BRPI0415505A - agente terapêutico para mesotelioma - Google Patents
agente terapêutico para mesoteliomaInfo
- Publication number
- BRPI0415505A BRPI0415505A BRPI0415505-0A BRPI0415505A BRPI0415505A BR PI0415505 A BRPI0415505 A BR PI0415505A BR PI0415505 A BRPI0415505 A BR PI0415505A BR PI0415505 A BRPI0415505 A BR PI0415505A
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic agent
- mesothelioma
- mesothelioma therapeutic
- interleukin
- antagonist
- Prior art date
Links
- 206010027406 Mesothelioma Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229940124597 therapeutic agent Drugs 0.000 title abstract 3
- 229940124103 Interleukin 6 antagonist Drugs 0.000 abstract 4
- 102000004889 Interleukin-6 Human genes 0.000 abstract 2
- 108090001005 Interleukin-6 Proteins 0.000 abstract 2
- 102000010781 Interleukin-6 Receptors Human genes 0.000 abstract 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000003966 growth inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Mobile Radio Communication Systems (AREA)
Abstract
"AGENTE TERAPêUTICO PARA MESOTELIOMA". A presente invenção proporciona um agente terapêutico para mesotelioma que contém um antagonista de interleucina-6 (IL-6) tal como anticorpo para receptor de IL-6 (IL-6R), e um inibidor de crescimento celular de mesotelioma que contém um antagonista de IL-6 tal como anticorpo para IL-6R.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003358152 | 2003-10-17 | ||
PCT/JP2004/015674 WO2005037315A1 (ja) | 2003-10-17 | 2004-10-15 | 中皮腫治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0415505A true BRPI0415505A (pt) | 2006-12-12 |
Family
ID=34463281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0415505-0A BRPI0415505A (pt) | 2003-10-17 | 2004-10-15 | agente terapêutico para mesotelioma |
Country Status (23)
Country | Link |
---|---|
US (2) | US20070134242A1 (pt) |
EP (1) | EP1690550B1 (pt) |
JP (1) | JP4651541B2 (pt) |
KR (1) | KR101193708B1 (pt) |
CN (1) | CN1874790B (pt) |
AR (1) | AR046290A1 (pt) |
AU (1) | AU2004281139B2 (pt) |
BR (1) | BRPI0415505A (pt) |
CA (1) | CA2542691C (pt) |
DK (1) | DK1690550T3 (pt) |
ES (1) | ES2392824T3 (pt) |
HK (1) | HK1096588A1 (pt) |
IL (1) | IL174909A (pt) |
MX (1) | MXPA06003768A (pt) |
MY (1) | MY149856A (pt) |
NO (1) | NO20061906L (pt) |
NZ (1) | NZ546557A (pt) |
PL (1) | PL1690550T3 (pt) |
RU (2) | RU2392967C2 (pt) |
SI (1) | SI1690550T1 (pt) |
TW (1) | TWI350175B (pt) |
WO (1) | WO2005037315A1 (pt) |
ZA (1) | ZA200602973B (pt) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2284271C (en) | 1997-03-21 | 2012-05-08 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized t cell-mediated diseases comprising il-6 antagonist as an active ingredient |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
KR20110091822A (ko) * | 2002-02-14 | 2011-08-12 | 추가이 세이야쿠 가부시키가이샤 | 항체함유 용액제제 |
GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
EP3736295A1 (en) | 2004-03-24 | 2020-11-11 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleukin-6 receptor |
EP1941907B1 (en) | 2005-10-14 | 2016-03-23 | Fukuoka University | Inhibitor of transplanted islet dysfunction in islet transplantation |
BRPI0617664B8 (pt) | 2005-10-21 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | uso de um anticorpo que reconhece a il-6 para a produção de uma composição farmacêutica para tratar o enfarte do miocárdio ou suprimir a remodelagem ventricular esquerda depois do enfarte do miocárdio |
AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
EP3135298B1 (en) * | 2006-01-27 | 2018-06-06 | Keio University | Therapeutic agents for diseases involving choroidal neovascularization |
JP5624276B2 (ja) | 2006-03-31 | 2014-11-12 | 中外製薬株式会社 | 抗体の血中動態を制御する方法 |
EP2025346B1 (en) | 2006-04-07 | 2016-08-10 | Osaka University | Muscle regeneration promoter |
ES2564392T3 (es) | 2007-01-23 | 2016-03-22 | Shinshu University | Inhibidores de IL-6 para el tratamiento de rechazo crónico |
US8252286B2 (en) * | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
JP5859202B2 (ja) * | 2007-05-21 | 2016-02-10 | アルダーバイオ・ホールディングズ・エルエルシー | 新規のウサギ抗体ヒト化方法及びヒト化ウサギ抗体 |
US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8062864B2 (en) * | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
HUE043782T2 (hu) | 2007-05-21 | 2019-09-30 | Alderbio Holdings Llc | IL-6 elleni antitestek és alkalmazásuk |
EP4368721A2 (en) | 2007-09-26 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
AR068563A1 (es) | 2007-09-26 | 2009-11-18 | Chugai Pharmaceutical Co Ltd | Region constante de anticuerpo mutante |
PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
MY195714A (en) | 2008-04-11 | 2023-02-07 | Chugai Pharmaceutical Co Ltd | Antigen-Binding Molecule Capable of Binding to Two or More Antigen Molecules Repeatedly |
CN102256623A (zh) | 2008-06-05 | 2011-11-23 | 独立行政法人国立癌症研究中心 | 神经浸润抑制剂 |
WO2010013846A1 (ja) * | 2008-07-30 | 2010-02-04 | 国立大学法人岡山大学 | 新規悪性中皮腫治療剤及び免疫賦活化剤 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
AU2009323009B2 (en) * | 2008-11-25 | 2016-01-28 | Vitaeris Inc. | Antibodies to IL-6 and use thereof |
US20120183539A1 (en) * | 2009-07-31 | 2012-07-19 | Shin Maeda | Cancer Metastasis Inhibitor |
SI2493922T1 (sl) | 2009-10-26 | 2017-06-30 | F. Hoffmann-La Roche Ag | Postopek za proizvodnjo glikoziliranega imunoglobulina |
MX2012005927A (es) | 2009-11-24 | 2012-11-23 | Alder Biopharmaceuticals Inc | Anticuerpos para il-6 uso de los mismos. |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
TWI609698B (zh) | 2010-01-20 | 2018-01-01 | Chugai Pharmaceutical Co Ltd | 穩定化的含抗體溶液製劑 |
RS63800B1 (sr) * | 2010-05-28 | 2022-12-30 | Chugai Pharmaceutical Co Ltd | Poboljšanje antitumorskog odgovora t ćelije |
US20130123138A1 (en) * | 2010-07-25 | 2013-05-16 | New York University | Compositions and methods for prognosis of mesothelioma |
EP2638067A2 (en) | 2010-11-08 | 2013-09-18 | Genentech, Inc. | Subcutaneously administered anti-il-6 receptor antibody |
ES2847891T3 (es) | 2010-11-23 | 2021-08-04 | Vitaeris Inc | Anticuerpos anti-IL-6 para el tratamiento de la mucositis oral |
KR102385507B1 (ko) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
CA2827581A1 (en) * | 2011-03-03 | 2012-09-07 | Apexigen, Inc. | Anti-il-6 receptor antibodies and methods of use |
PL3446714T3 (pl) | 2011-06-02 | 2021-11-22 | University Of Louisville Research Foundation, Inc. | Nanocząstki sprzężone z cząsteczką skierowaną przeciwko nukleolinie |
MX339762B (es) | 2011-09-28 | 2016-05-27 | Univ Autonoma Del Estado De Morelos | Metalopeptidos inmunomoduladores (immp) y composiciones que los contienen. |
JO3370B1 (ar) | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
