BRPI0414862A - derivados de tropano substituìdos com imidazopiridina com atividade antagonista do receptor ccr5, para o tratamento do hiv e da inflamação - Google Patents

derivados de tropano substituìdos com imidazopiridina com atividade antagonista do receptor ccr5, para o tratamento do hiv e da inflamação

Info

Publication number
BRPI0414862A
BRPI0414862A BRPI0414862-2A BRPI0414862A BRPI0414862A BR PI0414862 A BRPI0414862 A BR PI0414862A BR PI0414862 A BRPI0414862 A BR PI0414862A BR PI0414862 A BRPI0414862 A BR PI0414862A
Authority
BR
Brazil
Prior art keywords
treatment
hiv
inflammation
ccr5 receptor
imidazopyridine
Prior art date
Application number
BRPI0414862-2A
Other languages
English (en)
Inventor
Paul Anthony Stupple
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en
Priority claimed from GB0325020A external-priority patent/GB0325020D0/en
Priority claimed from GB0418566A external-priority patent/GB0418566D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0414862A publication Critical patent/BRPI0414862A/pt

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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

"DERIVADOS DE TROPANO SUBSTITUìDOS COM IMIDAZOPIRIDINA COM ATIVIDADE ANTAGONISTA DO RECEPTOR CCR5, PARA O TRATAMENTO DO HIV E DA INFLAMAçãO". A presente invenção refere-se a compostos de fórmula (I) em que R¬ 1¬ e R¬ 2¬ são tais como foram definidos acima neste documento. Os compostos da presente invenção são moduladores, e em particular antagonistas, da atividade dos receptores CCR5 de quimiocinas. Os moduladores dos receptores CCR5 podem ser úteis para o tratamento de diversas doenças e condições inflamatórias, e para o tratamento da infecção por HIV e por retrovírus geneticamente relacionados com este.
BRPI0414862-2A 2003-10-03 2004-09-28 derivados de tropano substituìdos com imidazopiridina com atividade antagonista do receptor ccr5, para o tratamento do hiv e da inflamação BRPI0414862A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0323236.0A GB0323236D0 (en) 2003-10-03 2003-10-03 Chemical compounds
GB0325020A GB0325020D0 (en) 2003-10-27 2003-10-27 Chemical compounds
GB0418566A GB0418566D0 (en) 2004-08-19 2004-08-19 Tropane derivatives
PCT/IB2004/003153 WO2005033107A1 (en) 2003-10-03 2004-09-28 Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (1)

Publication Number Publication Date
BRPI0414862A true BRPI0414862A (pt) 2006-11-28

Family

ID=34426592

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414862-2A BRPI0414862A (pt) 2003-10-03 2004-09-28 derivados de tropano substituìdos com imidazopiridina com atividade antagonista do receptor ccr5, para o tratamento do hiv e da inflamação

Country Status (35)

Country Link
US (2) US7309790B2 (pt)
EP (1) EP1682545B1 (pt)
JP (1) JP4874107B2 (pt)
KR (1) KR100777885B1 (pt)
AP (1) AP2174A (pt)
AR (1) AR045856A1 (pt)
AT (1) ATE380813T1 (pt)
AU (1) AU2004278158B2 (pt)
BR (1) BRPI0414862A (pt)
CA (1) CA2540834C (pt)
CY (1) CY1107281T1 (pt)
DE (1) DE602004010708T2 (pt)
DK (1) DK1682545T3 (pt)
EA (1) EA009941B1 (pt)
EC (1) ECSP066475A (pt)
ES (1) ES2295924T3 (pt)
GE (1) GEP20084417B (pt)
HN (1) HN2004000383A (pt)
HR (1) HRP20080052T3 (pt)
IL (1) IL174208A0 (pt)
MA (1) MA28080A1 (pt)
MX (1) MXPA06003749A (pt)
MY (1) MY137609A (pt)
NO (1) NO20061978L (pt)
NZ (1) NZ545837A (pt)
OA (1) OA13266A (pt)
PA (1) PA8614301A1 (pt)
PE (1) PE20050961A1 (pt)
PL (1) PL1682545T3 (pt)
PT (1) PT1682545E (pt)
RS (1) RS20060198A (pt)
SI (1) SI1682545T1 (pt)
TW (1) TWI280244B (pt)
UY (1) UY28546A1 (pt)
WO (1) WO2005033107A1 (pt)

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KR100777885B1 (ko) 2007-11-28
EP1682545A1 (en) 2006-07-26
MXPA06003749A (es) 2006-06-14
SI1682545T1 (sl) 2008-04-30
TW200519112A (en) 2005-06-16
HRP20080052T3 (en) 2008-02-29
TWI280244B (en) 2007-05-01
US20050131011A1 (en) 2005-06-16
US7309790B2 (en) 2007-12-18
US20080045563A1 (en) 2008-02-21
DE602004010708T2 (de) 2008-12-04
ES2295924T3 (es) 2008-04-16
DE602004010708D1 (de) 2008-01-24
PT1682545E (pt) 2008-02-11
KR20060070571A (ko) 2006-06-23
MA28080A1 (fr) 2006-08-01
CY1107281T1 (el) 2012-11-21
MY137609A (en) 2009-02-27
IL174208A0 (en) 2006-08-01
DK1682545T3 (da) 2008-03-17
WO2005033107A1 (en) 2005-04-14
US7790740B2 (en) 2010-09-07
JP4874107B2 (ja) 2012-02-15
AU2004278158A1 (en) 2005-04-14
EA200600480A1 (ru) 2006-08-25
ATE380813T1 (de) 2007-12-15
AU2004278158B2 (en) 2009-08-13
OA13266A (en) 2007-01-31
AR045856A1 (es) 2005-11-16
EA009941B1 (ru) 2008-04-28
AP2006003580A0 (en) 2006-04-30
PL1682545T3 (pl) 2008-04-30
NO20061978L (no) 2006-07-03
CA2540834C (en) 2010-06-22
AP2174A (en) 2010-11-20
PE20050961A1 (es) 2005-11-29
GEP20084417B (en) 2008-07-10
HN2004000383A (es) 2008-10-14
RS20060198A (en) 2008-09-29
EP1682545B1 (en) 2007-12-12
UY28546A1 (es) 2005-05-31
CA2540834A1 (en) 2005-04-14
ECSP066475A (es) 2006-10-10
JP2007507483A (ja) 2007-03-29
PA8614301A1 (es) 2005-05-10
NZ545837A (en) 2009-12-24

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