EA200501506A1 - Антитела против il-20 и связывающие партнеры, а также способы их применения при воспалении - Google Patents
Антитела против il-20 и связывающие партнеры, а также способы их применения при воспаленииInfo
- Publication number
- EA200501506A1 EA200501506A1 EA200501506A EA200501506A EA200501506A1 EA 200501506 A1 EA200501506 A1 EA 200501506A1 EA 200501506 A EA200501506 A EA 200501506A EA 200501506 A EA200501506 A EA 200501506A EA 200501506 A1 EA200501506 A1 EA 200501506A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- binding partners
- inflammation
- ways
- application
- antibodies against
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Настоящее изобретение относится к блокированию, ингибированию, снижению, антагонистическому действию или нейтрализации активности полипептидных молекул IL-20. IL-20 и IL-22 являются цитокинами, которые вовлечены в воспалительные процессы и заболевания человека. Настоящее изобретение включает антитела против IL-20 и против IL-22RA и связывающие партнеры, а также способы антагонистического воздействия в отношении IL-20 с применением таких антител и связывающих партнеров.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45748103P | 2003-03-24 | 2003-03-24 | |
US52329503P | 2003-11-17 | 2003-11-17 | |
PCT/US2004/008955 WO2004085475A2 (en) | 2003-03-24 | 2004-03-24 | Anti-il-20 antibodies and binding partners and methods of using in inflammation |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200501506A1 true EA200501506A1 (ru) | 2006-06-30 |
EA009124B1 EA009124B1 (ru) | 2007-10-26 |
Family
ID=33101289
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501505A EA009026B1 (ru) | 2003-03-24 | 2004-03-24 | Антитела против il-22ra, их партнеры по связыванию и способы их применения при воспалениях |
EA200501506A EA009124B1 (ru) | 2003-03-24 | 2004-03-24 | Антитела против il-20 и связывающие партнеры, а также способы их применения при воспалении |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501505A EA009026B1 (ru) | 2003-03-24 | 2004-03-24 | Антитела против il-22ra, их партнеры по связыванию и способы их применения при воспалениях |
Country Status (16)
Country | Link |
---|---|
US (6) | US20040209330A1 (ru) |
EP (2) | EP1606316A2 (ru) |
JP (2) | JP2007525437A (ru) |
KR (3) | KR20050116392A (ru) |
CN (2) | CN102690350A (ru) |
AT (1) | ATE475673T1 (ru) |
AU (2) | AU2004223836A1 (ru) |
BR (2) | BRPI0408705A (ru) |
CA (2) | CA2519057A1 (ru) |
DE (1) | DE602004028347D1 (ru) |
DK (1) | DK1606317T3 (ru) |
EA (2) | EA009026B1 (ru) |
ES (1) | ES2347657T3 (ru) |
MX (2) | MXPA05010136A (ru) |
NO (1) | NO20054892L (ru) |
WO (2) | WO2004085475A2 (ru) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965704A (en) * | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
JP5015404B2 (ja) | 2000-08-08 | 2012-08-29 | ザイモジェネティクス, インコーポレイテッド | 可溶性zcytor11サイトカイン受容体 |
US7855269B2 (en) | 2000-09-15 | 2010-12-21 | Zymogenetics, Inc. | Method for treating inflammation |
WO2003051384A1 (en) | 2001-12-17 | 2003-06-26 | Zymogenetics, Inc. | Method for treating cervical cancer |
EA009026B1 (ru) * | 2003-03-24 | 2007-10-26 | Займоджинетикс, Инк. | Антитела против il-22ra, их партнеры по связыванию и способы их применения при воспалениях |
ATE447587T1 (de) * | 2003-11-21 | 2009-11-15 | Zymogenetics Inc | Anti-il-20-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen |
AU2005296064A1 (en) * | 2004-10-04 | 2006-04-27 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of macromolecules |
MX2007004770A (es) * | 2004-10-22 | 2007-11-22 | Zymogenetics Inc | Anticuerpos anti-il-22ra y moleculas y metodos para usarlos en inflamacion. |
CN100515491C (zh) * | 2005-01-04 | 2009-07-22 | 健能隆医药技术(上海)有限公司 | 白介素-22的医药用途 |
EP2192132A3 (en) * | 2005-02-08 | 2010-08-18 | ZymoGenetics, Inc. | Anti-IL-20, anti-IL22 and anti-IL-22RA antibodies and binding partners and methods of using in inflammation |
JP2009518314A (ja) * | 2005-12-02 | 2009-05-07 | ジェネンテック・インコーポレーテッド | Il−22に結合する抗体およびil−22rに結合する抗体を含む、サイトカインシグナリングに関連する疾患および障害の処置のための組成物および方法 |
WO2007067596A2 (en) * | 2005-12-05 | 2007-06-14 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of antibodies |
US20090148401A1 (en) * | 2005-12-05 | 2009-06-11 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of binding partners |
JP2009521503A (ja) * | 2005-12-22 | 2009-06-04 | ディー・エイチ・ワイ・アンド・カンパニー・リミテッド | インターロイキン−22結合タンパク質に対する抗体と、代謝性疾患の処置のためのその使用 |
CA2647168A1 (en) * | 2006-03-16 | 2007-09-27 | Trinity Biosystems, Inc. | Methods for increasing the size of animals using needleless delivery constructs |
ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
ES2429407T3 (es) | 2006-06-08 | 2013-11-14 | Chugai Seiyaku Kabushiki Kaisha | Agente preventivo o remedio para enfermedades inflamatorias |
US20090092660A1 (en) * | 2006-08-09 | 2009-04-09 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of particles |
SG10201605394SA (en) | 2007-09-26 | 2016-08-30 | Chugai Pharmaceutical Co Ltd | Modified Antibody Constant Region |
EP3689912A1 (en) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
RU2531521C2 (ru) | 2007-12-05 | 2014-10-20 | Чугаи Сейяку Кабусики Кайся | Антитело против nr10 и его применение |
MX2010006097A (es) | 2007-12-05 | 2010-08-04 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para tratar el prurito. |
EP4238993A3 (en) | 2008-04-11 | 2023-11-29 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
KR20110039218A (ko) | 2008-06-30 | 2011-04-15 | 노보 노르디스크 에이/에스 | 항-인간 인터루킨-20 항체 |
JP2010210772A (ja) * | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
US8454956B2 (en) * | 2009-08-31 | 2013-06-04 | National Cheng Kung University | Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies |
SG190727A1 (en) | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
PT2686347T (pt) | 2011-03-16 | 2018-07-05 | Argenx Bvba | Anticorpos dirigidos contra cd70 |
CN104302780B (zh) * | 2011-08-05 | 2017-04-12 | 艾克斯-马赛大学 | 纤维变性易感性il22ra2基因及其用途 |
US8597647B1 (en) | 2012-05-22 | 2013-12-03 | National Cheng Kung University | Humanized anti-IL-20 antibody and uses thereof |
WO2014006230A1 (en) * | 2012-07-06 | 2014-01-09 | Novo Nordisk A/S | Il-20 epitopes and il-20 ligands |
WO2014015133A1 (en) | 2012-07-19 | 2014-01-23 | National Cheng Kung University | Treatment of osteoarthritis using il-20 antagonists |
US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
US8852588B2 (en) | 2012-08-07 | 2014-10-07 | National Cheng Kung University | Treating allergic airway disorders using anti-IL-20 receptor antibodies |
IN2015DN00140A (ru) * | 2012-08-31 | 2015-06-12 | Argen X Bv | |
US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
