DE69728017D1 - Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben - Google Patents

Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben

Info

Publication number
DE69728017D1
DE69728017D1 DE69728017T DE69728017T DE69728017D1 DE 69728017 D1 DE69728017 D1 DE 69728017D1 DE 69728017 T DE69728017 T DE 69728017T DE 69728017 T DE69728017 T DE 69728017T DE 69728017 D1 DE69728017 D1 DE 69728017D1
Authority
DE
Germany
Prior art keywords
samples
detection
methods
devices
multiple analytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69728017T
Other languages
English (en)
Other versions
DE69728017T2 (de
Inventor
Uwe Richard Muller
David J Lane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Molecular Inc
Original Assignee
Vysis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vysis Inc filed Critical Vysis Inc
Application granted granted Critical
Publication of DE69728017D1 publication Critical patent/DE69728017D1/de
Publication of DE69728017T2 publication Critical patent/DE69728017T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69728017T 1996-12-06 1997-12-05 Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben Expired - Lifetime DE69728017T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US761131 1996-12-06
US08/761,131 US5804384A (en) 1996-12-06 1996-12-06 Devices and methods for detecting multiple analytes in samples

Publications (2)

Publication Number Publication Date
DE69728017D1 true DE69728017D1 (de) 2004-04-15
DE69728017T2 DE69728017T2 (de) 2004-07-22

Family

ID=25061260

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69728017T Expired - Lifetime DE69728017T2 (de) 1996-12-06 1997-12-05 Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben

Country Status (4)

