FR2918566B1 - Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. - Google Patents
Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.Info
- Publication number
- FR2918566B1 FR2918566B1 FR0756421A FR0756421A FR2918566B1 FR 2918566 B1 FR2918566 B1 FR 2918566B1 FR 0756421 A FR0756421 A FR 0756421A FR 0756421 A FR0756421 A FR 0756421A FR 2918566 B1 FR2918566 B1 FR 2918566B1
- Authority
- FR
- France
- Prior art keywords
- vinflunine
- pharmaceutical composition
- water soluble
- soluble salt
- stable pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0756421A FR2918566B1 (fr) | 2007-07-11 | 2007-07-11 | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. |
TW097125680A TW200914018A (en) | 2007-07-11 | 2008-07-08 | Stable pharmaceutical composition comprising a hydrosoluble vinflunine salt |
CN2008800239960A CN101730533B (zh) | 2007-07-11 | 2008-07-09 | 包含水溶性长春氟宁盐的稳定的药物组合物 |
EP08786000A EP2187886A1 (fr) | 2007-07-11 | 2008-07-09 | Composition pharmaceutique stable comprenant un sel de vinflunine hydrosoluble |
AU2008274223A AU2008274223A1 (en) | 2007-07-11 | 2008-07-09 | Stable pharmaceutical composition comprising a hydrosoluble vinflunine salt |
US12/668,367 US9173842B2 (en) | 2007-07-11 | 2008-07-09 | Stable pharmaceutical composition comprising a hydrosoluble vinflunine salt |
SA08290417A SA08290417B1 (ar) | 2007-07-11 | 2008-07-09 | تركيبة دوائية ثابتة تشمل ملح فينفلونين القابل للذوبان فى الماء |
KR1020107001420A KR20100047230A (ko) | 2007-07-11 | 2008-07-09 | 수용성 빈플루닌 염의 안정적인 약학적 조성물 |
PA20088789101A PA8789101A1 (es) | 2007-07-11 | 2008-07-09 | Composición farmacéutica estable que comprende una sal de vinflunina hidrosoluble |
NZ583040A NZ583040A (en) | 2007-07-11 | 2008-07-09 | Stable pharmaceutical composition comprising a hydrosoluble vinflunine |
RU2010103934/15A RU2462248C2 (ru) | 2007-07-11 | 2008-07-09 | Стабильная фармацевтическая композиция, содержащая водорастворимую соль винфлунина |
JP2010515500A JP2010533139A (ja) | 2007-07-11 | 2008-07-09 | 水溶性ビンフルニン塩を含んでなる安定な医薬組成物 |
BRPI0814216A BRPI0814216A2 (pt) | 2007-07-11 | 2008-07-09 | composição farmacêutica estável compreendendo um sal de vinflunina hidrossolúvel |
CA2695039A CA2695039A1 (fr) | 2007-07-11 | 2008-07-09 | Composition pharmaceutique stable comprenant un sel de vinflunine hydrosoluble |
PCT/EP2008/058893 WO2009007388A1 (fr) | 2007-07-11 | 2008-07-09 | Composition pharmaceutique stable comprenant un sel de vinflunine hydrosoluble |
ARP080102967A AR067499A1 (es) | 2007-07-11 | 2008-07-10 | Composicion farmaceutica estable que comprende una sal de vinflunina hidrosoluble |
TNP2010000013A TN2010000013A1 (en) | 2007-07-11 | 2010-01-08 | Stable pharmaceutical composition comprising a hydrosoluble vinflunine salt |
ZA201000335A ZA201000335B (en) | 2007-07-11 | 2010-01-18 | Stable pharmaceutical composition comprising a hydrosoluble vinflunine salt |
MA32552A MA32045B1 (fr) | 2007-07-11 | 2010-01-25 | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine |
CO10011475A CO6160316A2 (es) | 2007-07-11 | 2010-02-03 | Composicion farmaceutica estable que comprende una sal de vinflunina hidrosoluble |
CL2008002005A CL2008002005A1 (es) | 2007-07-11 | 2011-11-10 | Composicion faramceutica solida, estable para administracion oral, que comprende una sal de vinflunina hidrosoluble y al menos un diluyente definido y un lubricante; uso para tratar el cancer. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0756421A FR2918566B1 (fr) | 2007-07-11 | 2007-07-11 | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2918566A1 FR2918566A1 (fr) | 2009-01-16 |
FR2918566B1 true FR2918566B1 (fr) | 2009-10-09 |
Family
ID=38868376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0756421A Expired - Fee Related FR2918566B1 (fr) | 2007-07-11 | 2007-07-11 | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. |
