EA201490876A1 - Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей - Google Patents
Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детейInfo
- Publication number
- EA201490876A1 EA201490876A1 EA201490876A EA201490876A EA201490876A1 EA 201490876 A1 EA201490876 A1 EA 201490876A1 EA 201490876 A EA201490876 A EA 201490876A EA 201490876 A EA201490876 A EA 201490876A EA 201490876 A1 EA201490876 A1 EA 201490876A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- children
- liver
- treatment
- inhibitors
- acid recycling
- Prior art date
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract
Предложены детские лекарственные формы для применения в лечении холестатических заболеваний печени у детей путем несистемного введения пациенту терапевтически эффективного количества детской лекарственной формы, содержащей ингибитор апикального натрийзависимого транспортера желчных кислот (ASBTI) или его терапевтически приемлемую соль. Также предложены указанные детские лекарственные формы для применения в лечении заболеваний печени у детей для снижения содержания желчных кислот в сыворотке или печени, лечения зуда, уменьшения содержания ферментов печени или билирубина, включающие несистемное введение пациенту терапевтически эффективного количества детского препарата, содержащего ASBTI или его терапевтически приемлемую соль.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161553094P | 2011-10-28 | 2011-10-28 | |
US201261607503P | 2012-03-06 | 2012-03-06 | |
US201261607487P | 2012-03-06 | 2012-03-06 | |
PCT/US2012/062284 WO2013063512A1 (en) | 2011-10-28 | 2012-10-26 | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
Publications (2)
Publication Number | Publication Date |
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EA201490876A1 true EA201490876A1 (ru) | 2014-11-28 |
EA030839B1 EA030839B1 (ru) | 2018-10-31 |
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Application Number | Title | Priority Date | Filing Date |
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EA201891154A EA201891154A1 (ru) | 2011-10-28 | 2012-10-26 | Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей |
EA201490876A EA030839B1 (ru) | 2011-10-28 | 2012-10-26 | Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей |
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RU2776313C2 (ru) * | 2020-12-14 | 2022-07-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московская государственная академия ветеринарной медицины и биотехнологии - МВА имени К.И. Скрябина" (ФГБОУ ВО МГАВМиБ - МВА имени К.А. Скрябина) | Препарат для лечения мочекаменной болезни мелких домашних животных |
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