DK1598340T3 - 1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte - Google Patents

1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte

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Publication number
DK1598340T3
DK1598340T3 DK05014117T DK05014117T DK1598340T3 DK 1598340 T3 DK1598340 T3 DK 1598340T3 DK 05014117 T DK05014117 T DK 05014117T DK 05014117 T DK05014117 T DK 05014117T DK 1598340 T3 DK1598340 T3 DK 1598340T3
Authority
DK
Denmark
Prior art keywords
orl1
pain
treatment
benzoxazol
piperidinyl
Prior art date
Application number
DK05014117T
Other languages
Danish (da)
English (en)
Inventor
Qun Sun
Richard R Goehring
Donald Kyle
Zhengming Chen
John Whitehead
Sam Victory
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27501377&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1598340(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of DK1598340T3 publication Critical patent/DK1598340T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
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  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Finishing Walls (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK05014117T 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte DK1598340T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28466901P 2001-04-18 2001-04-18
US28466701P 2001-04-18 2001-04-18
US28466601P 2001-04-18 2001-04-18
US28466801P 2001-04-18 2001-04-18
PCT/US2002/012351 WO2002085357A1 (en) 2001-04-18 2002-04-18 Nociceptin analogs

Publications (1)

Publication Number Publication Date
DK1598340T3 true DK1598340T3 (da) 2009-05-11

Family

ID=27501377

Family Applications (4)

Application Number Title Priority Date Filing Date
DK05014115.9T DK1598338T5 (da) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-indol-2-on-derivater og relaterede forbindelser som nociceptinanaloger og ORL1-ligander til behandlingen af smerte
DK02764236T DK1379246T3 (da) 2001-04-18 2002-04-18 Nocieptin-analoger
DK05014116T DK1598339T3 (da) 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2H-benzimidazol-2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1-ligander til behandling af smerte
DK05014117T DK1598340T3 (da) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DK05014115.9T DK1598338T5 (da) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-indol-2-on-derivater og relaterede forbindelser som nociceptinanaloger og ORL1-ligander til behandlingen af smerte
DK02764236T DK1379246T3 (da) 2001-04-18 2002-04-18 Nocieptin-analoger
DK05014116T DK1598339T3 (da) 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2H-benzimidazol-2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1-ligander til behandling af smerte

Country Status (26)

Country Link
US (4) US6867222B2 (no)
EP (7) EP1598340B1 (no)
JP (4) JP4364513B2 (no)
KR (2) KR100847296B1 (no)
CN (1) CN100352816C (no)
AT (4) ATE424385T1 (no)
AU (1) AU2002307416B2 (no)
BR (1) BR0209129A (no)
CA (1) CA2444198C (no)
CL (2) CL2009001279A1 (no)
CY (4) CY1108707T1 (no)
CZ (1) CZ20032850A3 (no)
DE (4) DE60232752D1 (no)
DK (4) DK1598338T5 (no)
ES (4) ES2315394T3 (no)
HK (4) HK1063149A1 (no)
HU (1) HUP0401109A3 (no)
IL (4) IL158484A0 (no)
MX (1) MXPA03009600A (no)
NO (1) NO20034661L (no)
NZ (5) NZ528977A (no)
PL (1) PL367310A1 (no)
PT (4) PT1379246E (no)
SI (4) SI1598340T1 (no)
WO (1) WO2002085357A1 (no)
YU (1) YU82303A (no)

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US6615189B1 (en) * 1998-06-22 2003-09-02 Bank One, Delaware, National Association Debit purchasing of stored value card for use by and/or delivery to others
PT1379246E (pt) 2001-04-18 2009-01-14 Euro Celtique Sa Análogos de nociceptina
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
WO2004064835A1 (en) * 2003-01-17 2004-08-05 Neurosearch A/S Use of ion channel modulating agents for treating pain
JP5229853B2 (ja) 2003-02-28 2013-07-03 ニッポネックス インコーポレイテッド 癌その他の疾患の治療に有用な新規な二環尿素誘導体
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
JP2007520493A (ja) * 2004-02-03 2007-07-26 ユーロ−セルティーク エス．エイ． シアノイミノベンゾイミダゾールの合成
WO2006080519A1 (ja) * 2005-01-31 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. ジアミン誘導体
AU2006298852A1 (en) * 2005-09-30 2007-04-12 F. Hoffmann-La Roche Ag Indane derivatives as MCH receptor antagonists
WO2007084728A2 (en) * 2006-01-19 2007-07-26 Abbott Laboratories 2-imino-benzimidazoles
US8354434B2 (en) * 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
TW200813018A (en) 2006-06-09 2008-03-16 Astrazeneca Ab Novel compounds
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
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SI2076506T1 (sl) * 2007-01-16 2011-01-31 Purdue Pharma Lp Heterociklično substituirani piperidini kot ORL-1 ligandi
JP5313865B2 (ja) * 2007-03-01 2013-10-09 田辺三菱製薬株式会社 ベンゾイミダゾール化合物およびその医薬用途
EP2433936A1 (en) 2007-08-31 2012-03-28 Purdue Pharma LP Substituted-quinoxaline-type-piperidine compounds and the uses thereof
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
US20100184673A1 (en) * 2007-09-11 2010-07-22 Dorian Bevec Use of parathyroid hormone ( 1-34 ) as anti-hiv agent
US8697722B2 (en) 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
MX2011000872A (es) 2008-07-21 2011-07-29 Purdue Pharma Lp Compuestos de piperidina puenteada tipo quinoxalina sustituida y los usos de los mismos.
GB0817982D0 (en) * 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
RU2560729C2 (ru) 2010-01-11 2015-08-20 АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи Модуляторы никотиновых ацетилхолиновых рецепторов
IN2014CN02959A (no) * 2011-10-28 2015-07-03 Merck Sharp & Dohme
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US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
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