DK3833670T3 - 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorphenyl)-2-methylpyrimidin-4(3h)-on-derivater og lignende forbindelser som PTPN11- (SHP2) hæmmere til cancerbehandling - Google Patents
6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorphenyl)-2-methylpyrimidin-4(3h)-on-derivater og lignende forbindelser som PTPN11- (SHP2) hæmmere til cancerbehandling Download PDFInfo
- Publication number
- DK3833670T3 DK3833670T3 DK19759185.2T DK19759185T DK3833670T3 DK 3833670 T3 DK3833670 T3 DK 3833670T3 DK 19759185 T DK19759185 T DK 19759185T DK 3833670 T3 DK3833670 T3 DK 3833670T3
- Authority
- DK
- Denmark
- Prior art keywords
- ptpn11
- shp2
- methylpyrimidin
- decan
- azaspiro
- Prior art date
Links
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 title 2
- WYUIJDCKOPRFJO-UHFFFAOYSA-N 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4-one Chemical class NC1C(OCC11CCN(CC1)C1=CC(N(C(=N1)C)C1=C(C(=CC=C1)Cl)Cl)=O)C WYUIJDCKOPRFJO-UHFFFAOYSA-N 0.000 title 1
- 101001087416 Homo sapiens Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862717588P | 2018-08-10 | 2018-08-10 | |
US201862773921P | 2018-11-30 | 2018-11-30 | |
PCT/US2019/045903 WO2020033828A1 (en) | 2018-08-10 | 2019-08-09 | 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3833670T3 true DK3833670T3 (da) | 2024-05-13 |
Family
ID=67766350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19759185.2T DK3833670T3 (da) | 2018-08-10 | 2019-08-09 | 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorphenyl)-2-methylpyrimidin-4(3h)-on-derivater og lignende forbindelser som PTPN11- (SHP2) hæmmere til cancerbehandling |
Country Status (21)
Country | Link |
---|---|
US (2) | US11104675B2 (da) |
EP (2) | EP4356973A3 (da) |
JP (2) | JP2021534124A (da) |
KR (1) | KR20210043569A (da) |
CN (1) | CN112601750B (da) |
AU (1) | AU2019319971A1 (da) |
BR (1) | BR112021002327A2 (da) |
CA (1) | CA3109181A1 (da) |
CL (1) | CL2021000355A1 (da) |
CO (1) | CO2021003074A2 (da) |
CR (1) | CR20210132A (da) |
DK (1) | DK3833670T3 (da) |
FI (1) | FI3833670T3 (da) |
IL (2) | IL307361A (da) |
MX (1) | MX2021001608A (da) |
PE (1) | PE20211050A1 (da) |
PH (1) | PH12021550268A1 (da) |
PT (1) | PT3833670T (da) |
SG (1) | SG11202100199UA (da) |
TW (1) | TWI827646B (da) |
WO (1) | WO2020033828A1 (da) |
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CN115721648A (zh) | 2018-05-09 | 2023-03-03 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
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TW202019921A (zh) | 2018-07-24 | 2020-06-01 | 日商大鵬藥品工業股份有限公司 | 用於抑制shp2活性之雜雙環化合物 |
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EP4356973A3 (en) | 2018-08-10 | 2024-06-26 | Navire Pharma, Inc. | 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer |
EA202191498A1 (ru) | 2018-11-30 | 2021-08-20 | Мерк Шарп энд Доум Корп. | 9-замещенные производные аминотриазолохиназолина в качестве антагонистов аденозиновых рецепторов, фармацевтические композиции и их применение |
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AR117183A1 (es) | 2018-11-30 | 2021-07-14 | Syngenta Crop Protection Ag | Derivados de tiazol microbiocidas |
EP4342473A3 (en) | 2018-11-30 | 2024-05-15 | GlaxoSmithKline Intellectual Property Development Limited | Compounds useful in hiv therapy |
AU2019389169A1 (en) | 2018-11-30 | 2021-06-17 | Comet Therapeutics, Inc. | Cyclic pantetheine derivatives and uses thereof |
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TW202019900A (zh) | 2020-06-01 |
US20220041594A1 (en) | 2022-02-10 |
WO2020033828A1 (en) | 2020-02-13 |
CN112601750A (zh) | 2021-04-02 |
JP2023144075A (ja) | 2023-10-06 |
PE20211050A1 (es) | 2021-06-04 |
US11945815B2 (en) | 2024-04-02 |
PH12021550268A1 (en) | 2021-11-03 |
SG11202100199UA (en) | 2021-02-25 |
CN112601750B (zh) | 2023-10-31 |
IL280701B1 (en) | 2023-11-01 |
CA3109181A1 (en) | 2020-02-13 |
IL280701A (en) | 2021-03-25 |
EP4356973A3 (en) | 2024-06-26 |
PT3833670T (pt) | 2024-05-22 |
AU2019319971A1 (en) | 2021-03-25 |
FI3833670T3 (fi) | 2024-05-21 |
KR20210043569A (ko) | 2021-04-21 |
MX2021001608A (es) | 2021-07-15 |
CR20210132A (es) | 2021-07-20 |
US11104675B2 (en) | 2021-08-31 |
CO2021003074A2 (es) | 2021-06-10 |
TWI827646B (zh) | 2024-01-01 |
EP4356973A2 (en) | 2024-04-24 |
BR112021002327A2 (pt) | 2021-05-04 |
IL307361A (en) | 2023-11-01 |
EP3833670B1 (en) | 2024-04-17 |
IL280701B2 (en) | 2024-03-01 |
US20200048249A1 (en) | 2020-02-13 |
JP2021534124A (ja) | 2021-12-09 |
CL2021000355A1 (es) | 2021-08-27 |
EP3833670A1 (en) | 2021-06-16 |
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