DK1152750T3 - Spontant dispergerbare N-benzoyl-staurosporin-sammensætninger - Google Patents

Spontant dispergerbare N-benzoyl-staurosporin-sammensætninger

Info

Publication number: DK1152750T3
Authority: DK; Denmark
Prior art keywords: benzoyl; spontaneously dispersible; staurosporine; compositions; staurosporine compositions
Prior art date: 1999-02-16

Application number

DK00909165T

Other languages

English (en)

Inventor

Barbara Haeberlin

Graham Paul Matthews

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-16

Filing date

2000-02-14

Publication date

2009-08-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847896&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1152750(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-02-14 Application filed by Novartis Ag filed Critical Novartis Ag

2009-08-24 Application granted granted Critical

2009-08-24 Publication of DK1152750T3 publication Critical patent/DK1152750T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds

DK00909165T 1999-02-16 2000-02-14 Spontant dispergerbare N-benzoyl-staurosporin-sammensætninger DK1152750T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9903547.9A GB9903547D0 (en)	1999-02-16	1999-02-16	Organic compounds
PCT/EP2000/001196 WO2000048571A1 (en)	1999-02-16	2000-02-14	Spontaneously dispersible n-benzoyl staurosporine compositions

Publications (1)

Publication Number	Publication Date
DK1152750T3 true DK1152750T3 (da)	2009-08-24

Family

ID=10847896

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00909165T DK1152750T3 (da)	1999-02-16	2000-02-14	Spontant dispergerbare N-benzoyl-staurosporin-sammensætninger

Country Status (34)

Country	Link
US (3)	US20020061873A1 (da)
EP (1)	EP1152750B1 (da)
JP (2)	JP5057610B2 (da)
KR (2)	KR20080064914A (da)
CN (1)	CN100367930C (da)
AR (2)	AR022589A1 (da)
AT (1)	ATE430554T1 (da)
AU (1)	AU765776B2 (da)
BR (1)	BRPI0008228B8 (da)
CA (1)	CA2362277C (da)
CL (1)	CL2009001682A1 (da)
CZ (1)	CZ303979B6 (da)
DE (1)	DE60042151D1 (da)
DK (1)	DK1152750T3 (da)
EC (1)	ECSP083351A (da)
ES (1)	ES2326783T3 (da)
GB (1)	GB9903547D0 (da)
HK (1)	HK1045807B (da)
HU (1)	HUP0105364A3 (da)
ID (1)	ID30504A (da)
IL (3)	IL144512A0 (da)
MY (1)	MY128362A (da)
NO (1)	NO331232B1 (da)
NZ (1)	NZ513529A (da)
PE (1)	PE20001499A1 (da)
PL (1)	PL198330B1 (da)
PT (1)	PT1152750E (da)
RU (1)	RU2266121C2 (da)
SI (1)	SI1152750T1 (da)
SK (1)	SK286967B6 (da)
TR (1)	TR200102385T2 (da)
TW (1)	TWI240636B (da)
WO (1)	WO2000048571A1 (da)
ZA (1)	ZA200106677B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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US6200968B1 (en) *	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US7795246B2 (en)	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
EP1372611B1 (en) *	2001-03-26	2006-05-17	Novartis AG	Pharmaceutical composition comprising a poorly water-soluble staurosporine, a surfactant and a water-soluble polymer
KR20080091866A (ko)	2001-05-16	2008-10-14	노파르티스 아게	Ν-｛5-[4-(4-메틸-피페라지노-메틸)-벤조일아미도]-2-메틸페닐｝-4-(3-피리딜)-2-피리미딘-아민 및 화학치료제를 포함하는 배합물
ATE335490T1 (de)	2001-10-30	2006-09-15	Novartis Pharma Gmbh	Staurosporin-derivate als hemmer der flt3- rezeptor-tyrosinkinase-wirkung
GB0206215D0 (en)	2002-03-15	2002-05-01	Novartis Ag	Organic compounds
CA2492989C (en) *	2002-07-23	2012-11-20	Novartis Ag	Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
US7842791B2 (en)	2002-12-19	2010-11-30	Nancy Jean Britten	Dispersible pharmaceutical compositions
TWI324604B (en) *	2003-06-18	2010-05-11	Novartis Ag	New use of staurosporine derivatives
GB0512324D0 (en)	2005-06-16	2005-07-27	Novartis Ag	Organic compounds
GB0419159D0 (en) *	2004-08-27	2004-09-29	Novartis Ag	Organic compounds
GT200500310A (es)	2004-11-19	2006-06-19		Compuestos organicos
WO2008021347A2 (en) *	2006-08-16	2008-02-21	Novartis Ag	Method for making solid dispersions of highly crystalline therapeutic compounds
FR2918566B1 (fr)	2007-07-11	2009-10-09	Pierre Fabre Medicament Sa	Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
WO2009067221A2 (en) *	2007-11-20	2009-05-28	Cephalon, Inc.	Microemulsion containing indolocarbazole compound and dosage forms containing the same
EP2229936B1 (en) *	2009-03-09	2015-05-06	PharmaSol GmbH	Nanonized testosterone formulations for improved bioavailability
WO2011000811A2 (en) *	2009-06-30	2011-01-06	Novartis Ag	Organic compounds
CN102781425B (zh) *	2009-12-22	2014-08-13	利奥制药有限公司	含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物
JO3337B1 (ar)	2010-12-13	2019-03-13	Debiopharm Sa	تركيبات صيدلية تشمل أليسبوريفير
US9387446B2 (en)	2011-09-22	2016-07-12	Ariel-University Research And Development Company Ltd.	Emulsions and methods of making emulsions
KR20190032265A (ko) *	2015-12-09	2019-03-27	포스파제닉스 리미티드	약제학적 제형
CN108601732A (zh)	2015-12-09	2018-09-28	磷肌酸有限公司	药物制剂
WO2018112512A1 (en)	2016-12-21	2018-06-28	Phosphagenics Limited	Process
WO2021097256A1 (en)	2019-11-14	2021-05-20	Cohbar, Inc.	Cxcr4 antagonist peptides

