RS20060198A - Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activ ity for the treatment of hiv and inflammation - Google Patents
Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activ ity for the treatment of hiv and inflammationInfo
- Publication number
- RS20060198A RS20060198A YUP-2006/0198A YUP20060198A RS20060198A RS 20060198 A RS20060198 A RS 20060198A YU P20060198 A YUP20060198 A YU P20060198A RS 20060198 A RS20060198 A RS 20060198A
- Authority
- RS
- Serbia
- Prior art keywords
- treatment
- hiv
- inflammation
- receptor antagonist
- ccr5 receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Ovaj pronalazak obezbeđuje jedinjenja formule (I), pri čemu su R1 i R2 kako je ovde prethodno definisano. Jedinjenja iz ovog pronalaska su modulatori, posebno antagonisti, delovanja hemokin CCR5 receptora. Modulatori CCR5 receptora mogu da budu korisni u tretmanu različitih inflamatornih bolesti i stanja i u tretmanu infekcije HIV-om i genetički povezanim retrovirusima.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0323236.0A GB0323236D0 (en) | 2003-10-03 | 2003-10-03 | Chemical compounds |
GB0325020A GB0325020D0 (en) | 2003-10-27 | 2003-10-27 | Chemical compounds |
GB0418566A GB0418566D0 (en) | 2004-08-19 | 2004-08-19 | Tropane derivatives |
PCT/IB2004/003153 WO2005033107A1 (en) | 2003-10-03 | 2004-09-28 | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation |
Publications (1)
Publication Number | Publication Date |
---|---|
RS20060198A true RS20060198A (en) | 2008-09-29 |
Family
ID=34426592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2006/0198A RS20060198A (en) | 2003-10-03 | 2004-09-28 | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activ ity for the treatment of hiv and inflammation |
Country Status (35)
Country | Link |
---|---|
US (2) | US7309790B2 (sr) |
EP (1) | EP1682545B1 (sr) |
JP (1) | JP4874107B2 (sr) |
KR (1) | KR100777885B1 (sr) |
AP (1) | AP2174A (sr) |
AR (1) | AR045856A1 (sr) |
AT (1) | ATE380813T1 (sr) |
AU (1) | AU2004278158B2 (sr) |
BR (1) | BRPI0414862A (sr) |
CA (1) | CA2540834C (sr) |
CY (1) | CY1107281T1 (sr) |
DE (1) | DE602004010708T2 (sr) |
DK (1) | DK1682545T3 (sr) |
EA (1) | EA009941B1 (sr) |
EC (1) | ECSP066475A (sr) |
ES (1) | ES2295924T3 (sr) |
GE (1) | GEP20084417B (sr) |
HN (1) | HN2004000383A (sr) |
HR (1) | HRP20080052T3 (sr) |
IL (1) | IL174208A0 (sr) |
MA (1) | MA28080A1 (sr) |
MX (1) | MXPA06003749A (sr) |
MY (1) | MY137609A (sr) |
NO (1) | NO20061978L (sr) |
NZ (1) | NZ545837A (sr) |
OA (1) | OA13266A (sr) |
PA (1) | PA8614301A1 (sr) |
PE (1) | PE20050961A1 (sr) |
PL (1) | PL1682545T3 (sr) |
PT (1) | PT1682545E (sr) |
RS (1) | RS20060198A (sr) |
SI (1) | SI1682545T1 (sr) |
TW (1) | TWI280244B (sr) |
UY (1) | UY28546A1 (sr) |
WO (1) | WO2005033107A1 (sr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
CN1849318B (zh) | 2003-07-30 | 2011-10-12 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物预防和治疗自体免疫疾病的方法 |
US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
KR101312225B1 (ko) | 2005-06-08 | 2013-09-26 | 리겔 파마슈티칼스, 인크. | Jak 경로의 억제를 위한 조성물 및 방법 |
JP2009528295A (ja) | 2006-02-24 | 2009-08-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Jak経路の阻害のための組成物および方法 |
WO2007114921A2 (en) | 2006-04-05 | 2007-10-11 | Schering Corporation | Pharmaceutical formulations: salts of 8-[{1-(3,5-bis (trifluoromethy1)pheny1)-e thoxy}-methy1]-8-pheny1-1,7-diaza-spiro[4.5] decan-2-one and treatment methods using the same |
WO2008030853A2 (en) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
DE602007012363D1 (de) | 2006-10-19 | 2011-03-17 | Rigel Pharmaceuticals Inc | 2,4-pyridimediamon-derivate als hemmer von jak-kinasen zur behandlung von autoimmunerkrankungen |
WO2008085302A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
AR065802A1 (es) * | 2007-03-22 | 2009-07-01 | Schering Corp | Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas |
NZ585137A (en) * | 2007-10-25 | 2012-07-27 | Exelixis Inc | Tropane compounds useful as hsp90 inhibitors |
PL2265607T3 (pl) | 2008-02-15 | 2017-07-31 | Rigel Pharmaceuticals, Inc. | Związki pirymidyno-2-aminowe i ich zastosowanie jako inhibitory kinaz JAK |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
NZ589315A (en) | 2008-04-16 | 2012-11-30 | Portola Pharm Inc | 2,6-diamino-pyrimidin-5-yl-carboxamides as Spleen tryosine kinase (syk) or Janus kinase (JAK) inhibitors |
CA2723185A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
RU2017145628A (ru) | 2009-08-14 | 2019-02-19 | ОПКО Хельс, Инк. | Композиции антагонистов нейрокинина-1 для внутривенного введения |
BR112012024522A2 (pt) | 2010-04-02 | 2017-08-08 | Phivco 1 Llc | combinação, uso de uma combinação, composição farmacêutica, forma de dosagem única , kit, e, método para tratar um distúrbio |
US9102625B2 (en) | 2010-11-01 | 2015-08-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as JAK kinase modulators |
US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
EP2782579B1 (en) | 2011-11-23 | 2019-01-02 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
US9676756B2 (en) | 2012-10-08 | 2017-06-13 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
PL3049378T3 (pl) * | 2013-09-25 | 2019-06-28 | SpecGx LLC | Wytwarzanie radiojodowanego 3-fluoropropylo-nor-beta-CIT |
GB201321748D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
WO2023192360A1 (en) * | 2022-03-31 | 2023-10-05 | Incelldx, Inc. | Methods of treating a subject for post-treatment lyme disease (ptld) and compositions for use in the same |
WO2023192361A1 (en) * | 2022-03-31 | 2023-10-05 | Incelldx, Inc. | Methods of treating a subject for fibromyalgia and compositions for use in the same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
KR100210417B1 (ko) | 1994-04-19 | 1999-07-15 | 페더 벨링 | 신경전달물질 재흡수 억제제인 트로판-2-알독심 유도체 |
GB9518953D0 (en) * | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
ATE203023T1 (de) | 1996-02-22 | 2001-07-15 | Neurosearch As | Tropanderivate, deren herstellung und verwendung |
WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
TR200400541T4 (tr) * | 2000-05-26 | 2004-04-21 | Pfizer Inc. | Terapide faydalı tropan türevleri. |
CN1324025C (zh) * | 2002-04-08 | 2007-07-04 | 美国辉瑞有限公司 | 作为ccr5调节剂的托烷衍生物 |
US6855724B2 (en) * | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
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2004
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- 2004-09-28 RS YUP-2006/0198A patent/RS20060198A/sr unknown
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- 2004-09-28 WO PCT/IB2004/003153 patent/WO2005033107A1/en active IP Right Grant
- 2004-09-28 PL PL04769496T patent/PL1682545T3/pl unknown
- 2004-09-28 JP JP2006530737A patent/JP4874107B2/ja not_active Expired - Fee Related
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- 2004-09-28 US US10/953,136 patent/US7309790B2/en not_active Expired - Fee Related
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- 2004-09-28 AP AP2006003580A patent/AP2174A/xx active
- 2004-09-28 NZ NZ545837A patent/NZ545837A/en not_active IP Right Cessation
- 2004-09-28 GE GEAP20049330A patent/GEP20084417B/en unknown
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2007
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