RU2683020C2 (ru) * | 2014-11-11 | 2019-03-26 | Петр Иванович Никитин | Субстанция и способ для модуляции активности агента в организме |
MA43918A (fr) | 2015-04-14 | 2018-12-05 | Chugai Pharmaceutical Co Ltd | Composition pharmaceutique pour la prã‰vention et/ou le traitement de la dermatite atopique contenant comme principe actif un antagoniste de l'il-31 |
CN105601739B (zh) * | 2016-02-22 | 2019-01-18 | 王晨辉 | 一种人源化抗白介素22基因工程抗体及其应用 |
WO2017202813A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections |
GB201612337D0 (en) * | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
JOP20190155A1 (ar) | 2016-12-21 | 2019-06-23 | Novartis Ag | مترافقات عقار جسم مضاد لإزالة خلايا جذعية مكونة للدم |
WO2020210816A1 (en) * | 2019-04-12 | 2020-10-15 | Methodist Hospital Research Institute | Therapeutic particles that enable antigen presenting cells to attack cancer cells |
US20220307035A1 (en) * | 2019-06-12 | 2022-09-29 | Acurasysbio Co., Ltd. | Composition for preventing or treating cancer |
TW202128222A (zh) | 2019-11-20 | 2021-08-01 | 日商中外製藥股份有限公司 | 含有抗體之製劑 |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
NZ212437A (en) * | 1985-06-17 | 1992-06-25 | Mark Philip Best | Site-directed antibody conjugates, and their preparation |
WO1989004838A1 (en) * | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5436155A (en) * | 1991-12-31 | 1995-07-25 | Arch Development Corporation | Isolated DNA encoding a somatostatin receptor |
US5789192A (en) | 1992-12-10 | 1998-08-04 | Schering Corporation | Mammalian receptors for interleukin-10 (IL-10) |
DE69521789T2 (de) | 1994-02-01 | 2002-04-25 | Us Health | Fusionierte proteine die antikörper-teile und nicht-antikörper-teile enthalten |
JP3713074B2 (ja) * | 1995-08-30 | 2005-11-02 | 栄研化学株式会社 | 血清アミロイドaを認識するモノクローナル抗体 |
US5843697A (en) | 1996-07-17 | 1998-12-01 | University Of Medicine And Dentistry Of New Jersey | Cells expressing IL-10 receptor and the CRFB4 gene product, an IL-10 receptor accessory protein |
US5985614A (en) * | 1996-08-30 | 1999-11-16 | Human Genome Sciences, Inc. | Polynucleotides encoding interleukin-19 |
US5945511A (en) * | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
US6133426A (en) * | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
AU8571198A (en) | 1997-07-16 | 1999-02-10 | Human Genome Sciences, Inc. | Interleukin-20 |
US6486301B1 (en) | 1997-07-16 | 2002-11-26 | Human Genome Sciences, Inc. | Interleukin-20 |
KR100236609B1 (ko) * | 1997-08-01 | 2000-02-01 | 박호군 | 클로로하이드로실란 유도체 및 이의 제조방법 |
US5965704A (en) * | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
US6020163A (en) * | 1997-08-06 | 2000-02-01 | Zymogenetics, Inc. | Lipocalin homolog |
US6551799B2 (en) * | 1999-12-07 | 2003-04-22 | Genentech, Inc. | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
US6576743B1 (en) * | 1997-11-26 | 2003-06-10 | Zymogenetics, Inc. | Mammalian cytokine-like polypeptide-10 |
EP1424393A3 (en) | 1997-11-26 | 2004-06-09 | Zymogenetics Inc | Mammalian cytokine-like polypeptide-10 |
CA2318482C (en) | 1998-01-23 | 2010-04-13 | Immunex Corporation | Il-18 receptors |
AU2871899A (en) | 1998-03-09 | 1999-09-27 | Schering Corporation | Human receptor proteins; related reagents and methods |
ES2312205T3 (es) | 1998-03-10 | 2009-02-16 | Genentech, Inc. | Nuevo polipeptido y acidos nucleicos que lo codifican. |