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US4963367A (en)	1984-04-27	1990-10-16	Medaphore, Inc.	Drug delivery compositions and methods
US4735939A (en)	1987-02-27	1988-04-05	The Dow Chemical Company	Insecticidal activity of staurosporine
US5093330A (en) *	1987-06-15	1992-03-03	Ciba-Geigy Corporation	Staurosporine derivatives substituted at methylamino nitrogen
DE3824034C1 (da) *	1988-07-15	1989-09-14	Gustav 7290 Freudenstadt De Memminger
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
AU668509B2 (en)	1991-04-19	1996-05-09	Affinity Biotech, Inc.	Convertible microemulsion formulations
GB9113872D0 (en)	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
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US5639474A (en)	1993-07-01	1997-06-17	Hanmi Pharm. Ind., Ltd.	Cyclosporin soft capsule composition
EP0736041B1 (en)	1993-11-17	2006-02-08	Athena Neurosciences, Inc.	Transparent liquid for encapsulated drug delivery
GB9325395D0 (en) *	1993-12-11	1994-02-16	Ciba Geigy Ag	Compositions
AU1911095A (en)	1994-02-18	1995-09-04	Cephalon, Inc.	Aqueous indolocarbazole solutions
JPH10501527A (ja) *	1994-06-01	1998-02-10	チバ−ガイギーアクチェンゲゼルシャフト	多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体
GB2308545B (en)	1994-10-26	1999-06-02	Novartis Ag	Pharmaceutical microemulsion preconcentrates
IL115742A (en)	1994-10-26	2000-06-01	Novartis Ag	Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant
EP0711557A1 (de) *	1994-11-09	1996-05-15	Ciba-Geigy Ag	Pharmazeutische Formulierungsgrundlage
EP0733372A3 (de) *	1995-03-21	1998-05-20	Ciba-Geigy Ag	Pharmazeutische Formulierungsgrundlage für Nanosuspensionen
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DE19641672A1 (de)	1996-10-10	1998-04-16	Beiersdorf Ag	Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen
US5827522A (en)	1996-10-30	1998-10-27	Troy Corporation	Microemulsion and method
NZ314060A (en)	1997-01-13	1997-08-22	Bernard Charles Sherman	Pharmaceutical microemulsion preconcentrate comprising cyclosporin dissolved in a solvent system comprising hydrophobic solvent(s) and surfactant(s)
TR199901686T2 (xx) *	1997-01-30	1999-09-21	Norvartis Ag	Esasen ya�s�z farmakolojik kompozisyonlar� i�eren sert jelatin kaps�ller.
RU2203648C2 (ru)	1997-07-29	2003-05-10	Фармация Энд Апджон Компани	Самоэмульгирующаяся композиция для липофильных соединений
CZ297206B6 (cs)	1997-07-29	2006-10-11	Pharmacia & Upjohn Company	Farmaceutická kompozice a samoemulgující formulace pro lipofilní slouceniny
US6346511B1 (en)	1997-09-08	2002-02-12	Panacea Biotec Limited	Pharmaceutical composition comprising cyclosporin
US6979456B1 (en) *	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
GB9814527D0 (en) *	1998-07-03	1998-09-02	Cyclacel Ltd	Delivery system
AR013276A1 (es)	1998-07-31	2000-12-13	Panacea Biotec Ltd	Composicion de ciclosporina transparente
US6248363B1 (en) *	1999-11-23	2001-06-19	Lipocine, Inc.	Solid carriers for improved delivery of active ingredients in pharmaceutical compositions

