DE69937994D1 - Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörper - Google Patents
Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörperInfo
- Publication number
- DE69937994D1 DE69937994D1 DE69937994T DE69937994T DE69937994D1 DE 69937994 D1 DE69937994 D1 DE 69937994D1 DE 69937994 T DE69937994 T DE 69937994T DE 69937994 T DE69937994 T DE 69937994T DE 69937994 D1 DE69937994 D1 DE 69937994D1
- Authority
- DE
- Germany
- Prior art keywords
- antagonistic
- prophylactic
- therapeutic agents
- inflammatory diseases
- receptor antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6725098 | 1998-03-17 | ||
JP6725098 | 1998-03-17 | ||
PCT/JP1999/001298 WO1999047170A1 (fr) | 1998-03-17 | 1999-03-16 | Agents prophylactiques ou therapeutiques pour affections intestinales inflammatoires renfermant, comme ingredient actif, des antagonistes de il-6 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69937994D1 true DE69937994D1 (de) | 2008-03-06 |
DE69937994T2 DE69937994T2 (de) | 2008-12-24 |
Family
ID=13339502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69937994T Expired - Lifetime DE69937994T2 (de) | 1998-03-17 | 1999-03-16 | Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörper |
Country Status (19)
Country | Link |
---|---|
US (2) | US6723319B1 (de) |
EP (1) | EP1074268B1 (de) |
JP (1) | JP4124573B2 (de) |
KR (1) | KR100407811B1 (de) |
CN (2) | CN100374159C (de) |
AT (1) | ATE383875T1 (de) |
AU (1) | AU754006B2 (de) |
CA (1) | CA2324115C (de) |
CZ (1) | CZ297083B6 (de) |
DE (1) | DE69937994T2 (de) |
DK (1) | DK1074268T3 (de) |
ES (1) | ES2299241T3 (de) |
HK (2) | HK1033911A1 (de) |
HU (1) | HU225539B1 (de) |
NO (1) | NO327718B1 (de) |
PL (1) | PL201461B1 (de) |
PT (1) | PT1074268E (de) |
RU (1) | RU2195960C2 (de) |
WO (1) | WO1999047170A1 (de) |
Families Citing this family (109)
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US8017121B2 (en) * | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
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US20020187150A1 (en) * | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
EP1074268B1 (de) * | 1998-03-17 | 2008-01-16 | Chugai Seiyaku Kabushiki Kaisha | Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörper |
EP1085906B1 (de) * | 1998-06-10 | 2008-08-13 | Ophidian Pharmaceuticals, Inc. | Antikörper gegen il6 zur vorbeugung und behandlung entzündlicher darmerkrankungen |
JP4889187B2 (ja) * | 2000-10-27 | 2012-03-07 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤 |
UA80091C2 (en) * | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
KR101080021B1 (ko) * | 2002-02-14 | 2011-11-04 | 추가이 세이야쿠 가부시키가이샤 | 항체함유 용액제제 |
CN1678744B (zh) * | 2002-08-30 | 2010-05-26 | 财团法人化学及血清疗法研究所 | 人的抗人白细胞介素-6抗体以及所述抗体的片段 |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
WO2005028514A1 (en) * | 2003-09-22 | 2005-03-31 | Biovation Gmbh & Co. Kg. | Use of a compound for reducing the biological effectiveness of il-6 |
BRPI0415505A (pt) | 2003-10-17 | 2006-12-12 | Chugai Pharmaceutical Co Ltd | agente terapêutico para mesotelioma |
US8617550B2 (en) * | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
US8398980B2 (en) * | 2004-03-24 | 2013-03-19 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleuken-6 receptor |
WO2006106905A1 (ja) * | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
CA2625773C (en) | 2005-10-14 | 2015-05-12 | Fukuoka University | Inhibition of interleukin-6 (il-6) receptor promotes pancreatic islet transplantation |
JP5191235B2 (ja) | 2005-10-21 | 2013-05-08 | 中外製薬株式会社 | 心疾患治療剤 |
AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
AR057941A1 (es) * | 2005-11-25 | 2007-12-26 | Univ Keio | Agentes terapeuticos para el cancer de prostata |
AR059213A1 (es) * | 2006-01-27 | 2008-03-19 | Univ Keio | Agentes terapeuticos para enfermedades que involucran neovascularizacion coroidal |
ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
CN101495146B (zh) | 2006-04-07 | 2012-10-17 | 国立大学法人大阪大学 | 肌肉再生促进剂 |
RS52643B (en) | 2006-06-02 | 2013-06-28 | Regeneron Pharmaceuticals Inc. | HIGH AFINITY ANTIBODIES TO THE HUMAN IL-6 RECEPTOR |
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CN101528778A (zh) * | 2006-08-18 | 2009-09-09 | 埃博灵克斯股份有限公司 | 用于治疗与il-6-介导的信号传导相关的疾病和病症的针对il-6r的氨基酸序列以及包括其的多肽 |
US8153128B2 (en) * | 2006-11-30 | 2012-04-10 | Medimmune Limited | Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor |
JP2010095445A (ja) * | 2006-12-27 | 2010-04-30 | Tokyo Medical & Dental Univ | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
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CN101641339B (zh) | 2007-02-01 | 2013-07-17 | 雷斯韦洛吉克斯公司 | 用于预防和治疗心血管疾病的化合物 |
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EP2162469A4 (de) * | 2007-05-21 | 2012-08-01 | Alderbio Holdings Llc | Neue verfahren zur humanisierung von kaninchenantikörpern und humanisierte kaninchenantikörper |
EP3689912A1 (de) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstitution in cdr |
SG10201605394SA (en) | 2007-09-26 | 2016-08-30 | Chugai Pharmaceutical Co Ltd | Modified Antibody Constant Region |
CN101939425B (zh) * | 2007-09-26 | 2014-05-14 | 中外制药株式会社 | 抗il-6受体抗体 |
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EP4238993A3 (de) | 2008-04-11 | 2023-11-29 | Chugai Seiyaku Kabushiki Kaisha | Antigenbindendes molekül zur wiederholten bindung an zwei oder mehr antigenmoleküle |
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