SI2477648T1 - Sinergijska terapija proti CD47 za krvne rake - Google Patents
Sinergijska terapija proti CD47 za krvne rakeInfo
- Publication number
- SI2477648T1 SI2477648T1 SI201032114T SI201032114T SI2477648T1 SI 2477648 T1 SI2477648 T1 SI 2477648T1 SI 201032114 T SI201032114 T SI 201032114T SI 201032114 T SI201032114 T SI 201032114T SI 2477648 T1 SI2477648 T1 SI 2477648T1
- Authority
- SI
- Slovenia
- Prior art keywords
- therapy
- synergistic anti
- hematologic cancers
- hematologic
- cancers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27672609P | 2009-09-15 | 2009-09-15 | |
EP10817793.2A EP2477648B1 (en) | 2009-09-15 | 2010-09-15 | Synergistic anti-cd47 therapy for hematologic cancers |
PCT/US2010/048992 WO2011034969A1 (en) | 2009-09-15 | 2010-09-15 | Synergistic anti-cd47 therapy for hematologic cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2477648T1 true SI2477648T1 (sl) | 2022-09-30 |
Family
ID=43758999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201032114T SI2477648T1 (sl) | 2009-09-15 | 2010-09-15 | Sinergijska terapija proti CD47 za krvne rake |
Country Status (9)
Country | Link |
---|---|
US (4) | US8758750B2 (sl) |
EP (2) | EP4134095A1 (sl) |
AU (1) | AU2010295661B2 (sl) |
CA (2) | CA2771336C (sl) |
ES (1) | ES2927646T3 (sl) |
PL (1) | PL2477648T3 (sl) |
PT (1) | PT2477648T (sl) |
SI (1) | SI2477648T1 (sl) |
WO (1) | WO2011034969A1 (sl) |
Families Citing this family (62)
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CA2711370C (en) | 2008-01-15 | 2017-06-13 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
US11072655B2 (en) | 2008-01-15 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
CA3054220C (en) | 2008-01-15 | 2022-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manilpulating phagocytosis mediated by cd47 |
EP2111869A1 (en) * | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
US9873918B2 (en) | 2011-08-11 | 2018-01-23 | Albert Einstein College Of Medicine, Inc. | Treatment of acute myeloid leukemia and myelodysplastic syndromes |
MX360772B (es) | 2012-02-06 | 2018-11-15 | Inhibrx Inc | Anticuerpos cd47 y metodos de uso de los mismos. |
WO2013173820A2 (en) * | 2012-05-18 | 2013-11-21 | Scott & White Healthcare | Bispecific scfv immunofusion (bif) |
US11059910B2 (en) * | 2012-12-03 | 2021-07-13 | Novimmune Sa | Anti-CD47 antibodies and methods of use thereof |
BR112015013431A2 (pt) | 2012-12-12 | 2017-11-14 | Vasculox Inc | anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
US9873747B2 (en) | 2013-01-31 | 2018-01-23 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
AU2014244083B2 (en) * | 2013-03-13 | 2018-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for modulating chemotherapeutic cytotoxicity |
ES2728066T3 (es) | 2013-03-15 | 2019-10-22 | Univ Leland Stanford Junior | Métodos para la obtención de dosis terapéuticamente eficaces de agentes anti-CD47 |
WO2014186761A2 (en) * | 2013-05-17 | 2014-11-20 | The Board Of Trustes Of The Leland Stanford Junior University | Methods for determining responsiveness to an anti-cd47 agent |
NL2011904C2 (en) * | 2013-12-06 | 2015-06-09 | Stichting Vu Vumc | Leukemic stem cell markers. |
JP6560682B2 (ja) * | 2014-01-08 | 2019-08-14 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 小細胞肺癌に対する標的療法 |
AU2015229448B2 (en) | 2014-03-11 | 2020-09-03 | The Board Of Trustees Of The Leland Stanford Junior University | Anti SIRP-alpha antibodies and Bi-specific Macrophage Enhancing antibodies |