1999
- 1999-02-16 GB GBGB9903547.9A patent/GB9903547D0/en not_active Ceased
2000
- 2000-02-14 SI SI200031035T patent/SI1152750T1/sl unknown
- 2000-02-14 PE PE2000000113A patent/PE20001499A1/es not_active Application Discontinuation
- 2000-02-14 DE DE60042151T patent/DE60042151D1/de not_active Expired - Lifetime
- 2000-02-14 ES ES00909165T patent/ES2326783T3/es not_active Expired - Lifetime
- 2000-02-14 DK DK00909165T patent/DK1152750T3/da active
- 2000-02-14 RU RU2001124597/15A patent/RU2266121C2/ru active
- 2000-02-14 CZ CZ20012931A patent/CZ303979B6/cs not_active IP Right Cessation
- 2000-02-14 KR KR1020087015449A patent/KR20080064914A/ko not_active Application Discontinuation
- 2000-02-14 CN CNB008038244A patent/CN100367930C/zh not_active Expired - Lifetime
- 2000-02-14 NZ NZ513529A patent/NZ513529A/en not_active IP Right Cessation
- 2000-02-14 IL IL14451200A patent/IL144512A0/xx active IP Right Grant
- 2000-02-14 BR BRPI0008228A patent/BRPI0008228B8/pt not_active IP Right Cessation
- 2000-02-14 SK SK1172-2001A patent/SK286967B6/sk not_active IP Right Cessation
- 2000-02-14 AR ARP000100627A patent/AR022589A1/es not_active Application Discontinuation
- 2000-02-14 EP EP00909165A patent/EP1152750B1/en not_active Expired - Lifetime
- 2000-02-14 HU HU0105364A patent/HUP0105364A3/hu unknown
- 2000-02-14 PT PT00909165T patent/PT1152750E/pt unknown
- 2000-02-14 KR KR1020017009391A patent/KR100880859B1/ko active Protection Beyond IP Right Term
- 2000-02-14 TR TR2001/02385T patent/TR200102385T2/xx unknown
- 2000-02-14 ID IDW00200101649A patent/ID30504A/id unknown
- 2000-02-14 JP JP2000599363A patent/JP5057610B2/ja not_active Expired - Fee Related
- 2000-02-14 PL PL350556A patent/PL198330B1/pl unknown
- 2000-02-14 CA CA2362277A patent/CA2362277C/en not_active Expired - Lifetime
- 2000-02-14 AT AT00909165T patent/ATE430554T1/de active
- 2000-02-14 WO PCT/EP2000/001196 patent/WO2000048571A1/en active Application Filing
- 2000-02-14 AU AU31542/00A patent/AU765776B2/en active Active
- 2000-02-15 MY MYPI20000530A patent/MY128362A/en unknown
- 2000-03-13 TW TW089104503A patent/TWI240636B/zh not_active IP Right Cessation
2001
- 2001-02-14 ZA ZA200106677A patent/ZA200106677B/en unknown
- 2001-07-23 IL IL144512A patent/IL144512A/en not_active IP Right Cessation
- 2001-08-15 NO NO20013964A patent/NO331232B1/no not_active IP Right Cessation
- 2001-08-15 US US09/930,335 patent/US20020061873A1/en not_active Abandoned
2002
- 2002-09-13 HK HK02106758.7A patent/HK1045807B/zh not_active IP Right Cessation
2007
- 2007-09-21 US US11/859,077 patent/US8575147B2/en not_active Expired - Fee Related
2008
- 2008-07-04 EC EC2008003351A patent/ECSP083351A/es unknown
- 2008-07-07 IL IL192666A patent/IL192666A0/en unknown
2009
- 2009-07-31 CL CL2009001682A patent/CL2009001682A1/es unknown
2011
- 2011-08-05 AR ARP110102851A patent/AR082579A2/es not_active Application Discontinuation
2012
- 2012-01-05 JP JP2012000816A patent/JP2012111763A/ja active Pending
2013
- 2013-10-15 US US14/053,661 patent/US8722664B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL198330B1 (pl)	2008-06-30
CN1339963A (zh)	2002-03-13
US20080070897A1 (en)	2008-03-20
KR100880859B1 (ko)	2009-01-30
JP5057610B2 (ja)	2012-10-24
CA2362277C (en)	2010-03-30
BRPI0008228B1 (pt)	2016-08-23
TR200102385T2 (tr)	2002-09-23
ECSP083351A (es)	2008-08-29
AR022589A1 (es)	2002-09-04
NZ513529A (en)	2003-10-31
SK286967B6 (sk)	2009-08-06
TWI240636B (en)	2005-10-01
KR20080064914A (ko)	2008-07-09
IL144512A (en)	2011-03-31
US8722664B2 (en)	2014-05-13
US20140056974A1 (en)	2014-02-27
NO20013964L (no)	2001-10-15
PT1152750E (pt)	2009-08-07
HK1045807B (zh)	2008-12-05
PL350556A1 (en)	2002-12-16
SI1152750T1 (sl)	2009-10-31
MY128362A (en)	2007-01-31
US8575147B2 (en)	2013-11-05
NO20013964D0 (no)	2001-08-15
GB9903547D0 (en)	1999-04-07
CN100367930C (zh)	2008-02-13
ATE430554T1 (de)	2009-05-15
CL2009001682A1 (es)	2010-07-23
NO331232B1 (no)	2011-11-07
US20020061873A1 (en)	2002-05-23
PE20001499A1 (es)	2001-01-12
ID30504A (id)	2001-12-13
AR082579A2 (es)	2012-12-19
KR20010093281A (ko)	2001-10-27
CZ303979B6 (cs)	2013-07-31
WO2000048571A1 (en)	2000-08-24
BRPI0008228B8 (pt)	2021-05-25
ZA200106677B (en)	2003-01-14
AU3154200A (en)	2000-09-04
JP2002537242A (ja)	2002-11-05
SK11722001A3 (sk)	2001-12-03
CA2362277A1 (en)	2000-08-24
ES2326783T3 (es)	2009-10-20
EP1152750B1 (en)	2009-05-06
AU765776B2 (en)	2003-10-02
IL192666A0 (en)	2009-02-11
HUP0105364A2 (hu)	2002-05-29
DE60042151D1 (de)	2009-06-18
BR0008228A (pt)	2001-10-30
IL144512A0 (en)	2002-05-23
EP1152750A1 (en)	2001-11-14
CZ20012931A3 (cs)	2001-11-14
HUP0105364A3 (en)	2003-02-28
HK1045807A1 (en)	2002-12-13
RU2266121C2 (ru)	2005-12-20
JP2012111763A (ja)	2012-06-14

