EA199800449A1 - Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов, используемые в этом способе промежуточные соединения и общий способ эпоксидирования двойных этиленовых связей - Google Patents

Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов, используемые в этом способе промежуточные соединения и общий способ эпоксидирования двойных этиленовых связей

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Publication number
EA199800449A1
EA199800449A1 EA199800449A EA199800449A EA199800449A1 EA 199800449 A1 EA199800449 A1 EA 199800449A1 EA 199800449 A EA199800449 A EA 199800449A EA 199800449 A EA199800449 A EA 199800449A EA 199800449 A1 EA199800449 A1 EA 199800449A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sup
group
chr
hydroxyalkyl
alpha
Prior art date
Application number
EA199800449A
Other languages
English (en)
Other versions
EA009176B1 (ru
Inventor
Джон С. Нг
Пин Т. Ван
Хулио А. Баес
Синь Лю
Деннис К. Андерсон
Джон П. Лосан
Дернхард Эрб
Джозеф Виецзорек
Дженнаро Муссиарьелло
Фортунато Ванцанелла
Сэстри А. Кунда
Лео Дж. Летендре
Марк Дж. Поццо
Юань-Лун Син
Original Assignee
Дж.Д.Серл Энд Ко.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дж.Д.Серл Энд Ко. filed Critical Дж.Д.Серл Энд Ко.
Publication of EA199800449A1 publication Critical patent/EA199800449A1/ru
Publication of EA009176B1 publication Critical patent/EA009176B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

В заявке описаны многочисленные новые схемы реакций, новые стадии способов и новые промежуточные продукты для синтеза эпоксимексренона и других соединений формулы (I),в которой -А-А- обозначает группу -CHR-CHR- или -CR=CR-; R, Rи Rнезависимо друг от друга выбирают из группы, включающей водород, галоген, гидроксил, (низш.)алкил, (низш.)алкоксигруппу, гидроксиалкил, алкоксиалкил, гидроксикарбонил, цианогруппу и арилоксигруппу; Rобозначает альфа-ориентированный (низш.)алкоксикарбонильный или гидроксиалкильный радикал; -В-В- обозначает группу -CHR-CHR- или альфа- или бета-ориентированную группу формулы (III),где Rи Rнезависимо друг от друга выбирают из группы, включающей водород, галоген, (низш.)алкоксигруппу, ацил, гидроксиалкил, алкоксиалкил, гидроксикарбонил, алкил, алкоксикарбонил, ацилоксиалкил, цианогруппу и арилоксигруппу, а Rи Rнезависимо друг от друга выбирают из группы, включающей водород, галоген, (низш.)алкоксигруппу, ацил, гидроксиалкил, алкоксиалкил, гидроксикарбонил, алкил, алкоксикарбонил, ацилоксиалкил, цианогруппу и арилоксигруппу, или Rи Rсовместно образуют карбоциклическую или гетероциклическую структуру, или либо R, либо Rсовместно с Rили с Rобразуют карбоциклическую или гетероциклическую структуру, конденсированную с пентациклическим D-кольцом.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800449A 1995-12-11 1996-12-11 Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов и промежуточных продуктов, используемых для их получения, и общий способ эпоксидирования по олефиновым двойным связям EA009176B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US845595P 1995-12-11 1995-12-11
US08/763,910 US5981744A (en) 1995-12-11 1996-12-11 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
PCT/US1996/020780 WO1997021720A2 (en) 1995-12-11 1996-12-11 Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds

Publications (2)

Publication Number Publication Date
EA199800449A1 true EA199800449A1 (ru) 1999-02-25
EA009176B1 EA009176B1 (ru) 2007-12-28

Family

ID=26678218

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800449A EA009176B1 (ru) 1995-12-11 1996-12-11 Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов и промежуточных продуктов, используемых для их получения, и общий способ эпоксидирования по олефиновым двойным связям

Country Status (12)

Country Link
US (13) US5981744A (ru)
EP (1) EP0973791B1 (ru)
JP (2) JP4146897B2 (ru)
CN (1) CN100384866C (ru)
AT (1) ATE365171T1 (ru)
DE (1) DE69637140T2 (ru)
DK (1) DK0973791T3 (ru)
EA (1) EA009176B1 (ru)
ES (1) ES2287943T3 (ru)
IL (2) IL124631A (ru)
PT (1) PT973791E (ru)
WO (1) WO1997021720A2 (ru)

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JP6835836B2 (ja) 2015-10-13 2021-02-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 脈絡膜血管新生の処置のための方法及び医薬組成物
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
US20190262363A1 (en) 2016-07-26 2019-08-29 INSERM (Institut National de la Santé et de la Recherche Médicale Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
CN106501388A (zh) * 2016-09-22 2017-03-15 北京万全德众医药生物技术有限公司 一种用气相色谱法分离测定依普利酮中三氯乙酰胺的方法
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Also Published As

Publication number Publication date
IL175299A0 (en) 2006-09-05
US20020019522A1 (en) 2002-02-14
US6331622B1 (en) 2001-12-18
EP0973791B1 (en) 2007-06-20
IL124631A (en) 2004-03-28
US6630587B2 (en) 2003-10-07
US20030100541A1 (en) 2003-05-29
DE69637140T2 (de) 2008-04-10
ES2287943T3 (es) 2007-12-16
US6258946B1 (en) 2001-07-10
CN1209136A (zh) 1999-02-24
WO1997021720A2 (en) 1997-06-19
JP2002504077A (ja) 2002-02-05
US20020016455A1 (en) 2002-02-07
JP2008100996A (ja) 2008-05-01
EP0973791A2 (en) 2000-01-26
PT973791E (pt) 2007-09-26
DE69637140D1 (de) 2007-08-02
US6180780B1 (en) 2001-01-30
ATE365171T1 (de) 2007-07-15
US7038040B2 (en) 2006-05-02
DK0973791T3 (da) 2007-09-17
US20020042507A1 (en) 2002-04-11
IL124631A0 (en) 1999-01-26
US20040067917A1 (en) 2004-04-08
US6335441B1 (en) 2002-01-01
JP4146897B2 (ja) 2008-09-10
US6586591B2 (en) 2003-07-01
US5981744A (en) 1999-11-09
US7129345B2 (en) 2006-10-31
US6953851B2 (en) 2005-10-11
EA009176B1 (ru) 2007-12-28
US20040191874A1 (en) 2004-09-30
US20050239761A1 (en) 2005-10-27
WO1997021720A3 (en) 1997-10-30
CN100384866C (zh) 2008-04-30
US20070060746A1 (en) 2007-03-15

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