Country Status (21)
Country | Link |
---|---|
US (1) | US9173842B2 (fr) |
EP (1) | EP2187886A1 (fr) |
JP (1) | JP2010533139A (fr) |
KR (1) | KR20100047230A (fr) |
CN (1) | CN101730533B (fr) |
AR (1) | AR067499A1 (fr) |
AU (1) | AU2008274223A1 (fr) |
BR (1) | BRPI0814216A2 (fr) |
CA (1) | CA2695039A1 (fr) |
CL (1) | CL2008002005A1 (fr) |
CO (1) | CO6160316A2 (fr) |
FR (1) | FR2918566B1 (fr) |
MA (1) | MA32045B1 (fr) |
NZ (1) | NZ583040A (fr) |
PA (1) | PA8789101A1 (fr) |
RU (1) | RU2462248C2 (fr) |
SA (1) | SA08290417B1 (fr) |
TN (1) | TN2010000013A1 (fr) |
TW (1) | TW200914018A (fr) |
WO (1) | WO2009007388A1 (fr) |
ZA (1) | ZA201000335B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012135856A2 (fr) * | 2011-04-01 | 2012-10-04 | Spectrum Pharmaceuticals, Inc. | Vinorelbine à très faible dose pour le traitement du cancer |
WO2013145750A1 (fr) * | 2012-03-29 | 2013-10-03 | 杏林製薬株式会社 | Préparation pharmaceutique de capsule |
CN108289890B (zh) | 2015-12-02 | 2021-04-27 | 日本新药株式会社 | 含有2-{4-[n-(5,6-二苯基吡嗪-2-基)-n-异丙基氨基]丁氧基}-n-(甲磺酰基)乙酰胺的医药组合物 |
CN106994121B (zh) * | 2016-01-26 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 一种用于治疗癌症的药物组合物 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4558053A (en) | 1983-12-21 | 1985-12-10 | Eli Lilly And Company | Naphthalene-1,5-disulfonate salts of dimeric indole-dihydroindole alkaloids |
US5369094A (en) * | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
FR2707988B1 (fr) * | 1993-07-21 | 1995-10-13 | Pf Medicament | Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant. |
FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
FR2761990B1 (fr) * | 1997-04-10 | 1999-06-25 | Pf Medicament | Derives halogenes antimitotiques d'alcaloides de vinca |
GB9903547D0 (en) | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
AU2002213119A1 (en) | 2000-10-13 | 2002-04-22 | Bristol-Myers Squibb Company | Oral dosage forms for administration of the combination of tegafur, uracil, folinic acid, and vinorelbine and method of using the same |
US6890558B2 (en) * | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
EP1530459B1 (fr) | 2002-05-31 | 2010-03-31 | R.P. Scherer Technologies, LLC | Composition pharmaceutique orale pour capsules souples contenant de la vinorelbine et procede de traitement correspondant |
US20070232533A1 (en) * | 2003-05-09 | 2007-10-04 | Kazuo Umezawa | Use of Vinca Alkaloids and Salts Thereof |
FR2863891B1 (fr) * | 2003-12-23 | 2006-03-24 | Pf Medicament | Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation |
CZ2004964A3 (cs) | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
WO2006040779A2 (fr) | 2004-10-11 | 2006-04-20 | Natco Pharma Limited | Formule à matrice flottante gastrique à libération contrôlée contenant la substance imatinib |
BRPI0519466B8 (pt) * | 2004-12-30 | 2021-05-25 | Pf Medicament | dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo |
FR2880274B1 (fr) | 2004-12-30 | 2007-04-13 | Pierre Fabre Medicament Sa | Dispersion solide stable d'un derive d'alcaloides de vinca et son procede de fabrication |
FR2894966B1 (fr) * | 2005-12-20 | 2008-03-14 | Pierre Fabre Medicament Sa | Nouvelle forme cristalline de la vinflunine |
WO2009105937A1 (fr) | 2008-02-29 | 2009-09-03 | 江苏豪森药业股份有限公司 | Gélule molle de vinorelbine, son procédé de préparation et son application. |
-
2007
- 2007-07-11 FR FR0756421A patent/FR2918566B1/fr not_active Expired - Fee Related
-
2008
- 2008-07-08 TW TW097125680A patent/TW200914018A/zh unknown
- 2008-07-09 US US12/668,367 patent/US9173842B2/en not_active Expired - Fee Related
- 2008-07-09 RU RU2010103934/15A patent/RU2462248C2/ru not_active IP Right Cessation
- 2008-07-09 PA PA20088789101A patent/PA8789101A1/es unknown
- 2008-07-09 KR KR1020107001420A patent/KR20100047230A/ko not_active Application Discontinuation
