DK2001466T3 - Lav-dosis rapamycin til behandling af vaskulær permeabilitets-relaterede sygdomme - Google Patents

Lav-dosis rapamycin til behandling af vaskulær permeabilitets-relaterede sygdomme Download PDF

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Publication number
DK2001466T3
DK2001466T3 DK07753937.7T DK07753937T DK2001466T3 DK 2001466 T3 DK2001466 T3 DK 2001466T3 DK 07753937 T DK07753937 T DK 07753937T DK 2001466 T3 DK2001466 T3 DK 2001466T3
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Prior art keywords
rapamycin
variations
subject
formulation
formulations
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DK07753937.7T
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English (en)
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Thierry Nivaggioli
Mary Gerritsen
David A Weber
David M Kleinman
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Santen Pharmaceutical Co Ltd
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Publication of DK2001466T3 publication Critical patent/DK2001466T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Claims (7)

1. Rapamycin til anvendelse i behandling afen sygdom eller lidelse valgt fra gruppen bestående af retinal ødem, influenza, viral hjernebetændelse, neuroretinitis, endotoxin-induceret ødem, vaskulitis, toksisk stofskifte-hjerneødem, hæmangiom, Von Hippel-Lindaus sygdom, angioneurotisk ødem, slangebid, højdehjerneødem (HACE), højdelungeødem (HAPE), lungeødem associeret med røginhalation, lungeødem associeret med iltmangel, hyponatræmisk hjerneødem, ødem associeret med stumpt traume, hjerneødem som følge af slagtilfælde eller lukket hovedtraume og hornhindeødem, hvor rapamycinen er i en form for administration til individet med en dosis ikke højere end 2 mg/kg.
2. Rapamycin til anvendelse ifølge krav 1, hvor rapamycinen er i en form for administration til individet med en dosis ikke højere end 0,5 mg/kg.
3. Rapamycin til anvendelse ifølge krav 1, hvor rapamycinen er i en form for administration til individet med en dosis ikke højere end 0,27 mg/kg.
4. Rapamycin til anvendelse ifølge krav 1, hvor rapamycinen er i en form for administration til individet med en dosis ikke højere end 0,07 mg/kg.
5. Rapamycin til anvendelse ifølge krav 1, hvor rapamycinen er i en form for administration til individet med en dosis ikke højere end 0,014 mg/kg.
6. Rapamycin til anvendelse ifølge et hvilket som helst af de foregående krav, hvor rapamycinen er i en form for administration indeholdende 2% vægt/vægt rapamycin, 4% vægt/vægt etanol og 94% vægt/vægt PEG400.
7. Rapamycin til anvendelse ifølge et hvilket som helst af de foregående krav, hvor individet er et menneskeligt individ.
DK07753937.7T 2006-03-23 2007-03-23 Lav-dosis rapamycin til behandling af vaskulær permeabilitets-relaterede sygdomme DK2001466T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78581406P 2006-03-23 2006-03-23
PCT/US2007/007353 WO2007112052A2 (en) 2006-03-23 2007-03-23 Formulations and methods for vascular permeability-related diseases or conditions

Publications (1)

Publication Number Publication Date
DK2001466T3 true DK2001466T3 (da) 2016-02-29

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DK07753937.7T DK2001466T3 (da) 2006-03-23 2007-03-23 Lav-dosis rapamycin til behandling af vaskulær permeabilitets-relaterede sygdomme

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Country Link
US (3) US8222271B2 (da)
EP (1) EP2001466B1 (da)
JP (2) JP5506378B2 (da)
KR (2) KR101520408B1 (da)
CN (2) CN103127100A (da)
AU (1) AU2007230964B2 (da)
BR (1) BRPI0709016A2 (da)
CA (1) CA2645488C (da)
DK (1) DK2001466T3 (da)
ES (1) ES2563288T3 (da)
HK (1) HK1126427A1 (da)
PL (1) PL2001466T3 (da)
WO (1) WO2007112052A2 (da)

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