DK2424562T3 - Pneumokokvaccine og anvendelser deraf - Google Patents

Pneumokokvaccine og anvendelser deraf Download PDF

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DK2424562T3
DK2424562T3 DK10712546.0T DK10712546T DK2424562T3 DK 2424562 T3 DK2424562 T3 DK 2424562T3 DK 10712546 T DK10712546 T DK 10712546T DK 2424562 T3 DK2424562 T3 DK 2424562T3
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vaccine
pneumococcal
cpg
seq
serotypes
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DK10712546.0T
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Heather Lynn Davis
Arthur Mertz Krieg
Nicolai Lohse
Lars Ostergaard
Henrik Carl Schonheyder
Ole Schmeltz Sogaard
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Coley Pharm Group Inc
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

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Claims (9)

1. Pneumokokvaccine omfattende saccharid fra serotyper 4, 6B, 9V, 14, 18C, 19F og 23F, som enkeltvis er konjugeret med CRM197, og mindst en TLR-9-agonist som adjuvans, hvor den i det mindste ene TLR-9-agonist er et CpG-oligonukleotid med nukleinsyresekvensen udvalgt fra gruppen bestående af:5' TCGTCGTTTTTCGGTGCTTTT 3’ (SEQ ID NO:3), 5’ TCGTCGTTTTTCGGTCGTTTT 3’ (SEQ ID NO:4), 5’ TCGTCGTTTTGTCGTTTTGTCGTT 3’ (SEQ ID NO:5), 5’ TCGTCGTTTCGTCGTTTTGTCGTT 3’ (SEQ ID NO:6) og 5’ TCGTCGTTTTGTCGTTTTTTTCGA 3’ (SEQ ID NO:7) til anvendelse ved forebyggelse eller behandling af sygdomme forårsaget af en S. pneumoni-infektion i et immunsvækket individ, hvor det immunsvækkede individ lider af en HIV-infektion eller erhvervet immundefektsyndrom (AIDS) og er i højaktiv antiretroviral terapi (HAART).
2. Pneumokokvaccine til anvendelse ifølge krav 1, hvor CpG-oligonukleotidet er udvalgt fra gruppen bestående af: 5’ T*C*G*T*C*G*T*T*T*T*T*C*G*G*T*G*C*T*T*T*T 3' (SEQ ID NO:8) eller 5' T*C*G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T 3' (SEQ ID NO:9) eller 5' T*C*G*T*C*G*T*T*T*T*G*T*C*G*T*T*T*T*G*T*C*G*T*T 3' (SEQ ID NO:10) eller 5’ T*C*G*T*C*G*T*T*T*C*G*T*C*G*T*T*T*T*G*T*C*G*T*T 3' (SEQ ID NO:11) eller 5' T*C*G*T*C*G*T*T*T*T*G*T*C*G*T*T*T*T*T*T*T*C*G*A 3' (SEQ ID NO:12)' hvor * refererer til en phosphorothioat-binding.
3. Pneumokokvaccine til anvendelse ifølge krav 1 eller 2 omfattende fra 0,2 mg til 10 mg af CpG-oligonukleotid.
4. Pneumokokvaccine til anvendelse ifølge krav 1-3 omfattende saccharid fra serotyper 1,3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F og 23F, som enkeltvis er konjugeret med CRM197.
5. Pneumokokvaccine til anvendelse ifølge krav 1-4, hvor mængden af kon-jugat i hver vaccinedosis er fra 2 til 100 pg.
6. Pneumokokvaccine til anvendelse ifølge krav 1-5, som indeholder hvert S. pneumoni-kapselsaccharid i en dosis på mellem 1- 5 pg af saccharid.
7. Pneumokokvaccine til anvendelse ifølge krav 1-6, som indeholder natriumchlorid og/eller natriumsuccinatbuffer som hjælpestoffer.
8. Pneumokokvaccine til anvendelse ifølge krav 1-7, som omfatter alun, aluminiumhydroxid, aluminumfosfat eller aluminumsulfat som yderligere ad-juvans til den i det mindste ene TLR-9-agonistadjuvans.
9. Pneumokokvaccine til anvendelse ifølge krav 1 til 8, hvor det immunsvæk-kede individ, der skal vaccineres, er et voksent menneske på 55 år eller ældre.
DK10712546.0T 2009-04-30 2010-03-17 Pneumokokvaccine og anvendelser deraf DK2424562T3 (da)

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US17406809P 2009-04-30 2009-04-30
US23831309P 2009-08-31 2009-08-31
PCT/IB2010/051150 WO2010125480A1 (en) 2009-04-30 2010-03-17 Pneumococcal vaccine and uses thereof

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US (2) US20120052088A1 (da)
EP (1) EP2424562B1 (da)
JP (1) JP5823670B2 (da)
KR (1) KR101450958B1 (da)
CN (1) CN102413838A (da)
AU (1) AU2010243285B2 (da)
BR (1) BRPI1014494A2 (da)
CA (1) CA2757620C (da)
DK (1) DK2424562T3 (da)
ES (1) ES2552153T3 (da)
IL (1) IL215389A (da)
MX (1) MX340830B (da)
RU (1) RU2536248C2 (da)
WO (1) WO2010125480A1 (da)

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