CY1112679T1 - Κινολινες και θεραπευτικη χρηση αυτων - Google Patents
Κινολινες και θεραπευτικη χρηση αυτωνInfo
- Publication number
- CY1112679T1 CY1112679T1 CY20121100048T CY121100048T CY1112679T1 CY 1112679 T1 CY1112679 T1 CY 1112679T1 CY 20121100048 T CY20121100048 T CY 20121100048T CY 121100048 T CY121100048 T CY 121100048T CY 1112679 T1 CY1112679 T1 CY 1112679T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydrogen
- halogen
- kinolines
- therapeutic use
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Ενώσεις του τύπου (I) είναι συνδετήρες CRTH2, χρήσιμοι στη θεραπεία, για παράδειγμα, άσθματος και COPD όπου: το R1 είναι αλογόνο ή κύανο, το R2 είναι υδρογόνο ή μεθύλ, τα R3 και R4 ανεξαρτήτως είναι -OR6, C1-C6αλκύλ ή C3-C6κυκλοαλκύλ, με τις τελευταίες δύο ομάδες προαιρετικά να είναι υποκατεστημένες με ένα ή περισσότερα άτομα αλογόνου, το R5 είναι υδρογόνο ή αλογόνο, το R6 είναι C1-C6αλκύλ ή C3-C6κυκλοαλκύλ, εκάτερο των οποίων προαιρετικά είναι υποκατεστημένο με ένα ή περισσότερα άτομα αλογόνου, το Χ είναι -CH2-, -S- ή -Ο-, ένα των Υ και Υ1 είναι υδρογόνο και το άλλο είναι OR6, -C(=O)R7, NR8SO2R6 ή ετεροκυκλική ομάδα επιλεγόμενη από αυτές που αναφέρονται στην προδιαγραφή και τα R6, R7 και R8 είναι όπως ορίζεται στην προδιαγραφή.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0706636A GB0706636D0 (en) | 2007-04-04 | 2007-04-04 | Receptor ligands |
GB0724430A GB0724430D0 (en) | 2007-12-14 | 2007-12-14 | Receptor ligands |
EP08736891A EP2139881B1 (en) | 2007-04-04 | 2008-04-03 | Quinolines and their therapeutic use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112679T1 true CY1112679T1 (el) | 2016-02-10 |
Family
ID=39561800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100048T CY1112679T1 (el) | 2007-04-04 | 2012-01-17 | Κινολινες και θεραπευτικη χρηση αυτων |
Country Status (22)
Country | Link |
---|---|
US (2) | US8173812B2 (el) |
EP (1) | EP2139881B1 (el) |
JP (1) | JP5187862B2 (el) |
CN (1) | CN101679359B (el) |
AT (1) | ATE532780T1 (el) |
AU (1) | AU2008235282B2 (el) |
BR (1) | BRPI0809983A2 (el) |
CA (1) | CA2680682C (el) |
CY (1) | CY1112679T1 (el) |
DK (1) | DK2139881T3 (el) |
EA (1) | EA017093B1 (el) |
ES (1) | ES2375588T3 (el) |
HK (1) | HK1142604A1 (el) |
HR (1) | HRP20110987T1 (el) |
IL (1) | IL201013A (el) |
MX (1) | MX2009010461A (el) |
NZ (1) | NZ579659A (el) |
PL (1) | PL2139881T3 (el) |
PT (1) | PT2139881E (el) |
SI (1) | SI2139881T1 (el) |
WO (1) | WO2008122784A1 (el) |
ZA (1) | ZA200906384B (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101679359B (zh) * | 2007-04-04 | 2013-03-06 | 普尔玛根治疗(哮喘)有限公司 | 喹啉类化合物及它们的治疗用途 |
SI2327693T1 (sl) | 2007-12-14 | 2012-09-28 | Pulmagen Therapeutics Asthma Ltd Fulmer Hal Windmil Road | Indoli in njihova terapevtska raba |
CN102958914B (zh) * | 2010-07-05 | 2015-05-27 | 埃科特莱茵药品有限公司 | 1-苯基取代的杂环衍生物及其作为***素d2受体调节剂的用途 |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
AR089360A1 (es) | 2011-12-21 | 2014-08-20 | Actelion Pharmaceuticals Ltd | Derivados de heterociclilo y su uso como moduladores del receptor d₂ de prostaglandina |
CA2876808A1 (en) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
EP2885285B1 (en) * | 2012-07-17 | 2016-10-19 | Boehringer Ingelheim International GmbH | Pyrazole drivatives which inhibit leukotriene production |
CA2940439C (en) * | 2014-02-24 | 2024-03-19 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
