EA201692474A1 - Производные 1-(циклопент-2-ен-1-ил)-3-(2-гидрокси-3-(арилсульфонил)фенил)мочевины в качестве ингибиторов cxcr2 - Google Patents

Производные 1-(циклопент-2-ен-1-ил)-3-(2-гидрокси-3-(арилсульфонил)фенил)мочевины в качестве ингибиторов cxcr2

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EA201692474A1
EA201692474A1 EA201692474A EA201692474A EA201692474A1 EA 201692474 A1 EA201692474 A1 EA 201692474A1 EA 201692474 A EA201692474 A EA 201692474A EA 201692474 A EA201692474 A EA 201692474A EA 201692474 A1 EA201692474 A1 EA 201692474A1
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Eurasian Patent Office
Prior art keywords
derivatives
cyclopent
urechen
arylsulfonil
hydroxy
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EA201692474A
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English (en)
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EA031477B1 (ru
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Вэйчунь Чэнь
Ибер Ф Игбоко
Сичэнь Линь
Хунфу Лу
Фэн Жэнь
Пол Брайан Рен
Чжунмяо Сюй
Тин Ян
Линдун Чжу
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Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
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Publication of EA201692474A1 publication Critical patent/EA201692474A1/ru
Publication of EA031477B1 publication Critical patent/EA031477B1/ru

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    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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Abstract

Настоящее изобретение относится к производным 1-(3-сульфонилфенил)-3-(циклопент-2-ен-1-ил)мочевины и их применению для лечения или профилактики заболеваний и состояний, опосредованных рецептором CXCR2. Кроме того, настоящее изобретение относится к композициям, содержащим производные, и к способам их приготовления.
EA201692474A 2014-05-29 2015-05-27 Производные 1-(циклопент-2-ен-1-ил)-3-(2-гидрокси-3-(арилсульфонил)фенил)мочевины в качестве ингибиторов cxcr2 EA031477B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2014000545 2014-05-29
CN2014083380 2014-07-31
CN2015077947 2015-04-30
PCT/EP2015/061618 WO2015181186A1 (en) 2014-05-29 2015-05-27 1 -(cyclopent-2-en-1 -yl)-3-(2-hydroxy-3-(arylsulfonyl)phenyl)urea derivatives as cxcr2 inhibitors

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EA201692474A1 true EA201692474A1 (ru) 2017-04-28
EA031477B1 EA031477B1 (ru) 2019-01-31

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PH12016502347A1 (en) 2017-02-13
CL2016003024A1 (es) 2017-06-23
US20190010135A1 (en) 2019-01-10
KR20170007481A (ko) 2017-01-18
MX2016015642A (es) 2017-03-15
WO2015181186A1 (en) 2015-12-03
IL248824A0 (en) 2017-01-31
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US10106515B2 (en) 2018-10-23
TW201609618A (zh) 2016-03-16
UY36141A (es) 2016-02-29
EA031477B1 (ru) 2019-01-31
US20170190681A1 (en) 2017-07-06
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JP2017521375A (ja) 2017-08-03
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CA2950466A1 (en) 2015-12-03
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