EA201170771A1 - Органические соединения - Google Patents
Органические соединенияInfo
- Publication number
- EA201170771A1 EA201170771A1 EA201170771A EA201170771A EA201170771A1 EA 201170771 A1 EA201170771 A1 EA 201170771A1 EA 201170771 A EA201170771 A EA 201170771A EA 201170771 A EA201170771 A EA 201170771A EA 201170771 A1 EA201170771 A1 EA 201170771A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- organic compounds
- thioxo
- pyrazolo
- imino
- pyrimidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
Необязательно замещенные соединения 4,5,7,8-тетрагидро-(необязательно 4-тиоксо или 4-имино)-(1Н или 2Н)имидазо[1,2-а]пиразоло[4,3-е]пиримидина или 4,5,7,8,9-пентагидро-(необязательно 4-тиоксо или 4-имино)-(1Н или 2Н)пиримидо[1,2-а]пиразоло[4,3-е]пиримидина или соединения формулы (I), способы их получения, их применение в качестве лекарственных средств и фармацевтические композиции, содержащие их.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12044108P | 2008-12-06 | 2008-12-06 | |
PCT/US2009/006442 WO2010065151A1 (en) | 2008-12-06 | 2009-12-07 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201170771A1 true EA201170771A1 (ru) | 2012-01-30 |
Family
ID=42233535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170771A EA201170771A1 (ru) | 2008-12-06 | 2009-12-07 | Органические соединения |
Country Status (23)
Country | Link |
---|---|
US (3) | US8633180B2 (ru) |
EP (1) | EP2358723B1 (ru) |
JP (2) | JP5989993B2 (ru) |
KR (1) | KR20110096032A (ru) |
CN (1) | CN102232077A (ru) |
AU (1) | AU2009322903A1 (ru) |
BR (1) | BRPI0922808A2 (ru) |
CA (1) | CA2740394A1 (ru) |
CO (1) | CO6400146A2 (ru) |
CR (1) | CR20110313A (ru) |
DO (1) | DOP2011000175A (ru) |
EA (1) | EA201170771A1 (ru) |
EC (1) | ECSP11011182A (ru) |
ES (1) | ES2544976T3 (ru) |
GE (1) | GEP20146030B (ru) |
IL (1) | IL213313A0 (ru) |
MA (1) | MA32942B1 (ru) |
MX (1) | MX2011005937A (ru) |
PE (1) | PE20120209A1 (ru) |
SG (1) | SG171776A1 (ru) |
TN (1) | TN2011000247A1 (ru) |
WO (1) | WO2010065151A1 (ru) |
ZA (1) | ZA201103632B (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2652116C2 (ru) * | 2012-06-21 | 2018-04-25 | Интра-Селлулар Терапиз, Инк. | Кристаллы соли |
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KR20140022114A (ko) | 2005-06-06 | 2014-02-21 | 다케다 야쿠힌 고교 가부시키가이샤 | 유기 화합물 |
AU2007256633B2 (en) | 2006-06-06 | 2013-09-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
EP2081431B1 (en) * | 2006-11-13 | 2013-01-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP5837278B2 (ja) | 2006-12-05 | 2015-12-24 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規使用 |
WO2009073210A1 (en) * | 2007-12-06 | 2009-06-11 | Intra-Cellular Therapies, Inc | Organic compounds |
EP2240490B1 (en) | 2007-12-06 | 2013-09-04 | Takeda Pharmaceutical Company Limited | Organic compounds |
SG171775A1 (en) | 2008-12-06 | 2011-07-28 | Intra Cellular Therapies Inc | Organic compounds |
EP2358204B1 (en) * | 2008-12-06 | 2015-08-05 | Intra-Cellular Therapies, Inc. | 4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors. |
JP5813511B2 (ja) | 2008-12-06 | 2015-11-17 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
PE20110834A1 (es) | 2008-12-06 | 2011-12-14 | Intra Cellular Therapies Inc | DERIVADOS DE PIRROL[3,4-d]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1) |
EA201170773A1 (ru) | 2008-12-06 | 2012-01-30 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
