AU3809999A - Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes - Google Patents

Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes

Info

Publication number
AU3809999A
AU3809999A AU38099/99A AU3809999A AU3809999A AU 3809999 A AU3809999 A AU 3809999A AU 38099/99 A AU38099/99 A AU 38099/99A AU 3809999 A AU3809999 A AU 3809999A AU 3809999 A AU3809999 A AU 3809999A
Authority
AU
Australia
Prior art keywords
decanones
triazaspiro
novel
high affinity
opioid receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU38099/99A
Inventor
Rolf Hohlweg
Christian Thomsen
Brett Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of AU3809999A publication Critical patent/AU3809999A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
AU38099/99A 1998-05-18 1999-05-14 Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes Abandoned AU3809999A (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DK68198 1998-05-18
DK681/98 1998-05-18
DK71198 1998-05-20
DK711/98 1998-05-20
DK72998 1998-05-26
DKPA199800927 1998-07-10
DKPA 1998-10-12
DKPA199900111 1999-01-29
PCT/DK1999/000266 WO1999059997A1 (en) 1998-05-18 1999-05-14 Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes

Publications (1)

Publication Number Publication Date
AU3809999A true AU3809999A (en) 1999-12-06

Family

ID=27512746

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38099/99A Abandoned AU3809999A (en) 1998-05-18 1999-05-14 Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes

Country Status (4)

Country Link
EP (1) EP1080091A1 (en)
JP (1) JP2002515503A (en)
AU (1) AU3809999A (en)
WO (1) WO1999059997A1 (en)

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ATE289307T1 (en) * 1998-10-23 2005-03-15 Pfizer 1,3,8-TRIAZASPIRO(4,5) DECANONE COMPOUNDS AS ORL1 RECEPTOR AGONISTS
WO2001036418A1 (en) * 1999-11-17 2001-05-25 Novo Nordisk A/S Novel triazaspirodecanones with high affinity for opioid receptor subtypes
AU1623801A (en) 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
WO2001039767A1 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Tertiary amino compounds having opioid receptor affinity
WO2001039775A1 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Benzimidazole compounds having nociceptin receptor affinity
DE60033071T2 (en) * 1999-12-06 2007-08-23 Euro-Celtique S.A. TRIAZOSPIRO COMPOUNDS WITH NOCICEPTIN RECEPTORAFFINITY
JP2005231995A (en) * 1999-12-22 2005-09-02 Meiji Seika Kaisha Ltd SPIRO COMPOUND USEFUL AS OPIOID delta RECEPTOR AGONIST/ANTAGONIST
ES2248281T3 (en) * 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. USEFUL PHENOXIALQUILAMINE DERIVATIVES AS AGONISTS OF DELTA OPIOID RECEIVER.
US6846831B2 (en) 2000-08-15 2005-01-25 Cpd, Llc Method of treating the syndrome of lipodystrophy
AU2001275959A1 (en) * 2000-08-15 2002-02-25 Cpd Llc Method of treating the syndrome of type 2 diabetes in humans
US6528520B2 (en) 2000-08-15 2003-03-04 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
WO2002040019A1 (en) 2000-11-15 2002-05-23 Banyu Pharmaceutical Co.,Ltd. Benzimidazole derivatives
MXPA03009239A (en) 2001-04-10 2004-11-12 Johnson & Johnson 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders.
MXPA03009602A (en) 2001-04-18 2004-04-02 Euro Celtique Sa Nociceptin analogs.
DK1975164T3 (en) 2001-04-18 2010-05-25 Euro Celtique Sa Octahydrobenzimidazolone compounds as analgesics
ES2316559T3 (en) 2001-04-18 2009-04-16 Euro-Celtique S.A. ESPIROINDEN AND ESPIROINDANO COMPOUNDS.
HUP0401333A3 (en) * 2001-04-18 2004-11-29 Euro Celtique Sa Spiropyrazole compounds and pharmaceutical compositions containing them
EP1918279A3 (en) 2001-04-18 2008-07-16 Euro-Celtique S.A. 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2-one derivatives and related compounds as nociceptin analogs and opioid receptor like receptor (orl1) ligands for the treatment of pain
CA2451133C (en) 2001-05-08 2012-09-18 Toray Industries, Inc. Therapeutic agent for sepsis
WO2002100861A1 (en) * 2001-06-13 2002-12-19 Akzo Nobel N.V. 1-(3-phenyloxypropyl)piperidine derivatives
DK1491212T3 (en) 2002-03-29 2012-10-29 Mitsubishi Tanabe Pharma Corp Means for the treatment of sleep disorders
JP2005289816A (en) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd Benzimidazole derivative
US6995168B2 (en) * 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
NZ538307A (en) 2002-09-09 2008-04-30 Janssen Pharmaceutica Nv Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
PT1567164E (en) * 2002-11-26 2009-03-31 Alexza Pharmaceuticals Inc Use of loxapine for the manufacture of a medicament for the treatment of pain
EP1628978A2 (en) * 2003-05-23 2006-03-01 Zealand Pharma A/S Triaza-spiro compounds as nociceptin analogues and uses thereof
JP2009525269A (en) 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． Cyclic urea compounds as calcium channel blockers
CA2666846C (en) 2006-10-20 2018-04-10 Cpd, Llc Method of restoring the incretin effect
AU2007325355A1 (en) 2006-11-28 2008-06-05 Janssen Pharmaceutica N.V. Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl) -1,3,8-triaza-spiro[4.5]decan-4-one
US8741916B2 (en) 2007-04-09 2014-06-03 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor
DK2582701T3 (en) * 2010-06-18 2017-02-06 Altos Therapeutics Llc D2 ANTAGONISTS, SYNTHESIS PROCEDURES AND METHODS OF USE
WO2016073615A1 (en) 2014-11-07 2016-05-12 Regents Of The University Of Minnesota Salts and compositions useful for treating disease
US10787423B2 (en) * 2015-09-14 2020-09-29 The National Institute For Biotechnolgy In The Negev Ltd. Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
BE633914A (en) * 1962-06-22
US3238216A (en) * 1963-06-20 1966-03-01 Res Lab Dr C Janssen N V Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
JPS491573A (en) * 1972-04-28 1974-01-08
US3863011A (en) * 1973-06-28 1975-01-28 American Home Prod Process for treating neuroendocrinopathic diseases employing pimozide
US3923993A (en) * 1973-06-28 1975-12-02 American Home Prod Process for treating neuroendocrinopathic diseases employing fluspirilene
US4051248A (en) * 1975-07-14 1977-09-27 E. R. Squibb & Sons, Inc. 1,3,8-triazaspiro(4.5)decan-4-one derivatives
CA2077907C (en) * 1990-03-16 1998-06-09 Richard J. Sharpe Use of spiperone as an immunosuppressant and anti-inflammatory agent
CA2126678A1 (en) * 1991-12-27 1993-07-08 Richard J. Sharpe Use of spiperone or spiperone derivatives as immunosuppressant agents

Also Published As

Publication number Publication date
WO1999059997A1 (en) 1999-11-25
EP1080091A1 (en) 2001-03-07
JP2002515503A (en) 2002-05-28

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase