BR9608115A - Vacinas de pertussis acelular e processos de preparação destas - Google Patents
Vacinas de pertussis acelular e processos de preparação destasInfo
- Publication number
- BR9608115A BR9608115A BR9608115-5A BR9608115A BR9608115A BR 9608115 A BR9608115 A BR 9608115A BR 9608115 A BR9608115 A BR 9608115A BR 9608115 A BR9608115 A BR 9608115A
- Authority
- BR
- Brazil
- Prior art keywords
- agglutinogens
- pertussis vaccines
- processes
- preparation
- acellular pertussis
- Prior art date
Links
- 229940066827 pertussis vaccine Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 241001076388 Fimbria Species 0.000 abstract 2
- 241000588807 Bordetella Species 0.000 abstract 1
- 241000588832 Bordetella pertussis Species 0.000 abstract 1
- 101710154606 Hemagglutinin Proteins 0.000 abstract 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 1
- 101710176177 Protein A56 Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000185 hemagglutinin Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 108010021711 pertactin Proteins 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"VACINAS DE PERTUSSIS ACELULAR E PROCESSOS DE PREPARAçãO DESTAS". Vacinas de pertussis acelular compreendem toxina purificada ou toxóide desta, hemaglutinina purificada, pertactina e aglutinogênios fimbriais formulados para conferir proteção a pelo menos 70% da população em risco. Os aglutinogênios fimbriais podem ser preparados de uma cepa de Bordetella, particularmente uma B. pertussis, por um procedimento de múltiplas etapas envolvendo extração dos aglutinogênios fimbriais de uma pasta de célula e concentrando e purificando o material extraído.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/433,646 US5877298A (en) | 1995-05-04 | 1995-05-04 | Acellular pertussis vaccines and methods of preparing thereof |
US50174395A | 1995-07-12 | 1995-07-12 | |
PCT/CA1996/000278 WO1996034623A1 (en) | 1995-05-04 | 1996-05-02 | Acellular pertussis vaccines and methods of preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9608115A true BR9608115A (pt) | 2004-07-13 |
Family
ID=27029924
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9608115-5A BR9608115A (pt) | 1995-05-04 | 1996-05-02 | Vacinas de pertussis acelular e processos de preparação destas |
BR9608114-7A BR9608114A (pt) | 1995-05-04 | 1996-05-02 | Vacinas de pertussis a celular e processos para preparação das mesmas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9608114-7A BR9608114A (pt) | 1995-05-04 | 1996-05-02 | Vacinas de pertussis a celular e processos para preparação das mesmas |
Country Status (18)
Country | Link |
---|---|
US (1) | US6399076B2 (pt) |
EP (7) | EP1233022B1 (pt) |
CN (2) | CN1198099A (pt) |
AT (3) | ATE221081T1 (pt) |
AU (2) | AU715417B2 (pt) |
BR (2) | BR9608115A (pt) |
CA (3) | CA2220063C (pt) |
DE (3) | DE69638326D1 (pt) |
DK (3) | DK0826001T3 (pt) |
ES (2) | ES2180758T3 (pt) |
FR (1) | FR16C0015I2 (pt) |
HK (1) | HK1016191A1 (pt) |
LU (1) | LU93036I2 (pt) |
MX (1) | MX9708481A (pt) |
NL (1) | NL300804I2 (pt) |
NZ (2) | NZ306392A (pt) |
PT (3) | PT1393744E (pt) |
WO (2) | WO1996034883A1 (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2646776B1 (fr) * | 1989-05-12 | 1994-06-03 | Pasteur Institut | Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella |
CN1147259A (zh) * | 1994-04-28 | 1997-04-09 | 武田药品工业株式会社 | 分离百日咳杆菌保护性组分的方法 |
US6696065B1 (en) * | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
GB9611501D0 (en) * | 1996-06-03 | 1996-08-07 | Smithkline Beecham Biolog | Vaccine compositions |
BR9710460A (pt) * | 1996-07-02 | 1999-08-17 | Connaught Lab | Composi-Æo imunolÄgica multi-valente e seu uso em vacinas |
WO2000023107A1 (fr) * | 1998-10-21 | 2000-04-27 | The Kitasato Institute | Preparations de vaccin contenant des toxines attenuees |
CN1906307B (zh) * | 2003-11-20 | 2011-08-24 | 圣诺菲·帕斯图尔公司 | 纯化百日咳毒素的方法及其中有用的肽 |