ES2962260T3 (es) * | 2014-08-08 | 2024-03-18 | Univ Leland Stanford Junior | Proteínas de fusión SIRPa alfa-anticuerpo |
PL3180363T3 (pl) | 2014-08-15 | 2020-02-28 | Merck Patent Gmbh | Białka fuzyjne immunoglobulin sirp-alfa |
HUE052725T2 (hu) * | 2014-08-26 | 2021-05-28 | Univ Leland Stanford Junior | Õssejtek beültetése õssejteket célzó hatóanyag és immunszabályozó szignalizáció módosításának kombinációjával |
WO2016057980A1 (en) * | 2014-10-10 | 2016-04-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to eliminate cancer stem cells by targeting cd47 |
KR102313073B1 (ko) * | 2014-12-05 | 2021-10-18 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 분화 클러스터 47 유전자를 가진 비인간 동물 |
BR112017014258A2 (pt) | 2014-12-30 | 2018-03-06 | Celgene Corp | anticorpos anti-cd47 e usos dos mesmos |
KR20170136535A (ko) * | 2015-03-18 | 2017-12-11 | 메모리얼 슬로안-케터링 캔서 센터 | 조혈성 및 림프성 악성종양에서 cd99를 표적화하는 조성물 및 방법 |
PL3341015T5 (pl) | 2015-08-26 | 2024-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Zwiększona deplecja komórek docelowych z blokadą cd47 i immunologicznym agonistą kostymulatorowym |
RU2748401C2 (ru) | 2015-09-18 | 2021-05-25 | Арч Онколоджи, Инк. | Терапевтические антитела к CD47 |
AU2016326423A1 (en) | 2015-09-21 | 2018-04-26 | Erasmus University Medical Center | Anti-CD47 antibodies and methods of use |
PT3380525T (pt) * | 2015-11-25 | 2024-02-05 | Immunogen Inc | Formulações farmacêuticas e métodos que as utilizam |
EP3708587A1 (en) | 2015-11-27 | 2020-09-16 | Cartherics Pty. Ltd. | Genetically modified cells and uses thereof |
US10946042B2 (en) * | 2015-12-01 | 2021-03-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for selective phagocytosis of human cancer cells |
KR20220163516A (ko) | 2016-01-11 | 2022-12-09 | 포티 세븐, 인코포레이티드 | 인간화된, 마우스 또는 키메라 항-cd47 단클론 항체 |
CA3011429A1 (en) * | 2016-01-21 | 2017-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of cancer with combinations of immunoregulatory agents |
AU2017250029C1 (en) * | 2016-04-15 | 2022-03-24 | Pfizer Inc. | Macrophage stimulation in CD47 blockade therapy |
WO2017190148A1 (en) | 2016-04-29 | 2017-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for the prevention and treatment of surgical adhesions |
AU2017271588B2 (en) | 2016-05-27 | 2022-01-20 | Agenus Inc. | Anti-TIM-3 antibodies and methods of use thereof |
JP7241677B2 (ja) | 2016-07-19 | 2023-03-17 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗cd47併用療法 |
US20200181713A1 (en) * | 2016-08-03 | 2020-06-11 | Cbmed Gmbh Center For Biomarker Research In Medicine | Method for prognosing and diagnosing tumors |
CN109862910A (zh) | 2016-08-03 | 2019-06-07 | 小利兰·斯坦福大学托管委员会 | 破坏巨噬细胞上的Fc受体接合增强抗SIRPα抗体疗法的功效 |
WO2018057802A1 (en) | 2016-09-21 | 2018-03-29 | Aptevo Research And Development Llc | Cd123 binding proteins and related compositions and methods |
WO2018075960A1 (en) | 2016-10-21 | 2018-04-26 | Tioma Therapeutics, Inc. | Therapeutic cd47 antibodies |
WO2018081448A1 (en) | 2016-10-26 | 2018-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
EP3345924A1 (en) | 2017-01-10 | 2018-07-11 | Universität Duisburg-Essen | Use of cd47 antibodies |
CA3055957A1 (en) | 2017-03-09 | 2018-09-13 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of pediatric brain tumors with targeting of cd47 pathway |
KR20200019619A (ko) * | 2017-06-21 | 2020-02-24 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 혈액성 악성종양에 대한 cd47 표적 요법을 위한 투약 파라미터 |
US11401329B2 (en) | 2017-08-02 | 2022-08-02 | Phanes Therapeutics, Inc. | Anti-CD47 antibodies and uses thereof |
