DK0711282T3 - Forbindelser som PDE IV og TNF inhibitorer - Google Patents

Forbindelser som PDE IV og TNF inhibitorer

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Publication number
DK0711282T3
DK0711282T3 DK94922940T DK94922940T DK0711282T3 DK 0711282 T3 DK0711282 T3 DK 0711282T3 DK 94922940 T DK94922940 T DK 94922940T DK 94922940 T DK94922940 T DK 94922940T DK 0711282 T3 DK0711282 T3 DK 0711282T3
Authority
DK
Denmark
Prior art keywords
cyclic amp
tnf
compounds
amp phosphodiesterase
inhibiting
Prior art date
Application number
DK94922940T
Other languages
English (en)
Inventor
Garry Fenton
Tahir Nadeem Majid
Malcolm Norman Palfreyman
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939315581A external-priority patent/GB9315581D0/en
Priority claimed from GB939315632A external-priority patent/GB9315632D0/en
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of DK0711282T3 publication Critical patent/DK0711282T3/da

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
    • C07C2603/64—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings having a tricyclo[2.2.1.0(2,6)]heptstructure
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    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings
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ATE218549T1 (de) 2002-06-15
CA2160928A1 (en) 1995-02-09
US7652144B2 (en) 2010-01-26
EP0711282B1 (en) 2002-06-05
JP2010195787A (ja) 2010-09-09
JP2005225868A (ja) 2005-08-25
US20030013713A1 (en) 2003-01-16
US20060084809A1 (en) 2006-04-20
ZA945609B (en) 1995-05-12
JPH09501155A (ja) 1997-02-04
US20040171618A1 (en) 2004-09-02
EP0711282A1 (en) 1996-05-15
US6472412B1 (en) 2002-10-29
DE69430747D1 (de) 2002-07-11
JP4521283B2 (ja) 2010-08-11
DE69430747T2 (de) 2003-03-06
PT711282E (pt) 2002-11-29
AU7267094A (en) 1995-02-28
IL110492A0 (en) 1994-10-21
US8129537B2 (en) 2012-03-06
US7045660B2 (en) 2006-05-16
ES2176251T3 (es) 2002-12-01
US20080132706A1 (en) 2008-06-05
US20100240677A1 (en) 2010-09-23
CA2160928C (en) 2005-07-05
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