US8048433B2 (en) * | 2004-12-17 | 2011-11-01 | Nvi Nederlands Vaccininstituut | Deacylation of LPS in gram negative bacteria |
WO2008039171A2 (en) | 2005-08-08 | 2008-04-03 | Oregon Health & Science University | Inactivating pathogens with hydrogen peroxide for vaccine production |
EP1867638A1 (de) * | 2006-06-16 | 2007-12-19 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf |
PL2097102T3 (pl) | 2006-09-07 | 2012-10-31 | Glaxosmithkline Biologicals Sa | Szczepionka skojarzona o zmniejszonej ilości antygenu wirusa polio |
CN100537767C (zh) * | 2007-04-29 | 2009-09-09 | 中国药品生物制品检定所 | 百日咳疫苗保护性抗原的重组表达及其应用 |
GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
US20100330158A1 (en) * | 2009-03-31 | 2010-12-30 | Innopharma, Llc | Protein-assisted drug delivery system for the targeted administration of active agents |
WO2010131111A1 (en) | 2009-05-11 | 2010-11-18 | Novartis Ag | Antigen purification process for pertactin antigen |
US20130267690A1 (en) * | 2011-09-20 | 2013-10-10 | Bio-Rad Laboratories, Inc. | Removal of virucidal agents from biomolecule preparations |
US20140234360A1 (en) | 2011-09-30 | 2014-08-21 | The United States of America, as represented by the Secretary, Dept.of Health and Human Services | Influenza vaccine |
CN102584958A (zh) * | 2012-02-08 | 2012-07-18 | 北京天坛生物制品股份有限公司 | 百日咳杆菌69kd外膜蛋白的纯化方法 |
CN102793915B (zh) * | 2012-07-25 | 2013-10-23 | 天津康希诺生物技术有限公司 | 一种无细胞百日咳疫苗的生产方法 |
PE20151720A1 (es) * | 2013-03-08 | 2015-12-10 | Crucell Holland Bv | Vacuna acelular contra pertussis |
SG10201911134QA (en) | 2015-06-05 | 2020-01-30 | Grace W R & Co | Adsorbent bioprocessing clarification agents and methods of making and using the same |
CN105106947A (zh) * | 2015-07-21 | 2015-12-02 | 华兰生物工程股份有限公司 | 过氧化氢脱毒的无细胞百日咳疫苗及其制备方法 |
EP3518968B1 (en) | 2016-10-03 | 2022-01-05 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Hiv-1 env fusion peptide immunogens and their use |
WO2018081832A1 (en) | 2016-10-31 | 2018-05-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Peptide fragments from filoviruses and their uses |
EP3600405A1 (en) | 2017-03-24 | 2020-02-05 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Glycan-masked engineered outer domains of hiv-1 gp120 and their use |
KR102426041B1 (ko) * | 2017-08-01 | 2022-07-29 | 주식회사 녹십자 | 냉동 및 해동 과정을 포함하는 백일해균 유래 단백질 수득 방법 |
WO2019079337A1 (en) | 2017-10-16 | 2019-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE |
WO2020061564A1 (en) | 2018-09-23 | 2020-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use |
CA3117390A1 (en) | 2018-10-22 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant gp120 protein with v1-loop deletion |
CN110358802B (zh) * | 2019-08-16 | 2021-06-18 | 长春百克生物科技股份公司 | 一种去除百日咳组分菌毛蛋白2/3内毒素的方法 |
CN112094354B (zh) * | 2020-11-05 | 2021-02-02 | 苏州世诺生物技术有限公司 | 副鸡禽杆菌基因工程亚单位疫苗、其制备方法及应用 |
AU2022323509A1 (en) | 2021-08-03 | 2024-02-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection |
WO2023192835A1 (en) | 2022-03-27 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Base-covered hiv-1 envelope ectodomains and their use |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
DE3521994A1 (de) | 1985-06-20 | 1987-01-02 | Bayer Ag | N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
GB8601279D0 (en) * | 1986-01-20 | 1986-02-26 | Public Health Lab Service | Purification of pertussis antigens |
US4705686A (en) | 1986-05-09 | 1987-11-10 | American Cyanamid | Process for the preparation of acellular Bordetalla pertussis vaccine |
JP2918895B2 (ja) * | 1987-09-04 | 1999-07-12 | アムジエン・インコーポレーテツド | 組換え型dna由来ボルデテラ毒素サブユニット類似体 |
GB8727489D0 (en) | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
GB8807860D0 (en) | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
US4967176A (en) * | 1988-07-15 | 1990-10-30 | Raychem Corporation | Assemblies of PTC circuit protection devices |
