DE60129222D1 - Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3 - Google Patents
Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3Info
- Publication number
- DE60129222D1 DE60129222D1 DE60129222T DE60129222T DE60129222D1 DE 60129222 D1 DE60129222 D1 DE 60129222D1 DE 60129222 T DE60129222 T DE 60129222T DE 60129222 T DE60129222 T DE 60129222T DE 60129222 D1 DE60129222 D1 DE 60129222D1
- Authority
- DE
- Germany
- Prior art keywords
- glycogen synthase
- synthase kinase
- disease
- heterocyclic inhibitors
- gsk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/13—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/597—Unsaturated compounds containing a keto groups being part of a ring of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001185A ES2166328B1 (es) | 2000-05-11 | 2000-05-11 | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
ES200001185 | 2000-05-11 | ||
GB0030284 | 2000-12-12 | ||
GB0030284A GB0030284D0 (en) | 2000-05-11 | 2000-12-12 | Enzyme inhibitors |
PCT/GB2001/002100 WO2001085685A1 (en) | 2000-05-11 | 2001-05-11 | Heterocyclic inhibitors of glycogen synthase kinase gsk-3 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60129222D1 true DE60129222D1 (de) | 2007-08-16 |
DE60129222T2 DE60129222T2 (de) | 2008-03-06 |
Family
ID=26156184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60129222T Expired - Lifetime DE60129222T2 (de) | 2000-05-11 | 2001-05-11 | Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3 |
Country Status (19)
Country | Link |
---|---|
US (3) | US6872737B2 (de) |
EP (1) | EP1286964B1 (de) |
KR (1) | KR100812407B1 (de) |
CN (1) | CN100358867C (de) |
AT (1) | ATE366238T1 (de) |
AU (1) | AU783615B2 (de) |
BR (1) | BR0110734A (de) |
CA (1) | CA2408747C (de) |
CY (1) | CY1106826T1 (de) |
CZ (1) | CZ296087B6 (de) |
DE (1) | DE60129222T2 (de) |
DK (1) | DK1286964T3 (de) |
ES (1) | ES2288948T3 (de) |
HU (1) | HUP0302002A3 (de) |
IL (1) | IL152721A0 (de) |
MX (1) | MXPA02011079A (de) |
PL (1) | PL209780B1 (de) |
RU (1) | RU2294931C2 (de) |
WO (1) | WO2001085685A1 (de) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2294931C2 (ru) * | 2000-05-11 | 2007-03-10 | Консехо Супериор Инвестигасионес Сьентификас | Гетероциклические ингибиторы гликоген-синтазы киназы gsk-3 |
WO2003018554A1 (en) * | 2001-08-24 | 2003-03-06 | Wyeth Holdings Corporation | 3-substituted-3-(substitutedsulfonyl or sulfanyl)pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase |
WO2003018011A1 (en) * | 2001-08-24 | 2003-03-06 | Wyeth Holdings Corporation | 5-(substituted)-5-(substitutedsulfonyl or sulfanyl)thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase |
JP2006508939A (ja) * | 2002-10-29 | 2006-03-16 | エンジーン, インコーポレイテッド | 癌処置のための組成物 |
GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
GB0327908D0 (en) * | 2003-12-02 | 2004-01-07 | Neuropharma Sa | GSK-3 inhibitors isolated from marine organisms |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
EP1574499A1 (de) * | 2004-03-08 | 2005-09-14 | DKFZ Deutsches Krebsforschungszentrum | DNA-Methylerungshemmer in Tumorzellen |
EP1586318A1 (de) * | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiadiazolidinone als GSK3-Inhibitoren |
US8771754B2 (en) * | 2004-09-17 | 2014-07-08 | Vanderbilt University | Use of GSK3 inhibitors in combination with radiation therapies |
WO2006045581A1 (en) * | 2004-10-21 | 2006-05-04 | Neuropharma, S.A. | The use of 1, 2, 4-thiadiazolidine-3, 5-diones as ppar activators |
SE0500058D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 5 |
SE0500056D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 4 |
