DE69516152T2 - Zusammensetzungen und verfahren zur anewndung in nachweis von analyten - Google Patents

Zusammensetzungen und verfahren zur anewndung in nachweis von analyten

Info

Publication number
DE69516152T2
DE69516152T2 DE69516152T DE69516152T DE69516152T2 DE 69516152 T2 DE69516152 T2 DE 69516152T2 DE 69516152 T DE69516152 T DE 69516152T DE 69516152 T DE69516152 T DE 69516152T DE 69516152 T2 DE69516152 T2 DE 69516152T2
Authority
DE
Germany
Prior art keywords
compositions
methods
analytical detection
analytical
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69516152T
Other languages
English (en)
Other versions
DE69516152D1 (de
Inventor
Parameswara Reddy
C Sternberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of DE69516152D1 publication Critical patent/DE69516152D1/de
Publication of DE69516152T2 publication Critical patent/DE69516152T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69516152T 1994-08-30 1995-08-10 Zusammensetzungen und verfahren zur anewndung in nachweis von analyten Expired - Lifetime DE69516152T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/298,523 US5648213A (en) 1994-08-30 1994-08-30 Compositions and methods for use in detection of analytes
PCT/US1995/010226 WO1996006948A1 (en) 1994-08-30 1995-08-10 Compositions and methods for use in detection of analytes

Publications (2)

Publication Number Publication Date
DE69516152D1 DE69516152D1 (de) 2000-05-11
DE69516152T2 true DE69516152T2 (de) 2000-09-28

Family

ID=23150889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69516152T Expired - Lifetime DE69516152T2 (de) 1994-08-30 1995-08-10 Zusammensetzungen und verfahren zur anewndung in nachweis von analyten

Country Status (6)