US6197582B1 (en) * | 1998-03-18 | 2001-03-06 | The Trustees Of Columbia University In The City Of New York | Development of human monoclonal antibodies and uses thereof |
US6982320B2 (en) | 1998-03-19 | 2006-01-03 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
AU5203199A (en) | 1998-05-26 | 1999-12-13 | Procter & Gamble Company, The | Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system |
NZ531664A (en) | 1998-09-01 | 2005-07-29 | Genentech Inc | Pro1317 polypeptides and sequences thereof with homology to the semaphorin B glycoprotein family |
US6274710B1 (en) * | 1998-10-26 | 2001-08-14 | Ludwig Institute For Cancer Research | Antibodies which specifically bind T Cell inducible factors (TIFs) |
EP1131333B1 (en) | 1998-10-26 | 2010-06-02 | Wyeth a Corporation of the State of Delaware | ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE T CELL INDUCIBLE FACTORS (TIFs), THE PROTEINS ENCODED, AND USES THEREOF |
EP1141008A1 (en) | 1998-12-31 | 2001-10-10 | Millennium Pharmaceuticals, Inc. | Class ii cytokine receptor-like proteins and nucleic acids encoding them |
PT1177312E (pt) | 1999-04-28 | 2008-01-22 | Genetics Inst Llc | Proteínas gil-19/ae289 humanas e polinucleótidos codificadores das mesmas |
EP1179066A2 (en) | 1999-05-19 | 2002-02-13 | Incyte Genomics, Inc. | Extracellular signaling molecules |
AU5047600A (en) | 1999-05-27 | 2000-12-18 | Schering Corporation | Mammalian interleukin-10 homologs: il-d110 and il-d210 |
ATE449109T1 (de) | 1999-06-15 | 2009-12-15 | Genentech Inc | Sekretierte und transmembran-polypeptide sowie nukleinsäuren zu deren kodierung |
AU2883700A (en) | 1999-06-23 | 2001-01-09 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
ES2364086T3 (es) | 1999-07-07 | 2011-08-24 | Zymogenetics, Inc. | Receptor de citoquina humana. |
EP1208202A2 (en) | 1999-09-01 | 2002-05-29 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
EP1230368A2 (en) | 1999-11-18 | 2002-08-14 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
US6897292B2 (en) | 1999-12-03 | 2005-05-24 | Zymogenetics, Inc. | Human cytokine receptor |
US6610286B2 (en) * | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
ATE407950T1 (de) | 1999-12-23 | 2008-09-15 | Zymogenetics Inc | Löslicher interleukin-20 rezeptor |
JP2003524415A (ja) | 1999-12-23 | 2003-08-19 | ザイモジェネティクス,インコーポレイティド | サイトカインzcyto18 |
DK1616575T3 (da) * | 1999-12-23 | 2012-09-10 | Zymogenetics Inc | Fremgangsmåde til behandling af inflammation |
NZ523122A (en) | 2000-06-22 | 2004-06-25 | Smithkline Beecham Corp | Polypeptides and polynucleotides and methods of identifying agonists and antagonists in relation to treatment of diseases |
JP2002015498A (ja) * | 2000-06-29 | 2002-01-18 | Fujitsu Ltd | センス電流の設定方法 |
JP5015404B2 (ja) * | 2000-08-08 | 2012-08-29 | ザイモジェネティクス, インコーポレイテッド | 可溶性zcytor11サイトカイン受容体 |
EP2298789B1 (en) | 2000-09-08 | 2012-03-14 | Schering Corporation | Mammalian genes; related reagents and methods |
US7855269B2 (en) * | 2000-09-15 | 2010-12-21 | Zymogenetics, Inc. | Method for treating inflammation |
US7268223B2 (en) | 2000-09-22 | 2007-09-11 | Wyeth | Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof |
US20030022827A1 (en) * | 2000-09-25 | 2003-01-30 | Bertram Weiss | Three new members of the cytokine receptor family class 2 |
AU2002249948B2 (en) | 2001-01-12 | 2007-08-23 | Genetics Institute, Llc | Type 2 cytokine receptor and nucleic acids encoding same |