WO2006073363A1 (en) * | 2005-01-10 | 2006-07-13 | Astrazeneca Ab | Derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x receptor modulators |
SE0500055D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 3 |
JP2008526842A (ja) * | 2005-01-10 | 2008-07-24 | アストラゼネカ アクチボラグ | 肝x受容体モジュレーターとしてのイソチアゾール−3(2h)−チオン1,1−ジオキシドのアニリン誘導体 |
US7713969B2 (en) | 2005-02-09 | 2010-05-11 | Arqule, Inc. | Compositions and methods for treatment of cancer |
ES2258406B1 (es) * | 2005-02-10 | 2007-12-01 | Neuropharma, S.A. | Uso de compuestos heterociclicos como agentes neurogenicos. |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2377530A3 (de) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation von Neurogenese durch PDE-Hemmung |
WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2026813A2 (de) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5-ht-rezeptor-vermittelte neurogenese |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
US8168667B2 (en) | 2006-05-31 | 2012-05-01 | Galapagos Nv | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
US9180118B2 (en) | 2006-07-18 | 2015-11-10 | University Of Rochester | Thiadiazolidinone derivatives |
KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20100222304A1 (en) | 2006-11-02 | 2010-09-02 | Lillian W Chiang | Methods of Treating Neuropathic Pain by Modulation of Glycogenolysis or Glycolysis |
CA2912546A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Compositions and methods for treatment of cancer |
EP2173724B1 (de) | 2007-06-22 | 2012-12-05 | ArQule, Inc. | Chinazolinonverbindungen und verfahren zu ihrer anwendung |
JP5425060B2 (ja) | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−2,5−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
MX2010014066A (es) * | 2008-06-16 | 2011-06-01 | Univ Tennessee Res Foundation | Compuestos para el tratamiento del cancer. |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
GB2463514C (en) | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
CN101519372B (zh) * | 2009-04-01 | 2011-07-20 | 深圳市盛捷生物技术有限公司 | 用作GSK3抑制剂的苯并[e]异吲哚-1,3-二酮化合物及其制备 |
WO2011004162A2 (en) * | 2009-07-08 | 2011-01-13 | Betagenon Ab | Compounds useful as medicaments |
ITNA20090047A1 (it) * | 2009-07-16 | 2011-01-17 | Adele Bolognese | Agenti antitumorali con attività inibitoria di proteine di prenilazione, processo di preparazione e impieghi in campo medico |
US8765920B2 (en) | 2009-12-23 | 2014-07-01 | The Scripps Research Institute | Tyrosine bioconjugation through aqueous Ene-like reactions |
WO2011109059A1 (en) | 2010-03-01 | 2011-09-09 | Gtx, Inc. | Compounds for treatment of cancer |
WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
BR112013015774A2 (pt) | 2010-12-01 | 2018-05-22 | Nissan Chemical Industries Ltd | compostos de pirazol tendo efeito terapêutico sobre mieloma múltiplo. |
WO2012149335A2 (en) * | 2011-04-28 | 2012-11-01 | Richard Neubig | Small molecule inhibitors of rgs proteins |
EP2527323A1 (de) | 2011-05-24 | 2012-11-28 | Noscira, S.A. | Harnstoffcarbonyldisulfidderivate und deren therapeutische Verwendungen |
WO2013020024A2 (en) * | 2011-08-03 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Maleimide compounds and methods of treatment |
WO2013108026A1 (en) | 2012-01-17 | 2013-07-25 | Baltic Bio Ab | Thiadiazolone derivatives useful in the treatment of diabetes |
IN2014DN07885A (de) | 2012-02-24 | 2015-04-24 | Asd Therapeutics Partners Llc | |
CN103992312A (zh) * | 2013-02-18 | 2014-08-20 | 江苏欧威医药有限公司 | 1,2,4-噻二唑-3,5-二酮衍生物及其药物组合物和应用 |
ES2908026T3 (es) | 2013-03-14 | 2022-04-27 | Brigham & Womens Hospital Inc | Composiciones y procedimientos para la expansión y el cultivo de células madre epiteliales |
