DE69231644D1 - Verwendung von makrolid-verbindungen gegen augenerkrankungen - Google Patents

Verwendung von makrolid-verbindungen gegen augenerkrankungen

Info

Publication number
DE69231644D1
DE69231644D1 DE69231644T DE69231644T DE69231644D1 DE 69231644 D1 DE69231644 D1 DE 69231644D1 DE 69231644 T DE69231644 T DE 69231644T DE 69231644 T DE69231644 T DE 69231644T DE 69231644 D1 DE69231644 D1 DE 69231644D1
Authority
DE
Germany
Prior art keywords
compounds
pct
eye diseases
date
macrolid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69231644T
Other languages
English (en)
Other versions
DE69231644T2 (de
Inventor
Manabu Mochizuki
Yoichi Iwaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919109060A external-priority patent/GB9109060D0/en
Priority claimed from GB919121661A external-priority patent/GB9121661D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69231644D1 publication Critical patent/DE69231644D1/de
Publication of DE69231644T2 publication Critical patent/DE69231644T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
DE69231644T 1991-04-26 1992-04-24 Verwendung von makrolid-verbindungen gegen augenerkrankungen Expired - Lifetime DE69231644T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919109060A GB9109060D0 (en) 1991-04-26 1991-04-26 New use
GB919121661A GB9121661D0 (en) 1991-10-11 1991-10-11 New use
PCT/JP1992/000545 WO1992019278A1 (en) 1991-04-26 1992-04-24 Use of macrolide compounds for eye diseases

Publications (2)

Publication Number Publication Date
DE69231644D1 true DE69231644D1 (de) 2001-02-22
DE69231644T2 DE69231644T2 (de) 2001-05-23

Family

ID=26298796

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231644T Expired - Lifetime DE69231644T2 (de) 1991-04-26 1992-04-24 Verwendung von makrolid-verbindungen gegen augenerkrankungen

Country Status (11)

Country Link
US (1) US5514686A (de)
EP (1) EP0581959B1 (de)
JP (1) JP3158437B2 (de)
KR (1) KR100237715B1 (de)
AT (1) ATE198708T1 (de)
CA (1) CA2102241C (de)
DE (1) DE69231644T2 (de)
DK (1) DK0581959T3 (de)
ES (1) ES2154262T3 (de)
GR (1) GR3035269T3 (de)
WO (1) WO1992019278A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
WO1999042104A1 (en) * 1998-02-23 1999-08-26 Fujisawa Pharmaceutical Co., Ltd. Use of macrolide compounds for treating glaucoma
US7265150B1 (en) * 1998-08-14 2007-09-04 Gpi Nil Holdings Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US7410995B1 (en) 1998-08-14 2008-08-12 Gpi Nil Holdings Inc. N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
KR20020015316A (ko) * 1999-04-30 2002-02-27 수캄포 아게 안구 건조증 치료를 위한 매크로라이드 화합물의 용도
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
WO2003004098A1 (en) * 2001-07-06 2003-01-16 Sucampo Ag Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent
BR0214244A (pt) * 2001-11-19 2004-09-21 Novartis Ag Uso de uma ascomicina
AU2002366028A1 (en) * 2001-11-21 2003-06-10 Sucampo Ag Use of fk506 and analogues for treating allergic diseases
EP1536793A1 (de) * 2002-08-09 2005-06-08 Sucampo Pharmaceuticals, Inc. Ophthalmische zusammensetzungen enthaltend derivative von fk506 und deren verwendung in der behandlung von augenallergien
PT1539157E (pt) * 2002-09-18 2013-10-04 Univ Pennsylvania Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal
AR042890A1 (es) * 2003-01-16 2005-07-06 Sucampo Pharmaceuticals Inc Metodo de tratamiento del ojo seco con una composicion oftalmica que contiene un compuesto macrolido
EP1682132A1 (de) * 2003-09-18 2006-07-26 Macusight, Inc. Transsklerale abgabe
EP1848431B1 (de) 2005-02-09 2016-02-03 Santen Pharmaceutical Co., Ltd. Flüssige formulierungen zur behandlung von erkrankungen oder leiden
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
WO2007092620A2 (en) 2006-02-09 2007-08-16 Macusight, Inc. Stable formulations, and methods of their preparation and use
ES2563288T3 (es) 2006-03-23 2016-03-14 Santen Pharmaceutical Co., Ltd Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
JP2010515753A (ja) * 2007-01-10 2010-05-13 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 肺内送達用免疫抑制剤組成物の送達の増強
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
EP3691654A4 (de) 2017-09-25 2021-11-24 Surface Pharmaceuticals, Inc. Ophthalmische pharmazeutische zusammensetzungen und verfahren zur behandlung von augenoberflächenerkrankungen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
GB8616089D0 (en) * 1986-07-02 1986-08-06 Univ Manchester Organic compounds
WO1989005304A1 (en) * 1987-12-09 1989-06-15 Fisons Plc Macrocyclic compounds
EP0356399A3 (de) * 1988-08-26 1991-03-20 Sandoz Ag Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen
DE3906214A1 (de) * 1989-02-28 1990-08-30 Boehringer Mannheim Gmbh Verwendung von macrolactone als antiallergica
WO1990009760A1 (en) * 1989-03-02 1990-09-07 Ensoniq Corporation Apparatus and a method for fitting a hearing aid
IE64214B1 (en) * 1989-06-06 1995-07-26 Fujisawa Pharmaceutical Co Macrolides for the treatment of reversible obstructive airways diseases
US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
KR920700212A (ko) * 1989-06-14 1992-02-19 쟝 크라머·한스 루돌프 하우스 헤테로원자-함유 트리사이클릭 화합물
ZA905202B (en) * 1989-07-05 1991-04-24 Fujisawa Pharmaceutical Co Aqueous liquid composition for external use
ZA924953B (en) * 1991-07-25 1993-04-28 Univ Louisville Res Found Method of treating ocular inflammation

