AR103414A1 - Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3 - Google Patents

Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3

Info

Publication number
AR103414A1
AR103414A1 ARP160100086A ARP160100086A AR103414A1 AR 103414 A1 AR103414 A1 AR 103414A1 AR P160100086 A ARP160100086 A AR P160100086A AR P160100086 A ARP160100086 A AR P160100086A AR 103414 A1 AR103414 A1 AR 103414A1
Authority
AR
Argentina
Prior art keywords
heteroaryl
alkyl
alkoxy
cxcr3
hydroxialquil
Prior art date
Application number
ARP160100086A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR103414A1 publication Critical patent/AR103414A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Sales farmacéuticamente aceptables de los mismos y al uso de dichos compuestos como medicamentos, especialmente como moduladores del receptor CXCR3. Reivindicación 1: Un compuesto de fórmula (1), en donde n representa el número entero 1 ó 2; X representa N o CH; R¹ representa heteroarilo, en donde el heteroarilo es un anillo aromático monocíclico o bicíclico de 5 a 10 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados de manera independiente de oxígeno, nitrógeno y azufre, y en donde el heteroarilo está, de manera independiente, no sustituido o mono- o di-sustituido, en donde los sustituyentes se seleccionan, de manera independiente, del grupo integrado por alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, alcoxi C₁₋₂-alquilo C₁₋₂, alquilo C₁₋₂-carbonilo, hidroxi-alquilo C₁₋₄, halógeno, fluoroalquilo C₁₋₂, fenilo y heteroarilo, en donde el heteroarilo es un anillo aromático monocíclico de 5 ó 6 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados de manera independiente de oxígeno, nitrógeno y azufre, y en donde el heteroarilo está, de manera independiente, no sustituido o mono-sustituido con alquilo C₁₋₄; y R² representa cicloalquilo C₃₋₆, alcoxi C₁₋₄ o fluoroalquilo C₁₋₂; o una sal del mismo.
ARP160100086A 2015-01-15 2016-01-14 Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3 AR103414A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2015050696 2015-01-15

Publications (1)

Publication Number Publication Date
AR103414A1 true AR103414A1 (es) 2017-05-10

Family

ID=55129886

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160100086A AR103414A1 (es) 2015-01-15 2016-01-14 Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3

Country Status (38)

Country Link
US (1) US10053457B2 (es)
EP (1) EP3245203B1 (es)
JP (1) JP6337218B2 (es)
KR (1) KR101967083B1 (es)
CN (1) CN107250133B (es)
AR (1) AR103414A1 (es)
AU (1) AU2016207988B2 (es)
BR (1) BR112017015093A2 (es)
CA (1) CA2972952C (es)
CL (1) CL2017001831A1 (es)
CO (1) CO2017008156A2 (es)
CY (1) CY1121361T1 (es)
DK (1) DK3245203T3 (es)
EA (1) EA032927B1 (es)
ES (1) ES2709985T3 (es)
HK (1) HK1246789B (es)
HR (1) HRP20190024T1 (es)
HU (1) HUE042559T2 (es)
IL (1) IL253411B (es)
LT (1) LT3245203T (es)
MA (1) MA41337A (es)
MX (1) MX2017009288A (es)
MY (1) MY187614A (es)
NZ (1) NZ734542A (es)
PE (1) PE20171100A1 (es)
PH (1) PH12017501280B1 (es)
PL (1) PL3245203T3 (es)
PT (1) PT3245203T (es)
RS (1) RS58349B1 (es)
SA (1) SA517381905B1 (es)
SG (1) SG11201705617XA (es)
SI (1) SI3245203T1 (es)
TN (1) TN2017000278A1 (es)
TR (1) TR201900680T4 (es)
TW (1) TWI693221B (es)
UA (1) UA119805C2 (es)
WO (1) WO2016113344A1 (es)
ZA (1) ZA201705486B (es)

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TWI630205B (zh) 2013-07-22 2018-07-21 瑞士商愛杜西亞製藥有限公司 １－（哌－１－基）－２－（［１，２，４］***－１－基）－乙酮衍生物
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AU2016207988B2 (en) * 2015-01-15 2019-08-15 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
WO2018011265A1 (en) * 2016-07-13 2018-01-18 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
WO2020060964A1 (en) * 2018-09-18 2020-03-26 Alxerion Biotech Corp. 1, 2, 4-oxadiazole derivatives and uses thereof
KR20230137401A (ko) 2021-01-28 2023-10-04 이도르시아 파마슈티컬스 리미티드 피페라지닐-티아졸 유도체의 결정질 형태
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