DK1292561T3 - Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater - Google Patents

Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater

Info

Publication number: DK1292561T3
Authority: DK; Denmark
Prior art keywords: derivatives; preparation; acid esters; cyclopropylcarboxylic acid; cyclopropylcarboxylic
Prior art date: 2000-06-02

Application number

DK01937110T

Other languages

English (en)

Inventor

Adrian Clark

Elfyn Jones

Ulf Larsson

Anna Minidis

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-02

Filing date

2001-05-31

Publication date

2008-05-26

2000-06-02 Priority claimed from GB0013487A external-priority patent/GB0013487D0/en

2000-06-06 Priority claimed from SE0002101A external-priority patent/SE0002101D0/xx

2001-05-31 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-05-26 Application granted granted Critical

2008-05-26 Publication of DK1292561T3 publication Critical patent/DK1292561T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/20—Compounds containing azido groups with azido groups acylated by carboxylic acids
- C07C247/22—Compounds containing azido groups with azido groups acylated by carboxylic acids with the acylating carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/64—Acyl halides
- C07C57/66—Acyl halides with only carbon-to-carbon double bonds as unsaturation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

DK01937110T 2000-06-02 2001-05-31 Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater DK1292561T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0013487A GB0013487D0 (en)	2000-06-02	2000-06-02	Novel process
SE0002101A SE0002101D0 (sv)	2000-06-06	2000-06-06	Novel Process
PCT/SE2001/001240 WO2001092200A1 (en)	2000-06-02	2001-05-31	Process for the preparation of cyclopropyl carboxylic acid esters and derivatives

Publications (1)

Publication Number	Publication Date
DK1292561T3 true DK1292561T3 (da)	2008-05-26

Family

ID=26244412

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01937110T DK1292561T3 (da)	2000-06-02	2001-05-31	Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater

Country Status (31)

