UA93179C2 - Антитело, kotopoe специфически связывается c il-22ra, и способы его применения - Google Patents

Антитело, kotopoe специфически связывается c il-22ra, и способы его применения

Info

Publication number
UA93179C2
UA93179C2 UAA200509928A UA2005009928A UA93179C2 UA 93179 C2 UA93179 C2 UA 93179C2 UA A200509928 A UAA200509928 A UA A200509928A UA 2005009928 A UA2005009928 A UA 2005009928A UA 93179 C2 UA93179 C2 UA 93179C2
Authority
UA
Ukraine
Prior art keywords
antibody
specifically binds
antibodies
methods
mammal
Prior art date
Application number
UAA200509928A
Other languages
English (en)
Ukrainian (uk)
Inventor
Веньфен Сюй
Уейн Киндсвогель
Ясмин A. Чандрасекер
Стейси P. Диллон
Джойс M. Ленер
Энтони У. Сиадак
Паллавур B. Сивакумар
Маргарет Д. Myp
Original Assignee
Займоджинетикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Займоджинетикс, Инк. filed Critical Займоджинетикс, Инк.
Publication of UA93179C2 publication Critical patent/UA93179C2/ru

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Изобретение относится к моноклональному антителу или его фрагменту, которое специфически связывается с эпитопом, который состоит из остатков 93-120 трансмембранного домена IL-22RA (zcytor 11), где антитело или его фрагмент снижают противовоспалительную активность IL-22. Изобретение также относится к способу подавления IL-22-индуцированной пролиферации или дифференцирования гемопоэтических клеток и предшественников гемопоэтических клеток, способа ослабления IL-22-индуцированного воспаления, способа подавления воспалительного ответа у млекопитающего с воспалением, которое предусматривает сравнение уровня амилоидного белка А в сыворотке до введения композиции, которая содержит заявленное антитело, и после указанного введения.
UAA200509928A 2003-03-24 2004-03-24 Антитело, kotopoe специфически связывается c il-22ra, и способы его применения UA93179C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45748103P 2003-03-24 2003-03-24

Publications (1)

Publication Number Publication Date
UA93179C2 true UA93179C2 (ru) 2011-01-25

Family

ID=36819185

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200509928A UA93179C2 (ru) 2003-03-24 2004-03-24 Антитело, kotopoe специфически связывается c il-22ra, и способы его применения

Country Status (2)

Country Link
CN (2) CN1798768B (ru)
UA (1) UA93179C2 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110091598A (ko) * 2003-03-24 2011-08-11 지모제넥틱스, 인코포레이티드 항-ｉｌ-22ｒａ 항체 및 결합 파트너 및 염증에 있어서의 사용 방법
CN107019795A (zh) * 2009-01-27 2017-08-08 博格有限责任公司 用于减轻与化疗有关的副作用的维生素d3化合物
WO2014033252A1 (en) * 2012-08-31 2014-03-06 arGEN-X BV Method for producing antibody molecules having inter-species, intra-target cross-reactivity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965704A (en) * 1997-08-05 1999-10-12 Zymogenetics, Inc. Class two cytokine receptor-11
ES2381650T3 (es) * 2000-08-08 2012-05-30 Zymogenetics, Inc. Receptores de citoquinas Zcytor11 solubles

Also Published As

Publication number Publication date
CN1798768B (zh) 2013-05-08
CN1798768A (zh) 2006-07-05
CN1845937A (zh) 2006-10-11

Similar Documents

Publication Publication Date Title
Han et al. Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning
Sabag et al. Interleukin‐17 is a potential player and treatment target in severe chronic spontaneous urticaria
Detlefsen et al. Deposition of complement C3c, immunoglobulin (Ig) G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis
Granne et al. ST2 and IL-33 in pregnancy and pre-eclampsia
RU2007139452A (ru) СПОСОБЫ И КОМПОЗИЦИИ ДЛЯ МОДУЛИРОВАНИЯ ГИПЕРСТАБИЛИЗИРОВАННОГО c-met
BG111004A (bg) Антитела, които се свързват с човешки интерлевкин-18, и методи за получаване и използване
CR20130154A (es) Proteínas de la unión a il-12/p40 (divisional exp. 9599)
BRPI0408705A (pt) método para produzir um anticorpo para um polipeptìdeo, anticorpo produzido pelo mesmo, anticorpo ou fragmento de anticorpo que se liga a um polipeptìdeo, métodos para reduzir ou inibir a proliferação ou diferenciação induzida pela il-20 de células hematopoiéticas e progenitores de célula hematopoiética, para reduzir a inflamação induzida pela il-20, para suprimir uma resposta inflamatória em um mamìfero com inflamação, para tratar um mamìfero afligido com uma doença inflamatória, para tratar um condição patológica em um paciente associada com a atividade de il-20
Eberhardt et al. Differential expression of inwardly rectifying K+ channels and aquaporins 4 and 5 in autoimmune uveitis indicates misbalance in Müller glial cell‐dependent ion and water homeostasis
Walraven et al. Healthy human second‐trimester fetal skin is deficient in leukocytes and associated homing chemokines
DE69531679D1 (de) Für e-selectin und p-selectin spezifische kreuzreaktive monoklonale antikörper
HK1074670A1 (en) Sets of digital antibodies directed against short epitopes, and methods using same
WO2008045962A3 (en) Methods and materials related to anti-a (beta) antibodies
EP2053408A3 (en) A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
WO2005120557A3 (en) Inhibition of macrophage-stimulating protein receptor (ron)
Rosado et al. Expression of human leukocyte antigen-G in systemic lupus erythematosus
WO2005025604A3 (en) Use of hmgb and hmgb fragments to decrease specific immune response
CA2451680A1 (en) Human dr4 antibodies and uses thereof
Ghoreishi et al. Type 1 IFN‐induced protein MxA and plasmacytoid dendritic cells in lesions of morphea
Thaler et al. Abundant glutamic acid decarboxylase (GAD)‐reactive B cells in gad‐antibody–associated neurological disorders
Shi et al. IL‐22 produced by Th22 cells aggravates atherosclerosis development in ApoE−/− mice by enhancing DC‐induced Th17 cell proliferation
WO2005013912A3 (en) Anti-fcrn antibodies for treatment of auto/allo immune conditions
JOP20220193A1 (ar) صياغات من الأجسام المضادة لـ tslp البشرية وطرق لاستخدامها
Wee et al. Tissue-resident natural killer cells exacerbate tubulointerstitial fibrosis by activating transglutaminase 2 and syndecan-4 in a model of aristolochic acid-induced nephropathy
Kremer et al. Successful treatment of COVID‐19 infection with convalescent plasma in B‐cell‐depleted patients may promote cellular immunity