DE69622555D1 - Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung - Google Patents

Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung

Info

Publication number: DE69622555D1
Authority: DE; Germany
Prior art keywords: pref; iii; pertussis; toxoid; agg
Prior art date: 1995-05-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69622555T

Other languages

English (en)

Other versions

DE69622555T2 (de

Inventor

E Fahim

R Vose

John Thipphawong

Luis Barreto

E Jackson

U Tan

Andrew Herbert

H Klein

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Pasteur Ltd

Original Assignee

Aventis Pasteur Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-04

Filing date

1996-05-02

Publication date

2002-08-29

1995-05-04 Priority claimed from US08/433,646 external-priority patent/US5877298A/en

1996-05-02 Application filed by Aventis Pasteur Ltd filed Critical Aventis Pasteur Ltd

2002-08-29 Application granted granted Critical

2002-08-29 Publication of DE69622555D1 publication Critical patent/DE69622555D1/de

2003-03-27 Publication of DE69622555T2 publication Critical patent/DE69622555T2/de

2016-05-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

229940124832 acellular pertussis vaccine Drugs 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
201000005702 Pertussis Diseases 0.000 abstract 2
229960005486 vaccine Drugs 0.000 abstract 2
241000588807 Bordetella Species 0.000 abstract 1
241000588832 Bordetella pertussis Species 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
229940037003 alum Drugs 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
229960003983 diphtheria toxoid Drugs 0.000 abstract 1
238000010255 intramuscular injection Methods 0.000 abstract 1
239000007927 intramuscular injection Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
108010021711 pertactin Proteins 0.000 abstract 1
238000010254 subcutaneous injection Methods 0.000 abstract 1
239000007929 subcutaneous injection Substances 0.000 abstract 1
229960000814 tetanus toxoid Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE69622555T 1995-05-04 1996-05-02 Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung Expired - Lifetime DE69622555T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/433,646 US5877298A (en)	1995-05-04	1995-05-04	Acellular pertussis vaccines and methods of preparing thereof
US50174395A	1995-07-12	1995-07-12
PCT/CA1996/000279 WO1996034883A1 (en)	1995-05-04	1996-05-02	Acellular pertussis vaccines and methods of preparation thereof

Publications (2)

Publication Number	Publication Date
DE69622555D1 true DE69622555D1 (de)	2002-08-29
DE69622555T2 DE69622555T2 (de)	2003-03-27

Family

ID=27029924

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE69638326T Expired - Lifetime DE69638326D1 (de)	1995-05-04	1996-05-02	Azelluläre Pertussis-Impfstoffe und Verfahren zu deren Herstellung
DE69622555T Expired - Lifetime DE69622555T2 (de)	1995-05-04	1996-05-02	Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
DE69625191T Expired - Lifetime DE69625191T2 (de)	1995-05-04	1996-05-02	Azelluläre pertussis impfstoffe und verfahren zur herstellung

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69638326T Expired - Lifetime DE69638326D1 (de)	1995-05-04	1996-05-02	Azelluläre Pertussis-Impfstoffe und Verfahren zu deren Herstellung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69625191T Expired - Lifetime DE69625191T2 (de)	1995-05-04	1996-05-02	Azelluläre pertussis impfstoffe und verfahren zur herstellung

Country Status (18)

Country	Link
US (1)	US6399076B2 (de)
EP (7)	EP1233022B1 (de)
CN (2)	CN1198099A (de)
AT (3)	ATE221081T1 (de)
AU (2)	AU715417B2 (de)
BR (2)	BR9608115A (de)
CA (3)	CA2220063C (de)
DE (3)	DE69638326D1 (de)
DK (3)	DK0826001T3 (de)
ES (2)	ES2180758T3 (de)
FR (1)	FR16C0015I2 (de)
HK (1)	HK1016191A1 (de)
LU (1)	LU93036I2 (de)
MX (1)	MX9708481A (de)
NL (1)	NL300804I2 (de)
NZ (2)	NZ306392A (de)
PT (3)	PT1393744E (de)
WO (2)	WO1996034883A1 (de)

Families Citing this family (33)

