |
MX2019014318A (es) | Proteinas de union a nectina-4 y metodos de uso de las mismas. | |
EA201791093A1 (ru) | Антитела к cd47, способы и применение | |
PH12016500137B1 (en) | Afucosylated anti-fgfr2iiib antibodies | |
EA201792221A1 (ru) | Антитела против сортилина и способы их применения | |
EA202090204A1 (ru) | Анти-cd137 антитела | |
EA201690617A1 (ru) | Комбинирование anti-lag-3-антител и анти-pd-1-антител для лечения опухолей | |
MX2018009011A (es) | Anticuerpos anti receptor 1 transmembrana de tirosina-proteina cinasa (ror1) y usos de los mismos. | |
EA201900561A1 (ru) | Конъюгаты циклодекстрин-белок-лекарственное средство | |
MX2015004105A (es) | Anticuerpos monoclonales humanos anti-pd-l1 y metodos de uso. | |
WO2017015622A8 (en) | Gdf11 binding proteins and uses thereof | |
EA201890754A1 (ru) | Соединения и способы их применения | |
EA201590997A1 (ru) | Соединения и способы их применения | |
EA201592203A1 (ru) | Способы лечения таупатии | |
EA201690159A1 (ru) | Способы и композиции для лечения рака | |
EA201892225A1 (ru) | АНТИТЕЛА К ФАКТОРУ Bb КОМПЛЕМЕНТА И ИХ ПРИМЕНЕНИЕ |