US9949961B2 (en) * | 2013-03-14 | 2018-04-24 | Rahimdzhan Roziev | Agent for the prophylaxis and/or treatment of neoplastic diseases |
WO2015017549A1 (en) | 2013-07-30 | 2015-02-05 | University Of South Florida (A Florida Non-Profit Corporation) | Treating an atypical protein kinase c enzyme abnormality |
CA2945263A1 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
US10568883B2 (en) | 2014-09-03 | 2020-02-25 | Massachusetts Institute Of Technology | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
WO2016090355A2 (en) * | 2014-12-05 | 2016-06-09 | Massachusetts Institute Of Technology | Catechol-rich polymers from n-substituted maleimides |
SG11201707585UA (en) | 2015-03-17 | 2017-10-30 | Regeneron Pharma | Amino acid acylation reagents and methods of using the same |
CA3010610A1 (en) | 2016-01-08 | 2017-07-13 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
AU2017386417B2 (en) | 2016-12-30 | 2022-07-14 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
RU2761429C2 (ru) * | 2018-06-13 | 2021-12-08 | Общество с ограниченной ответственностью "Тиацен" | Средство, обладающее противоопухолевым действием, для лечения онкологических заболеваний |
EP3837352A1 (de) | 2018-08-17 | 2021-06-23 | Frequency Therapeutics, Inc. | Zusammensetzungen und verfahren zur erzeugung von haarzellen durch hochregulieren von jag-1 |
US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
WO2020163812A1 (en) | 2019-02-08 | 2020-08-13 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
CN110698380B (zh) * | 2019-10-24 | 2021-01-15 | 华东理工大学 | 一种内酰胺衍生物及其制备方法与应用 |
US20220249448A1 (en) * | 2021-02-11 | 2022-08-11 | Venca Research, Inc. | Compositions and methods for treating arrhythmogenic cardiomyopathy |
WO2022243973A1 (en) | 2021-05-21 | 2022-11-24 | Amo Pharma Ltd. | Method of treating rna repeat mediated diseases with rna repeat binding compound |
EP4094760A1 (de) | 2021-05-24 | 2022-11-30 | Consejo Superior De Investigaciones Científicas | Thiadiazolidinone zur verwendung in der behandlung von gliedergürtel-muskeldystrophie |
CN115197167B (zh) * | 2022-07-22 | 2023-07-28 | 中国药科大学 | 1,2,4-噻二唑烷-3,5-二酮化合物及其制备方法和应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863803A (en) | 1957-05-13 | 1958-12-09 | Stauffer Chemical Co | Protecting materials against fungi by applying substituted dithiono and thiono-oxo-thiadiazolidines |
US3301894A (en) * | 1964-11-16 | 1967-01-31 | Olin Mathieson | S-[nu'-(chlorocarbonyl)-amino] isothiocarbamyl chlorides and their preparation |
DE1670701A1 (de) | 1966-05-23 | 1970-11-12 | Bayer Ag | Verfahren zur Darstellung von Thiaimidazolidinen |
US3900485A (en) | 1967-02-10 | 1975-08-19 | Velsicol Chemical Corp | New substituted 1,2,4-thiadiazolidine-3,5-diones |
US3534057A (en) * | 1968-05-28 | 1970-10-13 | Velsicol Chemical Corp | Halogenation process for the production of certain oxadiazolidines and thiadiazolidines |
DE2109755A1 (de) | 1971-03-02 | 1972-09-07 | Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen | Substituierte Thiadiazolidindione |
US4183816A (en) * | 1978-11-01 | 1980-01-15 | Olin Corporation | Use of 2,4-di(lower alkyl)-1,2,4-thiadiazolidin-3,5-diones as additives for functional fluids |
JPS58216177A (ja) | 1982-06-10 | 1983-12-15 | Sumitomo Chem Co Ltd | フエニルチアジアゾリジンジオン誘導体、その製造法および該化合物を有効成分として含有する除草剤 |
ES2236702T3 (es) * | 1993-12-23 | 2005-07-16 | Eli Lilly And Company | Inhibidores de la proteina quinasa c. |
JP3714685B2 (ja) * | 1994-05-18 | 2005-11-09 | 第一サントリーファーマ株式会社 | ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体 |