KR20150090107A (ko) | 2012-12-06 | 2015-08-05 | 도쿠리츠다이가쿠호징 가나자와다이가쿠 | 중피종의 치료 방법 |
EP3009518B1 (en) | 2013-06-11 | 2020-08-12 | National Center of Neurology and Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy |
RU2674996C2 (ru) | 2013-07-04 | 2018-12-14 | Ф. Хоффманн-Ля Рош Аг | Иммуноферментный анализ с подавлением интерференции для определения антител к лекарствам в образцах сыворотки |
KR101892883B1 (ko) | 2015-02-27 | 2018-10-05 | 추가이 세이야쿠 가부시키가이샤 | Il-6 관련 질환 치료용 조성물 |
CA3020885A1 (en) | 2015-05-05 | 2016-11-10 | Mohammad Tariq MALIK | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents |
PL3299810T3 (pl) | 2015-05-19 | 2021-12-13 | National Center Of Neurology And Psychiatry | Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm) |
US11484591B2 (en) | 2016-02-22 | 2022-11-01 | Ohio State Innovation Foundation | Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
AU2018234844B2 (en) | 2017-03-17 | 2024-01-25 | Ohio State Innovation Foundation | Nanoparticles for delivery of chemopreventive agents |
JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法 |
WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗il-6受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
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US521628A (en) | 1894-06-19 | Housekeeping-cabinet | ||
US5670373A (en) * | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
JP2914672B2 (ja) | 1989-01-17 | 1999-07-05 | 中外製薬株式会社 | Bsf▲下2▼アンタゴニスト |
ATE144713T1 (de) * | 1989-07-20 | 1996-11-15 | Tadamitsu Kishimoto | Antikörper gegen menschlichen interleukin-6- rezeptor |
JP2898040B2 (ja) | 1990-01-26 | 1999-05-31 | 忠三 岸本 | gp130蛋白質に対する抗体 |
US5210075A (en) | 1990-02-16 | 1993-05-11 | Tanabe Seiyaku Co., Ltd. | Interleukin 6 antagonist peptides |
DE69229482T2 (de) | 1991-04-25 | 1999-11-18 | Chugai Pharmaceutical Co Ltd | Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor |
FR2694767B1 (fr) | 1992-08-13 | 1994-10-21 | Innotherapie Lab Sa | Anticorps monoclonaux anti-IL6R, et leurs applications. |
US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
AU7967294A (en) | 1993-10-06 | 1995-05-01 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
JPH07324097A (ja) | 1994-05-30 | 1995-12-12 | Daicel Chem Ind Ltd | インターロイキン6拮抗剤、及びペプチド類または医薬として許容されるその塩類 |
PL182089B1 (en) | 1994-10-21 | 2001-11-30 | Chugai Pharmaceutical Co Ltd | Pharmaceutic compositions for treating diseases caused by production of il-6 |
IT1274350B (it) | 1994-12-06 | 1997-07-17 | Angeletti P Ist Richerche Bio | Antagonisti di interleuchina-6(il-6) che consistono di forme solubili del ricettore alfa di il-6, mutate nell'interfaccia che si lega a gp 130 |
IT1274782B (it) | 1994-12-14 | 1997-07-24 | Angeletti P Ist Richerche Bio | Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130 |
JPH08245414A (ja) | 1995-01-27 | 1996-09-24 | Private Biolog Corp | Il−6関連疾患の治療用組成物および方法 |
FR2733250B1 (fr) | 1995-04-21 | 1997-07-04 | Diaclone | Anticorps monoclonaux anti-gp130, et leurs utilisations |
JPH08311098A (ja) | 1995-05-22 | 1996-11-26 | Daicel Chem Ind Ltd | 新規ペプチド類およびそれを含有するインターロイキン6拮抗剤 |
US5571513A (en) | 1995-05-31 | 1996-11-05 | The Board Of Regents Of The University Of Oklahoma | Anti-gp130 monoclonal antibodies |
AU6038196A (en) * | 1995-06-07 | 1996-12-30 | Private Biologicals Corporation | Compositions and methods of treating il-6 associated disease s |