- 2008-07-09 BR BRPI0814216A patent/BRPI0814216A2/pt not_active IP Right Cessation
- 2008-07-09 AU AU2008274223A patent/AU2008274223A1/en not_active Abandoned
- 2008-07-09 JP JP2010515500A patent/JP2010533139A/ja active Pending
- 2008-07-09 NZ NZ583040A patent/NZ583040A/en not_active IP Right Cessation
- 2008-07-09 SA SA08290417A patent/SA08290417B1/ar unknown
- 2008-07-09 CN CN2008800239960A patent/CN101730533B/zh not_active Expired - Fee Related
- 2008-07-09 WO PCT/EP2008/058893 patent/WO2009007388A1/fr active Application Filing
- 2008-07-09 EP EP08786000A patent/EP2187886A1/fr not_active Withdrawn
- 2008-07-09 CA CA2695039A patent/CA2695039A1/fr not_active Abandoned
- 2008-07-10 AR ARP080102967A patent/AR067499A1/es not_active Application Discontinuation
-
2010
- 2010-01-08 TN TNP2010000013A patent/TN2010000013A1/fr unknown
- 2010-01-18 ZA ZA201000335A patent/ZA201000335B/xx unknown
- 2010-01-25 MA MA32552A patent/MA32045B1/fr unknown
- 2010-02-03 CO CO10011475A patent/CO6160316A2/es unknown
-
2011
- 2011-11-10 CL CL2008002005A patent/CL2008002005A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2008274223A1 (en) | 2009-01-15 |
SA08290417B1 (ar) | 2013-01-22 |
RU2010103934A (ru) | 2011-08-20 |
RU2462248C2 (ru) | 2012-09-27 |
MA32045B1 (fr) | 2011-02-01 |
CA2695039A1 (fr) | 2009-01-15 |
PA8789101A1 (es) | 2009-04-23 |
JP2010533139A (ja) | 2010-10-21 |
CN101730533B (zh) | 2013-05-29 |
US9173842B2 (en) | 2015-11-03 |
BRPI0814216A2 (pt) | 2015-10-27 |
CL2008002005A1 (es) | 2009-06-26 |
CN101730533A (zh) | 2010-06-09 |
WO2009007388A1 (fr) | 2009-01-15 |
CO6160316A2 (es) | 2010-05-20 |
EP2187886A1 (fr) | 2010-05-26 |
TW200914018A (en) | 2009-04-01 |
TN2010000013A1 (en) | 2011-09-26 |
US20100196468A1 (en) | 2010-08-05 |
FR2918566A1 (fr) | 2009-01-16 |
ZA201000335B (en) | 2010-10-27 |
KR20100047230A (ko) | 2010-05-07 |
NZ583040A (en) | 2012-03-30 |
AR067499A1 (es) | 2009-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0810646A2 (pt) | " compostos farmacêuticos ". | |
HUE036378T2 (hu) | Humán embrionális õssejtek felhasználási módszerei a gyógyászatban alkalmazott vegyületek és egyéb vegyszerek toxicitásának értékelésére | |
BRPI0912326A2 (pt) | análogos de acetaminofeno hidrossolúveis | |
EP1862183A4 (fr) | Composition pharmaceutique contenant un médicament à peine soluble dans l'eau | |
FR2903003B1 (fr) | Utilisation d'un derive c-glycoside pour ameliorer la fonction barriere de la peau | |
FR2921143B1 (fr) | Bague d'etancheite | |
FR2907311B3 (fr) | Installation d'aquaculture pour micro-algues | |
FR2918566B1 (fr) | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. | |
BRPI0820389A2 (pt) | Formulação granulada usando um agente sequestrador de água | |
FR2906037B1 (fr) | Detecteur d'eau | |
IL177981A0 (en) | Rotary water sprinkler | |
GB2438311B (en) | Water velocity corrections | |
FR2918567B1 (fr) | Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine. | |
FR2935165B1 (fr) | Bague d'etancheite | |
FR2889407B1 (fr) | Pot d'exterieur pour plantes | |
FR2881026B1 (fr) | Pot pour plantes | |
FR2957341B1 (fr) | Produit solide compacte bicouche de purification d'eau | |
BRPI0821830A2 (pt) | Composição líquida autoemulsionável de florfenicol destinada a ser incorporada à água de bebida dos animais de criação | |
FR2951966B1 (fr) | Dispositif de mur d'eau modulaire | |
FR2922465B1 (fr) | Epurateur d'eau | |
FR2897520B3 (fr) | Ustensile d'assujettissement d'objets | |
TH85102B (th) | ตู้จ่ายน้ำ | |
TH89740B (th) | ปั๊มน้ำ | |
FR2890561B1 (fr) | Composition ophtalmique contenant un sel de cysteamine | |
TH91313B (th) | ก๊อกน้ำ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PLFP | Fee payment |
Year of fee payment: 10 |
|
PLFP | Fee payment |
Year of fee payment: 11 |
|
PLFP | Fee payment |
Year of fee payment: 12 |
|
ST | Notification of lapse |
Effective date: 20200306 |