Country Link
US (1) US5648213A (de)
EP (1) EP0779934B1 (de)
JP (1) JP3520298B2 (de)
AU (1) AU698206B2 (de)
DE (1) DE69516152T2 (de)
WO (1) WO1996006948A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569341B2 (en) * 1994-01-31 2009-08-04 Trustees Of Boston University Nucleic acid directed immobilization arrays and methods of assembly
GB9404709D0 (en) * 1994-03-11 1994-04-27 Multilyte Ltd Binding assay
GB9419001D0 (en) * 1994-09-21 1994-11-09 Applied Research Systems Assay method
SE9404166D0 (sv) * 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
FR2728687A1 (fr) * 1994-12-21 1996-06-28 Bio Merieux Procede de dosage d'un haptene selon une technique de competition
US6475721B2 (en) * 1995-03-04 2002-11-05 Boston Probes, Inc. Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
CA2255774C (en) * 1996-05-29 2008-03-18 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
JP4000605B2 (ja) 1996-07-24 2007-10-31 株式会社日立製作所 Ｄｎａ試料調整装置及びこれを用いる電気泳動分析装置
GB9624165D0 (en) * 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
SE9604575D0 (sv) 1996-12-12 1996-12-12 Biacore Ab Method and system for analyte determination
US5935523A (en) * 1997-05-29 1999-08-10 Medical Laboratory Automation, Inc. Apparatus for accessing a sealed container
US6133429A (en) * 1997-10-03 2000-10-17 Becton Dickinson And Company Chromophores useful for the preparation of novel tandem conjugates
DE19808003C2 (de) * 1998-02-26 2000-08-24 Michael G Weller Verfahren zur Beschleunigung der Dissoziation von Komplexen
US6303325B1 (en) * 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
WO2001006011A2 (en) * 1999-07-14 2001-01-25 Genometrix Genomics, Inc. Arrays comprising non-covalently associated nucleic acid probes and methods for making and using them
US20020045182A1 (en) * 1999-07-16 2002-04-18 Lynx Therapeutics, Inc. Multiplexed differential displacement for nucleic acid determinations
US7455965B2 (en) * 2000-04-14 2008-11-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
AU2001274869A1 (en) * 2000-05-20 2001-12-03 The Regents Of The University Of Michigan Method of producing a dna library using positional amplification
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
WO2003012147A1 (en) * 2001-02-20 2003-02-13 Datascope Investment Corp. Method for reusing standard blots and microarrays utilizing dna dendrimer technology
AU2002255699A1 (en) * 2001-03-09 2002-09-24 Apollo Biotechnology, Inc. Conjugate probes and optical detection of analytes
EP1249500A1 (de) * 2001-04-12 2002-10-16 chimera biotec GmbH Verfahren zum Nachweis einer Substanz
US6777187B2 (en) * 2001-05-02 2004-08-17 Rubicon Genomics, Inc. Genome walking by selective amplification of nick-translate DNA library and amplification from complex mixtures of templates
US20020197694A1 (en) * 2001-06-20 2002-12-26 Weiping Shao Conjugates of reduced antibodies and biomolecules
US20040197791A1 (en) * 2001-06-29 2004-10-07 Makarov Vladimir L. Methods of using nick translate libraries for snp analysis
JP2004534226A (ja) 2001-06-29 2004-11-11 メソ スケイル テクノロジーズ，エルエルシー 発光試験測定用のアッセイプレート、リーダシステム及び方法
US9777312B2 (en) 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US6942972B2 (en) * 2001-10-24 2005-09-13 Beckman Coulter, Inc. Efficient synthesis of protein-oligonucleotide conjugates
DE10155892A1 (de) * 2001-11-14 2003-05-28 Infineon Technologies Ag Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren und Biosensor zum Erfassen von makromolekularen Biopolymeren
US7413859B2 (en) * 2001-11-14 2008-08-19 Siemens Aktiengesellschaft Method and biosensors for detecting macromolecular biopolymers
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US20040049351A1 (en) * 2002-08-28 2004-03-11 Matson Robert S. Immunosorbent assay in microarray format
DE10245644A1 (de) * 2002-09-30 2004-04-08 Cibitest Gmbh & Co.Kg. Verfahren zum Nachweis von Analyten
ES2424269T3 (es) * 2002-11-01 2013-09-30 Iris International, Inc. Inmuno-PCR sándwich por desplazamiento
AU2003291249A1 (en) * 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
SE0300805D0 (sv) * 2003-03-25 2003-03-25 Biacore Ab Immobilization method and kit therefor
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US7229763B2 (en) * 2003-04-07 2007-06-12 Beckman Coulter, Inc. Assay system using labeled oligonucleotides
US7195875B2 (en) 2003-04-18 2007-03-27 Beckman Coulter, Inc. Oligonucleotide pairs for multiplexed binding assays
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
US20080254997A1 (en) * 2004-03-18 2008-10-16 Nissui Pharmaceutical Co., Ltd. Kit, Device and Method For Analyzing Biological Substance
DK1842226T3 (da) * 2004-11-03 2010-10-18 Iris Molecular Diagnostics Inc Homogen analytpåvisning
DK1815028T3 (da) * 2004-11-03 2012-01-30 Iris Molecular Diagnostics Inc Mikrobobler til affinitetsseparation
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
EP1712914A1 (de) * 2005-04-14 2006-10-18 Unisensor S.A. In vitro-Prozess zur gleichzeitigen Ermittlung und Identifizierung von Antibiotika verschiedener Klassen sowie Reagenzienkit zu dessen Durchführung.
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
US7494776B2 (en) * 2005-07-07 2009-02-24 Beckman Coulter, Inc. Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
US20120269728A1 (en) * 2006-08-02 2012-10-25 Antara Biosciences Inc. Methods and compositions for detecting one or more target agents using tracking components
US9222936B2 (en) 2007-04-18 2015-12-29 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
AU2009215799B2 (en) * 2008-02-21 2013-08-22 Iris International Inc. Method for early determination of recurrence after therapy for prostate cancer
US20120258881A1 (en) * 2010-11-22 2012-10-11 The University Of Chicago Methods and/or Use of Oligonucleotide Conjugates for Assays and Microscopy/Imaging Detections
WO2012094459A2 (en) 2011-01-06 2012-07-12 Glezer Eli N Assay cartridges and methods of using the same
DK2972353T3 (da) 2013-03-11 2023-03-27 Meso Scale Technologies Llc Forbedrede fremgangsmåder til udførelse af multipleksanalyser

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650675A (en) * 1983-08-18 1987-03-17 The Children's Medical Center Corporation Oligonucleotide conjugates
US4818680A (en) * 1985-12-18 1989-04-04 Mary Collins Method and kit involving displacement and rehybridization of labeled polynucleotide
DE3732145A1 (de) * 1987-09-24 1989-04-06 Merck Patent Gmbh Verfahren und reagenz zur durchfuehrung von hybridisierungsreaktionen
CA1339351C (en) * 1987-10-15 1997-08-26 Michael S. Urdea Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US4921788A (en) * 1988-04-12 1990-05-01 The Research Foundation Of State University Of New York Competitive nucleic acid immunoassay for the detection of analytes
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
JPH05149949A (ja) * 1991-11-26 1993-06-15 Nisshin Flour Milling Co Ltd 新規な微量物質測定法
DE69326685T2 (de) * 1992-02-04 2000-06-08 Nen Life Science Prod Inc Amplifikation von test reporters durch nukleinsäure replikation
FR2706618B1 (fr) * 1993-06-11 1995-09-01 Bio Merieux Dispositif pour le dosage d'haptènes et son utilisation.

Also Published As

Publication number Publication date
WO1996006948A1 (en) 1996-03-07
AU698206B2 (en) 1998-10-29
JP3520298B2 (ja) 2004-04-19
US5648213A (en) 1997-07-15
JPH10504962A (ja) 1998-05-19
EP0779934B1 (de) 2000-04-05
DE69516152D1 (de) 2000-05-11
AU3243195A (en) 1996-03-22
EP0779934A1 (de) 1997-06-25

Similar Documents

Publication Publication Date Title
DE69516152T2 (de) Zusammensetzungen und verfahren zur anewndung in nachweis von analyten
DE69728017D1 (de) Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben
ATE351910T1 (de) Ob-fusionsprotein enthaltende zusammensetzungen und verfahren
DE19581886T1 (de) Verfahren und Zusammensetzung zur internen Identifikation von Proben
DE69531497D1 (de) Verfahren zur spaltenbildung in und stützung von lagerstätten
DE69534399D1 (de) Verfahren und Gerät zur Bestimmung von Merkmalpunkten
DE69516201D1 (de) Verfahren zur Herstellung von unsichtbarer Markierung und Verfahren zur Erfassung von unsichtbarer Markierung
DE69406920T2 (de) Analyt-reagierende ktp zusammensetzung und verfahren
DE69827437D1 (de) Verfahren zur Analyse und zur Verhinderung von Korrosion
DE69619611T2 (de) Verfahren und Vorrichtung zur Bestimmung der petrologischen Eigenschaften von Schichtgesteinen
DE69932427D1 (de) Verfahren und testen verwendbar bei der behandlung von alkoholabhängigkeit oder -missbrauch
DE69718094T2 (de) Verfahren und Kit zur Messung von Hämoglobin A1c
DE69822830D1 (de) Verfahren und vorrichtung zur bestimmung und charakterisierung von teilchen
DE69029987D1 (de) Verfahren und Gerät zur parallelen Wiedergabe von Polygonen und Pixeln
DE69613063D1 (de) Zusammensetzungen und Verfahren zur Wirkungsverstärkung von Antibiotika mit Polyphenolen
DE59706787D1 (de) Verfahren und vorrichtung zur bestimmung der räumlichen koordinaten von gegenständen
DE59406795D1 (de) Vorrichtung zur dichte- und konzentrations-bestimmung von sichtbaren bestandteilen in fluiden
DE69510174D1 (de) Verfahren und Reagenz zur Bestimmung von menschlichen Störungen
DE69115541D1 (de) Verfahren und Vorrichtung zur Bestimmung von in der Luft schwebenden Bakterien
DE69524919T2 (de) Verfahren und Vorrichtung zur Bestimmung der Konzentration von Gaskomponenten
DE69119410D1 (de) Reagenz und verfahren zur kalziumbestimmung
DE69330077D1 (de) Testsatz und verfahren zur bestimmung von pestiziden
DE69524161D1 (de) Verfahren zur Bestimmung von Fibrinogen und Reagenz zu dessen Bestimmung
DE69406683D1 (de) Verfahren und vorrichtung zur bestimmung der formeigenschaften von teilchen
DE69602355T2 (de) Verfahren und zusammensetzung zur reinigung von oberflächen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BECKMAN COULTER, INC., BREA, CALIF., US