WO2002058724A2 (en) | 2001-01-26 | 2002-08-01 | Eli Lilly And Company | Use of lp82 to treat body weight disorders |
MXPA03007413A (es) | 2001-02-23 | 2003-11-18 | Inst Genetics Llc | Composicion y metodo para tratar enfermedades inflamatorias. |
US7101539B2 (en) * | 2001-02-28 | 2006-09-05 | Eli Lilly And Company | Use of LP82 to treat hematopoietic disorders |
CA2439636A1 (en) * | 2001-03-02 | 2002-09-12 | Zymogenetics, Inc. | Mouse cytokine receptor |
WO2002072607A2 (en) * | 2001-03-09 | 2002-09-19 | Zymogenetics, Inc. | Soluble heterodimeric cytokine receptor |
US20030099608A1 (en) | 2001-03-27 | 2003-05-29 | Presnell Scott R. | Human cytokine receptor |
WO2002092771A2 (en) * | 2001-05-11 | 2002-11-21 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
US20040204351A1 (en) | 2001-10-22 | 2004-10-14 | Rowlinson Scott William | Soluble proteins that inhibit cytokine signal transduction pathways |
DE10154579A1 (de) | 2001-11-07 | 2003-05-28 | Medigene Ag | Topikale Verwendung von Cytokinen und Chemokinen zur Behandlung von viralen oder mykotischen Hauterkrankungen oder Tumorerkrankungen |
WO2003051384A1 (en) | 2001-12-17 | 2003-06-26 | Zymogenetics, Inc. | Method for treating cervical cancer |
US20040236075A1 (en) * | 2002-07-24 | 2004-11-25 | Laure Dumoutier | Novel glass II cytokine receptors, and uses thereof |
UA93179C2 (ru) * | 2003-03-24 | 2011-01-25 | Займоджинетикс, Инк. | Антитело, kotopoe специфически связывается c il-22ra, и способы его применения |
EA009026B1 (ru) * | 2003-03-24 | 2007-10-26 | Займоджинетикс, Инк. | Антитела против il-22ra, их партнеры по связыванию и способы их применения при воспалениях |
ATE447587T1 (de) * | 2003-11-21 | 2009-11-15 | Zymogenetics Inc | Anti-il-20-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen |
MX2007004770A (es) * | 2004-10-22 | 2007-11-22 | Zymogenetics Inc | Anticuerpos anti-il-22ra y moleculas y metodos para usarlos en inflamacion. |
-
2004
- 2004-03-24 EA EA200501505A patent/EA009026B1/ru not_active IP Right Cessation
- 2004-03-24 MX MXPA05010136A patent/MXPA05010136A/es active IP Right Grant
- 2004-03-24 AT AT04749427T patent/ATE475673T1/de active
- 2004-03-24 MX MXPA05010134A patent/MXPA05010134A/es unknown
- 2004-03-24 EP EP04758097A patent/EP1606316A2/en not_active Withdrawn
- 2004-03-24 KR KR1020057017960A patent/KR20050116392A/ko not_active Application Discontinuation
- 2004-03-24 AU AU2004223836A patent/AU2004223836A1/en not_active Abandoned
- 2004-03-24 ES ES04749427T patent/ES2347657T3/es not_active Expired - Lifetime
- 2004-03-24 KR KR1020057017908A patent/KR20050116390A/ko not_active Application Discontinuation
- 2004-03-24 DE DE602004028347T patent/DE602004028347D1/de not_active Expired - Lifetime
- 2004-03-24 AU AU2004223837A patent/AU2004223837C1/en not_active Ceased
- 2004-03-24 CA CA002519057A patent/CA2519057A1/en not_active Abandoned
- 2004-03-24 KR KR1020117017412A patent/KR20110091598A/ko not_active Application Discontinuation
- 2004-03-24 DK DK04749427.3T patent/DK1606317T3/da active
- 2004-03-24 CN CN2011101100944A patent/CN102690350A/zh active Pending
- 2004-03-24 WO PCT/US2004/008955 patent/WO2004085475A2/en active Application Filing
- 2004-03-24 CA CA2519089A patent/CA2519089C/en not_active Expired - Fee Related
- 2004-03-24 BR BRPI0408705-4A patent/BRPI0408705A/pt not_active Application Discontinuation