Country Link
US (1) US5804384A (de)
EP (1) EP0846776B1 (de)
JP (1) JP4025403B2 (de)
DE (1) DE69728017T2 (de)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
WO1998053300A2 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparaus for sequential processing of analytes
SE9404166D0 (sv) * 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
US6392241B1 (en) * 1996-07-10 2002-05-21 Packard Instrument Company, Inc. Fiber optic coupling device for detecting fluorescence samples
EP2295988A2 (de) 1996-12-31 2011-03-16 High Throughput Genomics, Inc. Multiplex-Analysevorrichtung zur Analyse von Molekülen und zugehöriges Herstellungsverfahren
US20020042048A1 (en) * 1997-01-16 2002-04-11 Radoje Drmanac Methods and compositions for detection or quantification of nucleic acid species
US6056859A (en) * 1997-02-12 2000-05-02 Lockheed Martin Energy Research Corporation Method and apparatus for staining immobilized nucleic acids
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
WO1998049344A1 (en) 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
IL124275A (en) * 1997-05-02 2002-03-10 Bio Merieux Vitek Inc A method to produce sequences of nucleic acids
US6558901B1 (en) * 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
EP0878552A1 (de) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molekularer Nachweis von chromosomalen Veränderungen
US6337214B1 (en) 1997-06-09 2002-01-08 Acgt Medico, Inc. Detection of DNA, RNA and proteins using a test column with two snares
GB9711941D0 (en) 1997-06-09 1997-08-06 Acgt Medico Inc Detection of pathogens
US6849400B1 (en) 1997-07-23 2005-02-01 Gen-Probe Incorporated Methods for detecting and measuring spliced nucleic acids
US6238869B1 (en) * 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6458533B1 (en) 1997-12-19 2002-10-01 High Throughput Genomics, Inc. High throughput assay system for monitoring ESTs
JP3944996B2 (ja) * 1998-03-05 2007-07-18 株式会社日立製作所 Ｄｎａプローブアレー
EP1078098A1 (de) 1998-05-04 2001-02-28 Dako A/S Verfahren und sonden zur detektion chromosomaler aberrationen
WO1999064628A1 (en) * 1998-06-08 1999-12-16 Acgt Medico, Inc. Detection of dna, rna and proteins
US7195867B2 (en) * 1998-06-08 2007-03-27 Acgt Medico Inc. Method for detection of multiple test materials in a sample
JP2002518060A (ja) * 1998-06-24 2002-06-25 グラクソ グループ リミテッド ヌクレオチド検出法
EP2045334A1 (de) 1998-06-24 2009-04-08 Illumina, Inc. Dekodierung von Arraysensoren mit Mikrosphären
ATE269417T1 (de) * 1998-07-23 2004-07-15 Gen Probe Inc Verfahren zur erkennung und messung von gespleisten nukleinsäuren
CA2339163C (en) * 1998-08-10 2010-01-12 Genomic Solutions, Inc. Thermal and fluidic cycling device for nucleic acid hybridization
US6107038A (en) * 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US6413780B1 (en) * 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
WO2000026412A1 (en) * 1998-11-02 2000-05-11 Kenneth Loren Beattie Nucleic acid analysis using sequence-targeted tandem hybridization
US6268147B1 (en) * 1998-11-02 2001-07-31 Kenneth Loren Beattie Nucleic acid analysis using sequence-targeted tandem hybridization
US6638760B1 (en) 1998-11-25 2003-10-28 Pe Corporation (Ny) Method and apparatus for flow-through hybridization
US7116407B2 (en) * 1998-12-15 2006-10-03 Union Biometrica, Inc. System for axial pattern analysis of multicellular organisms
US20030032029A1 (en) * 1998-12-21 2003-02-13 Nanogen, Inc. Three dimensional apparatus and method for integrating sample preparation and multiplex assays
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
ES2221841T3 (es) * 1999-02-26 2005-01-16 Exact Sciences Corporation Dispositivos de purificacion bioquimica con sondas de captacion inmovilizadas y su utilizacion.
US6410231B1 (en) * 1999-02-26 2002-06-25 Incyte Genomics, Inc. SNP detection
DE60020840T2 (de) * 1999-03-11 2006-05-04 Combimatrix Corp., Snoqualmie Sich selbst anordnende matrix
AU4058100A (en) * 1999-04-09 2000-11-14 Arcturus Engineering, Inc. Generic cdna or protein array for customized assays
US20050100943A1 (en) * 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
EP1177441A1 (de) * 1999-05-10 2002-02-06 Prolinx, Inc. Vorrichtung zur zelltrennung und verfahren zur anwendung
JP3911909B2 (ja) 1999-06-09 2007-05-09 株式会社日立製作所 Ｄｎａ試料調製方法及びｄｎａ試料調製装置
US7045287B2 (en) * 1999-07-20 2006-05-16 Agilent Technologies, Inc. Method for contacting fluid components with moieties on a surface
US6294392B1 (en) * 1999-07-21 2001-09-25 The Regents Of The University Of California Spatially-encoded analyte detection
ATE328277T1 (de) * 1999-07-26 2006-06-15 Us Gov Health & Human Serv Schichtvorrichtung mit einfangbereichen zur zellulären analyse
US6613581B1 (en) * 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6613561B1 (en) 1999-11-26 2003-09-02 Olympus Optical Co., Ltd. High-density capillary array for reaction and detection of fluid
DE10000629C5 (de) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Verfahren zur Identifizierung einer auf einen festen Körper aufgebrachten Markierung
JP2004500891A (ja) 2000-06-22 2004-01-15 クリノミクス　バイオサイエンシズ，インク． 凍結組織マイクロアレイ及びその使用法
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US6534307B1 (en) 2001-02-08 2003-03-18 Clinomics Biosciences, Inc. Frozen tissue microarrayer
US6716619B1 (en) 2001-02-08 2004-04-06 Clinomics Biosciences, Inc. Stylet for use with tissue microarrayer and molds
US20020150966A1 (en) * 2001-02-09 2002-10-17 Muraca Patrick J. Specimen-linked database
US7157047B2 (en) * 2001-02-09 2007-01-02 Pss Bio Instruments, Inc. Device for containing, reacting and measuring, and method of containing, reacting and measuring
WO2002080647A2 (en) * 2001-04-03 2002-10-17 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
JP2005509138A (ja) * 2001-05-09 2005-04-07 株式会社荏原製作所 アフィニティー反応プローブ検出分析チップ、及びそれを用いる検出システムと装置
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US9777312B2 (en) 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US6767731B2 (en) * 2001-08-27 2004-07-27 Intel Corporation Electron induced fluorescent method for nucleic acid sequencing
DE10149947A1 (de) 2001-10-10 2003-04-17 Febit Ferrarius Biotech Gmbh Mikrofluidisches Extraktionsverfahren
AU2002347872A1 (en) * 2001-10-12 2003-04-22 Vysis, Inc. Imaging microarrays
DE10153963A1 (de) * 2001-11-06 2003-05-22 Aventis Behring Gmbh Intellect Testsystem zur Untersuchung einer biologischen Flüssigkeit
US7413859B2 (en) * 2001-11-14 2008-08-19 Siemens Aktiengesellschaft Method and biosensors for detecting macromolecular biopolymers
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
EP1487568A4 (de) * 2002-03-12 2005-10-05 Syngenta Participations Ag Mikrokapillaren-hybridisierungskammer
JP2005521425A (ja) 2002-04-01 2005-07-21 フルイディグム コーポレイション 微小流体粒子分析システム
CN101078718A (zh) * 2002-05-08 2007-11-28 松下电器产业株式会社 含生物分子珠粒的管和使用它的分析装置
US20060086309A1 (en) 2002-06-24 2006-04-27 Fluiding Corporation Recirculating fluidic network and methods for using the same
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
JP2005536769A (ja) 2002-08-20 2005-12-02 シヴェラ コーポレイション 回折格子をベースとする光学同定要素
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
AU2003278827A1 (en) 2002-09-12 2004-04-30 Cyvera Corp. Method and apparatus for labelling using diffraction grating-based encoded optical identification elements
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
AU2003274979A1 (en) 2002-09-12 2004-04-30 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
EP2213615A3 (de) 2002-09-25 2012-02-29 California Institute of Technology Mikrofluidische Großintegration
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
US20040101861A1 (en) * 2002-11-27 2004-05-27 Little Roger G. Resonant cavity photodiode array for rapid DNA microarray readout
JP4751328B2 (ja) * 2003-03-27 2011-08-17 コーニング インコーポレイテッド 生物剤と化学剤の、標識を用いないエバネッセント場検出
JP2004344036A (ja) * 2003-05-21 2004-12-09 Fujitsu Ltd 物質導入装置及び物質導入システム
US20050016552A1 (en) * 2003-06-10 2005-01-27 Rubbermaid Commercial Products Llc Smoking-waste receptacle with disposable container
US20040253141A1 (en) * 2003-06-16 2004-12-16 Schembri Carol T. Apparatus and method for nucleic acid spatial ordering
US20050026304A1 (en) * 2003-07-30 2005-02-03 Laurakay Bruhn Microarray based affinity purification and analysis device coupled with secondary analysis technologies
US20050037424A1 (en) * 2003-08-13 2005-02-17 Schembri Carol T. Selectable length linear microarrays
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20050084866A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for sample mixing
US20050084867A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Hybridization and scanning apparatus
US7147362B2 (en) * 2003-10-15 2006-12-12 Agilent Technologies, Inc. Method of mixing by intermittent centrifugal force
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US20050112588A1 (en) * 2003-11-25 2005-05-26 Caren Michael P. Methods and apparatus for analyzing arrays
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
WO2006025866A2 (en) * 2004-03-05 2006-03-09 Creatv Microtech, Inc. Integrated multistep biosensor
WO2005086703A2 (en) * 2004-03-05 2005-09-22 Creatv Microtech, Inc. Flow-through chemical and biological sensor
US20050221418A1 (en) * 2004-04-06 2005-10-06 U.S. Army Research Laboratory Enhanced bacterial endospore detection method and system
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US7935479B2 (en) * 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
US7935489B2 (en) * 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
US7846676B2 (en) * 2004-07-19 2010-12-07 Cell Biosciences, Inc. Methods and devices for analyte detection
EP1627926A1 (de) * 2004-08-19 2006-02-22 Roche Diagnostics GmbH Eine Methode zur Reduktion von falsch-positiven Messergebnissen
ES2401879T3 (es) * 2004-08-31 2013-04-25 Eiken Kagaku Kabushiki Kaisha Método de análisis de ácidos nucleicos
JP4839051B2 (ja) * 2004-10-08 2011-12-14 シスメックス株式会社 核酸プローブを用いる被検物質の検出方法
WO2006055736A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. And methods and apparatus for reading coded microbeads
US7545969B2 (en) * 2004-12-16 2009-06-09 Alliant Techsystems Inc. Method and system for wide-area ultraviolet detection of forensic evidence
JP4626350B2 (ja) * 2005-03-22 2011-02-09 ソニー株式会社 ハイブリダイゼーション検出に適する反応部などを有する流路系、該流路系を用いるハイブリダイゼーション検出装置
US7618809B2 (en) 2005-03-23 2009-11-17 Gebing Ronald A Microarrayer with coaxial multiple punches
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
JP2008536128A (ja) * 2005-04-09 2008-09-04 セル バイオサイエンシズ，インコーポレイテッド 自動化微小体積アッセイシステム
US20060292576A1 (en) * 2005-06-23 2006-12-28 Quest Diagnostics Investments Incorporated Non-in situ hybridization method for detecting chromosomal abnormalities
US8945361B2 (en) 2005-09-20 2015-02-03 ProteinSimple Electrophoresis standards, methods and kits
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
WO2008115185A2 (en) * 2006-04-24 2008-09-25 Nimblegen Systems, Inc. Use of microarrays for genomic representation selection
US20080194414A1 (en) * 2006-04-24 2008-08-14 Albert Thomas J Enrichment and sequence analysis of genomic regions
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
JP4940756B2 (ja) * 2006-05-22 2012-05-30 ソニー株式会社 マイクロ流路系
US20080017512A1 (en) * 2006-07-24 2008-01-24 Bordunov Andrei V Coatings for capillaries capable of capturing analytes
JP5034438B2 (ja) * 2006-10-20 2012-09-26 ソニー株式会社 流路系、及びハイブリダイゼーション検出装置
US20080108804A1 (en) * 2006-11-02 2008-05-08 Kabushiki Kaisha Dnaform Method for modifying RNAS and preparing DNAS from RNAS
EP2089532A4 (de) * 2006-12-01 2010-02-17 Cedars Sinai Medical Center Positivauswahl von serumsproteinen zur proteom-analyse
US8080372B2 (en) * 2007-04-11 2011-12-20 Canon Kabushiki Kaisha Method for detecting nucleic acid in sample, method for designing probes, system for designing probes therefor
US20090023156A1 (en) * 2007-07-20 2009-01-22 Voss Karl O Methods and reagents for quantifying analytes
BRPI0819739A2 (pt) * 2007-11-21 2017-05-09 Univ Erasmus Med Ct Rotterdam sondas de fret otimizadas e usos das mesmas
US8093063B2 (en) * 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
WO2009082242A2 (en) * 2007-12-21 2009-07-02 University Of Otago Optical analyte detection incorporating a micromirror device
US10107782B2 (en) 2008-01-25 2018-10-23 ProteinSimple Method to perform limited two dimensional separation of proteins and other biologicals
EP2331704B1 (de) * 2008-08-14 2016-11-30 Nanostring Technologies, Inc Stabile nanoreporter
DE102008052223A1 (de) * 2008-10-17 2010-04-22 Albert-Ludwigs-Universität Freiburg Lumineszenzscanner sowie Verfahren zur Detektion von Lumineszenz in Halbleiterbauteilen
JP2012018039A (ja) * 2010-07-07 2012-01-26 Sony Corp マイクロ流路と核酸ハイブリダイゼーションのためのマイクロチップとカラム及び装置並びに方法
MX2012012250A (es) 2010-10-18 2013-03-05 Originoil Inc Sistemas, aparatos, y metodos para extraer lipidos no polares de una lechada acuosa de algas y lipidos producidos de la misma.
KR20120062327A (ko) * 2010-12-06 2012-06-14 한국전자통신연구원 바이오센서 장치 및 이의 제조방법
US20120295338A1 (en) * 2011-05-20 2012-11-22 Paul Reep Monitoring systems for biomass processing systems
US20120322064A1 (en) * 2011-05-23 2012-12-20 Board Of Trustees Of Michigan State University Hybridization probes and methods of their use
EP2839276B1 (de) 2012-04-19 2018-06-27 ProteinSimple Isoelektrische fokussierung mit zwei wellenlängen zur bestimmung der wirkstofflast in antikörper-wirkstoff-konjugaten
JP6095058B2 (ja) * 2013-03-14 2017-03-15 国立研究開発法人産業技術総合研究所 メチルシトシン検出法
US9766206B2 (en) 2013-09-27 2017-09-19 ProteinSimple Apparatus, systems, and methods for capillary electrophoresis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603114A (en) * 1980-09-23 1986-07-29 California Institute Of Technology Method for the sequential performance of chemical processes
EP0063810B1 (de) * 1981-04-29 1986-03-05 Ciba-Geigy Ag Prüfmittel und Ausrüstung für immunologische Analysen
US4786600A (en) * 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4960691A (en) * 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
US5447837A (en) * 1987-08-05 1995-09-05 Calypte, Inc. Multi-immunoassay diagnostic system for antigens or antibodies or both
US5202010A (en) * 1987-11-25 1993-04-13 Princeton Biochemicals, Inc. Automated capillary electrophoresis apparatus
US5045172A (en) * 1987-11-25 1991-09-03 Princeton Biochemicals, Inc. Capillary electrophoresis apparatus
JP2539528B2 (ja) * 1990-03-02 1996-10-02 株式会社日立製作所 毛細管を用いた分析方法および分析装置
CA2046713A1 (en) * 1990-10-16 1992-04-17 Richard M. Martinelli Amplification of midivariant dna templates
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
EP0672249B1 (de) * 1993-10-07 1999-05-12 Beckman Coulter, Inc. Verwendung von kapillarer elektroforese zur quantitativen bestimmung von proteinkomponenten und des gesamten proteingehaltes in flussigkeiten
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5534123A (en) * 1995-07-10 1996-07-09 Molecular Dynamics Denaturing separation matrix having hydroxyethyl cellulose for nucleic acid electrophoresis
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries

Also Published As

Publication number Publication date
US5804384A (en) 1998-09-08
JP4025403B2 (ja) 2007-12-19
DE69728017T2 (de) 2004-07-22
EP0846776A2 (de) 1998-06-10
EP0846776A3 (de) 1999-08-11
JPH10185922A (ja) 1998-07-14
EP0846776B1 (de) 2004-03-10

Similar Documents

Publication Publication Date Title
DE69728017D1 (de) Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben
DE69737258D1 (de) Verfahren und Vorrichtung zur Detektion von akutem myokardischem Infarkt
DE69829089D1 (de) Vorrichtung und Apparat zur gleichzeitigen Detektion von mehreren Analyten
DE69516152T2 (de) Zusammensetzungen und verfahren zur anewndung in nachweis von analyten
DE69915926D1 (de) Verfahren und Echographiegerät zur Erfassung von Elastizitätsveränderungen
DE69428749D1 (de) Analyt-nachweis Gerät und Verfahren
DE69727993D1 (de) Vorrichtung und Verfahren zur Detektion von Halbbildsynchronsignalen bei HDTV
DE69815085D1 (de) System und verfahren zur klassifizierrung von zellproben
DE59708311D1 (de) Volumenunabhängiger diagnostischer Testträger und Verfahren zur Bestimmung von Analyten mit dessen Hilfe
DE69935760D1 (de) Gerät und verfahren zur impedanzdetektion
DE69837544D1 (de) Testgerät und methode zur entdeckung von analyten in proben
DE69907878D1 (de) Verfahren und vorrichtung zur elektrokoagulation von flüssigkeiten
DE69723474D1 (de) Verfahren und vorrichtung zur erhöhung der zuverlässigkeit von visueller authentifikation
DE69712937D1 (de) Verfahren zur Bestimmung einer Kalibrierungskurve und Analyseverfahren und diesen Verfahren verwendendes Gerät.
DE69010143D1 (de) Testeinrichtung und Verfahren zur Bestimmung von Fructoasminen.
DE59710226D1 (de) Einrichtung und verfahren zur leckageerkennung
DE69700087D1 (de) Gerät und Verfahren zur Signalanalyse
DE69822830D1 (de) Verfahren und vorrichtung zur bestimmung und charakterisierung von teilchen
DE69429230T2 (de) Vorrichtung und verfahren zur automatischen prüfung von proben
DE69719477T2 (de) Vorrichtung und Verfahren zur Eingabe von Buchstaben
DE69710842D1 (de) Verfahren und Einrichtung zur Ruhestrombestimmung
DE69724681D1 (de) Vorrichtung und Verfahren zur Analyse von Kristallstruktur
DE69614958T2 (de) Gerät und Verfahren zur Detektion von Fingerabdruckmerkmalen
DE59610934D1 (de) Vorrichtung und verfahren zur steifigkeitsmessung von flachen sendungen
DE59804984D1 (de) Verfahren zur Unwuchtbestimmung und Unwuchtmesseinrichtung

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: BOECK, TAPPE, KIRSCHNER RECHTSANWAELTE PATENTANWAELTE