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FR2646776B1 (fr) *	1989-05-12	1994-06-03	Pasteur Institut	Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella
CN1147259A (zh) *	1994-04-28	1997-04-09	武田药品工业株式会社	分离百日咳杆菌保护性组分的方法
US6696065B1 (en) *	1995-05-04	2004-02-24	Aventis Pastuer Limited	Acellular pertussis vaccines and methods of preparation thereof
GB9611501D0 (en) *	1996-06-03	1996-08-07	Smithkline Beecham Biolog	Vaccine compositions
BR9710460A (pt) *	1996-07-02	1999-08-17	Connaught Lab	Composi-Æo imunolÄgica multi-valente e seu uso em vacinas
WO2000023107A1 (fr) *	1998-10-21	2000-04-27	The Kitasato Institute	Preparations de vaccin contenant des toxines attenuees
CN1906307B (zh) *	2003-11-20	2011-08-24	圣诺菲·帕斯图尔公司	纯化百日咳毒素的方法及其中有用的肽
US8048433B2 (en) *	2004-12-17	2011-11-01	Nvi Nederlands Vaccininstituut	Deacylation of LPS in gram negative bacteria
WO2008039171A2 (en)	2005-08-08	2008-04-03	Oregon Health & Science University	Inactivating pathogens with hydrogen peroxide for vaccine production
EP1867638A1 (de) *	2006-06-16	2007-12-19	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf
PL2097102T3 (pl)	2006-09-07	2012-10-31	Glaxosmithkline Biologicals Sa	Szczepionka skojarzona o zmniejszonej ilości antygenu wirusa polio
CN100537767C (zh) *	2007-04-29	2009-09-09	中国药品生物制品检定所	百日咳疫苗保护性抗原的重组表达及其应用
GB0822633D0 (en) *	2008-12-11	2009-01-21	Novartis Ag	Formulation
US20100330158A1 (en) *	2009-03-31	2010-12-30	Innopharma, Llc	Protein-assisted drug delivery system for the targeted administration of active agents
WO2010131111A1 (en)	2009-05-11	2010-11-18	Novartis Ag	Antigen purification process for pertactin antigen
US20130267690A1 (en) *	2011-09-20	2013-10-10	Bio-Rad Laboratories, Inc.	Removal of virucidal agents from biomolecule preparations
US20140234360A1 (en)	2011-09-30	2014-08-21	The United States of America, as represented by the Secretary, Dept.of Health and Human Services	Influenza vaccine
CN102584958A (zh) *	2012-02-08	2012-07-18	北京天坛生物制品股份有限公司	百日咳杆菌69kd外膜蛋白的纯化方法
CN102793915B (zh) *	2012-07-25	2013-10-23	天津康希诺生物技术有限公司	一种无细胞百日咳疫苗的生产方法
PE20151720A1 (es) *	2013-03-08	2015-12-10	Crucell Holland Bv	Vacuna acelular contra pertussis
SG10201911134QA (en)	2015-06-05	2020-01-30	Grace W R & Co	Adsorbent bioprocessing clarification agents and methods of making and using the same
CN105106947A (zh) *	2015-07-21	2015-12-02	华兰生物工程股份有限公司	过氧化氢脱毒的无细胞百日咳疫苗及其制备方法
EP3518968B1 (de)	2016-10-03	2022-01-05	The U.S.A. as represented by the Secretary, Department of Health and Human Services	Hiv-1-env-fusionspeptid-immunogene und deren verwendung
WO2018081832A1 (en)	2016-10-31	2018-05-03	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Peptide fragments from filoviruses and their uses
EP3600405A1 (de)	2017-03-24	2020-02-05	The U.S.A. As Represented By The Secretary, Department Of Health And Human Services	Glycanmaskierte manipulierte äussere domänen von hiv-1 gp120 und deren verwendung
KR102426041B1 (ko) *	2017-08-01	2022-07-29	주식회사 녹십자	냉동 및 해동 과정을 포함하는 백일해균 유래 단백질 수득 방법
WO2019079337A1 (en)	2017-10-16	2019-04-25	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE
WO2020061564A1 (en)	2018-09-23	2020-03-26	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use
CA3117390A1 (en)	2018-10-22	2020-04-30	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Recombinant gp120 protein with v1-loop deletion
CN110358802B (zh) *	2019-08-16	2021-06-18	长春百克生物科技股份公司	一种去除百日咳组分菌毛蛋白2/3内毒素的方法
CN112094354B (zh) *	2020-11-05	2021-02-02	苏州世诺生物技术有限公司	副鸡禽杆菌基因工程亚单位疫苗、其制备方法及应用
AU2022323509A1 (en)	2021-08-03	2024-02-08	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
WO2023192835A1 (en)	2022-03-27	2023-10-05	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Base-covered hiv-1 envelope ectodomains and their use

