DK1945186T3 - Faste orale farmaceutiske sammensætninger til dosering en gang daglig indeholdende pregabalin, et matrixdannende middel og et kvældemiddel - Google Patents
Faste orale farmaceutiske sammensætninger til dosering en gang daglig indeholdende pregabalin, et matrixdannende middel og et kvældemiddel Download PDFInfo
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- DK1945186T3 DK1945186T3 DK06809154.5T DK06809154T DK1945186T3 DK 1945186 T3 DK1945186 T3 DK 1945186T3 DK 06809154 T DK06809154 T DK 06809154T DK 1945186 T3 DK1945186 T3 DK 1945186T3
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Claims (12)
1. Farmaceutisk sammensætning omfattende et aktivt farmaceutisk stof og excipienser, idet det aktive farmaceutiske stof omfatter pregabalin eller et farmaceutisk acceptabelt kompleks, salt, solvat eller hydrat deraf, og excipienserne omfatter et matrixdannende middel og et kvældemiddel, idet det matrixdannende middel omfatter polyvinylacetat og polyvinylpyrrolidon, og kvældemidlet omfatter tværbunden polyvinyl-pyrrolidon, idet den farmaceutiske sammensætning er tilpasset til dosering én gang daglig.
2. Farmaceutisk sammensætning ifølge krav 1, hvor den farmaceutiske sammensætning ekspanderer til en størrelse på ca. 9 mm eller derover, når den kommer i kontakt med vand.
3. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den farmaceutiske sammensætning tilbageholdes i et individs mave efter oral dosering i ca. 3 timer til ca. 14 timer.
4. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvori det farmaceutisk aktive stof frigives i løbet af et tidsrum, der er ca. 4 timer til ca. 6 timer længere end den tid, den farmaceutiske sammensætning tilbageholdes i et individs mave efter oral dosering.
5. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor det farmaceutisk aktive stof frigives i løbet af et tidsrum fra ca. 12 timer til ca. 20 timer.
6. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvori det farmaceutisk aktive stof udviser en in-vivo-steady-state-CMAx på ca. 9 pg/ml eller derunder eller en in-vivo-steady-state-CMiN på ca. 0,7 pg/ml eller derover eller en in-vivo-steady-state-CMAx på ca. 9 pg/ml eller derunder og en in-vivo-steady-state-CMiN på ca. 0,7 pg/ml eller derover.
7. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvori kvældemidlet endvidere omfatter polyethylenoxid.
8. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den farmaceutiske sammensætning er bioækvivalent med et præparat med øjeblikkelig frigivelse, som omfatter pregabalin, lactosemonohydrat, majsstivelse og talkum.
9. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav til behandling af en tilstand eller lidelse i et individ, som reagerer på pregabalin.
10. Farmaceutisk sammensætning ifølge krav 9, hvor tilstanden eller lidelsen er valgt blandt epilepsi, smerte, diabetisk perifer neuropati, postherpetisk neuralgi, fysiologiske tilstande i forbindelse med psykomotoriske stimulanser, inflammation, gastrointestinal skade, alkoholisme, søvnløshed, fibromyalgi, angst, depression, mani og bipolær lidelse.
11. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 8 til anvendelse ved en fremgangsmåde til behandling af en tilstand eller lidelse i et individ, som reagerer på pregabalin, idet den farmaceutiske sammensætning indgives en gang daglig.
12. Farmaceutisk sammensætning til anvendelse ved en fremgangsmåde ifølge krav 11, hvor tilstanden eller lidelsen er valgt blandt epilepsi, smerte, diabetisk perifer neuropati, postherpetisk neuralgi, fysiologiske tilstande i forbindelse med psykomotoriske stimulanser, inflammation, gastrointestinal skade, alkoholisme, søvnløshed, fibromyalgi, angst, depression, mani og bipolær lidelse.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US73258905P | 2005-11-02 | 2005-11-02 | |
PCT/IB2006/003063 WO2007052125A2 (en) | 2005-11-02 | 2006-10-23 | Solid oral pharmaceutical compositions for once daily dosing containing pregabalin, a matrix forming agent and a swelling agent |
Publications (1)
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DK1945186T3 true DK1945186T3 (da) | 2014-03-17 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DK06809154.5T DK1945186T3 (da) | 2005-11-02 | 2006-10-23 | Faste orale farmaceutiske sammensætninger til dosering en gang daglig indeholdende pregabalin, et matrixdannende middel og et kvældemiddel |
Country Status (34)
Country | Link |
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US (11) | US20070269511A1 (da) |
EP (1) | EP1945186B1 (da) |
JP (1) | JP4334610B2 (da) |
KR (1) | KR101012533B1 (da) |
CN (1) | CN101330907B (da) |
AP (1) | AP2008004465A0 (da) |
AR (1) | AR058175A1 (da) |
AU (1) | AU2006310217B2 (da) |
BR (1) | BRPI0618211B8 (da) |
CA (1) | CA2628200C (da) |
CR (1) | CR9950A (da) |
DK (1) | DK1945186T3 (da) |
DO (1) | DOP2006000241A (da) |
EA (1) | EA012377B1 (da) |
EC (1) | ECSP088422A (da) |
ES (1) | ES2449231T3 (da) |
GT (1) | GT200600474A (da) |
HK (1) | HK1126394A1 (da) |
IL (1) | IL190827A (da) |
MA (1) | MA30135B1 (da) |
ME (1) | ME00482B (da) |
NL (1) | NL2000281C2 (da) |
NO (1) | NO20081816L (da) |
NZ (1) | NZ567414A (da) |
PE (1) | PE20070693A1 (da) |
PL (1) | PL1945186T3 (da) |
PT (1) | PT1945186E (da) |
RS (1) | RS20080181A (da) |
SI (1) | SI1945186T1 (da) |
TN (1) | TNSN08194A1 (da) |
TW (1) | TWI330080B (da) |
UY (1) | UY29890A1 (da) |
WO (1) | WO2007052125A2 (da) |
ZA (1) | ZA200803115B (da) |
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