DK1682545T3 - Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation - Google Patents

Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation

Info

Publication number: DK1682545T3
Authority: DK; Denmark
Prior art keywords: imidazopyridine; hiv; inflammation; treatment; receptor antagonist
Prior art date: 2003-10-03

Application number

DK04769496T

Other languages

Danish (da)

English (en)

Inventor

Paul Anthony Stupple

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2004-09-28

Publication date

2008-03-17

2003-10-03 Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en

2003-10-27 Priority claimed from GB0325020A external-priority patent/GB0325020D0/en

2004-08-19 Priority claimed from GB0418566A external-priority patent/GB0418566D0/en

2004-09-28 Application filed by Pfizer filed Critical Pfizer

2008-03-17 Application granted granted Critical

2008-03-17 Publication of DK1682545T3 publication Critical patent/DK1682545T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Immunology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Tropical Medicine & Parasitology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biotechnology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
AIDS & HIV (AREA)
Neurology (AREA)
Child & Adolescent Psychology (AREA)

DK04769496T 2003-10-03 2004-09-28 Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation DK1682545T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB0323236.0A GB0323236D0 (en)	2003-10-03	2003-10-03	Chemical compounds
GB0325020A GB0325020D0 (en)	2003-10-27	2003-10-27	Chemical compounds
GB0418566A GB0418566D0 (en)	2004-08-19	2004-08-19	Tropane derivatives
PCT/IB2004/003153 WO2005033107A1 (en)	2003-10-03	2004-09-28	Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (1)

Publication Number	Publication Date
DK1682545T3 true DK1682545T3 (da)	2008-03-17

Family

ID=34426592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04769496T DK1682545T3 (da)	2003-10-03	2004-09-28	Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation

Country Status (35)

Country	Link
US (2)	US7309790B2 (sr)
EP (1)	EP1682545B1 (sr)
JP (1)	JP4874107B2 (sr)
KR (1)	KR100777885B1 (sr)
AP (1)	AP2174A (sr)
AR (1)	AR045856A1 (sr)
AT (1)	ATE380813T1 (sr)
AU (1)	AU2004278158B2 (sr)
BR (1)	BRPI0414862A (sr)
CA (1)	CA2540834C (sr)
CY (1)	CY1107281T1 (sr)
DE (1)	DE602004010708T2 (sr)
DK (1)	DK1682545T3 (sr)
EA (1)	EA009941B1 (sr)
EC (1)	ECSP066475A (sr)
ES (1)	ES2295924T3 (sr)
GE (1)	GEP20084417B (sr)
HN (1)	HN2004000383A (sr)
HR (1)	HRP20080052T3 (sr)
IL (1)	IL174208A0 (sr)
MA (1)	MA28080A1 (sr)
MX (1)	MXPA06003749A (sr)
MY (1)	MY137609A (sr)
NO (1)	NO20061978L (sr)
NZ (1)	NZ545837A (sr)
OA (1)	OA13266A (sr)
PA (1)	PA8614301A1 (sr)
PE (1)	PE20050961A1 (sr)
PL (1)	PL1682545T3 (sr)
PT (1)	PT1682545E (sr)
RS (1)	RS20060198A (sr)
SI (1)	SI1682545T1 (sr)
TW (1)	TWI280244B (sr)
UY (1)	UY28546A1 (sr)
WO (1)	WO2005033107A1 (sr)

