DK0652868T3 - Hæmmere af c-AMP-phosphodiesterase - Google Patents

Hæmmere af c-AMP-phosphodiesterase

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Publication number
DK0652868T3
DK0652868T3 DK93917937T DK93917937T DK0652868T3 DK 0652868 T3 DK0652868 T3 DK 0652868T3 DK 93917937 T DK93917937 T DK 93917937T DK 93917937 T DK93917937 T DK 93917937T DK 0652868 T3 DK0652868 T3 DK 0652868T3
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DK
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Prior art keywords
compounds
directed
amp phosphodiesterase
inhibitors
pharmaceutical use
Prior art date
Application number
DK93917937T
Other languages
English (en)
Inventor
Garry Fenton
Andrew David Morley
Malcolm Norman Palfreyman
Andrew James Ratcliffe
Brian William Sharp
Keith Alfred James Stuttle
Sukanthini Thurairatnam
Bernard Yvon Jack Vacher
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929216008A external-priority patent/GB9216008D0/en
Priority claimed from GB929216005A external-priority patent/GB9216005D0/en
Priority claimed from GB929216006A external-priority patent/GB9216006D0/en
Priority claimed from GB929215989A external-priority patent/GB9215989D0/en
Priority claimed from GB929216764A external-priority patent/GB9216764D0/en
Priority claimed from GB939310633A external-priority patent/GB9310633D0/en
Priority claimed from GB939310938A external-priority patent/GB9310938D0/en
Priority claimed from GB939311281A external-priority patent/GB9311281D0/en
Priority claimed from GB939314847A external-priority patent/GB9314847D0/en
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of DK0652868T3 publication Critical patent/DK0652868T3/da

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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GB929216008A GB9216008D0 (en) 1992-07-28 1992-07-28 Novel compositions of matter
GB929216005A GB9216005D0 (en) 1992-07-28 1992-07-28 New compounds
GB929216006A GB9216006D0 (en) 1992-07-28 1992-07-28 New use
GB929215989A GB9215989D0 (en) 1992-07-28 1992-07-28 Novel compounds
GB929216764A GB9216764D0 (en) 1992-08-07 1992-08-07 Novel compounds
GB939310633A GB9310633D0 (en) 1993-05-21 1993-05-21 New compositions of matter
GB939310938A GB9310938D0 (en) 1993-05-27 1993-05-27 New compositions of matter
GB939311281A GB9311281D0 (en) 1993-06-01 1993-06-01 Novel composition of matter
GB939314847A GB9314847D0 (en) 1993-07-16 1993-07-16 New use
PCT/GB1993/001597 WO1994002465A1 (en) 1992-07-28 1993-07-28 INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF

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NZ254881A (en) 1996-09-25
AU4717693A (en) 1994-02-14
CZ14795A3 (en) 1996-07-17
EP0652868B1 (en) 2004-11-10
JP3775684B2 (ja) 2006-05-17
IL106517A0 (en) 1994-08-26
HU9500265D0 (en) 1995-03-28
JPH08503925A (ja) 1996-04-30
FI950375A (fi) 1995-01-27
ATE282025T1 (de) 2004-11-15
CA2140441C (en) 2006-11-21
MX9304571A (es) 1994-05-31
NO950319D0 (no) 1995-01-27
PL307265A1 (en) 1995-05-15
FI950375A0 (fi) 1995-01-27
NO950319L (no) 1995-03-27
DE69333688T2 (de) 2005-11-03
DE69333688D1 (de) 2004-12-16
CA2140441A1 (en) 1994-02-03
HUT72656A (en) 1996-05-28
ES2227519T3 (es) 2005-04-01
PT652868E (pt) 2005-01-31
WO1994002465A1 (en) 1994-02-03
EP0652868A1 (en) 1995-05-17

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