US20020187150A1 (en) * | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
CZ297083B6 (cs) | 1998-03-17 | 2006-09-13 | Chugai Seiyaku Kabushiki Kaisha | Cinidlo pro prevenci a lécbu zánetlivého onemocnení streva obsahující aktivní slozku antagonistu IL-6 |
EP1244807A1 (en) * | 1999-12-09 | 2002-10-02 | Human Genome Sciences, Inc. | Il-6 like polynucleotide |
WO2002034292A1 (fr) | 2000-10-25 | 2002-05-02 | Chugai Seiyaku Kabushiki Kaisha | Agents preventifs ou therapeutiques contre le psoriasis renfermant l'antagoniste de l'il-6 comme substance active |
AU2000279625A1 (en) * | 2000-10-27 | 2002-05-15 | Chugai Seiyaku Kabushiki Kaisha | Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient |
UA80091C2 (en) * | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
US20050090453A1 (en) * | 2003-01-15 | 2005-04-28 | Solbec Pharmaceuticals Co., Ltd. | Methods of modulating IL-6 |
AU2004204261A1 (en) * | 2003-01-15 | 2004-07-29 | Solbec Pharmaceuticals Limited | Method of modulating IL-6 |
JP2006516617A (ja) * | 2003-02-04 | 2006-07-06 | セントコア・インコーポレイテッド | アポトーシスを増強させるための、il−6アンタゴニストとステロイドの併用 |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
US20060094645A1 (en) * | 2004-10-06 | 2006-05-04 | Oliver Lawless | Method for defining and treating chemically-induced immune disorders using tumor necrosis factor (TFNalpha), interleukin-1 (lL-1), and interleulin-6R(lL-6R) antagonists |
-
2004
- 2004-10-15 US US10/575,455 patent/US20070134242A1/en not_active Abandoned
- 2004-10-15 AR ARP040103743A patent/AR046290A1/es unknown
- 2004-10-15 PL PL04792816T patent/PL1690550T3/pl unknown
- 2004-10-15 JP JP2005514876A patent/JP4651541B2/ja active Active
- 2004-10-15 AU AU2004281139A patent/AU2004281139B2/en not_active Ceased
- 2004-10-15 EP EP04792816A patent/EP1690550B1/en active Active
- 2004-10-15 WO PCT/JP2004/015674 patent/WO2005037315A1/ja active Application Filing
- 2004-10-15 RU RU2006116896/15A patent/RU2392967C2/ru not_active IP Right Cessation
- 2004-10-15 KR KR1020067007246A patent/KR101193708B1/ko not_active IP Right Cessation
- 2004-10-15 SI SI200431946T patent/SI1690550T1/sl unknown
- 2004-10-15 MY MYPI20044273A patent/MY149856A/en unknown
- 2004-10-15 MX MXPA06003768A patent/MXPA06003768A/es active IP Right Grant
- 2004-10-15 ES ES04792816T patent/ES2392824T3/es active Active
- 2004-10-15 NZ NZ546557A patent/NZ546557A/en not_active IP Right Cessation
- 2004-10-15 BR BRPI0415505-0A patent/BRPI0415505A/pt not_active IP Right Cessation
- 2004-10-15 RU RU2010102911/15A patent/RU2554942C2/ru not_active IP Right Cessation
- 2004-10-15 CA CA2542691A patent/CA2542691C/en not_active Expired - Fee Related
- 2004-10-15 DK DK04792816.3T patent/DK1690550T3/da active
- 2004-10-15 TW TW093131346A patent/TWI350175B/zh not_active IP Right Cessation
- 2004-10-15 CN CN200480031888XA patent/CN1874790B/zh not_active Expired - Fee Related
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2006
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- 2006-04-12 ZA ZA200602973A patent/ZA200602973B/en unknown
- 2006-04-28 NO NO20061906A patent/NO20061906L/no not_active Application Discontinuation
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2007
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2008
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