Publication	Publication Date	Title
DK1152750T3 (da)	2009-08-24	Spontant dispergerbare N-benzoyl-staurosporin-sammensætninger
AR023440A1 (es)	2002-09-04	Composiciones antitranspirantes
DE60000944D1 (de)	2003-01-23	Bohrlochzementzusammensetzungen
DE60027029D1 (de)	2006-05-18	Kombinierte impfstoffzusammensetzungen
DE69933200D1 (de)	2006-10-26	Kombinierte impfstoffzusammensetzungen
ATE303787T1 (de)	2005-09-15	Schergelzusammensetzungen
IS6120A (is)	2001-10-22	Lyfjablanda
ID26549A (id)	2001-01-18	Komposisi-komposisi epotilon
ATE367793T1 (de)	2007-08-15	Schweisshemmende zusammensetzungen
DK1175220T3 (da)	2005-08-29	Nanopartikulære eplerenonkompositioner
AR027896A1 (es)	2003-04-16	Composiciones valdecoxib
ID29785A (id)	2001-10-11	Komposisi-komposisi sampo
AR028197A1 (es)	2003-04-30	Composiciones antitranspirantes
ATE469550T1 (de)	2010-06-15	Antiparasitäre zusammensetzungen
DE60007731D1 (de)	2004-02-19	Schweisshemmende zusammensetzungen
DE69927758D1 (de)	2006-03-02	Imidosilan-Zusammensetzungen
ATE369830T1 (de)	2007-09-15	Schweisshemmende zusammensetzungen
ATE314049T1 (de)	2006-01-15	Schweisshemmende zusammensetzungen
IS6398A (is)	2002-05-27	Lyfjablöndur
ID27889A (id)	2001-05-03	Komposisi-komposisi kopolimer polisiklik
DE69943245D1 (de)	2011-04-14	Gaserzeugende zusammensetzung
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