BR112019002529A2 - anticorpo isolado, composição, método para modular o equilíbrio de células t, método para tratar uma doença ou afecção tratável com terapia, método para tratar câncer, combinação de anticorpo igg1, anticorpo anti-icos, mamífero não humano transgênico, e método para produzir um anticorpo - Google Patents

anticorpo isolado, composição, método para modular o equilíbrio de células t, método para tratar uma doença ou afecção tratável com terapia, método para tratar câncer, combinação de anticorpo igg1, anticorpo anti-icos, mamífero não humano transgênico, e método para produzir um anticorpo

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Publication number
BR112019002529A2
BR112019002529A2 BR112019002529A BR112019002529A BR112019002529A2 BR 112019002529 A2 BR112019002529 A2 BR 112019002529A2 BR 112019002529 A BR112019002529 A BR 112019002529A BR 112019002529 A BR112019002529 A BR 112019002529A BR 112019002529 A2 BR112019002529 A2 BR 112019002529A2
Authority
BR
Brazil
Prior art keywords
antibody
treating
producing
ics
modulating
Prior art date
Application number
BR112019002529A
Other languages
English (en)
Inventor
Van Krinks Cassandra
Deantonio Cecilia
Lee E-Chiang
Kirby Ian
Iain Campbell Jamie
John Mccourt Matthew
KOSMAC Miha
Hanif Ali Mohammed
Sandy Nikole
Charles Alfred Sainson Richard
Douglas Gillies Stephen
John Arkinstall Stephen
Gallagher Thomas
Germaschewski Volker
Original Assignee
Kymab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1615224.1A external-priority patent/GB201615224D0/en
Priority claimed from GBGB1615335.5A external-priority patent/GB201615335D0/en
Priority claimed from US15/354,971 external-priority patent/US9617338B1/en
Priority claimed from GBGB1620414.1A external-priority patent/GB201620414D0/en
Priority claimed from GBGB1621782.0A external-priority patent/GB201621782D0/en
Priority claimed from GBGB1702339.1A external-priority patent/GB201702339D0/en
Priority claimed from GBGB1702338.3A external-priority patent/GB201702338D0/en
Priority claimed from GBGB1703071.9A external-priority patent/GB201703071D0/en
Priority claimed from TW106120564A external-priority patent/TWI640536B/zh
Priority claimed from GBGB1709818.7A external-priority patent/GB201709818D0/en
Application filed by Kymab Ltd filed Critical Kymab Ltd
Priority claimed from PCT/GB2017/052352 external-priority patent/WO2018029474A2/en
Publication of BR112019002529A2 publication Critical patent/BR112019002529A2/pt

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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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Abstract

trata-se de anticorpos que se ligam ao icos (coestimulador induzível de células t). uso terapêutico de anticorpos anti-icos para modular a razão entre células t reguladoras e células t efetoras afim de estimular o sistema imunológico de pacientes, incluindo o uso no tratamento de cânceres. métodos para produzir anticorpos anti-icos, incluindo anticorpos de reação cruzada de espécie, com o uso de camundongos knockout transgênicos.
BR112019002529A 2016-08-09 2017-08-09 anticorpo isolado, composição, método para modular o equilíbrio de células t, método para tratar uma doença ou afecção tratável com terapia, método para tratar câncer, combinação de anticorpo igg1, anticorpo anti-icos, mamífero não humano transgênico, e método para produzir um anticorpo BR112019002529A2 (pt)

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GB201613683 2016-08-09
GBGB1615224.1A GB201615224D0 (en) 2016-09-07 2016-09-07 Antibodies
GBGB1615335.5A GB201615335D0 (en) 2016-09-09 2016-09-09 Antibodies and immunocytokines
US15/354,971 US9617338B1 (en) 2016-06-20 2016-11-17 Antibodies and immunocytokines
GBGB1620414.1A GB201620414D0 (en) 2016-12-01 2016-12-01 Antibodies
GBGB1621782.0A GB201621782D0 (en) 2016-12-20 2016-12-20 Antibodies and immunocytokines PD-L1 specific antibodies and PD-L1 specific immunocytokines
GBGB1702339.1A GB201702339D0 (en) 2017-02-13 2017-02-13 Antibodies and immunocytokines PD-L1 Specific antiboies and PD-L1 Specific immunocytokines
GBGB1702338.3A GB201702338D0 (en) 2017-02-13 2017-02-13 Antibodies and immunocytokines PD-L1 specific antibodies and specific immunocytokines
GBGB1703071.9A GB201703071D0 (en) 2017-02-24 2017-02-24 Antibodies
US15/480,525 US10604576B2 (en) 2016-06-20 2017-04-06 Antibodies and immunocytokines
TW106120564A TWI640536B (zh) 2016-06-20 2017-06-20 抗體
GBGB1709818.7A GB201709818D0 (en) 2017-06-20 2017-06-20 Antibodies
PCT/GB2017/051796 WO2017220990A1 (en) 2016-06-20 2017-06-20 Anti-pd-l1 antibodies
TW106120563A TW201803905A (zh) 2016-06-20 2017-06-20 用於免疫腫瘤學之多重專一性抗體
PCT/GB2017/051795 WO2017220989A1 (en) 2016-06-20 2017-06-20 Anti-pd-l1 and il-2 cytokines
PCT/GB2017/051794 WO2017220988A1 (en) 2016-06-20 2017-06-20 Multispecific antibodies for immuno-oncology
TW106120562A TWI784957B (zh) 2016-06-20 2017-06-20 免疫細胞介素
PCT/GB2017/052352 WO2018029474A2 (en) 2016-08-09 2017-08-09 Anti-icos antibodies

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