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US4258029A (en)	1979-04-23	1981-03-24	Connaught Laboratories Limited	Synthetic adjuvants for stimulation of antigenic responses
DE3521994A1 (de)	1985-06-20	1987-01-02	Bayer Ag	N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8601279D0 (en) *	1986-01-20	1986-02-26	Public Health Lab Service	Purification of pertussis antigens
US4705686A (en)	1986-05-09	1987-11-10	American Cyanamid	Process for the preparation of acellular Bordetalla pertussis vaccine
JP2918895B2 (ja) *	1987-09-04	1999-07-12	アムジエン・インコーポレーテツド	組換え型ｄｎａ由来ボルデテラ毒素サブユニット類似体
GB8727489D0 (en)	1987-11-24	1987-12-23	Connaught Lab	Detoxification of pertussis toxin
GB8807860D0 (en)	1988-04-05	1988-05-05	Connaught Lab	Pertussis vaccine
US4967176A (en) *	1988-07-15	1990-10-30	Raychem Corporation	Assemblies of PTC circuit protection devices
US5101014A (en)	1989-02-10	1992-03-31	United States Of America	Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis
WO1990012086A1 (en) *	1989-03-31	1990-10-18	Washington University	Bordetella vaccines
US5276142A (en)	1989-12-11	1994-01-04	American Cyanamid Company	Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis
GB9007657D0 (en) *	1990-04-04	1990-05-30	Connaught Lab	Purification of a pertussis outer membrane protein(omp69)
EP0484621A3 (en) *	1990-07-11	1992-08-26	American Cyanamid Company	Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
CN1147259A (zh) *	1994-04-28	1997-04-09	武田药品工业株式会社	分离百日咳杆菌保护性组分的方法
FR2728170A1 (fr) *	1994-12-15	1996-06-21	Pasteur Institut	Vaccin de type acellulaire anti-bordetella
US5877298A (en) *	1995-05-04	1999-03-02	Connaught Lab	Acellular pertussis vaccines and methods of preparing thereof

1996
- 1996-05-02 CA CA002220063A patent/CA2220063C/en not_active Expired - Lifetime
- 1996-05-02 AT AT96911887T patent/ATE221081T1/de active
- 1996-05-02 DK DK96911887T patent/DK0826001T3/da active
- 1996-05-02 DE DE69638326T patent/DE69638326D1/de not_active Expired - Lifetime
- 1996-05-02 DE DE69622555T patent/DE69622555T2/de not_active Expired - Lifetime
- 1996-05-02 EP EP02077074.9A patent/EP1233022B1/de not_active Expired - Lifetime
- 1996-05-02 PT PT03078355T patent/PT1393744E/pt unknown
- 1996-05-02 AT AT03078355T patent/ATE496634T1/de active
- 1996-05-02 NZ NZ306392A patent/NZ306392A/en not_active IP Right Cessation
- 1996-05-02 MX MX9708481A patent/MX9708481A/es active IP Right Grant
- 1996-05-02 EP EP02012064A patent/EP1234580A1/de not_active Withdrawn
- 1996-05-02 PT PT96911887T patent/PT826001E/pt unknown
- 1996-05-02 BR BR9608115-5A patent/BR9608115A/pt not_active Application Discontinuation
- 1996-05-02 DK DK03078355.9T patent/DK1393744T3/da active
- 1996-05-02 EP EP96911886A patent/EP0824358B1/de not_active Expired - Lifetime
- 1996-05-02 BR BR9608114-7A patent/BR9608114A/pt not_active Application Discontinuation
- 1996-05-02 WO PCT/CA1996/000279 patent/WO1996034883A1/en active IP Right Grant
- 1996-05-02 AU AU54940/96A patent/AU715417B2/en not_active Expired
- 1996-05-02 CA CA002433502A patent/CA2433502A1/en not_active Abandoned
- 1996-05-02 AU AU54941/96A patent/AU710538B2/en not_active Expired
- 1996-05-02 EP EP20030078354 patent/EP1405643A1/de not_active Withdrawn
- 1996-05-02 NZ NZ306391A patent/NZ306391A/xx not_active IP Right Cessation
- 1996-05-02 WO PCT/CA1996/000278 patent/WO1996034623A1/en active IP Right Grant
- 1996-05-02 CN CN96195230A patent/CN1198099A/zh active Pending
- 1996-05-02 CA CA002220048A patent/CA2220048C/en not_active Expired - Lifetime
- 1996-05-02 AT AT96911886T patent/ATE228851T1/de active
- 1996-05-02 DK DK96911886T patent/DK0824358T3/da active
- 1996-05-02 EP EP03078355A patent/EP1393744B1/de not_active Expired - Lifetime
- 1996-05-02 US US08/945,750 patent/US6399076B2/en not_active Expired - Lifetime
- 1996-05-02 PT PT96911886T patent/PT824358E/pt unknown
- 1996-05-02 EP EP02012063A patent/EP1234579A1/de not_active Withdrawn
- 1996-05-02 DE DE69625191T patent/DE69625191T2/de not_active Expired - Lifetime
- 1996-05-02 ES ES96911887T patent/ES2180758T3/es not_active Expired - Lifetime
- 1996-05-02 EP EP96911887A patent/EP0826001B1/de not_active Expired - Lifetime
- 1996-05-02 CN CNB961952296A patent/CN100387618C/zh not_active Expired - Lifetime
- 1996-05-02 ES ES96911886T patent/ES2182971T3/es not_active Expired - Lifetime
1999
- 1999-03-15 HK HK99101064.1A patent/HK1016191A1/xx not_active IP Right Cessation
2016
- 2016-04-21 LU LU93036C patent/LU93036I2/xx unknown
- 2016-04-27 FR FR16C0015C patent/FR16C0015I2/fr active Active
- 2016-04-28 NL NL300804C patent/NL300804I2/nl unknown