Also Published As

Publication number Publication date
DE69231644T2 (de) 2001-05-23
WO1992019278A1 (en) 1992-11-12
KR100237715B1 (ko) 2000-02-01
EP0581959A1 (de) 1994-02-09
JP3158437B2 (ja) 2001-04-23
CA2102241A1 (en) 1992-10-27
KR940701264A (ko) 1994-05-28
US5514686A (en) 1996-05-07
JPH07500570A (ja) 1995-01-19
CA2102241C (en) 2003-12-30
GR3035269T3 (en) 2001-04-30
DK0581959T3 (da) 2001-01-29
ATE198708T1 (de) 2001-02-15
EP0581959B1 (de) 2001-01-17
ES2154262T3 (es) 2001-04-01

Similar Documents

Publication Publication Date Title
DE69231644T2 (de) Verwendung von makrolid-verbindungen gegen augenerkrankungen
MX9203018A (es) Fluoroalcoxibencilamino-derivados de heterociclos nitrogenados.
DE122006000010I1 (de) Benzocyclobutyl- oder Indanyl-Alkyl-Amino-Alkyl substituierte 3- Benzazepin-2-ones, verwendbar in der Behandlung von kardiovaskularen Krankheiten
FI934223A (fi) Heterocykliscykliska aminderivat
KR960701051A (ko) 이미다조피리딘 및 이를 위장 질환의 치료에 사용하는 방법(imidazopyridines and their use in treating castrointestinal diseases)
NO971766D0 (no) Anvendelsen av dioksomorfoliner for bekjempning av endoparasitter, nye dioksomorfoliner samt deres fremstilling
ATE167476T1 (de) Substituierte 2-phenyl-3-methocypropensäurenester als fungizide mittel.
ATE243694T1 (de) 4-mercaptoacetylamino-(2)benzazepinon(3)- derivate, und verwendung als enkephalinase- inhibitoren
ATE172735T1 (de) Tropyl 7-azaindol-3-ylcarboxamide als antitussivum
DE69907418D1 (de) Verwendung von makroliden zur behandlung von glaukom
ES2193241T3 (es) Nuevas n-2-oxo2.3.4.5-tetrajodrp-1h-1,5-benzodiazepin-3-il)-3-amidas.
ATE180781T1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
FI962323A0 (fi) N-substituoidut atsabisykloheptaanijohdannaiset, kuten esim. neuroleptit
CS9100438A2 (en) New derivative of beta-phenylisoserine, method of its preparation and its application
FI955118A (fi) Herbisidiset substituoidut 1-fenyyli- tai 1-pyridinyyli-bentsotriatsolit
DE59006541D1 (de) Mittel zum Schutz von Pflanzen gegen Krankheiten.
GB9116056D0 (en) Compounds
DK259589A (da) Joderede, ikke-ioniske trijodbenzenforbindelser og kontrastmiddel indeholdende dem
DE59006159D1 (de) Verwendung von macrolactonen als antiallergica.
BR9306388A (pt) Polipetídios bloqueadores dos canais de cálcio derivados de filistata hibernalis
NO880405D0 (no) Fremgangsmaate til fremstilling av 3-fenyl-7h-tiazolo-/3,2-b//1,2,4/-tiazine-7-oner.
NO305556B1 (no) Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
ATE3751T1 (de) Wasserloesliche polyester und polycarbonate zur verwendung als antitumorwirkstoffe.
DE59208712D1 (de) Neue cytarabin-derivate, ihre herstellung und verwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP

R071 Expiry of right

Ref document number: 581959

Country of ref document: EP