MA32727B1 - Pyrazolylaminopyridines au titre d'inhibiteurs de fak - Google Patents
Pyrazolylaminopyridines au titre d'inhibiteurs de fakInfo
- Publication number
- MA32727B1 MA32727B1 MA33791A MA33791A MA32727B1 MA 32727 B1 MA32727 B1 MA 32727B1 MA 33791 A MA33791 A MA 33791A MA 33791 A MA33791 A MA 33791A MA 32727 B1 MA32727 B1 MA 32727B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrazolylaminoperidine
- fak inhibitors
- fak
- inhibitors
- cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
Abstract
LA PRÉSENTE INVENTION CONCERNE UN COMPOSÉ DE FORMULE (I) OU L'UN DE SES SELS DE QUALITÉ PHARMACEUTIQUE, OÙ R1, R2, R3, R11, R12, R13, Q, Z ET P SONT TELS QUE DÉCRITS DANS LA PRÉSENTE INVENTION. LES COMPOSÉS SELON LA PRÉSENTE INVENTION PEUVENT ÊTRE EMPLOYÉS DANS LE TRAITEMENT DE CANCERS.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10856808P | 2008-10-27 | 2008-10-27 | |
US17851709P | 2009-05-15 | 2009-05-15 | |
US24243209P | 2009-09-15 | 2009-09-15 | |
PCT/US2009/062163 WO2010062578A1 (fr) | 2008-10-27 | 2009-10-27 | Pyrazolylaminopyridines au titre d'inhibiteurs de fak |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32727B1 true MA32727B1 (fr) | 2011-10-02 |
Family
ID=42132177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33791A MA32727B1 (fr) | 2008-10-27 | 2011-04-22 | Pyrazolylaminopyridines au titre d'inhibiteurs de fak |
Country Status (36)
Country | Link |
---|---|
US (6) | US20110207743A1 (fr) |
EP (1) | EP2421537B1 (fr) |
JP (1) | JP5642689B2 (fr) |
KR (1) | KR101512217B1 (fr) |
CN (1) | CN102264371B (fr) |
AR (1) | AR073993A1 (fr) |
AU (1) | AU2009320144B2 (fr) |
BR (1) | BRPI0920053B8 (fr) |
CA (1) | CA2741760C (fr) |
CL (1) | CL2011000933A1 (fr) |
CO (1) | CO6361929A2 (fr) |
CR (1) | CR20110264A (fr) |
CY (1) | CY1116399T1 (fr) |
DK (1) | DK2421537T3 (fr) |
DO (1) | DOP2011000113A (fr) |
EA (1) | EA021927B1 (fr) |
ES (1) | ES2539835T3 (fr) |
HK (1) | HK1161680A1 (fr) |
HR (1) | HRP20150531T1 (fr) |
IL (1) | IL212444A (fr) |
JO (1) | JO3067B1 (fr) |
MA (1) | MA32727B1 (fr) |
MX (1) | MX2011004369A (fr) |
MY (1) | MY161890A (fr) |
NZ (1) | NZ592477A (fr) |
PE (1) | PE20110941A1 (fr) |
PL (1) | PL2421537T3 (fr) |
PT (1) | PT2421537E (fr) |
RS (1) | RS54045B1 (fr) |
SG (1) | SG195608A1 (fr) |
SI (1) | SI2421537T1 (fr) |
SM (1) | SMT201500157B (fr) |
TW (1) | TWI454467B (fr) |
UY (1) | UY32200A (fr) |
WO (1) | WO2010062578A1 (fr) |
ZA (1) | ZA201102892B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
BR112013018565A2 (pt) * | 2011-01-26 | 2016-09-27 | Univ Texas | combinações |
ES2691673T3 (es) | 2011-02-17 | 2018-11-28 | Cancer Therapeutics Crc Pty Limited | Inhibidores de Fak |
DK2675794T3 (da) | 2011-02-17 | 2019-05-06 | Cancer Therapeutics Crc Pty Ltd | Selektive fak-inhibitorer |
WO2013003575A1 (fr) * | 2011-06-28 | 2013-01-03 | Glaxosmithkline Llc | Procédé d'administration et de traitement |
US10106834B2 (en) | 2013-10-09 | 2018-10-23 | The General Hospital Corporation | Methods of diagnosing and treating B cell acute lymphoblastic leukemia |
CN108289892B (zh) | 2015-06-29 | 2021-11-23 | 维瑞斯特姆股份有限公司 | 治疗组合物、组合和使用方法 |
CN108948019B (zh) * | 2017-05-18 | 2022-07-08 | 广东东阳光药业有限公司 | 黏着斑激酶抑制剂及其用途 |
WO2019117813A1 (fr) * | 2017-12-15 | 2019-06-20 | National University Of Singapore | Agents thérapeutiques ciblant une kinase d'adhésion focale pour le traitement du glaucome et de la fibrose |
AU2019236402A1 (en) | 2018-03-12 | 2020-10-01 | Assistance Publique-Hôpitaux De Paris (Aphp) | Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers |
CN108912095B (zh) * | 2018-08-09 | 2019-08-20 | 广州安岩仁医药科技有限公司 | 苯并咪唑类化合物及其制备方法和应用 |
AU2019348011A1 (en) * | 2018-09-27 | 2021-02-11 | Dana-Farber Cancer Institute, Inc. | Degradation of FAK or FAK and ALK by conjugation of FAK and ALK inhibitors with E3 ligase ligands and methods of use |