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TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
KR20120062863A (ko)	2003-07-30	2012-06-14	리겔 파마슈티칼스, 인크.	자가면역 질환의 치료 또는 예방에 사용하기 위한 2,4-피리미딘디아민 화합물
WO2006133426A2 (en)	2005-06-08	2006-12-14	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
US20070203161A1 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
US8962643B2 (en)	2006-02-24	2015-02-24	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the JAK pathway
CN103751186B (zh)	2006-04-05	2016-08-24	欧科生医股份有限公司	药物制剂：8-[{1-(3,5-双-(三氟甲基)苯基)-乙氧基}-甲基]-8-苯基-1,7-二氮杂-螺[4.5]癸-2-酮的盐及用其治疗的方法
US20080108586A1 (en) *	2006-09-06	2008-05-08	Incyte Corporation	Combination therapy for human immunodeficiency virus infection
CA2673125C (en)	2006-10-19	2015-04-21	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
EP2120938A4 (en) *	2006-12-20	2010-12-08	Merck Sharp & Dohme	IMIDAZOPYRIDINE ANALOGUE AS CB2 RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES
PE20081891A1 (es) *	2007-03-22	2008-12-27	Opko Health Inc	Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas
PL2074120T3 (pl) *	2007-10-25	2010-08-31	Exelixis Inc	Związki tropanu
NZ587589A (en)	2008-02-15	2012-10-26	Rigel Pharmaceuticals Inc	Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases
PT2323993E (pt)	2008-04-16	2015-10-12	Portola Pharm Inc	2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
CN103224497A (zh)	2008-04-22	2013-07-31	波托拉医药品公司	蛋白激酶抑制剂
EP2116618A1 (en)	2008-05-09	2009-11-11	Agency for Science, Technology And Research	Diagnosis and treatment of Kawasaki disease
EP3143996A1 (en)	2009-08-14	2017-03-22	OPKO Health, Inc.	Intravenous formulations of neurokinin 1-antagonists
MX2012011415A (es)	2010-04-02	2013-02-26	Phivco 1 Llc	Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico.
US9102625B2 (en)	2010-11-01	2015-08-11	Portola Pharmaceuticals, Inc.	Nicotinamides as JAK kinase modulators
US20140271680A1 (en)	2011-08-12	2014-09-18	Universite Paris-Est Creteil Val De Marne	Methods and pharmaceutical compositions for treatment of pulmonary hypertension
AU2012340555B2 (en)	2011-11-23	2016-10-20	Portola Pharmaceuticals, Inc.	Pyrazine kinase inhibitors
WO2014058921A2 (en)	2012-10-08	2014-04-17	Portola Pharmaceuticals, Inc.	Substituted pyrimidinyl kinase inhibitors
AU2014326601B2 (en) *	2013-09-25	2018-01-18	SpecGx LLC	Preparation of radioiodinated 3-fluoropropyl-nor-beta-CIT
GB201321748D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
WO2023192360A1 (en) *	2022-03-31	2023-10-05	Incelldx, Inc.	Methods of treating a subject for post-treatment lyme disease (ptld) and compositions for use in the same
WO2023192361A1 (en) *	2022-03-31	2023-10-05	Incelldx, Inc.	Methods of treating a subject for fibromyalgia and compositions for use in the same

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KR0166088B1 (ko)	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
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WO2003084954A1 (en) *	2002-04-08	2003-10-16	Pfizer Limited	Tropane derivatives as ccr5 modulators

