MX2019014318A - Proteinas de union a nectina-4 y metodos de uso de las mismas. - Google Patents

Proteinas de union a nectina-4 y metodos de uso de las mismas.

Info

Publication number
MX2019014318A
MX2019014318A MX2019014318A MX2019014318A MX2019014318A MX 2019014318 A MX2019014318 A MX 2019014318A MX 2019014318 A MX2019014318 A MX 2019014318A MX 2019014318 A MX2019014318 A MX 2019014318A MX 2019014318 A MX2019014318 A MX 2019014318A
Authority
MX
Mexico
Prior art keywords
methods
nectin
binding proteins
assessing
cancer
Prior art date
Application number
MX2019014318A
Other languages
English (en)
Inventor
Karen Jane Meyrick Morrison
Fernando Donate
Peng Yang
Original Assignee
Agensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agensys Inc filed Critical Agensys Inc
Publication of MX2019014318A publication Critical patent/MX2019014318A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Se proporcionado en la presente composiciones, métodos y usos que implican anticuerpos que se unen específicamente a Nectina-4. También se proporciona en la presente métodos para evaluar la expresión de Nectina-4 en una muestra o un paciente y métodos para evaluar la capacidad de respuesta de un cáncer a un agente terapéutico anti-cáncer.
MX2019014318A 2017-06-05 2018-06-04 Proteinas de union a nectina-4 y metodos de uso de las mismas. MX2019014318A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762515454P 2017-06-05 2017-06-05
PCT/US2018/035840 WO2018226578A1 (en) 2017-06-05 2018-06-04 Nectin-4-binding proteins and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2019014318A true MX2019014318A (es) 2020-08-13

Family

ID=64566092

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014318A MX2019014318A (es) 2017-06-05 2018-06-04 Proteinas de union a nectina-4 y metodos de uso de las mismas.

Country Status (10)

Country Link
US (1) US11292837B2 (es)
EP (1) EP3635013A4 (es)
JP (1) JP7168590B2 (es)
KR (1) KR20200024788A (es)
CN (2) CN111051345A (es)
BR (1) BR112019025513A2 (es)
CA (1) CA3065514A1 (es)
MX (1) MX2019014318A (es)
TW (1) TW201902922A (es)
WO (1) WO2018226578A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110904074B (zh) * 2019-05-31 2020-12-01 江南大学 一种脂肪酶突变体及其在去污方面的应用
KR20220079614A (ko) * 2019-10-07 2022-06-13 위니베르시떼 덱스-마르세이유 넥틴-4에 대한 특이성을 갖는 항체 및 이의 용도
KR102280672B1 (ko) * 2019-12-20 2021-07-23 주식회사 베르티스 암의 진단용 조성물
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
CN113527486A (zh) * 2020-04-21 2021-10-22 迈威(上海)生物科技股份有限公司 一种抗Nectin-4的抗体及其应用
US20230235054A1 (en) * 2020-06-18 2023-07-27 Bioatla, Inc. Conditionally active anti-nectin-4 antibodies
KR20230040989A (ko) * 2020-06-19 2023-03-23 어젠시스 인코포레이티드 항체 약물 접합체(adc)로 암을 치료하는 방법에서 사용하기 위한 마커
WO2022051591A2 (en) * 2020-09-04 2022-03-10 Novarock Biotherapeutics, Ltd. Nectin-4 antibodies and uses thereof
WO2022057651A1 (zh) 2020-09-16 2022-03-24 四川科伦博泰生物医药股份有限公司 抗Nectin-4抗体、包含所述抗体的缀合物及其应用
WO2022112356A1 (en) * 2020-11-25 2022-06-02 Innate Pharma Treatment of cancer
CN112386687B (zh) * 2020-12-09 2021-05-04 爱龄医美国际健康咨询服务(北京)有限公司 一种干细胞外泌体及其在药品和化妆品中的应用
TW202328204A (zh) * 2022-01-12 2023-07-16 納維再生科技股份有限公司 Nectin細胞黏附分子4之特異性抗體及其用途
WO2023180490A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing nectin-4
WO2023198007A1 (en) * 2022-04-11 2023-10-19 Bj Bioscience Inc. Anti-nectin-4 antibodies and bispecific antibodies
WO2023198011A1 (en) * 2022-04-11 2023-10-19 Bj Bioscience Inc. Single domain anti-nectin-4 antibodies
WO2023198008A1 (en) * 2022-04-11 2023-10-19 Bj Bioscience Inc. Compositions and methods for treating cancer
EP4310101A1 (en) * 2022-07-22 2024-01-24 Emergence Therapeutics AG Novel anti-nectin-4 antibodies and antibody-drug conjugates
KR102584898B1 (ko) * 2022-10-24 2023-10-04 연세대학교 산학협력단 자궁내막암 진단 방법 및 이를 이용한 키트

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005111076A1 (en) * 2004-05-12 2005-11-24 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nectin 4 (n4) as a marker for cancer prognosis
GB0807018D0 (en) * 2008-04-17 2008-05-21 Fusion Antibodies Ltd Antibodies and treatment
JP2012511305A (ja) * 2008-12-12 2012-05-24 オンコセラピー・サイエンス株式会社 癌の治療および診断の標的遺伝子としてのネクチン−４
LT2621526T (lt) 2010-09-29 2018-09-25 Agensys, Inc. Antikūno-vaisto konjugatai (adc), kurie jungiasi prie 191p4d12 baltymų
EP3311173A2 (en) * 2015-06-18 2018-04-25 Thomas Mole Herd Methods of characterising cancer
ES2794557T3 (es) * 2015-09-09 2020-11-18 Inst Nat Sante Rech Med Anticuerpos que tienen especificidad hacia nectina-4 y usos de los mismos

Also Published As

Publication number Publication date
CN111675761A (zh) 2020-09-18
US20200231670A1 (en) 2020-07-23
US11292837B2 (en) 2022-04-05
TW201902922A (zh) 2019-01-16
JP7168590B2 (ja) 2022-11-09
RU2019144030A (ru) 2021-07-09
RU2019144030A3 (es) 2021-12-28
WO2018226578A8 (en) 2019-05-31
CN111675761B (zh) 2023-10-20
WO2018226578A1 (en) 2018-12-13
EP3635013A4 (en) 2021-02-24
CN111051345A (zh) 2020-04-21
KR20200024788A (ko) 2020-03-09
BR112019025513A2 (pt) 2020-06-23
EP3635013A1 (en) 2020-04-15
JP2020522261A (ja) 2020-07-30
CA3065514A1 (en) 2018-12-13

Similar Documents

Publication Publication Date Title
MX2019014318A (es) Proteinas de union a nectina-4 y metodos de uso de las mismas.
PH12017502390A1 (en) Constructs targeting ny-eso-1 peptide/mhc complexes and uses thereof
MX2021006786A (es) Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y metodos de uso de los mismos.
PH12018501882A1 (en) Binding proteins and methods of use thereof
EA201890278A1 (ru) Антитела к pd-l1
PH12016501644B1 (en) Binding proteins and methods of use thereof
BR112019024654A2 (pt) proteína de ligação nkg2d, cd16 e ror1 ou ror2
SA517381703B1 (ar) C10orf54 - أجسام مضادة لـ واستخداماتها
GEP20227419B (en) Pd-1-binding molecules and methods of use thereof
PH12018500380A1 (en) Anti-dll3 antibody drug conjugates and methods of use
NZ720353A (en) Fabs-in-tandem immunoglobulin and uses thereof
MX2018003689A (es) Proteinas de union a pd-1 y metodos para usarlas.
MX2017004311A (es) Anticuerpos del receptor del factor de necrosis tumoral inducido por glucocorticoide (gitr) y metodos de uso de los mismos.
EA201992757A1 (ru) Биспецифические антитела-ингибиторы контрольной точки
JOP20160131B1 (ar) الأجسام المضادة للعامل xi وطرق الاستخدام
GEP20227343B (en) Anti-lag3 antibodies and antigen-binding fragments
MX2018009011A (es) Anticuerpos anti receptor 1 transmembrana de tirosina-proteina cinasa (ror1) y usos de los mismos.
BR112018068678A2 (pt) anticorpos anti-mica
ECSP12012272A (es) Proteínas que se unen al tnf-?
MX2017014056A (es) Construcciones dirigidas a complejos de peptido e7 del subtipo 16 del virus de papiloma humano (hpv16-e7)/complejo principal de histocompatibilidad (mhc) y sus usos.
MA40527A (fr) Protéines de liaison à l'antigène se liant à wisp5
BR112019012796A2 (pt) proteínas de ligação ao antígeno antineuropilina e métodos de uso das mesmas
MX2018006249A (es) Nuevos anticuerpos anti-emr2 y metodos de uso.
PH12018500159A1 (en) Constructs targeting psa peptide/mhc complexes and uses thereof
BR112015031950A2 (pt) métodos para tratamento de câncer de ovário