CN109422811A (zh) | 2017-08-29 | 2019-03-05 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
CN117771364A (zh) | 2017-10-18 | 2024-03-29 | 四十七公司 | 基于抗cd47剂的卵巢癌疗法 |
WO2019086574A1 (en) * | 2017-11-01 | 2019-05-09 | Hummingbird Bioscience Holdings Pte. Ltd. | Cd47 and cd33 antigen-binding molecules |
US20220298254A1 (en) | 2017-11-01 | 2022-09-22 | Hummingbird Bioscience Holdings Pte. Ltd. | Cd47 antigen-binding molecules |
CN111699005A (zh) | 2018-02-12 | 2020-09-22 | 四十七公司 | 使用抗cd47抗体和抗cd20抗体的抗癌方案 |
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KR20210032454A (ko) * | 2018-07-17 | 2021-03-24 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 면역조작된 만능성 세포로부터의 분화 세포 |
US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
MX2021006134A (es) | 2018-11-26 | 2021-06-23 | Forty Seven Inc | Anticuerpos humanizados contra c-kit. |
AR117327A1 (es) | 2018-12-20 | 2021-07-28 | 23Andme Inc | Anticuerpos anti-cd96 y métodos de uso de estos |
US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
CA3153636A1 (en) * | 2019-10-31 | 2021-05-06 | Forty Seven, Inc. | Anti-cd47 and anti-cd20 based treatment of blood cancer |
CN110755635B (zh) * | 2019-11-14 | 2022-10-11 | 天津大学 | Flu@α-cd47@RGD制剂的合成方法 |
US20210221886A1 (en) * | 2019-12-05 | 2021-07-22 | Sorrento Therapeutics, Inc. | Compositions and Methods Comprising an Anti-CD47 Antibody in Combination with a Tumor Targeting Antibody |
EP4262828A1 (en) | 2020-12-18 | 2023-10-25 | Instil Bio (Uk) Limited | Tumor infiltrating lymphocytes and anti-cd47 therapeutics |
US20230071148A1 (en) * | 2021-07-15 | 2023-03-09 | Vcreate, Inc. | Compositions and Methods for Making Novel T-Cell Receptors |
WO2023165618A1 (en) * | 2022-03-04 | 2023-09-07 | Nanjing University | Methods for treating cancer |
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-
2010
- 2010-09-15 EP EP22185805.3A patent/EP4134095A1/en active Pending
- 2010-09-15 EP EP10817793.2A patent/EP2477648B1/en active Active
- 2010-09-15 US US13/394,060 patent/US8758750B2/en active Active
- 2010-09-15 PT PT108177932T patent/PT2477648T/pt unknown
- 2010-09-15 CA CA2771336A patent/CA2771336C/en active Active
- 2010-09-15 PL PL10817793.2T patent/PL2477648T3/pl unknown
- 2010-09-15 CA CA 3057650 patent/CA3057650A1/en not_active Abandoned
- 2010-09-15 WO PCT/US2010/048992 patent/WO2011034969A1/en active Application Filing
- 2010-09-15 ES ES10817793T patent/ES2927646T3/es active Active
- 2010-09-15 SI SI201032114T patent/SI2477648T1/sl unknown
- 2010-09-15 AU AU2010295661A patent/AU2010295661B2/en active Active
-
2014
- 2014-05-12 US US14/275,628 patent/US20140369924A1/en not_active Abandoned
-
2018
- 2018-04-03 US US15/944,669 patent/US20190048075A1/en not_active Abandoned
-
2021
- 2021-01-15 US US17/150,881 patent/US20210214437A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2771336A1 (en) | 2011-03-24 |
US20210214437A1 (en) | 2021-07-15 |
US8758750B2 (en) | 2014-06-24 |
US20140369924A1 (en) | 2014-12-18 |
EP2477648A4 (en) | 2013-05-08 |
PL2477648T3 (pl) | 2022-11-07 |
US20120282174A1 (en) | 2012-11-08 |
ES2927646T3 (es) | 2022-11-08 |
AU2010295661A1 (en) | 2012-03-22 |
EP2477648B1 (en) | 2022-07-20 |
EP2477648A1 (en) | 2012-07-25 |
EP4134095A1 (en) | 2023-02-15 |
CA3057650A1 (en) | 2011-03-24 |
AU2010295661B2 (en) | 2015-04-30 |
US20190048075A1 (en) | 2019-02-14 |
PT2477648T (pt) | 2022-10-27 |
WO2011034969A1 (en) | 2011-03-24 |
CA2771336C (en) | 2019-11-26 |
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