DK1598340T3 - 1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte - Google Patents

1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte

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Publication number
DK1598340T3
DK1598340T3 DK05014117T DK05014117T DK1598340T3 DK 1598340 T3 DK1598340 T3 DK 1598340T3 DK 05014117 T DK05014117 T DK 05014117T DK 05014117 T DK05014117 T DK 05014117T DK 1598340 T3 DK1598340 T3 DK 1598340T3
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Denmark
Prior art keywords
orl1
pain
treatment
benzoxazol
piperidinyl
Prior art date
Application number
DK05014117T
Other languages
English (en)
Inventor
Qun Sun
Richard R Goehring
Donald Kyle
Zhengming Chen
John Whitehead
Sam Victory
Original Assignee
Euro Celtique Sa
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Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
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Publication of DK1598340T3 publication Critical patent/DK1598340T3/da

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DK05014117T 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte DK1598340T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28466901P 2001-04-18 2001-04-18
US28466801P 2001-04-18 2001-04-18
US28466601P 2001-04-18 2001-04-18
US28466701P 2001-04-18 2001-04-18
PCT/US2002/012351 WO2002085357A1 (en) 2001-04-18 2002-04-18 Nociceptin analogs

Publications (1)

Publication Number Publication Date
DK1598340T3 true DK1598340T3 (da) 2009-05-11

Family

ID=27501377

Family Applications (4)

Application Number Title Priority Date Filing Date
DK05014117T DK1598340T3 (da) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte
DK02764236T DK1379246T3 (da) 2001-04-18 2002-04-18 Nocieptin-analoger
DK05014115.9T DK1598338T5 (da) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-indol-2-on-derivater og relaterede forbindelser som nociceptinanaloger og ORL1-ligander til behandlingen af smerte
DK05014116T DK1598339T3 (da) 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2H-benzimidazol-2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1-ligander til behandling af smerte

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK02764236T DK1379246T3 (da) 2001-04-18 2002-04-18 Nocieptin-analoger
DK05014115.9T DK1598338T5 (da) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2H-indol-2-on-derivater og relaterede forbindelser som nociceptinanaloger og ORL1-ligander til behandlingen af smerte
DK05014116T DK1598339T3 (da) 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2H-benzimidazol-2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1-ligander til behandling af smerte

Country Status (26)

Country Link
US (4) US6867222B2 (da)
EP (7) EP1918279A3 (da)
JP (4) JP4364513B2 (da)
KR (2) KR100878774B1 (da)
CN (1) CN100352816C (da)
AT (4) ATE410165T1 (da)
AU (1) AU2002307416B2 (da)
BR (1) BR0209129A (da)
CA (1) CA2444198C (da)
CL (2) CL2009001279A1 (da)
CY (4) CY1108707T1 (da)
CZ (1) CZ20032850A3 (da)
DE (4) DE60231442D1 (da)
DK (4) DK1598340T3 (da)
ES (4) ES2315394T3 (da)
HK (4) HK1088892A1 (da)
HU (1) HUP0401109A3 (da)
IL (4) IL158484A0 (da)
MX (1) MXPA03009600A (da)
NO (1) NO20034661L (da)
NZ (5) NZ540234A (da)
PL (1) PL367310A1 (da)
PT (4) PT1598340E (da)
SI (4) SI1598340T1 (da)
WO (1) WO2002085357A1 (da)
YU (1) YU82303A (da)

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