Country	Link
US (4)	US7122695B2 (da)
EP (4)	EP1292561B1 (da)
JP (2)	JP4944344B2 (da)
KR (1)	KR100755170B1 (da)
CN (2)	CN1211344C (da)
AR (2)	AR028110A1 (da)
AT (1)	ATE386011T1 (da)
AU (2)	AU2001262875B2 (da)
BG (4)	BG65922B1 (da)
BR (2)	BR0111329A (da)
CA (3)	CA2746622C (da)
CY (1)	CY1108100T1 (da)
CZ (2)	CZ302384B6 (da)
DE (1)	DE60132771T2 (da)
DK (1)	DK1292561T3 (da)
EE (1)	EE05215B1 (da)
ES (1)	ES2300331T3 (da)
HK (1)	HK1052171B (da)
HU (1)	HU230303B1 (da)
IL (4)	IL152778A0 (da)
IS (1)	IS8828A (da)
MX (1)	MXPA02011794A (da)
MY (2)	MY157627A (da)
NO (1)	NO20025664L (da)
NZ (2)	NZ535112A (da)
PL (1)	PL205232B1 (da)
PT (1)	PT1292561E (da)
SI (1)	SI1292561T1 (da)
SK (1)	SK287215B6 (da)
TW (1)	TWI290549B (da)
WO (1)	WO2001092200A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI290549B (en) *	2000-06-02	2007-12-01	Astrazeneca Ab	Process for the preparation of cyclopropyl carboxylic acid ester and derivatives
JP2006265171A (ja) *	2005-03-24	2006-10-05	Toyotama Koryo Kk	香料組成物及び芳香製品の芳香性を改良又は増強する新しい方法
GB0615620D0 (en) *	2006-08-05	2006-09-13	Astrazeneca Ab	A process for the preparation of optically active intermediates
GB0615619D0 (en) *	2006-08-05	2006-09-13	Astrazeneca Ab	Chemical process for preparation of intermediates
JP2010508350A (ja)	2006-10-31	2010-03-18	ヤンセンファーマシューティカエヌ．ベー．	Ａｄｐｐ２ｙ１２レセプターアンタゴニストとしてのトリアゾロピリミジン誘導体
KR101669297B1 (ko)	2008-09-09	2016-10-25	아스트라제네카 아베	[1Ｓ-[1-알파,2-알파,3-베타(1Ｓ,2Ｒ),5-베타]]-3-[7-[2-(3,4-디플루오로페닐)-사이클로프로필아미노]-5-(프로필티오)-3Ｈ-1,2,3-트리아졸로[4,5-ｄ]피리미딘-3-일]-5-(2-하이드록시에톡시)사이클로펜탄-1,2-디올의 제조 방법 및 그 중간체
WO2011132083A2 (en)	2010-04-20	2011-10-27	Actavis Group Ptc Ehf	Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates
AU2011273101A1 (en)	2010-06-30	2013-01-17	Actavis Group Ptc Ehf	Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor
RS57331B1 (sr) *	2010-07-29	2018-08-31	Oryzon Genomics Sa	Inhibitori demetilaze za lsd1 zasnovani na arilciklopropilaminu i njihova medicinska upotreba
WO2012063126A2 (en)	2010-11-09	2012-05-18	Actavis Group Ptc Ehf	Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material
WO2012085665A2 (en)	2010-12-20	2012-06-28	Actavis Group Patc Ehf	Novel processes for preparing triazolo[4,5-d]pyrimidine derivatives and intermediates thereof
CN102249929A (zh) *	2011-05-19	2011-11-23	博瑞生物医药技术(苏州)有限公司	反式-(1r,2s)-2-(3,4-二氟代苯基）环丙胺的合成方法
AU2012270017A1 (en)	2011-06-15	2014-01-16	Actavis Group Ptc Ehf	Improved process for preparing cyclopentylamine derivatives and intermediates thereof
EP2589587A1 (en)	2011-11-04	2013-05-08	Chemo Ibérica, S.A.	Synthesis of nitrogen substituted cyclopropanes
EP2628721A1 (en)	2012-02-20	2013-08-21	LEK Pharmaceuticals d.d.	Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
EP2644590A1 (en)	2012-03-30	2013-10-02	LEK Pharmaceuticals d.d.	Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
CN104603098B (zh)	2012-03-30	2016-06-29	桑多斯股份公司	2-(3,4-二氟苯基)环丙胺衍生物和盐的合成
US9233966B2 (en)	2012-04-05	2016-01-12	Dr. Reddy's Laboratories Limited	Preparation of ticagrelor
CN103588674B (zh) *	2012-08-14	2015-02-11	上海医药工业研究院	一种具有光学活性的环丙烷酰阱化合物、其制备和应用
CN102796007B (zh) *	2012-08-14	2014-03-26	济南瑞丰医药科技有限公司	一种替卡格雷中间体的制备方法
CN102863341B (zh) *	2012-10-22	2014-05-07	南通大学	一种（1r,2s）-2-芳基环丙胺衍生物的化学合成方法
WO2014206187A1 (zh)	2013-06-24	2014-12-31	苏州明锐医药科技有限公司	替卡格雷及其中间体的制备方法
CN103739483B (zh) *	2013-12-23	2015-05-20	王桂霞	一种反式-(1r,2r)-2-(3,4-二氟苯基)-1-环丙烷甲酸的制备方法
WO2015162630A1 (en)	2014-04-25	2015-10-29	Anlon Chemical Research Organization	Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
EP3157907B1 (en)	2014-06-18	2018-08-29	Flamma S.P.A.	Process for the preparation of triazolo[4,5-d]pyrimidine cyclopentane compounds