- 2004-03-24 JP JP2006507519A patent/JP2007525437A/ja active Pending
- 2004-03-24 US US10/807,837 patent/US20040209330A1/en not_active Abandoned
- 2004-03-24 EA EA200501506A patent/EA009124B1/ru not_active IP Right Cessation
- 2004-03-24 CN CN201310173876.1A patent/CN103864934A/zh active Pending
- 2004-03-24 BR BRPI0408683-0A patent/BRPI0408683A/pt not_active Application Discontinuation
- 2004-03-24 WO PCT/US2004/008956 patent/WO2004085476A2/en active Application Filing
- 2004-03-24 JP JP2006507520A patent/JP2007525438A/ja active Pending
- 2004-03-24 US US10/807,997 patent/US20060134756A1/en not_active Abandoned
- 2004-03-24 EP EP04749427A patent/EP1606317B1/en not_active Revoked
-
2005
- 2005-10-21 NO NO20054892A patent/NO20054892L/no not_active Application Discontinuation
-
2007
- 2007-11-27 US US11/945,975 patent/US20080233115A1/en not_active Abandoned
-
2008
- 2008-07-21 US US12/177,029 patent/US20090074661A1/en not_active Abandoned
-
2009
- 2009-10-16 US US12/580,987 patent/US8163286B2/en not_active Expired - Lifetime
-
2012
- 2012-03-22 US US13/427,077 patent/US20120207761A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200501506A1 (ru) | Антитела против il-20 и связывающие партнеры, а также способы их применения при воспалении | |
EA200700916A1 (ru) | Антитела против il-22ra и связывающие партнёры и способы применения указанных веществ при лечении воспаления | |
WO2005052000A3 (en) | Anti-il-20 antibodies and binding partners and methods of using in inflammation | |
WO2006086396A3 (en) | Anti-il-20, anti-il-22 and anti-il-22ra antibodies and binding partners and methods of using in inflammation | |
MXPA06014465A (es) | Zcytor14 soluble, anticuerpos anti-zcytor14 y moleculas de union y metodos de uso en inflamacion. | |
BR0314814A (pt) | Variantes otimizadas de fc e métodos para sua geração | |
DK1368060T3 (da) | HMGB1-proteininhibitorer og/eller antagonister til behandlingen af vaskulære sygdomme | |
EA200800956A1 (ru) | Антагонисты il-17a и il-17f и способы их использования | |
NO20054170L (no) | Antistoff mot human IL-21 reseptor og anvendelser derav | |
MA29226B1 (fr) | Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations | |
EA200600254A1 (ru) | Человеческие нейтрализующие антитела к фактору роста нервов (ngf) в качестве селективных ингибиторов метаболического пути ngf | |
ATE433973T1 (de) | Azolylaminoazine als inhibitoren von proteinkinasen | |
EA200400312A1 (ru) | АНТАГОНИСТИЧЕСКИЕ АНТИТЕЛА ПРОТИВ hTNFSF13b ЧЕЛОВЕКА | |
EA201070623A1 (ru) | Конструкция из полипептидов однодоменных антител, применение композиции, ее содержащей, и способ лечения ревматоидного артрита | |
NO20083697L (no) | Fremgangsmater for anvendelse av antistoffer mot human IL-22 | |
EA200700823A1 (ru) | Растворимый zcytor21, анти-zcytor21 антитела и связывающие партнёры и способы применения при воспалении | |
EA200600314A1 (ru) | Использование растворимого cd164 при воспалительных и/или аутоимунных нарушениях | |
EA200600956A1 (ru) | Молекулы-антагонисты цитокинов | |
EA200500624A1 (ru) | Промотор для il-18bp, его получение и применение | |
DE60206153D1 (de) | Verwendung von Efrapeptin Oligopeptiden zur Hemmung der Angiogenese | |
TH126202B (th) | แอนติบอดีเพื่อการทำให้เป็นกลางต้าน-ngf ของมนุษย์ดังที่เป็นสารยับยั้งวิถี ngf แบบคัดสรร |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |