DK1666028T3 - Tørre pulversammensætninger med forbedret dispersitet - Google Patents

Tørre pulversammensætninger med forbedret dispersitet

Info

Publication number
DK1666028T3
DK1666028T3 DK05027610.4T DK05027610T DK1666028T3 DK 1666028 T3 DK1666028 T3 DK 1666028T3 DK 05027610 T DK05027610 T DK 05027610T DK 1666028 T3 DK1666028 T3 DK 1666028T3
Authority
DK
Denmark
Prior art keywords
dry powder
powder compositions
formulation
tripeptide
lung
Prior art date
Application number
DK05027610.4T
Other languages
English (en)
Inventor
David Lechuga-Ballesteros
Mei-Chang Kuo
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK1666028T3 publication Critical patent/DK1666028T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
DK05027610.4T 1999-10-29 2000-04-12 Tørre pulversammensætninger med forbedret dispersitet DK1666028T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16245199P 1999-10-29 1999-10-29
US16423699P 1999-11-08 1999-11-08
US17276999P 1999-12-20 1999-12-20
US17838300P 2000-01-27 2000-01-27
US17841500P 2000-01-27 2000-01-27
EP00922117A EP1223915B1 (en) 1999-10-29 2000-04-12 Dry powder compositions having improved dispersivity

Publications (1)

Publication Number Publication Date
DK1666028T3 true DK1666028T3 (da) 2010-06-21

Family

ID=27538661

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00922117T DK1223915T3 (da) 1999-10-29 2000-04-12 Törpulverpræparater med forbedret dispersivitet
DK05027610.4T DK1666028T3 (da) 1999-10-29 2000-04-12 Tørre pulversammensætninger med forbedret dispersitet

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00922117T DK1223915T3 (da) 1999-10-29 2000-04-12 Törpulverpræparater med forbedret dispersivitet

Country Status (21)

Country Link
US (4) US6518239B1 (da)
EP (2) EP1666028B1 (da)
JP (2) JP4859320B2 (da)
KR (1) KR100702878B1 (da)
CN (1) CN1188111C (da)
AT (2) ATE313318T1 (da)
AU (1) AU775565B2 (da)
CA (1) CA2389219C (da)
CY (1) CY1110136T1 (da)
DE (2) DE60025019T2 (da)
DK (2) DK1223915T3 (da)
ES (2) ES2343124T3 (da)
HK (1) HK1092687A1 (da)
HU (1) HU229310B1 (da)
IL (2) IL149085A0 (da)
MX (1) MXPA02004193A (da)
NO (1) NO332144B1 (da)
NZ (1) NZ518401A (da)
PT (1) PT1666028E (da)
TW (1) TWI310688B (da)
WO (1) WO2001032144A1 (da)

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WO1994007514A1 (en) * 1992-09-29 1994-04-14 Inhale Therapeutic Systems Pulmonary delivery of active fragments of parathyroid hormone
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US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
KR100384353B1 (ko) * 1994-05-18 2003-10-04 네크타르 테라퓨틱스 인터페론의건조분말제형을제조하기위한방법및조성물
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US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
CA2387016C (en) 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
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CA2635489A1 (en) * 2000-02-11 2001-08-16 Respironics Respiratory Drug Delivery (Uk) Ltd Drug delivery apparatus
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