DE4420522A1 (de) * | 1994-06-13 | 1995-12-14 | Bayer Ag | Bakterizide Thiadiazolidinone |
ATE284387T1 (de) * | 1998-10-08 | 2004-12-15 | Smithkline Beecham Plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
GB9828640D0 (en) * | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
GB9918180D0 (en) * | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
RU2294931C2 (ru) | 2000-05-11 | 2007-03-10 | Консехо Супериор Инвестигасионес Сьентификас | Гетероциклические ингибиторы гликоген-синтазы киназы gsk-3 |
GB0012056D0 (en) | 2000-05-18 | 2000-07-12 | Consejo Superior Investigacion | Model for neurodegenerative disease |
EP1586318A1 (de) | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiadiazolidinone als GSK3-Inhibitoren |
-
2001
- 2001-05-11 RU RU2002133222/04A patent/RU2294931C2/ru not_active IP Right Cessation
- 2001-05-11 WO PCT/GB2001/002100 patent/WO2001085685A1/en active IP Right Grant
- 2001-05-11 CA CA2408747A patent/CA2408747C/en not_active Expired - Lifetime
- 2001-05-11 HU HU0302002A patent/HUP0302002A3/hu unknown
- 2001-05-11 DE DE60129222T patent/DE60129222T2/de not_active Expired - Lifetime
- 2001-05-11 CZ CZ20023692A patent/CZ296087B6/cs not_active IP Right Cessation
- 2001-05-11 DK DK01928117T patent/DK1286964T3/da active
- 2001-05-11 EP EP01928117A patent/EP1286964B1/de not_active Expired - Lifetime
- 2001-05-11 CN CNB01812738XA patent/CN100358867C/zh not_active Expired - Lifetime
- 2001-05-11 MX MXPA02011079A patent/MXPA02011079A/es active IP Right Grant
- 2001-05-11 AT AT01928117T patent/ATE366238T1/de active
- 2001-05-11 ES ES01928117T patent/ES2288948T3/es not_active Expired - Lifetime
- 2001-05-11 KR KR1020027015132A patent/KR100812407B1/ko not_active IP Right Cessation
- 2001-05-11 AU AU54981/01A patent/AU783615B2/en not_active Ceased
- 2001-05-11 IL IL15272101A patent/IL152721A0/xx unknown
- 2001-05-11 PL PL359671A patent/PL209780B1/pl unknown
- 2001-05-11 BR BR0110734-8A patent/BR0110734A/pt not_active Application Discontinuation
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2002
- 2002-11-08 US US10/290,569 patent/US6872737B2/en not_active Expired - Lifetime
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2004
- 2004-08-12 US US10/917,175 patent/US7666885B2/en not_active Expired - Lifetime
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- 2007-04-20 US US11/788,755 patent/US7781463B2/en not_active Expired - Fee Related
- 2007-08-30 CY CY20071101111T patent/CY1106826T1/el unknown
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CZ296087B6 (cs) | 2006-01-11 |
CA2408747A1 (en) | 2001-11-15 |
IL152721A0 (en) | 2003-06-24 |
AU783615B2 (en) | 2005-11-17 |
MXPA02011079A (es) | 2004-08-19 |
CZ20023692A3 (cs) | 2003-06-18 |
US7781463B2 (en) | 2010-08-24 |
US20050014803A1 (en) | 2005-01-20 |
CN1568310A (zh) | 2005-01-19 |
EP1286964B1 (de) | 2007-07-04 |
ES2288948T3 (es) | 2008-02-01 |
US20030195238A1 (en) | 2003-10-16 |
PL209780B1 (pl) | 2011-10-31 |
US7666885B2 (en) | 2010-02-23 |
CY1106826T1 (el) | 2012-05-23 |
RU2294931C2 (ru) | 2007-03-10 |
KR100812407B1 (ko) | 2008-03-11 |
WO2001085685A1 (en) | 2001-11-15 |
HUP0302002A3 (en) | 2007-02-28 |
HUP0302002A2 (hu) | 2003-09-29 |
US6872737B2 (en) | 2005-03-29 |
DK1286964T3 (da) | 2007-10-01 |
PL359671A1 (en) | 2004-09-06 |
KR20030025919A (ko) | 2003-03-29 |
CA2408747C (en) | 2011-04-05 |
CN100358867C (zh) | 2008-01-02 |
BR0110734A (pt) | 2003-02-04 |
EP1286964A1 (de) | 2003-03-05 |
ATE366238T1 (de) | 2007-07-15 |
DE60129222T2 (de) | 2008-03-06 |
AU5498101A (en) | 2001-11-20 |
US20080033012A1 (en) | 2008-02-07 |
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