US5101014A (en) | 1989-02-10 | 1992-03-31 | United States Of America | Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis |
WO1990012086A1 (en) * | 1989-03-31 | 1990-10-18 | Washington University | Bordetella vaccines |
US5276142A (en) | 1989-12-11 | 1994-01-04 | American Cyanamid Company | Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis |
GB9007657D0 (en) * | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
EP0484621A3 (en) * | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
CN1147259A (zh) * | 1994-04-28 | 1997-04-09 | 武田药品工业株式会社 | 分离百日咳杆菌保护性组分的方法 |
FR2728170A1 (fr) * | 1994-12-15 | 1996-06-21 | Pasteur Institut | Vaccin de type acellulaire anti-bordetella |
US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
-
1996
- 1996-05-02 CA CA002220063A patent/CA2220063C/en not_active Expired - Lifetime
- 1996-05-02 AT AT96911887T patent/ATE221081T1/de active
- 1996-05-02 DK DK96911887T patent/DK0826001T3/da active
- 1996-05-02 DE DE69638326T patent/DE69638326D1/de not_active Expired - Lifetime
- 1996-05-02 DE DE69622555T patent/DE69622555T2/de not_active Expired - Lifetime
- 1996-05-02 EP EP02077074.9A patent/EP1233022B1/en not_active Expired - Lifetime
- 1996-05-02 PT PT03078355T patent/PT1393744E/pt unknown
- 1996-05-02 AT AT03078355T patent/ATE496634T1/de active
- 1996-05-02 NZ NZ306392A patent/NZ306392A/en not_active IP Right Cessation
- 1996-05-02 MX MX9708481A patent/MX9708481A/es active IP Right Grant
- 1996-05-02 EP EP02012064A patent/EP1234580A1/en not_active Withdrawn
- 1996-05-02 PT PT96911887T patent/PT826001E/pt unknown
- 1996-05-02 BR BR9608115-5A patent/BR9608115A/pt not_active Application Discontinuation
- 1996-05-02 DK DK03078355.9T patent/DK1393744T3/da active
- 1996-05-02 EP EP96911886A patent/EP0824358B1/en not_active Expired - Lifetime
- 1996-05-02 BR BR9608114-7A patent/BR9608114A/pt not_active Application Discontinuation
- 1996-05-02 WO PCT/CA1996/000279 patent/WO1996034883A1/en active IP Right Grant
- 1996-05-02 AU AU54940/96A patent/AU715417B2/en not_active Expired
- 1996-05-02 CA CA002433502A patent/CA2433502A1/en not_active Abandoned
- 1996-05-02 AU AU54941/96A patent/AU710538B2/en not_active Expired
- 1996-05-02 EP EP20030078354 patent/EP1405643A1/en not_active Withdrawn
- 1996-05-02 NZ NZ306391A patent/NZ306391A/xx not_active IP Right Cessation
- 1996-05-02 WO PCT/CA1996/000278 patent/WO1996034623A1/en active IP Right Grant
- 1996-05-02 CN CN96195230A patent/CN1198099A/zh active Pending
- 1996-05-02 CA CA002220048A patent/CA2220048C/en not_active Expired - Lifetime
- 1996-05-02 AT AT96911886T patent/ATE228851T1/de active
- 1996-05-02 DK DK96911886T patent/DK0824358T3/da active
- 1996-05-02 EP EP03078355A patent/EP1393744B1/en not_active Expired - Lifetime
- 1996-05-02 US US08/945,750 patent/US6399076B2/en not_active Expired - Lifetime
- 1996-05-02 PT PT96911886T patent/PT824358E/pt unknown
- 1996-05-02 EP EP02012063A patent/EP1234579A1/en not_active Withdrawn
- 1996-05-02 DE DE69625191T patent/DE69625191T2/de not_active Expired - Lifetime
- 1996-05-02 ES ES96911887T patent/ES2180758T3/es not_active Expired - Lifetime
- 1996-05-02 EP EP96911887A patent/EP0826001B1/en not_active Expired - Lifetime
- 1996-05-02 CN CNB961952296A patent/CN100387618C/zh not_active Expired - Lifetime
- 1996-05-02 ES ES96911886T patent/ES2182971T3/es not_active Expired - Lifetime
-
1999
- 1999-03-15 HK HK99101064.1A patent/HK1016191A1/xx not_active IP Right Cessation
-
2016
- 2016-04-21 LU LU93036C patent/LU93036I2/xx unknown
- 2016-04-27 FR FR16C0015C patent/FR16C0015I2/fr active Active
- 2016-04-28 NL NL300804C patent/NL300804I2/nl unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1762 DE 20041013 POR TEREM SIDO APRESENTADAS COPIAS DE PETICOES. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ART. 8O DA LPI. |