WO2022175829A1 (en) * | 2021-02-17 | 2022-08-25 | Cellix Bio Private Limited | Topical formulations and compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58225065A (ja) * | 1982-06-21 | 1983-12-27 | Nippon Shinyaku Co Ltd | 2−キノロン誘導体 |
TW297025B (el) * | 1992-02-14 | 1997-02-01 | Squibb & Sons Inc | |
SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
PT1928457E (pt) * | 2005-09-30 | 2013-02-19 | Pulmagen Therapeutics Asthma Ltd | Quinolinas e sua utilização terapêutica |
CN101679359B (zh) * | 2007-04-04 | 2013-03-06 | 普尔玛根治疗(哮喘)有限公司 | 喹啉类化合物及它们的治疗用途 |
-
2008
- 2008-04-03 CN CN2008800110606A patent/CN101679359B/zh not_active Expired - Fee Related
- 2008-04-03 PT PT08736891T patent/PT2139881E/pt unknown
- 2008-04-03 AT AT08736891T patent/ATE532780T1/de active
- 2008-04-03 BR BRPI0809983-9A2A patent/BRPI0809983A2/pt not_active Application Discontinuation
- 2008-04-03 SI SI200830512T patent/SI2139881T1/sl unknown
- 2008-04-03 JP JP2010501594A patent/JP5187862B2/ja not_active Expired - Fee Related
- 2008-04-03 AU AU2008235282A patent/AU2008235282B2/en not_active Ceased
- 2008-04-03 CA CA2680682A patent/CA2680682C/en not_active Expired - Fee Related
- 2008-04-03 EA EA200970911A patent/EA017093B1/ru not_active IP Right Cessation
- 2008-04-03 WO PCT/GB2008/001201 patent/WO2008122784A1/en active Application Filing
- 2008-04-03 EP EP08736891A patent/EP2139881B1/en not_active Not-in-force
- 2008-04-03 PL PL08736891T patent/PL2139881T3/pl unknown
- 2008-04-03 MX MX2009010461A patent/MX2009010461A/es active IP Right Grant
- 2008-04-03 ES ES08736891T patent/ES2375588T3/es active Active
- 2008-04-03 US US12/531,935 patent/US8173812B2/en not_active Expired - Fee Related
- 2008-04-03 NZ NZ579659A patent/NZ579659A/en not_active IP Right Cessation
- 2008-04-03 DK DK08736891.6T patent/DK2139881T3/da active
-
2009
- 2009-09-14 ZA ZA2009/06384A patent/ZA200906384B/en unknown
- 2009-09-17 IL IL201013A patent/IL201013A/en active IP Right Grant
-
2010
- 2010-09-24 HK HK10109142.6A patent/HK1142604A1/xx not_active IP Right Cessation
-
2011
- 2011-12-30 HR HR20110987T patent/HRP20110987T1/hr unknown
-
2012
- 2012-01-17 CY CY20121100048T patent/CY1112679T1/el unknown
- 2012-03-30 US US13/435,242 patent/US8394830B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN101679359B (zh) | 2013-03-06 |
AU2008235282B2 (en) | 2011-02-24 |
ES2375588T3 (es) | 2012-03-02 |
CA2680682C (en) | 2015-05-26 |
US8173812B2 (en) | 2012-05-08 |
PL2139881T3 (pl) | 2012-04-30 |
JP2010523537A (ja) | 2010-07-15 |
US20120184579A1 (en) | 2012-07-19 |
MX2009010461A (es) | 2010-02-18 |
US8394830B2 (en) | 2013-03-12 |
JP5187862B2 (ja) | 2013-04-24 |
EA017093B1 (ru) | 2012-09-28 |
CA2680682A1 (en) | 2008-10-16 |
IL201013A0 (en) | 2010-05-17 |
HRP20110987T1 (hr) | 2012-01-31 |
EA200970911A1 (ru) | 2010-04-30 |
NZ579659A (en) | 2012-01-12 |
EP2139881B1 (en) | 2011-11-09 |
SI2139881T1 (sl) | 2012-05-31 |
PT2139881E (pt) | 2012-01-17 |
AU2008235282A8 (en) | 2009-11-26 |
CN101679359A (zh) | 2010-03-24 |
BRPI0809983A2 (pt) | 2014-10-14 |
DK2139881T3 (da) | 2012-01-30 |
IL201013A (en) | 2015-01-29 |
US20100144787A1 (en) | 2010-06-10 |
EP2139881A1 (en) | 2010-01-06 |
AU2008235282A1 (en) | 2008-10-16 |
ZA200906384B (en) | 2010-11-24 |
HK1142604A1 (en) | 2010-12-10 |
ATE532780T1 (de) | 2011-11-15 |
WO2008122784A1 (en) | 2008-10-16 |
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