PE20050961A1 - Compuestos de imidazopiridina tropano sustituidos como antagonistas del receptor ccr5 - Google Patents

Compuestos de imidazopiridina tropano sustituidos como antagonistas del receptor ccr5

Info

Publication number
PE20050961A1
PE20050961A1 PE2004000965A PE2004000965A PE20050961A1 PE 20050961 A1 PE20050961 A1 PE 20050961A1 PE 2004000965 A PE2004000965 A PE 2004000965A PE 2004000965 A PE2004000965 A PE 2004000965A PE 20050961 A1 PE20050961 A1 PE 20050961A1
Authority
PE
Peru
Prior art keywords
imidazopyridine
azabicyclo
endo
pyridin
acetamide
Prior art date
Application number
PE2004000965A
Other languages
English (en)
Inventor
Paul Anthony Stupple
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en
Priority claimed from GB0325020A external-priority patent/GB0325020D0/en
Priority claimed from GB0418566A external-priority patent/GB0418566D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20050961A1 publication Critical patent/PE20050961A1/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61P31/12—Antivirals
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

SE REFIERE A COMPUESTOS IMIDAZOPIRIDINA TROPANO SUSTITUIDOS, DE FORMULA (I), EN DONDE R1 ES ALQUILO(C1-C6); R2 ES ALQUILO(C1-C6) O CICLOALQUILO(C3-C7), EL CUAL ESTA OPCIONALMENTE SUSTITUIDO CON CF3. SON COMPUESTOS PREFERIDOS: N-{(1S)-3-[3-ENDO-(5-ACETIL-2-METIL-4,5,6,7-TETRAHIDRO-1H-IMIDAZOL[4,5-c]PIRIDIN-1-IL)-8-AZABICICLO[3.2.1]OCT-8-IL]-1-(3-FLUOROFENIL)PROPIL}ACETAMIDA, N-{(1S)-3-[3-ENDO-(5-ISOBUTIRIL-2-METIL-4,5,6,7-TETRAHIDRO-1H-IMIDAZOL[4,5-c]PIRIDIN-1-IL)-8-AZABICICLO[3.2.1]OCT-8-IL]-1-(3-FLUOROFENIL)PROPIL}ACETAMIDA, N-{(1S)-3-[3-ENDO-(5-CICLOPROPANOCARBONIL-2-METIL-4,5,6,7-TETRAHIDRO-1H-IMIDAZOL[4,5-c]PIRIDIN-1-IL)-8-AZABICICLO[3.2.1]OCT-8-IL]-1-(3-FLUOROFENIL)PROPIL}ACETAMIDA, ENTRE OTROS. ESTOS COMPUESTOS SON ANTAGONISTAS DE LA ACTIVIDAD DE RECEPTORES CCR5, POR LO QUESON UTILES EN EL TRATAMIENTO DE DIVERSAS ENFERMEDADES Y AFECCIONES INFLAMATORIAS Y EN EL TRATAMIENTO DE INFECCION POR VIH Y RETROVIRUS GENETICAMENTE RELACIONADOS
PE2004000965A 2003-10-03 2004-10-01 Compuestos de imidazopiridina tropano sustituidos como antagonistas del receptor ccr5 PE20050961A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0323236.0A GB0323236D0 (en) 2003-10-03 2003-10-03 Chemical compounds
GB0325020A GB0325020D0 (en) 2003-10-27 2003-10-27 Chemical compounds
GB0418566A GB0418566D0 (en) 2004-08-19 2004-08-19 Tropane derivatives

Publications (1)

Publication Number Publication Date
PE20050961A1 true PE20050961A1 (es) 2005-11-29

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PE2004000965A PE20050961A1 (es) 2003-10-03 2004-10-01 Compuestos de imidazopiridina tropano sustituidos como antagonistas del receptor ccr5

Country Status (35)

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US (2) US7309790B2 (es)
EP (1) EP1682545B1 (es)
JP (1) JP4874107B2 (es)
KR (1) KR100777885B1 (es)
AP (1) AP2174A (es)
AR (1) AR045856A1 (es)
AT (1) ATE380813T1 (es)
AU (1) AU2004278158B2 (es)
BR (1) BRPI0414862A (es)
CA (1) CA2540834C (es)
CY (1) CY1107281T1 (es)
DE (1) DE602004010708T2 (es)
DK (1) DK1682545T3 (es)
EA (1) EA009941B1 (es)
EC (1) ECSP066475A (es)
ES (1) ES2295924T3 (es)
GE (1) GEP20084417B (es)
HN (1) HN2004000383A (es)
HR (1) HRP20080052T3 (es)
IL (1) IL174208A0 (es)
MA (1) MA28080A1 (es)
MX (1) MXPA06003749A (es)
MY (1) MY137609A (es)
NO (1) NO20061978L (es)
NZ (1) NZ545837A (es)
OA (1) OA13266A (es)
PA (1) PA8614301A1 (es)
PE (1) PE20050961A1 (es)
PL (1) PL1682545T3 (es)
PT (1) PT1682545E (es)
RS (1) RS20060198A (es)
SI (1) SI1682545T1 (es)
TW (1) TWI280244B (es)
UY (1) UY28546A1 (es)
WO (1) WO2005033107A1 (es)

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KR100777885B1 (ko) 2007-11-28
EP1682545A1 (en) 2006-07-26
MXPA06003749A (es) 2006-06-14
SI1682545T1 (sl) 2008-04-30
TW200519112A (en) 2005-06-16
HRP20080052T3 (en) 2008-02-29
TWI280244B (en) 2007-05-01
US20050131011A1 (en) 2005-06-16
US7309790B2 (en) 2007-12-18
US20080045563A1 (en) 2008-02-21
DE602004010708T2 (de) 2008-12-04
ES2295924T3 (es) 2008-04-16
DE602004010708D1 (de) 2008-01-24
PT1682545E (pt) 2008-02-11
KR20060070571A (ko) 2006-06-23
MA28080A1 (fr) 2006-08-01
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