US9468637B2 (en) | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP2013507360A (ja) | 2009-10-08 | 2013-03-04 | イントラ−セルラー・セラピーズ・インコーポレイテッド | ホスホジエステラーゼ1−標的トレーサーおよび方法 |
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-
2009
- 2009-12-07 PE PE2011001172A patent/PE20120209A1/es not_active Application Discontinuation
- 2009-12-07 SG SG2011036597A patent/SG171776A1/en unknown
- 2009-12-07 AU AU2009322903A patent/AU2009322903A1/en not_active Abandoned
- 2009-12-07 MA MA33973A patent/MA32942B1/fr unknown
- 2009-12-07 ES ES09830746.5T patent/ES2544976T3/es active Active
- 2009-12-07 US US13/133,082 patent/US8633180B2/en active Active
- 2009-12-07 JP JP2011539521A patent/JP5989993B2/ja not_active Expired - Fee Related
- 2009-12-07 CN CN2009801481881A patent/CN102232077A/zh active Pending
- 2009-12-07 CA CA2740394A patent/CA2740394A1/en not_active Abandoned
- 2009-12-07 EP EP20090830746 patent/EP2358723B1/en active Active
- 2009-12-07 MX MX2011005937A patent/MX2011005937A/es not_active Application Discontinuation
- 2009-12-07 WO PCT/US2009/006442 patent/WO2010065151A1/en active Application Filing
- 2009-12-07 EA EA201170771A patent/EA201170771A1/ru unknown
- 2009-12-07 BR BRPI0922808A patent/BRPI0922808A2/pt not_active IP Right Cessation
- 2009-12-07 GE GEAP200912254A patent/GEP20146030B/en unknown
- 2009-12-07 KR KR1020117013125A patent/KR20110096032A/ko not_active Application Discontinuation
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2011
- 2011-05-17 TN TN2011000247A patent/TN2011000247A1/fr unknown
- 2011-05-17 ZA ZA2011/03632A patent/ZA201103632B/en unknown
- 2011-06-02 IL IL213313A patent/IL213313A0/en unknown
- 2011-06-06 DO DO2011000175A patent/DOP2011000175A/es unknown
- 2011-06-06 CR CR20110313A patent/CR20110313A/es unknown
- 2011-06-29 CO CO11081349A patent/CO6400146A2/es not_active Application Discontinuation
- 2011-07-05 EC EC2011011182A patent/ECSP11011182A/es unknown
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2013
- 2013-09-06 US US14/019,950 patent/US20140011783A1/en not_active Abandoned
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- 2014-06-04 US US14/296,145 patent/US20150080357A1/en not_active Abandoned
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2652116C2 (ru) * | 2012-06-21 | 2018-04-25 | Интра-Селлулар Терапиз, Инк. | Кристаллы соли |
Also Published As
Publication number | Publication date |
---|---|
TN2011000247A1 (en) | 2012-12-17 |
WO2010065151A1 (en) | 2010-06-10 |
JP2012510994A (ja) | 2012-05-17 |
US20140011783A1 (en) | 2014-01-09 |
PE20120209A1 (es) | 2012-03-18 |
JP2016006042A (ja) | 2016-01-14 |
US20150080357A1 (en) | 2015-03-19 |
AU2009322903A1 (en) | 2010-06-10 |
CO6400146A2 (es) | 2012-03-15 |
DOP2011000175A (es) | 2011-10-31 |
IL213313A0 (en) | 2011-07-31 |
CN102232077A (zh) | 2011-11-02 |
CR20110313A (es) | 2011-10-28 |
MX2011005937A (es) | 2011-12-16 |
BRPI0922808A2 (pt) | 2018-05-29 |
GEP20146030B (en) | 2014-02-10 |
KR20110096032A (ko) | 2011-08-26 |
ZA201103632B (en) | 2013-05-29 |
EP2358723B1 (en) | 2015-05-13 |
MA32942B1 (fr) | 2012-01-02 |
ES2544976T3 (es) | 2015-09-07 |
JP5989993B2 (ja) | 2016-09-07 |
CA2740394A1 (en) | 2010-06-10 |
SG171776A1 (en) | 2011-07-28 |
US20120071450A1 (en) | 2012-03-22 |
EP2358723A1 (en) | 2011-08-24 |
US8633180B2 (en) | 2014-01-21 |
EP2358723A4 (en) | 2012-10-10 |
ECSP11011182A (es) | 2011-10-31 |
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