WO2018020366A1 (en) *	2016-07-26	2018-02-01	Glaxosmithkline Intellectual Property (No.2) Limited	Crystalline (r)-mandelate salt of (1r,2s)-2-phenylcyclopropylamine
CN106496178A (zh) *	2016-10-19	2017-03-15	青岛辰达生物科技有限公司	一种替卡格雷中间体及其制备方法
CN107141236B (zh) *	2017-04-24	2019-03-22	台州职业技术学院	替卡格雷中间体(1r,2r)-2-(3,4-二氟代苯基)环丙烷腈的新合成方法
CN108863791B (zh) *	2018-08-17	2023-12-01	淄博齐翔腾达化工股份有限公司	顺酐回收用溶剂再生装置及其工艺方法
CN110894184B (zh) *	2019-11-25	2022-02-18	安徽一帆香料有限公司	一种基于绿色环保的替格瑞洛中间体的制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2734904A (en) *		1956-02-14		Xcxnhxc-nh
GB873018A (en) *	1958-09-22	1961-07-19	Smith Kline French Lab	Substituted phenylcyclopropylamines
US3106578A (en) *	1960-09-16	1963-10-08	Smith Kline French Lab	Nu-phenethyl-2-phenylcyclopropylamine derivatives
US3079403A (en) *	1960-09-19	1963-02-26	Smith Kline French Lab	Process for preparing amines
DE1251755B (de) *	1960-10-17	1967-10-12	Smith Kline &. French Laboratories, Philadelphia, Pa (V St A)	Verfahren zur Herstellung von 2 Phenyl-cyclopropyl carbaminsaurederivaten
US3134676A (en) *	1961-06-21	1964-05-26	Smith Kline French Lab	Animal feed compositions and methods for their administration
US3207785A (en) *	1963-01-17	1965-09-21	Smith Kline French Lab	N-(2-phenylcyclopropyl) formamides
DE3160641D1 (en) *	1980-05-13	1983-08-25	Ciba Geigy Ag	Process for the preparation of benzene or naphthalene alkenyl carboxylic acid derivatives
JPS6025952A (ja) *	1983-07-20	1985-02-08	Sumitomo Chem Co Ltd	光学活性２，２−ジメチルシクロプロパン−１−カルボン酸誘導体の製造法
GB8429932D0 (en) *	1984-11-27	1985-01-03	Pfizer Ltd	Triazole antifungal agents
JPH0296571A (ja) *	1988-09-30	1990-04-09	Morishita Pharmaceut Co Ltd	１−（２−フェニルエチル）−１ｈ−１，２，４−トリアゾール誘導体
DE3834437A1 (de) *	1988-10-10	1990-04-12	Basf Ag	Azolylmethylcyclopropane und ihre verwendung als pflanzenschutzmittel
JPH02289534A (ja) *	1989-02-16	1990-11-29	Sagami Chem Res Center	含フッ素α，ω―ジカルボン酸及びその製造方法
DE4037112A1 (de) *	1990-11-22	1992-05-27	Thomae Gmbh Dr K	Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5286736A (en) *	1990-11-22	1994-02-15	Dr. Karl Thomae Gmbh	Pyridyl compounds and pharmaceutical compositions containing these compounds
US5283736A (en) *	1990-11-29	1994-02-01	Konica Corporation	Radiographic image processing apparatus
IL112819A (en) *	1991-10-16	2001-11-25	Teva Pharma	Fluorinated 1-aminoindan compounds and a process for their preparation
JPH06179360A (ja) *	1992-12-14	1994-06-28	Toyota Motor Corp	ブレーキブースタ装置
JPH07304710A (ja) *	1994-05-16	1995-11-21	Fuji Photo Film Co Ltd	トリフエニレン誘導体の混合物
JP3542165B2 (ja) *	1994-05-19	2004-07-14	富山化学工業株式会社	新規なキノロンカルボン酸誘導体またはその塩
JP3716460B2 (ja) *	1995-09-01	2005-11-16	日産化学工業株式会社	不斉シクロプロパン化反応
EP0785212A1 (en) *	1996-01-22	1997-07-23	Laboratoire Theramex	New 19-nor-pregnene derivatives
DE69708368T2 (de) *	1996-04-09	2002-09-26	Givaudan Sa	Cyclopentanbutanolderivate als Duftstoffe
CA2294346A1 (en) *	1997-06-18	1998-12-23	Merck & Co., Inc.	Alpha 1a adrenergic receptor antagonists
AR017014A1 (es) *	1997-07-22	2001-08-22	Astrazeneca Ab	Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
JPH1160543A (ja) *	1997-08-19	1999-03-02	Ichikawa Gosei Kagaku Kk	１−アミノテトラリン−２−オールの光学分割方法と分割の過程で生じるジアステレオマー塩
MXPA00007634A (es) *	1998-02-17	2003-09-10	Astrazeneca Uk Ltd	Nuevos compuestos de triazol (4,5-d) pirimidina.
FR2784375B1 (fr) *	1998-10-12	2000-11-24	Adir	Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU1345900A (en) *	1998-11-10	2000-05-29	Merck & Co., Inc.	Oxazolidinones useful as alpha 1a adrenoceptor antagonists
TWI229674B (en) *	1998-12-04	2005-03-21	Astra Pharma Prod	Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
TWI290549B (en) *	2000-06-02	2007-12-01	Astrazeneca Ab	Process for the preparation of cyclopropyl carboxylic acid ester and derivatives