2004
- 2004-09-28 US US10/953,136 patent/US7309790B2/en not_active Expired - Fee Related
- 2004-09-28 JP JP2006530737A patent/JP4874107B2/ja not_active Expired - Fee Related
- 2004-09-28 EA EA200600480A patent/EA009941B1/ru not_active IP Right Cessation
- 2004-09-28 RS YUP-2006/0198A patent/RS20060198A/sr unknown
- 2004-09-28 PT PT04769496T patent/PT1682545E/pt unknown
- 2004-09-28 AU AU2004278158A patent/AU2004278158B2/en not_active Ceased
- 2004-09-28 KR KR1020067006293A patent/KR100777885B1/ko not_active IP Right Cessation
- 2004-09-28 AT AT04769496T patent/ATE380813T1/de active
- 2004-09-28 SI SI200430564T patent/SI1682545T1/sl unknown
- 2004-09-28 MX MXPA06003749A patent/MXPA06003749A/es active IP Right Grant
- 2004-09-28 EP EP04769496A patent/EP1682545B1/en active Active
- 2004-09-28 DE DE602004010708T patent/DE602004010708T2/de active Active
- 2004-09-28 NZ NZ545837A patent/NZ545837A/en not_active IP Right Cessation
- 2004-09-28 OA OA1200600114A patent/OA13266A/en unknown
- 2004-09-28 DK DK04769496T patent/DK1682545T3/da active
- 2004-09-28 PL PL04769496T patent/PL1682545T3/pl unknown
- 2004-09-28 GE GEAP20049330A patent/GEP20084417B/en unknown
- 2004-09-28 BR BRPI0414862-2A patent/BRPI0414862A/pt not_active IP Right Cessation
- 2004-09-28 CA CA2540834A patent/CA2540834C/en not_active Expired - Fee Related
- 2004-09-28 AP AP2006003580A patent/AP2174A/xx active
- 2004-09-28 ES ES04769496T patent/ES2295924T3/es active Active
- 2004-09-28 WO PCT/IB2004/003153 patent/WO2005033107A1/en active IP Right Grant
- 2004-09-29 HN HN2004000383A patent/HN2004000383A/es unknown
- 2004-09-29 TW TW093129475A patent/TWI280244B/zh not_active IP Right Cessation
- 2004-10-01 PE PE2004000965A patent/PE20050961A1/es not_active Application Discontinuation
- 2004-10-01 PA PA20048614301A patent/PA8614301A1/es unknown
- 2004-10-01 MY MYPI20044043A patent/MY137609A/en unknown
- 2004-10-01 UY UY28546A patent/UY28546A1/es unknown
- 2004-10-01 AR ARP040103581A patent/AR045856A1/es not_active Application Discontinuation
2006
- 2006-03-09 IL IL174208A patent/IL174208A0/en unknown
- 2006-04-03 MA MA28906A patent/MA28080A1/fr unknown
- 2006-04-03 EC EC2006006475A patent/ECSP066475A/es unknown
- 2006-05-03 NO NO20061978A patent/NO20061978L/no not_active Application Discontinuation
2007
- 2007-08-27 US US11/845,500 patent/US7790740B2/en not_active Expired - Fee Related
2008
- 2008-01-30 HR HR20080052T patent/HRP20080052T3/xx unknown
- 2008-02-14 CY CY20081100178T patent/CY1107281T1/el unknown

Also Published As

Publication number	Publication date
AP2006003580A0 (en)	2006-04-30
HRP20080052T3 (en)	2008-02-29
RS20060198A (en)	2008-09-29
MXPA06003749A (es)	2006-06-14
US7309790B2 (en)	2007-12-18
AR045856A1 (es)	2005-11-16
PL1682545T3 (pl)	2008-04-30
OA13266A (en)	2007-01-31
DE602004010708T2 (de)	2008-12-04
AU2004278158B2 (en)	2009-08-13
CA2540834C (en)	2010-06-22
US20050131011A1 (en)	2005-06-16
CA2540834A1 (en)	2005-04-14
UY28546A1 (es)	2005-05-31
EA009941B1 (ru)	2008-04-28
AU2004278158A1 (en)	2005-04-14
KR100777885B1 (ko)	2007-11-28
BRPI0414862A (pt)	2006-11-28
MA28080A1 (fr)	2006-08-01
DE602004010708D1 (de)	2008-01-24
ECSP066475A (es)	2006-10-10
PT1682545E (pt)	2008-02-11
MY137609A (en)	2009-02-27
JP2007507483A (ja)	2007-03-29
EP1682545A1 (en)	2006-07-26
US7790740B2 (en)	2010-09-07
NZ545837A (en)	2009-12-24
EP1682545B1 (en)	2007-12-12
JP4874107B2 (ja)	2012-02-15
IL174208A0 (en)	2006-08-01
ATE380813T1 (de)	2007-12-15
NO20061978L (no)	2006-07-03
PE20050961A1 (es)	2005-11-29
KR20060070571A (ko)	2006-06-23
ES2295924T3 (es)	2008-04-16
GEP20084417B (en)	2008-07-10
TW200519112A (en)	2005-06-16
HN2004000383A (es)	2008-10-14
CY1107281T1 (el)	2012-11-21
WO2005033107A1 (en)	2005-04-14
US20080045563A1 (en)	2008-02-21
TWI280244B (en)	2007-05-01
AP2174A (en)	2010-11-20
SI1682545T1 (sl)	2008-04-30
PA8614301A1 (es)	2005-05-10
EA200600480A1 (ru)	2006-08-25

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