EA201400854A1 - 4-(бензоимидазол-2-ил)тиазольные соединения и родственные аза производные - Google Patents
4-(бензоимидазол-2-ил)тиазольные соединения и родственные аза производныеInfo
- Publication number
- EA201400854A1 EA201400854A1 EA201400854A EA201400854A EA201400854A1 EA 201400854 A1 EA201400854 A1 EA 201400854A1 EA 201400854 A EA201400854 A EA 201400854A EA 201400854 A EA201400854 A EA 201400854A EA 201400854 A1 EA201400854 A1 EA 201400854A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- thiazolic
- benzoimidazol
- aza derivatives
- related aza
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Изобретение относится к соединениям формулы (I)где кольцо А, X, (R), R, R, R, R, R, n и р имеют значения, как указано в описании; к их фармацевтически приемлемым солям и к применению таких соединений в качестве лекарственных средств, в особенности в качестве модуляторов CXCR3 рецептора.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IBPCT/IB2012/050489 | 2012-02-02 | ||
PCT/IB2013/050870 WO2013114332A1 (en) | 2012-02-02 | 2013-02-01 | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201400854A1 true EA201400854A1 (ru) | 2015-04-30 |
EA027595B1 EA027595B1 (ru) | 2017-08-31 |
Family
ID=48014121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201400854A EA027595B1 (ru) | 2012-02-02 | 2013-02-01 | 4-(бензоимидазол-2-ил)тиазольные соединения и родственные азапроизводные |
Country Status (21)
Country | Link |
---|---|
US (1) | US9266876B2 (ru) |
EP (1) | EP2809668B1 (ru) |
JP (1) | JP6073931B2 (ru) |
KR (1) | KR101800607B1 (ru) |
CN (1) | CN104093715B (ru) |
AU (1) | AU2013216354B2 (ru) |
BR (1) | BR112014018714A8 (ru) |
CA (1) | CA2861020C (ru) |
CL (1) | CL2014002048A1 (ru) |
EA (1) | EA027595B1 (ru) |
ES (1) | ES2632237T3 (ru) |
HK (1) | HK1203939A1 (ru) |
IL (1) | IL233872A (ru) |
MX (1) | MX352181B (ru) |
MY (1) | MY170524A (ru) |
NZ (1) | NZ629795A (ru) |
PH (1) | PH12014501540A1 (ru) |
PL (1) | PL2809668T3 (ru) |
SG (1) | SG11201404144PA (ru) |
UA (1) | UA113638C2 (ru) |
WO (1) | WO2013114332A1 (ru) |
Families Citing this family (10)
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ES2671323T3 (es) * | 2013-07-22 | 2018-06-06 | Idorsia Pharmaceuticals Ltd | Derivados 1¿(piperazin¿1¿il)¿2¿([1,2,4]triazol¿1¿il)¿etanona |
EP3091984B1 (en) | 2014-01-09 | 2020-04-22 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Substituted benzoxazine and related compounds |
AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
AR103414A1 (es) * | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3 |
AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
WO2018011265A1 (en) | 2016-07-13 | 2018-01-18 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
FR3067028B1 (fr) | 2017-06-06 | 2019-07-12 | Adpuerivitam | Modulateurs de recepteurs nmda, compositions les comprenant et utilisation de ces composes dans le traitement de maladies impliquant le systeme nerveux central |
WO2022093552A2 (en) * | 2020-10-16 | 2022-05-05 | Saint Louis Univeristy | Rev-erb agonists |
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CN103347879A (zh) | 2011-02-10 | 2013-10-09 | 先正达参股股份有限公司 | 杀微生物的吡唑衍生物 |
US8748432B2 (en) | 2011-02-10 | 2014-06-10 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
CN103827112A (zh) | 2011-09-15 | 2014-05-28 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的哌啶吡唑 |
US20140228372A1 (en) | 2011-10-18 | 2014-08-14 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
US20140243371A1 (en) | 2011-10-18 | 2014-08-28 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
IN2012DE00620A (ru) | 2012-03-02 | 2015-08-21 | Syngenta Participations Ag | |
IN2012DE00621A (ru) | 2012-03-02 | 2015-07-17 | Syngenta Participations Ag | |
WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
WO2014075873A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
WO2014075874A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
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EP2809668A1 (en) | 2014-12-10 |
AU2013216354B2 (en) | 2017-08-31 |
CN104093715B (zh) | 2017-04-26 |
IL233872A (en) | 2017-05-29 |
KR20140120364A (ko) | 2014-10-13 |
CA2861020C (en) | 2018-07-17 |
US20140371204A1 (en) | 2014-12-18 |
CN104093715A (zh) | 2014-10-08 |
UA113638C2 (xx) | 2017-02-27 |
HK1203939A1 (en) | 2015-11-06 |
JP6073931B2 (ja) | 2017-02-01 |
SG11201404144PA (en) | 2014-10-30 |
AU2013216354A1 (en) | 2014-09-25 |
EP2809668B1 (en) | 2017-04-12 |
CA2861020A1 (en) | 2013-08-08 |
US9266876B2 (en) | 2016-02-23 |
PL2809668T3 (pl) | 2018-02-28 |
KR101800607B1 (ko) | 2017-11-23 |
ES2632237T3 (es) | 2017-09-12 |
JP2015506957A (ja) | 2015-03-05 |
NZ629795A (en) | 2016-06-24 |
MX352181B (es) | 2017-11-13 |
PH12014501540B1 (en) | 2014-09-22 |
PH12014501540A1 (en) | 2014-09-22 |
BR112014018714A2 (ru) | 2017-06-20 |
MX2014009355A (es) | 2014-09-01 |
EA027595B1 (ru) | 2017-08-31 |
CL2014002048A1 (es) | 2014-11-14 |
WO2013114332A1 (en) | 2013-08-08 |
MY170524A (en) | 2019-08-09 |
BR112014018714A8 (pt) | 2017-12-26 |
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