2001
- 2001-05-22 TW TW090112266A patent/TWI290549B/zh not_active IP Right Cessation
- 2001-05-22 AR ARP010102430A patent/AR028110A1/es active IP Right Grant
- 2001-05-31 BR BR0111329-1A patent/BR0111329A/pt active IP Right Grant
- 2001-05-31 US US10/275,547 patent/US7122695B2/en not_active Expired - Fee Related
- 2001-05-31 IL IL15277801A patent/IL152778A0/xx unknown
- 2001-05-31 WO PCT/SE2001/001240 patent/WO2001092200A1/en active Application Filing
- 2001-05-31 HU HU0302287A patent/HU230303B1/hu not_active IP Right Cessation
- 2001-05-31 SI SI200130822T patent/SI1292561T1/sl unknown
- 2001-05-31 NZ NZ535112A patent/NZ535112A/en unknown
- 2001-05-31 CA CA2746622A patent/CA2746622C/en not_active Expired - Lifetime
- 2001-05-31 CZ CZ20090623A patent/CZ302384B6/cs not_active IP Right Cessation
- 2001-05-31 CA CA2641976A patent/CA2641976C/en not_active Expired - Lifetime
- 2001-05-31 PT PT01937110T patent/PT1292561E/pt unknown
- 2001-05-31 CA CA2408591A patent/CA2408591C/en not_active Expired - Fee Related
- 2001-05-31 EP EP01937110A patent/EP1292561B1/en not_active Expired - Lifetime
- 2001-05-31 EP EP10183117A patent/EP2292591A3/en not_active Withdrawn
- 2001-05-31 JP JP2002500816A patent/JP4944344B2/ja not_active Expired - Lifetime
- 2001-05-31 MY MYPI20093489A patent/MY157627A/en unknown
- 2001-05-31 SK SK1684-2002A patent/SK287215B6/sk not_active IP Right Cessation
- 2001-05-31 MY MYPI20012579A patent/MY140938A/en unknown
- 2001-05-31 ES ES01937110T patent/ES2300331T3/es not_active Expired - Lifetime
- 2001-05-31 DE DE60132771T patent/DE60132771T2/de not_active Expired - Lifetime
- 2001-05-31 EE EEP200200666A patent/EE05215B1/xx not_active IP Right Cessation
- 2001-05-31 PL PL359268A patent/PL205232B1/pl not_active IP Right Cessation
- 2001-05-31 EP EP10183120A patent/EP2292582A3/en not_active Withdrawn
- 2001-05-31 NZ NZ522639A patent/NZ522639A/en unknown
- 2001-05-31 CZ CZ20023916A patent/CZ301747B6/cs not_active IP Right Cessation
- 2001-05-31 AT AT01937110T patent/ATE386011T1/de active
- 2001-05-31 MX MXPA02011794A patent/MXPA02011794A/es active IP Right Grant
- 2001-05-31 CN CNB018105637A patent/CN1211344C/zh not_active Expired - Fee Related
- 2001-05-31 CN CN201110096573.5A patent/CN102295555B/zh not_active Expired - Lifetime
- 2001-05-31 KR KR1020027016377A patent/KR100755170B1/ko active IP Right Grant
- 2001-05-31 AU AU2001262875A patent/AU2001262875B2/en not_active Ceased
- 2001-05-31 EP EP06014147A patent/EP1760066A3/en not_active Withdrawn
- 2001-05-31 DK DK01937110T patent/DK1292561T3/da active
- 2001-05-31 BR BRPI0111329-1A patent/BRPI0111329B1/pt unknown
- 2001-05-31 AU AU6287501A patent/AU6287501A/xx active Pending
2002
- 2002-11-11 IL IL152778A patent/IL152778A/en not_active IP Right Cessation
- 2002-11-25 NO NO20025664A patent/NO20025664L/no not_active Application Discontinuation
- 2002-11-25 BG BG107314A patent/BG65922B1/bg unknown
2003
- 2003-06-23 HK HK03104491.3A patent/HK1052171B/zh not_active IP Right Cessation
2006
- 2006-07-17 US US11/487,457 patent/US7906662B2/en active Active