CN113387947B (zh) * | 2021-07-12 | 2022-07-01 | 中国科学院成都生物研究所 | 调节***受体合成活性的吡唑并吡啶衍生物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US166139A (en) * | 1875-07-27 | Improvement in dental pluggers | ||
EP1109823B1 (fr) * | 1998-09-08 | 2005-11-16 | Agouron Pharmaceuticals, Inc. | Modification de la proteine recepteur 2 de vegf et ses methodes d'utilisation |
US7102009B2 (en) * | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
MY147449A (en) * | 2003-08-15 | 2012-12-14 | Novartis Ag | 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
GB0419160D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
EP1746096A1 (fr) * | 2005-07-15 | 2007-01-24 | 4Sc Ag | Analogues de 2-arylbenzothiazole utiles comme agents anticancereux |
ES2485040T3 (es) * | 2007-03-16 | 2014-08-12 | The Scripps Research Institute | Inhibidores de cinasa de adhesión focal |
JP2011512413A (ja) * | 2008-02-19 | 2011-04-21 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Fakの阻害剤としてのアニリノピリジン |
BRPI0914927B8 (pt) * | 2008-06-17 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica e uso de um composto |
-
2009
- 2009-10-25 JO JOP/2009/0395A patent/JO3067B1/ar active
- 2009-10-26 UY UY32200A patent/UY32200A/es not_active Application Discontinuation
- 2009-10-26 TW TW98136145A patent/TWI454467B/zh not_active IP Right Cessation
- 2009-10-27 AR ARP090104137 patent/AR073993A1/es not_active Application Discontinuation
- 2009-10-27 RS RS20150365A patent/RS54045B1/en unknown
- 2009-10-27 MY MYPI2011001828A patent/MY161890A/en unknown
- 2009-10-27 JP JP2011533421A patent/JP5642689B2/ja active Active
- 2009-10-27 SI SI200931192T patent/SI2421537T1/sl unknown
- 2009-10-27 AU AU2009320144A patent/AU2009320144B2/en not_active Ceased
- 2009-10-27 SG SG2013079579A patent/SG195608A1/en unknown
- 2009-10-27 NZ NZ59247709A patent/NZ592477A/xx not_active IP Right Cessation
- 2009-10-27 ES ES09829580.1T patent/ES2539835T3/es active Active
- 2009-10-27 MX MX2011004369A patent/MX2011004369A/es active IP Right Grant
- 2009-10-27 PL PL09829580T patent/PL2421537T3/pl unknown
- 2009-10-27 KR KR1020117011999A patent/KR101512217B1/ko active IP Right Grant
- 2009-10-27 PE PE2011000920A patent/PE20110941A1/es not_active Application Discontinuation
- 2009-10-27 US US13/126,064 patent/US20110207743A1/en not_active Abandoned
- 2009-10-27 CN CN2009801526261A patent/CN102264371B/zh active Active
- 2009-10-27 US US12/606,390 patent/US20100113475A1/en not_active Abandoned
- 2009-10-27 WO PCT/US2009/062163 patent/WO2010062578A1/fr active Application Filing
- 2009-10-27 CA CA2741760A patent/CA2741760C/fr active Active
- 2009-10-27 EA EA201170617A patent/EA021927B1/ru not_active IP Right Cessation
- 2009-10-27 BR BRPI0920053A patent/BRPI0920053B8/pt active IP Right Grant
- 2009-10-27 DK DK09829580.1T patent/DK2421537T3/da active
- 2009-10-27 EP EP20090829580 patent/EP2421537B1/fr active Active
- 2009-10-27 PT PT98295801T patent/PT2421537E/pt unknown
-
2011
- 2011-04-17 IL IL212444A patent/IL212444A/en not_active IP Right Cessation
- 2011-04-18 ZA ZA2011/02892A patent/ZA201102892B/en unknown
- 2011-04-22 MA MA33791A patent/MA32727B1/fr unknown
- 2011-04-26 CL CL2011000933A patent/CL2011000933A1/es unknown
- 2011-04-27 DO DO2011000113A patent/DOP2011000113A/es unknown
- 2011-04-29 US US13/097,271 patent/US20110269774A1/en not_active Abandoned
- 2011-05-11 CO CO11058067A patent/CO6361929A2/es active IP Right Grant
- 2011-05-17 CR CR20110264A patent/CR20110264A/es unknown
-
2012
- 2012-03-05 HK HK12102201.7A patent/HK1161680A1/xx not_active IP Right Cessation
-
2013
- 2013-10-07 US US14/047,688 patent/US9012479B2/en active Active
-
2015
- 2015-03-30 US US14/672,477 patent/US20150265589A1/en not_active Abandoned
- 2015-05-18 HR HRP20150531TT patent/HRP20150531T1/hr unknown
- 2015-05-22 CY CY20151100462T patent/CY1116399T1/el unknown
- 2015-07-03 SM SM201500157T patent/SMT201500157B/xx unknown
- 2015-10-20 US US14/887,763 patent/US9446034B2/en active Active
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