Also Published As

Publication number	Publication date
EP0826001A1 (de)	1998-03-04
FR16C0015I2 (fr)	2017-06-09
DE69625191D1 (de)	2003-01-16
EP0824358B1 (de)	2002-12-04
DK0824358T3 (da)	2003-01-27
PT826001E (pt)	2002-12-31
NL300804I2 (de)	2016-11-01
PT824358E (pt)	2003-02-28
WO1996034883A1 (en)	1996-11-07
FR16C0015I1 (de)	2016-06-10
EP1405643A1 (de)	2004-04-07
LU93036I2 (fr)	2016-06-21
US20010009666A1 (en)	2001-07-26
DE69625191T2 (de)	2003-07-10
ES2180758T3 (es)	2003-02-16
AU5494196A (en)	1996-11-21
CA2220048A1 (en)	1996-11-07
AU710538B2 (en)	1999-09-23
EP0826001B1 (de)	2002-07-24
EP0824358A1 (de)	1998-02-25
CA2220063A1 (en)	1996-11-07
EP1393744A1 (de)	2004-03-03
DE69638326D1 (de)	2011-03-10
BR9608115A (pt)	2004-07-13
CA2220063C (en)	2003-08-26
US6399076B2 (en)	2002-06-04
CN1198099A (zh)	1998-11-04
BR9608114A (pt)	2000-10-31
EP1393744B1 (de)	2011-01-26
DE69622555T2 (de)	2003-03-27
EP1234580A1 (de)	2002-08-28
ATE228851T1 (de)	2002-12-15
EP1234579A1 (de)	2002-08-28
AU715417B2 (en)	2000-02-03
CN1193324A (zh)	1998-09-16
CA2433502A1 (en)	1996-11-07
HK1016191A1 (en)	1999-10-29
MX9708481A (es)	1998-02-28
NZ306392A (en)	1999-04-29
ES2182971T3 (es)	2003-03-16
ATE496634T1 (de)	2011-02-15
WO1996034623A1 (en)	1996-11-07
EP1233022A1 (de)	2002-08-21
DK1393744T3 (da)	2011-05-30
NZ306391A (en)	1999-03-29
DK0826001T3 (da)	2002-11-18
ATE221081T1 (de)	2002-08-15
CN100387618C (zh)	2008-05-14
EP1233022B1 (de)	2015-12-09
AU5494096A (en)	1996-11-21
CA2220048C (en)	2006-03-07
PT1393744E (pt)	2011-05-03

Publication	Publication Date	Title
ATE221081T1 (de)	2002-08-15	Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
AU4267093A (en)	1993-11-29	Vaccine compositions for mucosal delivery
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