2008
- 2008-04-15 CY CY20081100409T patent/CY1108100T1/el unknown
- 2008-07-24 IL IL193071A patent/IL193071A/en active IP Right Grant
- 2008-07-29 AR ARP080103274A patent/AR070510A2/es active IP Right Grant
2009
- 2009-06-05 IS IS8828A patent/IS8828A/is unknown
- 2009-08-31 BG BG10110454A patent/BG66150B1/bg unknown
2010
- 2010-04-19 BG BG10110635A patent/BG66157B1/bg unknown
- 2010-04-28 BG BG10110640A patent/BG66158B1/bg unknown
2011
- 2011-02-08 US US12/929,687 patent/US8183412B2/en not_active Expired - Lifetime
- 2011-06-30 JP JP2011145213A patent/JP2011236229A/ja active Pending
- 2011-08-18 IL IL214718A patent/IL214718A0/en unknown
2012
- 2012-01-30 US US13/361,214 patent/US20120130097A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2641976A1 (en)	2001-12-06
IL214718A0 (en)	2011-09-27
CN1211344C (zh)	2005-07-20
NO20025664D0 (no)	2002-11-25
PL359268A1 (en)	2004-08-23
EP1292561A1 (en)	2003-03-19
PL205232B1 (pl)	2010-03-31
IS8828A (is)	2009-06-05
BRPI0111329B1 (pt)	2018-05-29
EP2292591A2 (en)	2011-03-09
CZ301747B6 (cs)	2010-06-09
CA2641976C (en)	2012-03-20
CA2408591A1 (en)	2001-12-06
KR20030007827A (ko)	2003-01-23
BG107314A (bg)	2003-07-31
NZ522639A (en)	2004-10-29
CA2746622A1 (en)	2001-12-06
IL152778A (en)	2008-12-29
EE05215B1 (et)	2009-10-15
DE60132771D1 (de)	2008-03-27
IL152778A0 (en)	2003-06-24
BG66158B1 (bg)	2011-09-30
HUP0302287A2 (hu)	2003-10-28
JP2003535072A (ja)	2003-11-25
AR028110A1 (es)	2003-04-23
EE200200666A (et)	2004-06-15
SK16842002A3 (sk)	2003-06-03
US20030120105A1 (en)	2003-06-26
MY140938A (en)	2010-02-12
HK1052171A1 (en)	2003-09-05
EP2292582A2 (en)	2011-03-09
BR0111329A (pt)	2003-06-10
CZ302384B6 (cs)	2011-04-27
NZ535112A (en)	2006-04-28
MY157627A (en)	2016-06-30
JP4944344B2 (ja)	2012-05-30
AU2001262875B2 (en)	2006-08-10
CA2408591C (en)	2010-06-22
US8183412B2 (en)	2012-05-22
CN102295555B (zh)	2014-05-28
JP2011236229A (ja)	2011-11-24
EP2292591A3 (en)	2011-11-02
KR100755170B1 (ko)	2007-09-04
PT1292561E (pt)	2008-04-21
BG65922B1 (bg)	2010-05-31
CA2746622C (en)	2014-01-21
CZ20023916A3 (cs)	2003-05-14
BG66157B1 (bg)	2011-09-30
US7906662B2 (en)	2011-03-15
IL193071A0 (en)	2009-02-11
SI1292561T1 (sl)	2008-06-30
EP1292561B1 (en)	2008-02-13
US20120130097A1 (en)	2012-05-24
AR070510A2 (es)	2010-04-14
US7122695B2 (en)	2006-10-17
ES2300331T3 (es)	2008-06-16
BG110640A (bg)	2010-09-30
BG66150B1 (bg)	2011-08-31
EP1760066A2 (en)	2007-03-07
EP1760066A3 (en)	2008-09-10
HUP0302287A3 (en)	2008-02-28
TWI290549B (en)	2007-12-01
BG110635A (bg)	2010-08-31
HK1052171B (zh)	2008-07-25
CN102295555A (zh)	2011-12-28
CN1431992A (zh)	2003-07-23
US20110190520A1 (en)	2011-08-04
ATE386011T1 (de)	2008-03-15
US20060258879A1 (en)	2006-11-16
DE60132771T2 (de)	2009-02-05
IL193071A (en)	2011-12-29
WO2001092200A1 (en)	2001-12-06
NO20025664L (no)	2002-11-25
EP2292582A3 (en)	2011-11-02
CY1108100T1 (el)	2014-02-12
HU230303B1 (hu)	2015-12-28
SK287215B6 (sk)	2010-03-08
AU6287501A (en)	2001-12-11
MXPA02011794A (es)	2003-04-10
BG110454A (bg)	2009-12-31

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